Analysis of Knowles QTL data
ERM
2023-09-28
Last updated: 2023-09-28
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Knit directory: Cardiotoxicity/
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package loading
library(limma)
library(RColorBrewer)
library(tidyverse)
library(ggsignif)
library(cowplot)
library(ggpubr)
library(scales)
library(sjmisc)
library(kableExtra)
library(broom)
library(ComplexHeatmap)
library(ggVennDiagram)function load
cpm_boxplot <-
function(cpmcounts,
GOI,
brewer_palette,
fill_colors,
ylab) {
##GOI needs to be ENTREZID
df <- cpmcounts
df_plot <- df %>%
dplyr::filter(rownames(.) == GOI) %>%
pivot_longer(everything(),
names_to = "treatment",
values_to = "counts") %>%
separate(treatment, c("drug", "indv", "time")) %>%
mutate(time = factor(time, levels = c("3h", "24h"))) %>%
mutate(indv = factor(indv, levels = c(1, 2, 3, 4, 5, 6))) %>%
mutate(
drug = case_match(
drug,
"Da" ~ "DNR",
"Do" ~ "DOX",
"Ep" ~ "EPI",
"Mi" ~ "MTX",
"Tr" ~ "TRZ",
"Ve" ~ "VEH",
.default = drug
)
) %>%
mutate(drug = factor(drug, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH')))
plot <- ggplot2::ggplot(df_plot, aes(x = drug, y = counts)) +
geom_boxplot(position = "identity", aes(fill = drug)) +
geom_point(aes(
col = indv,
size = 1.5,
alpha = 0.5
)) +
guides(alpha = "none", size = "none") +
scale_color_brewer(palette = brewer_palette, guide = "none") +
scale_fill_manual(values = fill_colors) +
facet_wrap("time", nrow = 1, ncol = 2) +
theme_bw() +
ylab(ylab) +
xlab("") +
theme(
strip.background = element_rect(
fill = "white",
linetype = 1,
linewidth = 0.5
),
plot.title = element_text(
size = 10,
hjust = 0.5,
face = "bold"
),
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(linewidth = 1.0),
axis.line = element_line(linewidth = 1.0),
axis.text.x = element_blank(),
strip.text.x = element_text(margin = margin(2, 0, 2, 0, "pt"), face = "bold")
)
print(plot)
}
cpm_boxplot_time <-
function(cpmcounts,
timex,
GOI,
brewer_palette,
fill_colors,
ylab) {
##GOI needs to be ENTREZID
df <- cpmcounts
df_plot <- df %>%
dplyr::filter(rownames(.)==GOI) %>%
pivot_longer(everything(),
names_to = "treatment",
values_to = "counts") %>%
separate(treatment, c("drug","indv","time")) %>%
dplyr::filter(time == paste(timex)) %>%
mutate(time=factor(time, levels =c("3h", "24h"), labels=c("3 hours", "24 hours"))) %>%
mutate(indv=factor(indv, levels = c(1,2,3,4,5,6))) %>%
mutate(drug =case_match(drug, "Da"~"DNR",
"Do"~"DOX",
"Ep"~"EPI",
"Mi"~"MTX",
"Tr"~"TRZ",
"Ve"~"VEH", .default = drug)) %>%
mutate(drug=factor(drug, levels = c('DOX','EPI','DNR','MTX','TRZ','VEH')))
plot <- ggplot2::ggplot(df_plot, aes(x=drug, y=counts))+
geom_boxplot(position="identity",aes(fill=drug))+
geom_point(aes(col=indv, size=1.5, alpha=0.5))+
guides(alpha= "none", size= "none")+
scale_color_brewer(palette = brewer_palette, guide = "none")+
scale_fill_manual(values=fill_colors)+
# try(facet_wrap("time", nrow=1, ncol=2))+
theme_bw()+
ylab(ylab)+
xlab("")+
theme(strip.background = element_rect(fill = "white",linetype=1, linewidth = 0.5),
plot.title = element_text(size=10,hjust = 0.5,face="bold"),
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(linewidth = 1.0),
axis.line = element_line(linewidth = 1.0),
axis.text.x = element_blank(),
strip.text.x = element_text(margin = margin(2,0,2,0, "pt"),face = "bold"))
print(plot)
}Knowles data
The code below is how I wrangled the knowles supplemental lists into entrezgene_ids to overlap with my expressed gene lists
Enrichment of Pairwise
A note on Knowles data sets: the intersection of the Knowles-4 and Knowles-5 sets yielded 104 genes in
backGL <- read.csv("data/backGL.txt")
# drug_palNoVeh <- c("#8B006D","#DF707E","#F1B72B", "#3386DD","#707031")
drug_palc <- c("#8B006D","#DF707E","#F1B72B", "#3386DD","#707031","#41B333")
time <- rep((rep(c("3h", "24h"), c(6,6))), 6)
time <- ordered(time, levels =c("3h", "24h"))
drug <- rep(c("DNR","DOX","EPI","MTX","TRZ", "Vehicle"),12)
mat_drug <- c("DNR","DOX","EPI","MTX")
indv <- as.factor(rep(c(1,2,3,4,5,6), c(12,12,12,12,12,12)))
labeltop <- (interaction(substring(drug, 0, 2), indv, time))
level_order2 <- c('75','87','77','79','78','71')
toplistall <- readRDS("data/toplistall.RDS")
knowles4 <-readRDS("output/knowles4.RDS")
knowles5 <-readRDS("output/knowles5.RDS")
DOXmeSNPs <- readRDS("output/DOXmeSNPs.RDS")
DOXreQTLs <- readRDS("output/DOXreQTLs.RDS")
DNRmeSNPs <- readRDS("output/DNRmeSNPs.RDS")
DNRreQTLs <- readRDS("output/DNRreQTLs.RDS")
EPImeSNPs <- readRDS("output/EPImeSNPs.RDS")
EPIreQTLs <- readRDS("output/EPIreQTLs.RDS")
MTXmeSNPs <- readRDS("output/MTXmeSNPs.RDS")
MTXreQTLs <- readRDS("output/MTXreQTLs.RDS")
cpmcounts <- readRDS("data/cpmcount.RDS")
toplist24hr <- toplistall %>%
mutate(id =case_match(id, "Da"~"DNR",
"Do"~"DOX",
"Ep"~"EPI",
"Mi"~"MTX",
"Tr"~"TRZ",
"Ve"~"VEH", .default = id)) %>%
mutate(id=factor(id, levels = c('DOX','EPI','DNR','MTX','TRZ','VEH'))) %>%
mutate(time=factor(time, levels=c("3_hours","24_hours"))) %>%
filter(time=="24_hours")
toplist3hr <- toplistall %>%
mutate(id =case_match(id, "Da"~"DNR",
"Do"~"DOX",
"Ep"~"EPI",
"Mi"~"MTX",
"Tr"~"TRZ",
"Ve"~"VEH", .default = id)) %>%
mutate(id=factor(id, levels = c('DOX','EPI','DNR','MTX','TRZ','VEH'))) %>%
mutate(id = as.factor(id)) %>%
mutate(time=factor(time, levels=c("3_hours","24_hours"))) %>%
filter(time=="3_hours")Determining the genetic basis of anthracycline-cardiotoxicity by
molecular response QTL mapping in induced cardiomyocytes
David A Knowles, Courtney K Burrows†, John D Blischak, Kristen M
Patterson, Daniel J Serie, Nadine Norton, Carole Ober, Jonathan K
Pritchard, Yoav Gilad
Knowles \(~~et~ al.~\) eLife 2018;7:e33480. DOI: https://doi.org/10.7554/eLife.33480
My first question was about transcriptional response at the 24 hour mark with my treatments. 3 hour RNA-seq had low numbers of DEGs,so my initial focus is at 24 hours. This time also happens to be when the Knowles paper collected their RNA-seq data.
Supplementary 4 contains a list of 518 SNPs within 1 Mb of TSS, which had a detectable marginal effect on expression (5% FDR). When converted from ensembl gene id to entrez gene id, my list of genes for this supplement = 417. I will call these meSNPS for marginal effect QTLs.
Supplementary 5 contains a list of 376 response eQTLs (reQTLs). These are variants that were associated with modulation of transcriptomic response to DOX treatment. After database name conversion, I have 273 genes.
meSNPdf <- toplistall %>%
mutate(id = factor(id, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH'))) %>%
mutate(time = factor(time, levels = c("3_hours", "24_hours"))) %>%
mutate(sigcount = if_else(adj.P.Val < 0.05, 'sig', 'notsig')) %>%
mutate(meSNP = if_else(ENTREZID %in% knowles4$entrezgene_id, "y" , "no")) %>%
dplyr::select(ENTREZID, id, time, meSNP, sigcount) %>%
group_by(id, time, meSNP, sigcount) %>%
tally() %>%
pivot_wider(
id_cols = c(id, time, sigcount),
names_from = meSNP,
names_glue = "meSNP_{meSNP}",
values_from = n
)
meSNPdf %>%
kable(., caption = "Number of genes from minimally expressed SNPs found in DEGs (sig and nonsig) broken down by drug,time, and significance") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped"),
font_size = 18
) %>%
scroll_box(width = "80%", height = "400px")| id | time | sigcount | meSNP_no | meSNP_y |
|---|---|---|---|---|
| DOX | 3_hours | notsig | 13665 | 400 |
| DOX | 3_hours | sig | 19 | NA |
| DOX | 24_hours | notsig | 7181 | 258 |
| DOX | 24_hours | sig | 6503 | 142 |
| EPI | 3_hours | notsig | 13477 | 397 |
| EPI | 3_hours | sig | 207 | 3 |
| EPI | 24_hours | notsig | 7484 | 272 |
| EPI | 24_hours | sig | 6200 | 128 |
| DNR | 3_hours | notsig | 13156 | 396 |
| DNR | 3_hours | sig | 528 | 4 |
| DNR | 24_hours | notsig | 6828 | 239 |
| DNR | 24_hours | sig | 6856 | 161 |
| MTX | 3_hours | notsig | 13611 | 398 |
| MTX | 3_hours | sig | 73 | 2 |
| MTX | 24_hours | notsig | 12585 | 384 |
| MTX | 24_hours | sig | 1099 | 16 |
| TRZ | 3_hours | notsig | 13684 | 400 |
| TRZ | 24_hours | notsig | 13684 | 400 |
reQTLdf <- toplistall %>%
mutate(id = factor(id, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH'))) %>%
mutate(time = factor(time, levels = c("3_hours", "24_hours"))) %>%
mutate(sigcount = if_else(adj.P.Val < 0.05, 'sig', 'notsig')) %>%
mutate(reQTL = if_else(ENTREZID %in% knowles5$entrezgene_id, "y" , "no")) %>%
dplyr::select(ENTREZID, id, time, reQTL, sigcount) %>%
group_by(id, time, reQTL, sigcount) %>%
tally() %>%
pivot_wider(
id_cols = c(id, time, sigcount),
names_from = reQTL,
names_glue = "reQTL_{reQTL}",
values_from = n
)
reQTLdf %>%
kable(., caption = "Number of genes from response eQTLS found in DEGs (sig and nonsig) broken down by drug,time, and significance") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped"),
font_size = 18
) %>%
scroll_box(width = "80%", height = "400px")| id | time | sigcount | reQTL_no | reQTL_y |
|---|---|---|---|---|
| DOX | 3_hours | notsig | 13794 | 271 |
| DOX | 3_hours | sig | 19 | NA |
| DOX | 24_hours | notsig | 7310 | 129 |
| DOX | 24_hours | sig | 6503 | 142 |
| EPI | 3_hours | notsig | 13606 | 268 |
| EPI | 3_hours | sig | 207 | 3 |
| EPI | 24_hours | notsig | 7616 | 140 |
| EPI | 24_hours | sig | 6197 | 131 |
| DNR | 3_hours | notsig | 13293 | 259 |
| DNR | 3_hours | sig | 520 | 12 |
| DNR | 24_hours | notsig | 6944 | 123 |
| DNR | 24_hours | sig | 6869 | 148 |
| MTX | 3_hours | notsig | 13739 | 270 |
| MTX | 3_hours | sig | 74 | 1 |
| MTX | 24_hours | notsig | 12725 | 244 |
| MTX | 24_hours | sig | 1088 | 27 |
| TRZ | 3_hours | notsig | 13813 | 271 |
| TRZ | 24_hours | notsig | 13813 | 271 |
dataframK_45 <- toplistall %>%
mutate(
id = case_match(
id,
"Da" ~ "DNR",
"Do" ~ "DOX",
"Ep" ~ "EPI",
"Mi" ~ "MTX",
"Tr" ~ "TRZ",
"Ve" ~ "VEH",
.default = id
)
) %>%
mutate(id = factor(id, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH'))) %>%
mutate(time = factor(time, levels = c("3_hours", "24_hours"))) %>%
mutate(K4 = if_else(ENTREZID %in% knowles4$entrezgene_id, 'y', 'no')) %>%
mutate(K5 = if_else(ENTREZID %in% knowles5$entrezgene_id, 'y', 'no')) %>%
filter(adj.P.Val < 0.05) %>%
group_by(time, id) %>%
dplyr::summarize(n = n(),
meSNP = sum(if_else(K4 == "y", 1, 0)),
reQTL = sum(if_else(K5 == "y", 1, 0))) %>%
as.data.frame()
dataframK_45 %>%
kable(., caption = "Summary of meSNPs and reQTLs found in my DEGs") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(font_size = 18) %>%
scroll_box(width = "80%", height = "400px")| time | id | n | meSNP | reQTL |
|---|---|---|---|---|
| 3_hours | DOX | 19 | 0 | 0 |
| 3_hours | EPI | 210 | 3 | 3 |
| 3_hours | DNR | 532 | 4 | 12 |
| 3_hours | MTX | 75 | 2 | 1 |
| 24_hours | DOX | 6645 | 142 | 142 |
| 24_hours | EPI | 6328 | 128 | 131 |
| 24_hours | DNR | 7017 | 161 | 148 |
| 24_hours | MTX | 1115 | 16 | 27 |
Visualization of proportions
toplistall %>%
mutate(id = factor(id, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH'))) %>%
mutate(time = factor(time, levels = c("3_hours", "24_hours"))) %>%
mutate(sigcount = if_else(adj.P.Val < 0.05, 'sig', 'notsig')) %>%
mutate(meSNP = if_else(ENTREZID %in% knowles4$entrezgene_id, "y", "no")) %>%
mutate(reQTL = if_else(ENTREZID %in% knowles5$entrezgene_id, "a", "b")) %>%
filter(time == "24_hours") %>%
group_by(id, sigcount, meSNP) %>%
summarize(K4count = n()) %>%
pivot_wider(
id_cols = c(id, sigcount),
names_from = c(meSNP),
values_from = K4count
) %>%
mutate(SNPprop = (y / (y + no) * 100)) %>%
ggplot(., aes(x = id, y = SNPprop)) +
geom_col() +
geom_text(aes(
x = id,
label = sprintf("%.2f", SNPprop),
vjust = -.2
)) +
facet_wrap( ~ sigcount) +
ggtitle("non-significant and significant enrichment proportions of Knowles meSNPs ")
toplistall %>%
mutate(id = factor(id, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH'))) %>%
mutate(time = factor(time, levels = c("3_hours", "24_hours"))) %>%
mutate(sigcount = if_else(adj.P.Val < 0.05, 'sig', 'notsig')) %>%
mutate(meSNP = if_else(ENTREZID %in% knowles4$entrezgene_id, "y", "no")) %>%
mutate(reQTL = if_else(ENTREZID %in% knowles5$entrezgene_id, "a", "b")) %>%
filter(time == "24_hours") %>%
group_by(id, sigcount, reQTL) %>%
summarize(K5count = n()) %>%
pivot_wider(
id_cols = c(id, sigcount),
names_from = c(reQTL),
values_from = K5count
) %>%
mutate(QTLprop = (a / (a + b) * 100)) %>%
ggplot(., aes(x = id, y = QTLprop)) +
geom_col() +
geom_text(aes(
x = id,
label = sprintf("%.2f", QTLprop),
vjust = -.2
)) +
facet_wrap( ~ sigcount) +
ggtitle("non-significant and significant enrichment proportions of Knowles reQTLs ")
chi_squarek4 <- toplistall %>%
mutate(id = factor(id, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH'))) %>%
dplyr::filter(id != "TRZ") %>%
mutate(sigcount = if_else(adj.P.Val < 0.05, 'sig', 'notsig')) %>%
mutate(meSNP = if_else(ENTREZID %in% knowles4$entrezgene_id, "y", "no")) %>%
group_by(id, time) %>%
summarise(pvalue = chisq.test(meSNP, sigcount)$p.value)
chi_squarek5 <- toplistall %>%
mutate(id = factor(id, levels = c('DOX', 'EPI', 'DNR', 'MTX', 'TRZ', 'VEH'))) %>%
dplyr::filter(id != "TRZ") %>%
mutate(sigcount = if_else(adj.P.Val < 0.05, 'sig', 'notsig')) %>%
mutate(reQTL = if_else(ENTREZID %in% knowles5$entrezgene_id, "a", "b")) %>%
group_by(id, time) %>%
summarise(pvalue = chisq.test(reQTL, sigcount)$p.value)
chi_squarek4 %>%
kable(., caption = "meSNPs (mininmally expressed QTLS) chi-squared pvalues") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "right",
bootstrap_options = c("striped"),
font_size = 18
) %>% scroll_box(width = "50%", height = "400px")| id | time | pvalue |
|---|---|---|
| DOX | 24_hours | 0.0000026 |
| DOX | 3_hours | 0.9563346 |
| EPI | 24_hours | 0.0000002 |
| EPI | 3_hours | 0.3023606 |
| DNR | 24_hours | 0.0001261 |
| DNR | 3_hours | 0.0047603 |
| MTX | 24_hours | 0.0043791 |
| MTX | 3_hours | 1.0000000 |
chi_squarek5 %>%
kable(., caption = "reQTLS (response eQTLS) chi-squared pvalues") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "right",
bootstrap_options = c("striped"),
font_size = 18
) %>% scroll_box(width = "50%", height = "400px")| id | time | pvalue |
|---|---|---|
| DOX | 24_hours | 0.0937665 |
| DOX | 3_hours | 1.0000000 |
| EPI | 24_hours | 0.2812223 |
| EPI | 3_hours | 0.7843268 |
| DNR | 24_hours | 0.1257321 |
| DNR | 3_hours | 0.6843822 |
| MTX | 24_hours | 0.2516965 |
| MTX | 3_hours | 1.0000000 |
We can “see” the proportions of SNPs are not enriched significantly
in the DE genes compared to the non-DE genes (chi square test).
We do not see significant enrichment of reQTLS in our DE gene sets over
the non-DE gene sets.
So what about enrichment of meSNPs in DE compared to reQTLs in significantly DE gene sets?
Knowles_count <-
toplistall %>%
filter(id != 'TRZ') %>%
mutate(id = as.factor(id)) %>%
mutate(time = factor(time, levels = c("3_hours", "24_hours"))) %>%
group_by(time, id) %>%
mutate(K4 = if_else(ENTREZID %in% knowles4$entrezgene_id, 1, 0)) %>%
mutate(K5 = if_else(ENTREZID %in% knowles5$entrezgene_id, 1, 0)) %>%
filter(adj.P.Val < 0.05) %>%
dplyr::summarize(n = n(),
K4 = sum(K4),
K5 = sum(K5)) %>%
as.tibble() %>%
dplyr::select(time, id, K4, K5) %>% rename("K4_y" = 'K4', "K5_y" = 'K5') %>%
mutate(time = case_match(time, '3_hours' ~ '3 hrs',
'24_hours' ~ '24 hrs', .default = time)) %>%
mutate(K4_n = 417 - K4_y, K5_n = 273 - K5_y) %>%
pivot_longer(!c(time, id), names_to = 'QTL', values_to = "gene_count") %>%
separate(QTL, into = c("QTL_type", 'group'), sep = '_') %>%
mutate(
QTL_type = case_match(
QTL_type,
'K4' ~ 'base\negenes',
'K5' ~ 'response\negenes',
.default = QTL_type
)
) %>%
mutate(time = factor(time, levels = c("3 hrs", "24 hrs"))) %>%
group_by(id, time, QTL_type) %>%
mutate(percent = gene_count / sum(gene_count) * 100) %>%
mutate(group = factor(
group,
levels = c("n", "y"),
labels = c("not DE", "DE")
))
ggplot(Knowles_count,
aes(
x = QTL_type,
y = gene_count,
group = group,
fill = group
)) +
geom_col(position = 'fill') +
# guides(fill="none")+
facet_wrap(time ~ id, nrow = 2, ncol = 4) +
theme_classic() +
scale_color_manual(values = drug_palc) +
scale_fill_manual(values = drug_palc) +
scale_y_continuous(labels = scales::percent) +
theme(
strip.text = element_text(size = 10, face = "bold"),
strip.text.x = element_text(margin = margin(2, 0, 2, 0, "pt")),
strip.background = element_rect (linetype = 1, linewidth = 0.5)
)
###This works
chi_frame <- Knowles_count %>%
pivot_wider(
id_cols = c(time, id, QTL_type),
names_from = group,
values_from = gene_count
)
testDNR3chi <- matrix(
c(4, 12, 413, 261),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
DNR_3chi <- chisq.test(testDNR3chi, correct = FALSE)$p.value
testDNR24chi <-
matrix(
c(161, 148, 256, 125),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
DNR_24chi <- chisq.test(testDNR24chi, correct = FALSE)$p.value
testDOX3chi <- matrix(
c(0, 0, 417, 273),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
DOX_3chi <- chisq.test(testDOX3chi, correct = FALSE)$p.value
testDOX24chi <-
matrix(
c(142, 142, 256, 125),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
DOX_24chi <- chisq.test(testDOX24chi, correct = FALSE)$p.value
testEPI3chi <- matrix(
c(3, 3, 414, 270),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
EPI_3chi <- chisq.test(testEPI3chi, correct = FALSE)$p.value
testEPI24chi <-
matrix(
c(128, 131, 289, 142),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
EPI_24chi <- chisq.test(testEPI24chi, correct = FALSE)$p.value
testMTX3chi <- matrix(
c(2, 1, 415, 272),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
MTX_3chi <- chisq.test(testMTX3chi, correct = FALSE)$p.value
testMTX24chi <-
matrix(
c(16, 27, 401, 246),
nrow = 2,
ncol = 2,
byrow = FALSE,
dimnames = list(c("k4", "k5"), c("y", "n"))
)
MTX_24chi <- chisq.test(testMTX24chi, correct = FALSE)$p.value
K4nK5chi <-
data.frame(
treatment = c(
'DNR_3',
'DNR_24',
'DOX_3',
'DOX_24',
'EPI_3',
'EPI_24',
'MTX_3',
'MTX_24'
),
chi_p.value = c(
DNR_3chi,
DNR_24chi,
DOX_3chi,
DOX_24chi,
EPI_3chi,
EPI_24chi,
MTX_3chi,
MTX_24chi
)
)
K4nK5chi %>%
separate(treatment, into = c('Drug', 'time')) %>%
pivot_wider(id_cols = Drug,
names_from = time,
values_from = chi_p.value) %>%
kable(., caption = "Chi Square p. values from chi-square test between proportions of sig-DE meQTLs and reQTLS by time and treatment") %>%
kable_paper("striped", full_width = TRUE) %>%
kable_styling(full_width = FALSE, font_size = 16) %>%
scroll_box(height = "500px")| Drug | 3 | 24 |
|---|---|---|
| DNR | 0.0033591 | 0.0000557 |
| DOX | NaN | 0.0000077 |
| EPI | 0.5995866 | 0.0000045 |
| MTX | 0.8249205 | 0.0012981 |
Here we found that 24 hour reQTLs are significantly enriched in sig-DEgens compared to meQTLS, with DNR 3 hour treatment also showing significant enrichment.
toplistall %>%
filter(time == "24_hours") %>%
group_by(time, id) %>%
mutate(sigcount = if_else(adj.P.Val < 0.05, 'sig', 'notsig')) %>%
ggplot(., aes(x = id, y = abs(logFC))) +
geom_boxplot(aes(fill = id)) +
ggpubr::fill_palette(palette = drug_palc) +
guides(fill = guide_legend(title = "Treatment")) +
facet_wrap(sigcount ~ time) +
theme_bw() +
xlab("") +
ylab("abs |Log Fold Change|") +
theme_bw() +
facet_wrap( ~ time) +
#ggtitle("All QTLs from all expressed genes (n=507)")+
theme(
plot.title = element_text(size = rel(1.5), hjust = 0.5),
axis.title = element_text(size = 15, color = "black"),
# axis.ticks = element_line(linewidth = 1.5),
axis.line = element_line(linewidth = 1.5),
strip.background = element_rect(fill = "transparent"),
axis.text = element_text(
size = 8,
color = "black",
angle = 0
),
strip.text.x = element_text(
size = 12,
color = "black",
face = "bold"
)
)
Dox-reQTLs
When I look ot the reQTLs across treatments at 24 hours, I see that dox has a total of 142 reQTLS. Because this gene set was specifically about DOX response eQTLs, I wanted to see if these reQTLs were only Dox specific, or had more in common with other treatments.
trtonly_24h_genes <- readRDS("data/trtonly_24h_genes.RDS")
list2env(trtonly_24h_genes, .GlobalEnv)<environment: R_GlobalEnv>siglist <- readRDS("data/siglist_final.RDS")
list2env(siglist, .GlobalEnv)<environment: R_GlobalEnv>reQTLcombine = list(DOXreQTLs$ENTREZID,
EPIreQTLs$ENTREZID,
DNRreQTLs$ENTREZID,
MTXreQTLs$ENTREZID)
length(unique(
c(
DNRreQTLs$ENTREZID,
DOXreQTLs$ENTREZID,
EPIreQTLs$ENTREZID,
MTXreQTLs$ENTREZID
)
))[1] 166print("number of unique genes expressed in pairwise DE set")[1] "number of unique genes expressed in pairwise DE set"QTLoverlaps <- VennDiagram::get.venn.partitions(reQTLcombine)
DoxonlyQTL <- QTLoverlaps$..values..[[14]]
ggVennDiagram::ggVennDiagram(
reQTLcombine,
category.names = c(
"DOX-142 \nsigDEG\n",
"EPI-131\nsigDEG\n",
"DNR-148\nsigDEG",
"MTX-27\nsigDEG"
),
label = "count"
) + scale_x_continuous(expand = expansion(mult = .2)) + scale_y_continuous(expand = expansion(mult = .1)) +
scale_fill_distiller(palette = "RdYlGn", direction = -1)
Here, I found 90 reQTLs that were related to only anthracyclines, with 23 reQTLS related to all Top2i drugs at 24 hours.
Venn of DOX egenes and all TOP2i DEGs
library(paletteer)
assignInNamespace(x="plot_venn", value=plot_venn, ns="ggVennDiagram")
reQTL_overlapDE24 <- list(DOXreQTLs$ENTREZID,sigVDA24$ENTREZID, sigVEP24$ENTREZID, sigVMT24$ENTREZID)
re_incommon <- c(DOXreQTLs$ENTREZID,sigVDA24$ENTREZID, sigVEP24$ENTREZID, sigVMT24$ENTREZID)
names(reQTL_overlapDE24) <- c("Dox_reQTLS", "DNR DEGs","EPI DEGs","MTX DEGs")
ggVennDiagram::ggVennDiagram(reQTL_overlapDE24,
category.names = c("DOX\negenes",
"DNR DEGs",
"EPI DEGs",
"MTX DEGs"),
show_intersect = FALSE,
set_color = "black",
category_size = c(6,6,6,6),
label = "count",
color = c("DOX\negenes" = "yellow","DNR DEGs" ="steelblue","EPI DEGs" = 'red', "MTX DEGs" = 'black') ,
label_percent_digit = 1,
label_size = 4,
label_alpha = 0,
label_color = "black",
edge_lty = "solid", set_size = 4.5)+
scale_x_continuous(expand = expansion(mult = .3))+
scale_y_continuous(expand = expansion(mult = .2))+
# scale_color_paletteer_d(palette = "fishualize::Bodianus_pulchellus")+
# scale_colour_gradientn(colours = cols,
# values = rescale(c(0, 20, 75, 1000, 5000)),
# guide = "colorbar", limits=c(0, 100)) +
scale_fill_distiller(palette="Spectral", direction = -1, limits= c(1,200),oob=scales::squish)+
# scale_fill_manual(values = cbp1)+
labs(title = "24 hour DOX egenes in other DEG sets",
caption = paste("n =", length(unique(re_incommon)),"genes"))+
theme(plot.title = element_text(size = rel(1.6), hjust = 0.5, vjust =1))
| Version | Author | Date |
|---|---|---|
| c91e068 | reneeisnowhere | 2023-07-28 |
DEG_incommon <-c(sigVDA24$ENTREZID, sigVEP24$ENTREZID, sigVMT24$ENTREZID)
uniqueDEGs_incommon <- unique(DEG_incommon)
two_venn <- list( DOXreQTLs$ENTREZID,uniqueDEGs_incommon)
ggVennDiagram::ggVennDiagram(two_venn,
category.names = c("DOX egenes\nn = 142","union of TOP2i DEGs\n n = 7838"),
show_intersect = FALSE,
set_color = "black",
category_size = c(6,6),
label = "count",
# color = c("DOX\negenes" = "yellow","DNR DEGs" ="steelblue","EPI DEGs" = 'red', "MTX DEGs" = 'black') ,
#
label_percent_digit = 1,
label_size = 4,
label_alpha = 0,
label_color = "black",
edge_lty = "solid", set_size = 4.5)+
scale_x_continuous(expand = expansion(mult = .3))+
scale_y_continuous(expand = expansion(mult = .1))+
scale_fill_distiller(palette="Spectral", direction = -1, limits= c(1,200),oob=scales::squish)#+
| Version | Author | Date |
|---|---|---|
| c91e068 | reneeisnowhere | 2023-07-28 |
# labs(title = "24 hour DOX egenes in other DEG sets",
# caption = paste("n =", length(unique(re_incommon)),"genes"))+
# theme(plot.title = element_text(size = rel(1.6), hjust = 0.5, vjust =1))
ggsave("output/Figures/DOXegenesVENN.eps") DOXeQTL_table <- toplistall %>%
mutate(sigcount = if_else(adj.P.Val < 0.05,'sig','notsig'))%>%
mutate(DOXreQTLs=if_else(ENTREZID %in%DOXreQTLs$ENTREZID,"y","no")) %>%
dplyr::filter(time =="24_hours") %>%
dplyr::select(ENTREZID,id,DOXreQTLs,sigcount) %>%
group_by(id,DOXreQTLs,sigcount) %>%
tally() %>% as.data.frame() %>%
pivot_wider(.,id_cols = c(id,DOXreQTLs),names_from = sigcount,values_from = n) %>%
dplyr::select(id,DOXreQTLs,sig)
DOXeQTL_table%>%
kable(., caption= "All 24 hour sigDEGs broken down by drug and DOXreQTL status") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(full_width = FALSE, position = "left",bootstrap_options = c("striped"),font_size = 18) %>%
scroll_box(width = "80%", height = "400px")| id | DOXreQTLs | sig |
|---|---|---|
| DNR | no | 6885 |
| DNR | y | 132 |
| DOX | no | 6503 |
| DOX | y | 142 |
| EPI | no | 6211 |
| EPI | y | 117 |
| MTX | no | 1089 |
| MTX | y | 26 |
| TRZ | no | NA |
| TRZ | y | NA |
DOXeQTL_table %>%
add_row(id=c("Dox-specific DEGs","Dox-specific DEGs"),DOXreQTLs=c("no","y"), sig = c(62,1)) %>%
dplyr::filter(DOXreQTLs=="y") %>%
mutate(opp= 142-sig) %>%
filter(id !=c('TRZ','DOX')) %>%
rename("yes"=sig, "no"=opp) %>%
mutate(y_percent= paste0(sprintf("%2.1f", yes/(yes+no)*100), "%"),n_percent = paste0(sprintf("%2.1f", no/(yes+no)*100),"%")) %>%
pivot_longer(!c(id,DOXreQTLs,y_percent,n_percent), names_to="group", values_to = "count") %>%
mutate(id=factor(id, levels=c("DNR","EPI", "MTX","Dox-specific DEGs"))) %>%
ggplot(., aes(y=id,x=count,fill=group))+
geom_col(position='fill')+
theme_classic()+
scale_color_manual(values=c("red4","navy"))+
scale_fill_manual(values=c("#2297E6","red2"))+
ggtitle("DOXreQTLs overlaps")+
scale_y_discrete(limits=rev)+
geom_text(aes(y=id,x=1, label = n_percent,hjust=.8))+
theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(linewidth = 1.0),
axis.line = element_line(linewidth = 1.0),
axis.text = element_text(size = 10, color = "black", angle = 0),
strip.text.x = element_text(size = 15, color = "black", face = "bold"))
DOX specific-Dox dE-reqtl
# DoxonlyQTL <- as.numeric(QTLoverlaps$..values..[[14]])
# geneDoxonlyQTL <- getBM(attributes=my_attributes,filters ='entrezgene_id',
# values =DoxonlyQTL, mart = ensembl)
# write.csv(geneDoxonlyQTL,"data/geneDoxonlyQTL.csv")
geneDoxonlyQTL <- read.csv("data/geneDoxonlyQTL.csv",row.names = 1)
cpmcounts <- readRDS("data/cpmcount.RDS")
for (g in seq(from=1, to=length(geneDoxonlyQTL$entrezgene_id))){
a <- geneDoxonlyQTL$hgnc_symbol[g]
cpm_boxplot(cpmcounts,GOI=geneDoxonlyQTL[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
Dox specific DEG examination
#pull list
total24 <-list(sigVDA24$ENTREZID,sigVDX24$ENTREZID,sigVEP24$ENTREZID,sigVMT24$ENTREZID)
## do venn partition and pull doxspe genes
# total24 <- list(sigVDA24$SYMBOL,sigVDX24$SYMBOL,sigVEP24$SYMBOL,sigVMT24$SYMBOL)
trtonly_24h_genes <- readRDS("data/trtonly_24h_genes.RDS")
list2env(trtonly_24h_genes, envir = .GlobalEnv)<environment: R_GlobalEnv># venn_24h <- VennDiagram::get.venn.partitions(total24)
# DoxonlyDEG <- venn_24h$..values..[[14]]# 355
# EpionlyDEG <- venn_24h$..values..[[12]] #444
# DnronlyDEG <- venn_24h$..values..[[15]] #615
# MtxonlyDEG <- venn_24h$..values..[[8]] #122
# trtonly_24h_genes <- list(DnronlyDEG,DoxonlyDEG,EpionlyDEG, MtxonlyDEG)
# names(trtonly_24h_genes) <-c("DnronlyDEG","DoxonlyDEG","EpionlyDEG", "MtxonlyDEG")
# saveRDS(trtonly_24h_genes,"data/trtonly_24h_genes.RDS")
length(DoxonlyDEG)[1] 355intersect(DoxonlyDEG,DOXreQTLs$ENTREZID)[1] "57338" "29097" "7027" "10179" "9852" Dox24_lfc <- toplist24hr %>%
filter(ENTREZID %in% DoxonlyDEG) %>%
# group_by(id) %>%
# dplyr::filter(adj.P.Val<0.05) #%>%
mutate(logFC=logFC*(-1)) %>%
ggplot(., aes(x= id, y=logFC))+
geom_boxplot(aes(fill=id))+
theme_classic()+
fill_palette(palette = drug_palc)+
ggtitle("LogFC of Dox specific DEGs")+
theme(
plot.title = element_text(size = rel(1.5), hjust = 0.5,face = "bold"),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 8, color = "black", angle = 20))
# strip.text.x = element_text(size = 12, color = "black", face = "italic"))
toplist24hr %>%
filter(ENTREZID %in% DoxonlyDEG) %>%
# filter(adj.P.Val<0.05) %>%
ggplot(., aes(x=adj.P.Val))+
# geom_histogram(aes(fill=id,position="dodge"))+
geom_density(aes(fill=id))+
# facet_wrap(~id)+
fill_palette(palette = drug_palc)
toplist24hr %>%
dplyr::filter(ENTREZID %in% DoxonlyDEG) %>%
# filter(adj.P.Val<0.5) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)
print(Dox24_lfc)
Plots of some genes:
Dox_eGene_sp <- intersect(DoxonlyDEG,DOXreQTLs$ENTREZID)
### making list
# #
# Doxonly_deg <- getBM(attributes=my_attributes,filters ='entrezgene_id',
# values =DoxonlyDEG, mart = ensembl)
# write.csv(Doxonly_deg,"output/Doxonly_deg.csv")
Doxonly_deg <- read.csv("output/Doxonly_deg.csv", row.names = 1)
set.seed(12345)
sampset <- Doxonly_deg %>%
distinct(entrezgene_id,.keep_all = TRUE) %>%
sample_n(.,12)
for (g in seq(from=1, to=length(sampset$entrezgene_id))){
a <- sampset$hgnc_symbol[g]
cpm_boxplot(cpmcounts,GOI=sampset[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
doxsponly <- Doxonly_deg %>%
distinct(entrezgene_id,.keep_all = TRUE) %>%
dplyr::filter(entrezgene_id %in%Dox_eGene_sp)
for (g in seq(from=1, to=length(doxsponly$entrezgene_id))){
a <- doxsponly$hgnc_symbol[g]
cpm_boxplot(cpmcounts,GOI=doxsponly[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
| Version | Author | Date |
|---|---|---|
| c91e068 | reneeisnowhere | 2023-07-28 |
| Version | Author | Date |
|---|---|---|
| c91e068 | reneeisnowhere | 2023-07-28 |
| Version | Author | Date |
|---|---|---|
| c91e068 | reneeisnowhere | 2023-07-28 |
| Version | Author | Date |
|---|---|---|
| c91e068 | reneeisnowhere | 2023-07-28 |
| Version | Author | Date |
|---|---|---|
| c91e068 | reneeisnowhere | 2023-07-28 |
More investigation of 24 hour specific genes
DOX
DOXdeg_sp <- toplist24hr %>%
dplyr::filter(ENTREZID %in% DoxonlyDEG) %>%
dplyr::filter(adj.P.Val<0.01) %>%
filter(id=="DOX") %>%
dplyr::select(ENTREZID, SYMBOL)
DOXdeg_sp %>%
kable(., caption= "68 DOX specific genes") %>%
kable_paper("striped", full_width = TRUE) %>%
kable_styling(full_width = FALSE, font_size = 16) %>%
scroll_box( height = "500px")| ENTREZID | SYMBOL | |
|---|---|---|
| 169200 | 169200 | TMEM64 |
| 1452 | 1452 | CSNK1A1 |
| 653082 | 653082 | ZDHHC11B |
| 202181 | 202181 | LOC202181 |
| 8501 | 8501 | SLC43A1 |
| 114882 | 114882 | OSBPL8 |
| 23108 | 23108 | RAP1GAP2 |
| 135154 | 135154 | SDHAF4 |
| 5000 | 5000 | ORC4 |
| 2130 | 2130 | EWSR1 |
| 122553 | 122553 | TRAPPC6B |
| 54165 | 54165 | DCUN1D1 |
| 57862 | 57862 | ZNF410 |
| 57181 | 57181 | SLC39A10 |
| 112858 | 112858 | TP53RK |
| 79065 | 79065 | ATG9A |
| 8515 | 8515 | ITGA10 |
| 25842 | 25842 | ASF1A |
| 284900 | 284900 | TTC28-AS1 |
| 2230 | 2230 | FDX1 |
| 9524 | 9524 | TECR |
| 256586 | 256586 | LYSMD2 |
| 57338 | 57338 | JPH3 |
| 440944 | 440944 | THUMPD3-AS1 |
| 10190 | 10190 | TXNDC9 |
| 805 | 805 | CALM2 |
| 100131211 | 100131211 | NEMP2 |
| 4987 | 4987 | OPRL1 |
| 79624 | 79624 | ARMT1 |
| 23548 | 23548 | TTC33 |
| 27430 | 27430 | MAT2B |
| 81532 | 81532 | MOB2 |
| 158234 | 158234 | TRMT10B |
| 147 | 147 | ADRA1B |
| 26001 | 26001 | RNF167 |
| 57186 | 57186 | RALGAPA2 |
| 5431 | 5431 | POLR2B |
| 8763 | 8763 | CD164 |
| 55234 | 55234 | SMU1 |
| 84752 | 84752 | B3GNT9 |
| 375056 | 375056 | MIA3 |
| 7917 | 7917 | BAG6 |
| 54629 | 54629 | MINDY2 |
| 102723508 | 102723508 | KANTR |
| 26994 | 26994 | RNF11 |
| 29944 | 29944 | PNMA3 |
| 9446 | 9446 | GSTO1 |
| 7881 | 7881 | KCNAB1 |
| 6139 | 6139 | RPL17 |
| 100133331 | 100133331 | NA |
| 101927720 | 101927720 | ZNF793-AS1 |
| 6653 | 6653 | SORL1 |
| 5966 | 5966 | REL |
| 5411 | 5411 | PNN |
| 6498 | 6498 | SKIL |
| 8218 | 8218 | CLTCL1 |
| 83695 | 83695 | RHNO1 |
| 1838 | 1838 | DTNB |
| 347918 | 347918 | EP400P1 |
| 9894 | 9894 | TELO2 |
| 10973 | 10973 | ASCC3 |
| 5598 | 5598 | MAPK7 |
| 8241 | 8241 | RBM10 |
| 27229 | 27229 | TUBGCP4 |
| 2281 | 2281 | FKBP1B |
| 116068 | 116068 | LYSMD3 |
| 56998 | 56998 | CTNNBIP1 |
| 2551 | 2551 | GABPA |
intersect(DOXreQTLs$ENTREZID, DOXdeg_sp$ENTREZID)[1] "57338"#still jph3
##lfc
toplist24hr %>%
group_by(time,id) %>%
dplyr::filter(ENTREZID %in% DOXdeg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
ggplot(., aes(x= id, y=logFC))+
geom_boxplot(aes(fill=id))+
theme_classic()+
fill_palette(palette = drug_palc)+
ggtitle("LogFC of n = 68 Dox specific DEGs")+
theme(
plot.title = element_text(size = rel(1.5), hjust = 0.5,face = "bold"),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 8, color = "black", angle = 20))
##histo check
toplist24hr %>%
dplyr::filter(ENTREZID %in% DOXdeg_sp$ENTREZID) %>%
dplyr::filter(adj.P.Val <0.05) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id))+
geom_vline(xintercept=0.01,linetype=2)+
# geom_histogram(aes(fill=id))+
facet_wrap(~id)+
ggtitle("all Dox specific DEG adj p. value <0.01")+
fill_palette(palette = drug_palc)+
theme_bw()
toplist24hr %>%
filter(ENTREZID %in% DoxonlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()
densityDOXsp <-
toplist24hr %>%
filter(ENTREZID %in% DoxonlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()
densityDOXsp
set.seed(12345)
sampset <- DOXdeg_sp %>%
sample_n(.,12)
for (g in seq(from=1, to=length(sampset$ENTREZID))){
a <- sampset$SYMBOL[g]
cpm_boxplot(cpmcounts,GOI=sampset[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
##most convincing of these is ZNF793-AS1 101927720MTX
MTXdeg_sp <- toplist24hr %>%
dplyr::filter(ENTREZID %in% MtxonlyDEG) %>%
dplyr::filter(adj.P.Val<0.01) %>%
filter(id=="MTX") %>%
dplyr::select(ENTREZID, SYMBOL)
MTXdeg_sp %>%
kable(., caption= "MTX specific genes") %>%
kable_paper("striped", full_width = TRUE) %>%
kable_styling(full_width = FALSE, font_size = 16) %>%
scroll_box( height = "500px")| ENTREZID | SYMBOL | |
|---|---|---|
| 25894 | 25894 | PLEKHG4 |
| 253714 | 253714 | MMS22L |
| 126432 | 126432 | RINL |
| 4001 | 4001 | LMNB1 |
| 6240 | 6240 | RRM1 |
| 83879 | 83879 | CDCA7 |
| 25886 | 25886 | POC1A |
| 100128191 | 100128191 | TMPO-AS1 |
| 84892 | 84892 | POMGNT2 |
| 27346 | 27346 | TMEM97 |
| 63827 | 63827 | BCAN |
| 55723 | 55723 | ASF1B |
| 4173 | 4173 | MCM4 |
| 54853 | 54853 | WDR55 |
| 8317 | 8317 | CDC7 |
| 57699 | 57699 | CPNE5 |
| 655 | 655 | BMP7 |
| 9401 | 9401 | RECQL4 |
| 126382 | 126382 | NR2C2AP |
| 79109 | 79109 | MAPKAP1 |
| 441478 | 441478 | NRARP |
| 22950 | 22950 | SLC4A1AP |
| 100996573 | 100996573 | NA |
| 55780 | 55780 | ERMARD |
| 3148 | 3148 | HMGB2 |
| 3983 | 3983 | ABLIM1 |
| 9134 | 9134 | CCNE2 |
| 25981 | 25981 | DNAH1 |
| 9811 | 9811 | CTIF |
| 56970 | 56970 | ATXN7L3 |
| 79758 | 79758 | DHRS12 |
| 55147 | 55147 | RBM23 |
| 65057 | 65057 | ACD |
| 645954 | 645954 | SVIL2P |
| 64116 | 64116 | SLC39A8 |
| 147645 | 147645 | VSIG10L |
| 23582 | 23582 | CCNDBP1 |
| 8321 | 8321 | FZD1 |
| 10432 | 10432 | RBM14 |
| 9820 | 9820 | CUL7 |
| 55706 | 55706 | NDC1 |
#intersect(DOXreQTLs$ENTREZID, MTXdeg_sp$ENTREZID)#none
##lfc
toplist24hr %>%
group_by(time,id) %>%
filter(ENTREZID %in% MtxonlyDEG) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment"=id)%>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
theme_classic()+
fill_palette(palette = drug_palc)+
ggtitle("LogFC of MTX specific DEGs (n = 48)")+
theme(
plot.title = element_text(size = rel(1.5), hjust = 0.5,face = "bold"),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 8, color = "black", angle = 0))
##histo check
toplist24hr %>%
dplyr::filter(ENTREZID %in% MTXdeg_sp$ENTREZID) %>%
dplyr::filter(adj.P.Val <0.05) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id))+
geom_vline(xintercept=0.01,linetype=2)+
# geom_histogram(aes(fill=id))+
facet_wrap(~id)+
ggtitle("all MTX specific DEG adj p. value <0.01")+
fill_palette(palette = drug_palc)+
theme_bw()
toplist24hr %>%
filter(ENTREZID %in% MtxonlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()
densityMTXsp <- toplist24hr %>%
filter(ENTREZID %in% MtxonlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()
densityMTXsp
set.seed(12345)
sampset <- MTXdeg_sp %>%
sample_n(.,12)
for (g in seq(from=1, to=length(sampset$ENTREZID))){
a <- sampset$SYMBOL[g]
cpm_boxplot(cpmcounts,GOI=sampset[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
##most convincing of these is 54853 WDR55 DNR
DNRdeg_sp <- toplist24hr %>%
filter(adj.P.Val<0.01) %>%
filter(ENTREZID %in% DnronlyDEG) %>%
filter(id=="DNR") %>%
dplyr::select(ENTREZID, SYMBOL)
##lfc
toplist24hr %>%
filter(ENTREZID %in% DNRdeg_sp$ENTREZID) %>%
group_by(time,id) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
theme_classic()+
fill_palette(palette = drug_palc)+
ggtitle("LogFC of DNR specific DEGs (n = 112)")+
theme(
plot.title = element_text(size = rel(1.5), hjust = 0.5,face = "bold"),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 8, color = "black", angle = 0))
##histo check
toplist24hr %>%
dplyr::filter(ENTREZID %in% DNRdeg_sp$ENTREZID) %>%
dplyr::filter(adj.P.Val <0.05) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id))+
geom_vline(xintercept=0.01,linetype=2)+
# geom_histogram(aes(fill=id))+
facet_wrap(~id)+
ggtitle("all DNR specific DEG adj p. value <0.01")+
fill_palette(palette = drug_palc)+
theme_bw()
toplist24hr %>%
filter(ENTREZID %in% DnronlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()
set.seed(12345)
sampset <- DNRdeg_sp %>%
sample_n(.,12)
for (g in seq(from=1, to=length(sampset$ENTREZID))){
a <- sampset$SYMBOL[g]
cpm_boxplot(cpmcounts,GOI=sampset[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
##most convincing of these is 114826 SMYD4EPI
EPIdeg_sp <- toplist24hr %>%
filter(adj.P.Val<0.01) %>%
filter(ENTREZID %in% EpionlyDEG) %>%
filter(id=="EPI") %>%
dplyr::select(ENTREZID, SYMBOL)
EPIdeg_sp %>%
kable(., caption= "EPI specific genes") %>%
kable_paper("striped", full_width = TRUE) %>%
kable_styling(full_width = FALSE, font_size = 16) %>%
scroll_box( height = "500px")| ENTREZID | SYMBOL | |
|---|---|---|
| 9685 | 9685 | CLINT1 |
| 9373 | 9373 | PLAA |
| 55006 | 55006 | TRMT61B |
| 79798 | 79798 | ARMC5 |
| 79759 | 79759 | ZNF668 |
| 51434 | 51434 | ANAPC7 |
| 54508 | 54508 | EPB41L4A-DT |
| 92140 | 92140 | MTDH |
| 11097 | 11097 | NUP42 |
| 64781 | 64781 | CERK |
| 57587 | 57587 | CFAP97 |
| 57325 | 57325 | KAT14 |
| 201627 | 201627 | DENND6A |
| 55702 | 55702 | YJU2 |
| 51132 | 51132 | RLIM |
| 55105 | 55105 | GPATCH2 |
| 64863 | 64863 | METTL4 |
| 90864 | 90864 | SPSB3 |
| 8624 | 8624 | PSMG1 |
| 60561 | 60561 | RINT1 |
| 56252 | 56252 | YLPM1 |
| 55339 | 55339 | WDR33 |
| 23086 | 23086 | EXPH5 |
| 1938 | 1938 | EEF2 |
| 493812 | 493812 | HCG11 |
| 7110 | 7110 | TMF1 |
| 83852 | 83852 | SETDB2 |
| 5884 | 5884 | RAD17 |
| 64860 | 64860 | ARMCX5 |
| 220963 | 220963 | SLC16A9 |
| 22796 | 22796 | COG2 |
| 11232 | 11232 | POLG2 |
| 1385 | 1385 | CREB1 |
| 10111 | 10111 | RAD50 |
| 10342 | 10342 | TFG |
| 57609 | 57609 | DIP2B |
| 55727 | 55727 | BTBD7 |
| 2043 | 2043 | EPHA4 |
| 339210 | 339210 | C17orf67 |
| 9972 | 9972 | NUP153 |
| 285636 | 285636 | RIMOC1 |
| 54942 | 54942 | ABITRAM |
| 143282 | 143282 | FGFBP3 |
| 340359 | 340359 | KLHL38 |
| 339122 | 339122 | RAB43 |
| 79038 | 79038 | ZFYVE21 |
| 5533 | 5533 | PPP3CC |
| 2966 | 2966 | GTF2H2 |
| 105371932 | 105371932 | LOC105371932 |
| 55223 | 55223 | TRIM62 |
| 84967 | 84967 | LSM10 |
| 7592 | 7592 | ZNF41 |
| 11282 | 11282 | MGAT4B |
| 7869 | 7869 | SEMA3B |
| 65260 | 65260 | COA7 |
| 9967 | 9967 | THRAP3 |
| 10240 | 10240 | MRPS31 |
| 130507 | 130507 | UBR3 |
| 9829 | 9829 | DNAJC6 |
| 349136 | 349136 | WDR86 |
| 55676 | 55676 | SLC30A6 |
| 64844 | 64844 | MARCHF7 |
| 23122 | 23122 | CLASP2 |
| 26046 | 26046 | LTN1 |
| 138241 | 138241 | C9orf85 |
| 10021 | 10021 | HCN4 |
| 84859 | 84859 | LRCH3 |
| 85457 | 85457 | CIPC |
| 79713 | 79713 | IGFLR1 |
| 79657 | 79657 | RPAP3 |
| 5887 | 5887 | RAD23B |
| 8899 | 8899 | PRPF4B |
| 54904 | 54904 | NSD3 |
| 27246 | 27246 | RNF115 |
| 23064 | 23064 | SETX |
| 6897 | 6897 | TARS1 |
| 55937 | 55937 | APOM |
| 79230 | 79230 | ZNF557 |
| 11054 | 11054 | OGFR |
| 1032 | 1032 | CDKN2D |
| 55958 | 55958 | KLHL9 |
| 5048 | 5048 | PAFAH1B1 |
| 728229 | 728229 | TMEM191B |
| 80176 | 80176 | SPSB1 |
##lfc
toplist24hr %>%
filter(ENTREZID %in% EPIdeg_sp$ENTREZID) %>%
group_by(time,id) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
theme_classic()+
fill_palette(palette = drug_palc)+
ggtitle("LogFC of EPI specific DEGs (n = 84) ")+
theme(
plot.title = element_text(size = rel(1.5), hjust = 0.5,face = "bold"),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 8, color = "black", angle = 0))
##histo check
toplist24hr %>%
dplyr::filter(ENTREZID %in% EPIdeg_sp$ENTREZID) %>%
dplyr::filter(adj.P.Val <0.05) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id))+
geom_vline(xintercept=0.01,linetype=2)+
# geom_histogram(aes(fill=id))+
facet_wrap(~id)+
ggtitle("all DNR specific DEG adj p. value <0.01")+
fill_palette(palette = drug_palc)+
theme_bw()
densityEPIsp <- toplist24hr %>%
filter(ENTREZID %in% EpionlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_histogram(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()
densityEPIsp
set.seed(12345)
sampset <- EPIdeg_sp %>%
sample_n(.,12)
for (g in seq(from=1, to=length(sampset$ENTREZID))){
a <- sampset$SYMBOL[g]
cpm_boxplot(cpmcounts,GOI=sampset[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
##most convincing of these is 220963 SLC16A9GO analysis 24h stringent adj.P.val <0.01 specific analysis
library(gprofiler2)
#
# DNRdeg_sp had NO enrichment
# EPIdeg_sp had NO enrichment
# MTXdeg_sep had 2, "DNA-templated DNA replication" "nuclear pore localization" "DNA replication"
# gostresMTXdeg_sp <- gost(query = c(MTXdeg_sp),
# organism = "hsapiens",
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = backGL$ENTREZID,
# sources=c("GO:BP", "KEGG"))
# saveRDS(gostresMTXdeg_sp,"data/DEG-GO/gostresMTXdeg_sp.RDS")
# saveRDS(gostresDOXdeg_sp,"data/DEG-GO/gostresDOXdeg_sp.RDS")
DX_sp_DEGgostres <- readRDS("data/DEG-GO/gostresDOXdeg_sp.RDS")
MT_sp_DEGgostres <- readRDS("data/DEG-GO/gostresMTXdeg_sp.RDS")
DX_spgenes <- gostplot(DX_sp_DEGgostres, capped = FALSE, interactive = TRUE)
DX_spgenesMT_spgenes <- gostplot(MT_sp_DEGgostres, capped = FALSE, interactive = TRUE)
MT_spgenesDX_sp_DEGtable <- DX_sp_DEGgostres$result %>%
dplyr::select(c(source, term_id,term_name,intersection_size,
term_size, p_value))
MT_sp_DEGtable <- MT_sp_DEGgostres$result %>%
dplyr::select(c(source, term_id,term_name,intersection_size,
term_size, p_value))
DX_sp_DEGtable %>%
dplyr::filter(source=="GO:BP") %>%
dplyr::select(p_value,term_name,intersection_size) %>%
slice_min(., n=10 ,order_by=p_value) %>%
mutate(log_val = -log10(p_value)) %>%
# slice_max(., n=10,order_by = p_value) %>%
ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col= intersection_size)) +
geom_point(aes(size = intersection_size)) +
scale_y_discrete(labels = wrap_format(30))+
guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
ggtitle('DOX specific gene set GO:BP terms') +
xlab(expression(" -"~log[10]~("adj. p-value")))+
ylab("GO: BP term")+
theme_bw()+
theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(linewidth = 1.5),
axis.line = element_line(linewidth = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0),
strip.text.x = element_text(size = 12, color = "black", face = "bold"))
| Version | Author | Date |
|---|---|---|
| 454978c | reneeisnowhere | 2023-07-14 |
DX_sp_DEGtable %>%
mutate_at(.vars = 6, .funs= scientific_format()) %>%
kable(., caption= "Significant (adj. P value of <0.01) DOX specific genes (n = 68) and top 10 enriched GO terms") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(full_width = FALSE, position = "left",bootstrap_options = c("striped","hover")) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:2001258 | negative regulation of cation channel activity | 5 | 30 | 4.78e-04 |
| GO:BP | GO:0032413 | negative regulation of ion transmembrane transporter activity | 5 | 51 | 1.98e-03 |
| GO:BP | GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 4 | 27 | 1.98e-03 |
| GO:BP | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 4 | 23 | 1.98e-03 |
| GO:BP | GO:0032410 | negative regulation of transporter activity | 5 | 58 | 1.98e-03 |
| GO:BP | GO:2001257 | regulation of cation channel activity | 6 | 100 | 1.98e-03 |
| GO:BP | GO:0034763 | negative regulation of transmembrane transport | 6 | 96 | 1.98e-03 |
| GO:BP | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 3 | 10 | 2.51e-03 |
| GO:BP | GO:1904063 | negative regulation of cation transmembrane transport | 5 | 64 | 2.51e-03 |
| GO:BP | GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol | 3 | 11 | 2.88e-03 |
| GO:BP | GO:1901019 | regulation of calcium ion transmembrane transporter activity | 5 | 71 | 2.95e-03 |
| GO:BP | GO:1903170 | negative regulation of calcium ion transmembrane transport | 4 | 35 | 2.95e-03 |
| GO:BP | GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 5 | 70 | 2.95e-03 |
| GO:BP | GO:0051284 | positive regulation of sequestering of calcium ion | 3 | 13 | 3.54e-03 |
| GO:BP | GO:0051926 | negative regulation of calcium ion transport | 4 | 45 | 7.02e-03 |
| GO:BP | GO:0043271 | negative regulation of monoatomic ion transport | 5 | 90 | 7.39e-03 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 9 | 391 | 9.58e-03 |
| GO:BP | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 3 | 20 | 1.07e-02 |
| GO:BP | GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 4 | 60 | 1.72e-02 |
| GO:BP | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 3 | 25 | 1.91e-02 |
| GO:BP | GO:1903169 | regulation of calcium ion transmembrane transport | 5 | 122 | 2.16e-02 |
| GO:BP | GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 6 | 190 | 2.16e-02 |
| GO:BP | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 3 | 27 | 2.16e-02 |
| GO:BP | GO:1903514 | release of sequestered calcium ion into cytosol by endoplasmic reticulum | 3 | 28 | 2.16e-02 |
| GO:BP | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 3 | 28 | 2.16e-02 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 4 | 70 | 2.28e-02 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 6 | 199 | 2.34e-02 |
| GO:BP | GO:0070296 | sarcoplasmic reticulum calcium ion transport | 3 | 31 | 2.62e-02 |
| GO:BP | GO:0032409 | regulation of transporter activity | 6 | 211 | 2.88e-02 |
| GO:BP | GO:0065009 | regulation of molecular function | 20 | 1939 | 2.88e-02 |
| GO:BP | GO:0051209 | release of sequestered calcium ion into cytosol | 4 | 82 | 3.49e-02 |
| GO:BP | GO:0051283 | negative regulation of sequestering of calcium ion | 4 | 83 | 3.54e-02 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 4 | 85 | 3.65e-02 |
| GO:BP | GO:0051282 | regulation of sequestering of calcium ion | 4 | 85 | 3.65e-02 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 6 | 230 | 3.78e-02 |
| GO:BP | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 2 | 9 | 3.78e-02 |
| GO:BP | GO:0051208 | sequestering of calcium ion | 4 | 89 | 3.98e-02 |
| GO:BP | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 4 | 90 | 4.04e-02 |
| GO:BP | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity | 2 | 10 | 4.35e-02 |
| GO:BP | GO:2001258 | negative regulation of cation channel activity | 4 | 30 | 1.88e-02 |
| GO:BP | GO:2001257 | regulation of cation channel activity | 5 | 100 | 4.45e-02 |
| GO:BP | GO:0032413 | negative regulation of ion transmembrane transporter activity | 4 | 51 | 4.45e-02 |
| GO:BP | GO:0034763 | negative regulation of transmembrane transport | 5 | 96 | 4.45e-02 |
| GO:BP | GO:0032410 | negative regulation of transporter activity | 4 | 58 | 4.63e-02 |
| GO:BP | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 3 | 23 | 4.63e-02 |
MT_sp_DEGtable %>%
mutate_at(.vars = 6, .funs= scientific_format()) %>%
kable(., caption= "Significant (adj. P value of <0.01) DOX specific genes (n = 41) and top 10 enriched GO terms") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(full_width = FALSE, position = "left",bootstrap_options = c("striped","hover")) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0006261 | DNA-templated DNA replication | 6 | 148 | 4.77e-03 |
| GO:BP | GO:0051664 | nuclear pore localization | 2 | 4 | 3.13e-02 |
| GO:BP | GO:0006260 | DNA replication | 6 | 255 | 3.47e-02 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | 6 | 148 | 4.77e-03 |
| GO:BP | GO:0051664 | nuclear pore localization | 2 | 4 | 3.13e-02 |
| GO:BP | GO:0006260 | DNA replication | 6 | 255 | 3.47e-02 |
Grid for supplement
densityDOXsp <- toplist24hr %>%
filter(ENTREZID %in% DoxonlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("DOX-only DEGs\n n = 355")+
guides(fill="none",alpha="none")+
theme(
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
densityDNRsp <- toplist24hr %>%
filter(ENTREZID %in% DnronlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("DNR-only DEGs\n n = 615")+
guides(fill="none",alpha="none")+
theme(
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
densityEPIsp <- toplist24hr %>%
filter(ENTREZID %in% EpionlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("EPI-only DEGs\n n = 444")+
guides(fill="none",alpha="none")+
theme(axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
densityMTXsp <- toplist24hr %>%
filter(ENTREZID %in% MtxonlyDEG) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("MTX-only DEGs\n n = 122")+
guides(fill="none",alpha="none")+
theme(axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0)) DoxBplot <- toplist24hr %>%
group_by(time,id) %>%
dplyr::filter(ENTREZID %in% DOXdeg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("DOX specific adj.P.V <0.01\n n = 68")+
theme_classic()+
fill_palette(palette = drug_palc)+
guides(fill= FALSE)+
theme(
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
DnrBplot <- toplist24hr %>%
group_by(time,id) %>%
dplyr::filter(ENTREZID %in% DNRdeg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("DNR-spec. adj.P.V <0.01\n n = 112")+
theme_classic()+
guides(fill= FALSE)+
fill_palette(palette = drug_palc)+
theme(
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
EpiBplot <- toplist24hr %>%
group_by(time,id) %>%
filter(ENTREZID %in% EPIdeg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("EPI-spec.adj.P.V <0.01\n n = 84")+
theme_classic()+
guides(fill= FALSE)+
fill_palette(palette = drug_palc)+
theme(axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
MtxBplot <- toplist24hr %>%
group_by(time,id) %>%
filter(ENTREZID %in% MtxonlyDEG) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("MTX-spec. adj.P.V <0.01\n n = 41")+
guides(fill= FALSE)+
theme_classic()+
fill_palette(palette = drug_palc)+
theme(axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
Doxgenesp_example <- cpm_boxplot_time(cpmcounts,"24h",GOI=101927720,"Dark2",drug_palc, ylab=bquote(~italic("ZNF793-AS1 ")~log[2]~"cpm "))+
theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
Dnrgenesp_example <- cpm_boxplot_time(cpmcounts,"24h",114826 ,"Dark2",drug_palc,
ylab=bquote(~italic("SMYD4")~log[2]~"cpm "))+
theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
Epigenesp_example <- cpm_boxplot_time(cpmcounts,"24h",GOI=220963,"Dark2",drug_palc,
ylab=bquote(~italic("SLC16A9")~log[2]~"cpm "))+
theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
Mtxgenesp_example <- cpm_boxplot_time(cpmcounts,"24h",GOI=54853,"Dark2",drug_palc,
ylab=bquote(~italic("WDR55")~log[2]~"cpm "))+
theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
# supp10_24hlist <- list(densityDNRsp, DnrBplot, Dnrgenesp_example,densityDOXsp, DoxBplot, Doxgenesp_example,densityEPIsp, EpiBplot, Epigenesp_example,densityMTXsp, MtxBplot, Mtxgenesp_example)
#
# names(supp10_24hlist) <- c("densityDNRsp", "DnrBplot", "Dnrgenesp_example","densityDOXsp", "DoxBplot", "Doxgenesp_example","densityEPIsp", "EpiBplot", "Epigenesp_example","densityMTXsp", "MtxBplot", "Mtxgenesp_example")
mitopg <- plot_grid(densityMTXsp, MtxBplot, Mtxgenesp_example,
nrow = 1,
rel_heights = c(.8,2,1),
rel_widths=c(1.2,1,1.5),
scale=c(1,0.8,0.8))
Daunpg <- plot_grid(densityDNRsp, DnrBplot, Dnrgenesp_example, nrow = 1, rel_heights = c(.8,2,1), rel_widths=c(1.2,1,1.5),scale=c(1,0.8,0.8))
Doxopg <- plot_grid(densityDOXsp, DoxBplot, Doxgenesp_example, nrow = 1, rel_heights = c(.8,2,1), rel_widths=c(1.2,1,1.5),scale=c(1,0.8,0.8))
Epipg <- plot_grid(densityEPIsp, EpiBplot, Epigenesp_example, nrow = 1, rel_heights = c(.8,2,1), rel_widths=c(1.2,1,1.5),scale=c(1,0.8,0.8))
allfinal <- plot_grid(Doxopg,Epipg,Daunpg,mitopg,nrow=4)
allfinal
# saveRDS(supp10_24hlist,"data/supp10_24hlist.RDS")
# saveRDS(allfinal,"output/allfinal_sup10.RDS")3 hour update
siglist <- readRDS("data/siglist_final.RDS")
list2env(siglist,.GlobalEnv)<environment: R_GlobalEnv>total3h <-list(sigVDA3$ENTREZID,sigVDX3$ENTREZID,sigVEP3$ENTREZID,sigVMT3$ENTREZID)
## do venn partition and pull doxspe genes
# venn_3h <- VennDiagram::get.venn.partitions(total3h)
# Dox3onlyDEG <- venn_3h$..values..[[14]]## no genes
# Epi3onlyDEG <- venn_3h$..values..[[12]]## 18 genes
# Dnr3onlyDEG <- venn_3h$..values..[[15]]## 322
# Mtx3onlyDEG <- venn_3h$..values..[[8]] ## 16
# trtonly_3h_genes <- list(Dnr3onlyDEG,Dox3onlyDEG,Epi3onlyDEG,Mtx3onlyDEG)
# names(trtonly_3h_genes) <-c("Dnr3onlyDEG","Dox3onlyDEG","Epi3onlyDEG","Mtx3onlyDEG")
# saveRDS(trtonly_3h_genes,"data/trtonly_3h_genes.RDS")
trtonly_3h_genes <- readRDS("data/trtonly_3h_genes.RDS")
list2env(trtonly_3h_genes,.GlobalEnv)<environment: R_GlobalEnv>DOX3deg_sp <- toplist3hr %>%
dplyr::filter(ENTREZID %in% Dox3onlyDEG) %>%
dplyr::filter(adj.P.Val<0.01) %>%
filter(id=="DOX") %>%
dplyr::select(ENTREZID, SYMBOL)
EPI3deg_sp <- toplist3hr %>%
dplyr::filter(ENTREZID %in% Epi3onlyDEG) %>%
dplyr::filter(adj.P.Val<0.01) %>%
filter(id=="EPI") %>%
dplyr::select(ENTREZID, SYMBOL)
DNR3deg_sp <- toplist3hr %>%
dplyr::filter(ENTREZID %in% Dnr3onlyDEG) %>%
dplyr::filter(adj.P.Val<0.01) %>%
filter(id=="DNR") %>%
dplyr::select(ENTREZID, SYMBOL)
MTX3deg_sp <- toplist3hr %>%
dplyr::filter(ENTREZID %in% Mtx3onlyDEG) %>%
dplyr::filter(adj.P.Val<0.01) %>%
filter(id=="MTX") %>%
dplyr::select(ENTREZID, SYMBOL)
# set.seed(12345)
# sampset <- EPI3deg_sp %>%
# sample_n(.,2)
#
# for (g in seq(from=1, to=length(sampset$ENTREZID))){
# a <- sampset$SYMBOL[g]
# cpm_boxplot(cpmcounts,GOI=sampset[g,1],"Dark2",drug_palc,
# ylab=bquote(~italic(.(a))~log[2]~"cpm "))
# }
set.seed(12345)
sampset <- DNR3deg_sp %>%
sample_n(.,5)
print("DNR specfic")[1] "DNR specfic"for (g in seq(from=1, to=length(sampset$ENTREZID))){
a <- sampset$SYMBOL[g]
cpm_boxplot_time(cpmcounts,"3h",GOI=sampset[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
set.seed(12345)
sampset <- MTX3deg_sp %>%
sample_n(.,2)
print("MTX specfic")[1] "MTX specfic"for (g in seq(from=1, to=length(sampset$ENTREZID))){
a <- sampset$SYMBOL[g]
cpm_boxplot_time(cpmcounts,"3h",GOI=sampset[g,1],"Dark2",drug_palc,
ylab=bquote(~italic(.(a))~log[2]~"cpm "))
}
| Version | Author | Date |
|---|---|---|
| 454978c | reneeisnowhere | 2023-07-14 |
library(paletteer)
in_common3sp <- c(Dnr3onlyDEG,Dox3onlyDEG,Epi3onlyDEG,Mtx3onlyDEG)
ggVennDiagram::ggVennDiagram(trtonly_3h_genes,
category.names = c("DNR_sp\nn = 322 ",
"DOX_sp\n n = 0\n",
"EPI_sp\n n = 18\n",
" MTX_sp\n n = 16"),
show_intersect = FALSE,
set_color = "black",
category_size = c(6,6,6,6),
label = "count",
label_percent_digit = 1,
label_size = 4,
label_alpha = 0,
label_color = "black",
edge_lty = "solid", set_size = 4.5)+
scale_x_continuous(expand = expansion(mult = .3))+
scale_y_continuous(expand = expansion(mult = .2))+
scale_color_paletteer_d(palette = "fishualize::Bodianus_pulchellus")+
scale_fill_distiller(palette="Spectral", direction = -1)+
labs(title = "3 hour treatment specific genes p.adj. <0.05",
caption = paste("n =", length(unique(in_common3sp)),"genes"))+
theme(plot.title = element_text(size = rel(1.6), hjust = 0.5, vjust =1))
| Version | Author | Date |
|---|---|---|
| 454978c | reneeisnowhere | 2023-07-14 |
GO analysis 3h stringent adj.P.val <0.01 specific analysis
#
# DNRdeg_sp had NO enrichment
# EPIdeg_sp had NO enrichment
# MTXdeg_sep had 3, "DNA-templated DNA replication" "nuclear pore localization" "DNA replication"
# gostres3Mtxdeg_sp <- gost(query = MTX3deg_sp$ENTREZID,
# organism = "hsapiens",
# ordered_query = FALSE,
# domain_scope = "custom",
# significant = FALSE,
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = backGL$ENTREZID,
# sources=c("GO:BP", "KEGG"))
# saveRDS(gostres3Dnrdeg_sp,"data/DEG-GO/gostres3Dnrdeg_sp.RDS")
# saveRDS(gostres3Mtxdeg_sp,"data/DEG-GO/gostres3Mtxdeg_sp.RDS")
gostres3Dnrdeg_sp <- readRDS("data/DEG-GO/gostres3Dnrdeg_sp.RDS")
gostres3Mtxdeg_sp <- readRDS("data/DEG-GO/gostres3Mtxdeg_sp.RDS")
Dnr3_spgenes <- gostplot(gostres3Dnrdeg_sp, capped = FALSE, interactive = TRUE)
Dnr3_spgenesMtx3_spgenes <- gostplot(gostres3Mtxdeg_sp, capped = FALSE, interactive = TRUE)
Mtx3_spgenesMtx3_sp_DEGtable <- gostres3Mtxdeg_sp$result %>%
dplyr::select(c(source, term_id,term_name,intersection_size,
term_size, p_value))
Dnr3_sp_DEGtable <- gostres3Dnrdeg_sp$result %>%
dplyr::select(c(source, term_id,term_name,intersection_size,
term_size, p_value))
Dnr3_sp_DEGtable %>%
dplyr::filter(source=="GO:BP") %>%
dplyr::select(p_value,term_name,intersection_size) %>%
slice_min(., n=10 ,order_by=p_value) %>%
mutate(log_val = -log10(p_value)) %>%
# slice_max(., n=10,order_by = p_value) %>%
ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col= intersection_size)) +
geom_point(aes(size = intersection_size)) +
scale_y_discrete(labels = wrap_format(30))+
guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
ggtitle('DNR 3 hour specific(stringent)\n gene set GO:BP terms') +
xlab(expression(" -"~log[10]~("adj. p-value")))+
ylab("GO: BP term")+
theme_bw()+
theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(linewidth = 1.5),
axis.line = element_line(linewidth = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0),
strip.text.x = element_text(size = 12, color = "black", face = "bold"))
| Version | Author | Date |
|---|---|---|
| 454978c | reneeisnowhere | 2023-07-14 |
Dnr3_sp_DEGtable %>%
mutate_at(.vars = 6, .funs= scientific_format()) %>%
kable(., caption= "Stringent (adj. P value of <0.01) DNR 3 hour specific genes (n = 100) enriched GO and KEGG terms") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(full_width = FALSE, position = "left",bootstrap_options = c("striped","hover")) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0006351 | DNA-templated transcription | 43 | 2683 | 4.90e-05 |
| GO:BP | GO:0097659 | nucleic acid-templated transcription | 43 | 2684 | 4.90e-05 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 57 | 4174 | 4.90e-05 |
| GO:BP | GO:0032774 | RNA biosynthetic process | 43 | 2714 | 5.13e-05 |
| GO:BP | GO:0016070 | RNA metabolic process | 50 | 3600 | 1.08e-04 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | 35 | 1995 | 1.08e-04 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | 40 | 2574 | 1.48e-04 |
| GO:BP | GO:0018130 | heterocycle biosynthetic process | 45 | 3132 | 1.48e-04 |
| GO:BP | GO:1901362 | organic cyclic compound biosynthetic process | 46 | 3237 | 1.48e-04 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | 40 | 2593 | 1.48e-04 |
| GO:BP | GO:1903506 | regulation of nucleic acid-templated transcription | 40 | 2576 | 1.48e-04 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | 33 | 1914 | 1.66e-04 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | 50 | 3730 | 1.66e-04 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | 42 | 2845 | 1.73e-04 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | 44 | 3080 | 1.88e-04 |
| GO:BP | GO:0019222 | regulation of metabolic process | 60 | 5017 | 1.97e-04 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | 52 | 4048 | 2.33e-04 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | 43 | 3012 | 2.33e-04 |
| GO:BP | GO:0019438 | aromatic compound biosynthetic process | 44 | 3133 | 2.42e-04 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | 44 | 3169 | 3.18e-04 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | 43 | 3070 | 3.39e-04 |
| GO:BP | GO:0031326 | regulation of cellular biosynthetic process | 43 | 3080 | 3.54e-04 |
| GO:BP | GO:1901576 | organic substance biosynthetic process | 55 | 4539 | 4.60e-04 |
| GO:BP | GO:0009058 | biosynthetic process | 55 | 4590 | 6.45e-04 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | 53 | 4417 | 1.09e-03 |
| GO:BP | GO:0046483 | heterocycle metabolic process | 53 | 4570 | 3.06e-03 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | 52 | 4455 | 3.17e-03 |
| GO:BP | GO:0010467 | gene expression | 53 | 4587 | 3.19e-03 |
| GO:BP | GO:0006725 | cellular aromatic compound metabolic process | 53 | 4596 | 3.27e-03 |
| GO:BP | GO:0044271 | cellular nitrogen compound biosynthetic process | 46 | 3750 | 3.48e-03 |
| GO:BP | GO:1901360 | organic cyclic compound metabolic process | 54 | 4747 | 3.48e-03 |
| GO:BP | GO:0044249 | cellular biosynthetic process | 50 | 4245 | 3.48e-03 |
| GO:BP | GO:0051171 | regulation of nitrogen compound metabolic process | 50 | 4292 | 4.63e-03 |
| GO:BP | GO:0010468 | regulation of gene expression | 44 | 3580 | 4.98e-03 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | 52 | 4617 | 7.08e-03 |
| GO:BP | GO:0140467 | integrated stress response signaling | 4 | 35 | 7.50e-03 |
| GO:BP | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 3 | 16 | 1.23e-02 |
| GO:BP | GO:0034641 | cellular nitrogen compound metabolic process | 53 | 4946 | 2.18e-02 |
| GO:BP | GO:0044237 | cellular metabolic process | 68 | 6996 | 2.19e-02 |
| GO:BP | GO:2000121 | regulation of removal of superoxide radicals | 2 | 6 | 4.47e-02 |
| GO:BP | GO:1903507 | negative regulation of nucleic acid-templated transcription | 17 | 1017 | 5.42e-02 |
| GO:BP | GO:0072593 | reactive oxygen species metabolic process | 6 | 156 | 5.42e-02 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 17 | 1015 | 5.42e-02 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 17 | 1026 | 5.84e-02 |
| GO:BP | GO:2000377 | regulation of reactive oxygen species metabolic process | 5 | 108 | 5.87e-02 |
| GO:BP | GO:0050794 | regulation of cellular process | 70 | 7552 | 7.07e-02 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | 7 | 240 | 9.07e-02 |
| GO:BP | GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress | 3 | 36 | 1.08e-01 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 18 | 1209 | 1.23e-01 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 18 | 1214 | 1.24e-01 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 13 | 740 | 1.24e-01 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 17 | 1119 | 1.25e-01 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 23 | 1735 | 1.25e-01 |
| GO:BP | GO:0065007 | biological regulation | 74 | 8320 | 1.35e-01 |
| GO:BP | GO:0043620 | regulation of DNA-templated transcription in response to stress | 3 | 41 | 1.38e-01 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 18 | 1239 | 1.40e-01 |
| GO:BP | GO:0050789 | regulation of biological process | 72 | 8061 | 1.52e-01 |
| GO:BP | GO:0043170 | macromolecule metabolic process | 65 | 7069 | 1.63e-01 |
| GO:BP | GO:2000379 | positive regulation of reactive oxygen species metabolic process | 3 | 46 | 1.78e-01 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 18 | 1280 | 1.85e-01 |
| GO:BP | GO:0042636 | negative regulation of hair cycle | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0035998 | 7,8-dihydroneopterin 3’-triphosphate biosynthetic process | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0014861 | regulation of skeletal muscle contraction via regulation of action potential | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 4 | 99 | 1.86e-01 |
| GO:BP | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress | 1 | 1 | 1.86e-01 |
| GO:BP | GO:1990114 | RNA polymerase II core complex assembly | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0036003 | positive regulation of transcription from RNA polymerase II promoter in response to stress | 2 | 18 | 1.86e-01 |
| GO:BP | GO:0002041 | intussusceptive angiogenesis | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0036499 | PERK-mediated unfolded protein response | 2 | 17 | 1.86e-01 |
| GO:BP | GO:0100001 | regulation of skeletal muscle contraction by action potential | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0060413 | atrial septum morphogenesis | 2 | 15 | 1.86e-01 |
| GO:BP | GO:0071241 | cellular response to inorganic substance | 5 | 164 | 1.86e-01 |
| GO:BP | GO:2000761 | positive regulation of N-terminal peptidyl-lysine acetylation | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0062197 | cellular response to chemical stress | 7 | 293 | 1.86e-01 |
| GO:BP | GO:0062000 | positive regulation of cardiac endothelial to mesenchymal transition | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0061999 | regulation of cardiac endothelial to mesenchymal transition | 1 | 1 | 1.86e-01 |
| GO:BP | GO:2000759 | regulation of N-terminal peptidyl-lysine acetylation | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 3 | 55 | 1.86e-01 |
| GO:BP | GO:0019430 | removal of superoxide radicals | 2 | 17 | 1.86e-01 |
| GO:BP | GO:0072714 | response to selenite ion | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0072715 | cellular response to selenite ion | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0008152 | metabolic process | 74 | 8518 | 1.86e-01 |
| GO:BP | GO:1903788 | positive regulation of glutathione biosynthetic process | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | 7 | 295 | 1.86e-01 |
| GO:BP | GO:1902217 | erythrocyte apoptotic process | 1 | 1 | 1.86e-01 |
| GO:BP | GO:1904574 | negative regulation of selenocysteine insertion sequence binding | 1 | 1 | 1.86e-01 |
| GO:BP | GO:1904570 | negative regulation of selenocysteine incorporation | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0051169 | nuclear transport | 7 | 295 | 1.86e-01 |
| GO:BP | GO:1904572 | negative regulation of mRNA binding | 1 | 1 | 1.86e-01 |
| GO:BP | GO:1901327 | response to tacrolimus | 1 | 1 | 1.86e-01 |
| GO:BP | GO:1904573 | regulation of selenocysteine insertion sequence binding | 1 | 1 | 1.86e-01 |
| GO:BP | GO:1904569 | regulation of selenocysteine incorporation | 1 | 1 | 1.86e-01 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 27 | 2293 | 1.86e-01 |
| GO:BP | GO:0090322 | regulation of superoxide metabolic process | 2 | 19 | 2.00e-01 |
| GO:BP | GO:0071450 | cellular response to oxygen radical | 2 | 19 | 2.00e-01 |
| GO:BP | GO:0071451 | cellular response to superoxide | 2 | 19 | 2.00e-01 |
| GO:BP | GO:0006406 | mRNA export from nucleus | 3 | 59 | 2.16e-01 |
| GO:BP | GO:0003170 | heart valve development | 3 | 65 | 2.28e-01 |
| GO:BP | GO:1901376 | organic heteropentacyclic compound metabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 26 | 2270 | 2.28e-01 |
| GO:BP | GO:0003283 | atrial septum development | 2 | 23 | 2.28e-01 |
| GO:BP | GO:0035026 | leading edge cell differentiation | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0043385 | mycotoxin metabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:1903508 | positive regulation of nucleic acid-templated transcription | 17 | 1315 | 2.28e-01 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 17 | 1322 | 2.28e-01 |
| GO:BP | GO:1901377 | organic heteropentacyclic compound catabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0003181 | atrioventricular valve morphogenesis | 2 | 25 | 2.28e-01 |
| GO:BP | GO:0030334 | regulation of cell migration | 11 | 706 | 2.28e-01 |
| GO:BP | GO:0034614 | cellular response to reactive oxygen species | 4 | 121 | 2.28e-01 |
| GO:BP | GO:1903786 | regulation of glutathione biosynthetic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0043387 | mycotoxin catabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0035544 | negative regulation of SNARE complex assembly | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0045065 | cytotoxic T cell differentiation | 1 | 2 | 2.28e-01 |
| GO:BP | GO:1901028 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 2 | 25 | 2.28e-01 |
| GO:BP | GO:0009407 | toxin catabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:1905215 | negative regulation of RNA binding | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 22 | 1849 | 2.28e-01 |
| GO:BP | GO:0008334 | histone mRNA metabolic process | 2 | 21 | 2.28e-01 |
| GO:BP | GO:2000120 | positive regulation of sodium-dependent phosphate transport | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0006542 | glutamine biosynthetic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0072752 | cellular response to rapamycin | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0001174 | transcriptional start site selection at RNA polymerase II promoter | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0001173 | DNA-templated transcriptional start site selection | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0060689 | cell differentiation involved in salivary gland development | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0060819 | inactivation of X chromosome by genomic imprinting | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0071704 | organic substance metabolic process | 71 | 8169 | 2.28e-01 |
| GO:BP | GO:2000448 | positive regulation of macrophage migration inhibitory factor signaling pathway | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0000349 | generation of catalytic spliceosome for first transesterification step | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0000305 | response to oxygen radical | 2 | 22 | 2.28e-01 |
| GO:BP | GO:0000303 | response to superoxide | 2 | 21 | 2.28e-01 |
| GO:BP | GO:2001055 | positive regulation of mesenchymal cell apoptotic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0006979 | response to oxidative stress | 7 | 352 | 2.28e-01 |
| GO:BP | GO:0070982 | L-asparagine metabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0051066 | dihydrobiopterin metabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0001827 | inner cell mass cell fate commitment | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0090164 | asymmetric Golgi ribbon formation | 1 | 2 | 2.28e-01 |
| GO:BP | GO:1990478 | response to ultrasound | 1 | 2 | 2.28e-01 |
| GO:BP | GO:1900407 | regulation of cellular response to oxidative stress | 3 | 67 | 2.28e-01 |
| GO:BP | GO:0044238 | primary metabolic process | 68 | 7806 | 2.28e-01 |
| GO:BP | GO:0045585 | positive regulation of cytotoxic T cell differentiation | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0046223 | aflatoxin catabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0046222 | aflatoxin metabolic process | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0001828 | inner cell mass cellular morphogenesis | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0045583 | regulation of cytotoxic T cell differentiation | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0140074 | cardiac endothelial to mesenchymal transition | 1 | 2 | 2.28e-01 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 17 | 1315 | 2.28e-01 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 5 | 195 | 2.28e-01 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 8 | 442 | 2.34e-01 |
| GO:BP | GO:0071772 | response to BMP | 4 | 131 | 2.34e-01 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | 4 | 131 | 2.34e-01 |
| GO:BP | GO:0003209 | cardiac atrium morphogenesis | 2 | 26 | 2.34e-01 |
| GO:BP | GO:0036010 | protein localization to endosome | 2 | 26 | 2.34e-01 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 4 | 132 | 2.38e-01 |
| GO:BP | GO:0003171 | atrioventricular valve development | 2 | 27 | 2.46e-01 |
| GO:BP | GO:0010966 | regulation of phosphate transport | 1 | 3 | 2.51e-01 |
| GO:BP | GO:2000446 | regulation of macrophage migration inhibitory factor signaling pathway | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0014916 | regulation of lung blood pressure | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0010821 | regulation of mitochondrion organization | 4 | 135 | 2.51e-01 |
| GO:BP | GO:2000145 | regulation of cell motility | 11 | 742 | 2.51e-01 |
| GO:BP | GO:1904906 | positive regulation of endothelial cell-matrix adhesion via fibronectin | 1 | 3 | 2.51e-01 |
| GO:BP | GO:1904904 | regulation of endothelial cell-matrix adhesion via fibronectin | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0006556 | S-adenosylmethionine biosynthetic process | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0008219 | cell death | 19 | 1596 | 2.51e-01 |
| GO:BP | GO:2000118 | regulation of sodium-dependent phosphate transport | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 24 | 2135 | 2.51e-01 |
| GO:BP | GO:0006405 | RNA export from nucleus | 3 | 78 | 2.51e-01 |
| GO:BP | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 19 | 1604 | 2.51e-01 |
| GO:BP | GO:1990737 | response to manganese-induced endoplasmic reticulum stress | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0010729 | positive regulation of hydrogen peroxide biosynthetic process | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 19 | 1564 | 2.51e-01 |
| GO:BP | GO:0006807 | nitrogen compound metabolic process | 65 | 7441 | 2.51e-01 |
| GO:BP | GO:1903300 | negative regulation of hexokinase activity | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 13 | 957 | 2.51e-01 |
| GO:BP | GO:0140468 | HRI-mediated signaling | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0035691 | macrophage migration inhibitory factor signaling pathway | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0003007 | heart morphogenesis | 5 | 216 | 2.51e-01 |
| GO:BP | GO:0090674 | endothelial cell-matrix adhesion via fibronectin | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 8 | 462 | 2.51e-01 |
| GO:BP | GO:0090162 | establishment of epithelial cell polarity | 2 | 29 | 2.51e-01 |
| GO:BP | GO:0038160 | CXCL12-activated CXCR4 signaling pathway | 1 | 3 | 2.51e-01 |
| GO:BP | GO:1901355 | response to rapamycin | 1 | 3 | 2.51e-01 |
| GO:BP | GO:1901031 | regulation of response to reactive oxygen species | 2 | 28 | 2.51e-01 |
| GO:BP | GO:0099578 | regulation of translation at postsynapse, modulating synaptic transmission | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0045776 | negative regulation of blood pressure | 2 | 30 | 2.51e-01 |
| GO:BP | GO:0031339 | negative regulation of vesicle fusion | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0043549 | regulation of kinase activity | 9 | 560 | 2.51e-01 |
| GO:BP | GO:0099547 | regulation of translation at synapse, modulating synaptic transmission | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 23 | 2035 | 2.51e-01 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 3 | 80 | 2.51e-01 |
| GO:BP | GO:1902882 | regulation of response to oxidative stress | 3 | 76 | 2.51e-01 |
| GO:BP | GO:0090076 | relaxation of skeletal muscle | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0051684 | maintenance of Golgi location | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0072740 | cellular response to anisomycin | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0033132 | negative regulation of glucokinase activity | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0060429 | epithelium development | 12 | 850 | 2.51e-01 |
| GO:BP | GO:0060591 | chondroblast differentiation | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 9 | 551 | 2.51e-01 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 6 | 294 | 2.51e-01 |
| GO:BP | GO:0071630 | nuclear protein quality control by the ubiquitin-proteasome system | 1 | 3 | 2.51e-01 |
| GO:BP | GO:0040012 | regulation of locomotion | 11 | 763 | 2.63e-01 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 18 | 1507 | 2.64e-01 |
| GO:BP | GO:0034250 | positive regulation of amide metabolic process | 4 | 149 | 2.64e-01 |
| GO:BP | GO:0030510 | regulation of BMP signaling pathway | 3 | 84 | 2.64e-01 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 6 | 303 | 2.64e-01 |
| GO:BP | GO:0070848 | response to growth factor | 9 | 572 | 2.64e-01 |
| GO:BP | GO:0051168 | nuclear export | 4 | 150 | 2.68e-01 |
| GO:BP | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 3 | 85 | 2.68e-01 |
| GO:BP | GO:0045943 | positive regulation of transcription by RNA polymerase I | 2 | 34 | 2.71e-01 |
| GO:BP | GO:0045588 | positive regulation of gamma-delta T cell differentiation | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0046645 | positive regulation of gamma-delta T cell activation | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 5 | 230 | 2.71e-01 |
| GO:BP | GO:0097345 | mitochondrial outer membrane permeabilization | 2 | 35 | 2.71e-01 |
| GO:BP | GO:1990441 | negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0048732 | gland development | 6 | 318 | 2.71e-01 |
| GO:BP | GO:0072739 | response to anisomycin | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0009894 | regulation of catabolic process | 12 | 875 | 2.71e-01 |
| GO:BP | GO:0090427 | activation of meiosis | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0006408 | snRNA export from nucleus | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0090673 | endothelial cell-matrix adhesion | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0010726 | positive regulation of hydrogen peroxide metabolic process | 1 | 4 | 2.71e-01 |
| GO:BP | GO:1902037 | negative regulation of hematopoietic stem cell differentiation | 1 | 4 | 2.71e-01 |
| GO:BP | GO:1902512 | positive regulation of apoptotic DNA fragmentation | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0003203 | endocardial cushion morphogenesis | 2 | 36 | 2.71e-01 |
| GO:BP | GO:1904029 | regulation of cyclin-dependent protein kinase activity | 3 | 88 | 2.71e-01 |
| GO:BP | GO:0003137 | Notch signaling pathway involved in heart induction | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0035470 | positive regulation of vascular wound healing | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0044341 | sodium-dependent phosphate transport | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0035480 | regulation of Notch signaling pathway involved in heart induction | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0035481 | positive regulation of Notch signaling pathway involved in heart induction | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0032447 | protein urmylation | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0035880 | embryonic nail plate morphogenesis | 1 | 4 | 2.71e-01 |
| GO:BP | GO:1904798 | positive regulation of core promoter binding | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0035910 | ascending aorta morphogenesis | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0038159 | C-X-C chemokine receptor CXCR4 signaling pathway | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0018076 | N-terminal peptidyl-lysine acetylation | 1 | 4 | 2.71e-01 |
| GO:BP | GO:1904886 | beta-catenin destruction complex disassembly | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0016477 | cell migration | 14 | 1081 | 2.71e-01 |
| GO:BP | GO:1905322 | positive regulation of mesenchymal stem cell migration | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0002143 | tRNA wobble position uridine thiolation | 1 | 4 | 2.71e-01 |
| GO:BP | GO:1905320 | regulation of mesenchymal stem cell migration | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0016480 | negative regulation of transcription by RNA polymerase III | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0003230 | cardiac atrium development | 2 | 34 | 2.71e-01 |
| GO:BP | GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator | 2 | 35 | 2.71e-01 |
| GO:BP | GO:0030513 | positive regulation of BMP signaling pathway | 2 | 34 | 2.71e-01 |
| GO:BP | GO:1905319 | mesenchymal stem cell migration | 1 | 4 | 2.71e-01 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 14 | 1107 | 2.74e-01 |
| GO:BP | GO:0000302 | response to reactive oxygen species | 4 | 160 | 2.74e-01 |
| GO:BP | GO:0010941 | regulation of cell death | 15 | 1219 | 2.81e-01 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 17 | 1441 | 2.83e-01 |
| GO:BP | GO:0006915 | apoptotic process | 17 | 1443 | 2.84e-01 |
| GO:BP | GO:0032879 | regulation of localization | 18 | 1555 | 2.84e-01 |
| GO:BP | GO:1902110 | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 2 | 38 | 2.84e-01 |
| GO:BP | GO:0045912 | negative regulation of carbohydrate metabolic process | 2 | 38 | 2.84e-01 |
| GO:BP | GO:0008038 | neuron recognition | 2 | 39 | 2.86e-01 |
| GO:BP | GO:0061419 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0060536 | cartilage morphogenesis | 1 | 5 | 2.86e-01 |
| GO:BP | GO:2000304 | positive regulation of ceramide biosynthetic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0070169 | positive regulation of biomineral tissue development | 2 | 39 | 2.86e-01 |
| GO:BP | GO:2001053 | regulation of mesenchymal cell apoptotic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0070309 | lens fiber cell morphogenesis | 1 | 5 | 2.86e-01 |
| GO:BP | GO:1903202 | negative regulation of oxidative stress-induced cell death | 2 | 40 | 2.86e-01 |
| GO:BP | GO:0032057 | negative regulation of translational initiation in response to stress | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0045053 | protein retention in Golgi apparatus | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0034227 | tRNA thio-modification | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0010728 | regulation of hydrogen peroxide biosynthetic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 14 | 1137 | 2.86e-01 |
| GO:BP | GO:0045900 | negative regulation of translational elongation | 1 | 5 | 2.86e-01 |
| GO:BP | GO:1990089 | response to nerve growth factor | 2 | 41 | 2.86e-01 |
| GO:BP | GO:1990090 | cellular response to nerve growth factor stimulus | 2 | 41 | 2.86e-01 |
| GO:BP | GO:1905166 | negative regulation of lysosomal protein catabolic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:1903626 | positive regulation of DNA catabolic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0046654 | tetrahydrofolate biosynthetic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0035905 | ascending aorta development | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 29 | 2880 | 2.86e-01 |
| GO:BP | GO:0090650 | cellular response to oxygen-glucose deprivation | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0009250 | glucan biosynthetic process | 2 | 39 | 2.86e-01 |
| GO:BP | GO:0090154 | positive regulation of sphingolipid biosynthetic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:1904351 | negative regulation of protein catabolic process in the vacuole | 1 | 5 | 2.86e-01 |
| GO:BP | GO:1904796 | regulation of core promoter binding | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0090425 | acinar cell differentiation | 1 | 5 | 2.86e-01 |
| GO:BP | GO:1902686 | mitochondrial outer membrane permeabilization involved in programmed cell death | 2 | 40 | 2.86e-01 |
| GO:BP | GO:0071362 | cellular response to ether | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0001826 | inner cell mass cell differentiation | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0006528 | asparagine metabolic process | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0005978 | glycogen biosynthetic process | 2 | 39 | 2.86e-01 |
| GO:BP | GO:0003289 | atrial septum primum morphogenesis | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0003274 | endocardial cushion fusion | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0003284 | septum primum development | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0000393 | spliceosomal conformational changes to generate catalytic conformation | 1 | 5 | 2.86e-01 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 5 | 251 | 2.88e-01 |
| GO:BP | GO:0050714 | positive regulation of protein secretion | 3 | 100 | 2.88e-01 |
| GO:BP | GO:0035295 | tube development | 11 | 821 | 2.88e-01 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 9 | 620 | 2.89e-01 |
| GO:BP | GO:0090132 | epithelium migration | 5 | 252 | 2.89e-01 |
| GO:BP | GO:0010631 | epithelial cell migration | 5 | 252 | 2.89e-01 |
| GO:BP | GO:0006801 | superoxide metabolic process | 2 | 42 | 2.91e-01 |
| GO:BP | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | 2 | 42 | 2.91e-01 |
| GO:BP | GO:0051030 | snRNA transport | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0140245 | regulation of translation at postsynapse | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0007023 | post-chaperonin tubulin folding pathway | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0140243 | regulation of translation at synapse | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0090303 | positive regulation of wound healing | 2 | 45 | 2.92e-01 |
| GO:BP | GO:0120183 | positive regulation of focal adhesion disassembly | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0050793 | regulation of developmental process | 20 | 1835 | 2.92e-01 |
| GO:BP | GO:0051661 | maintenance of centrosome location | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0045586 | regulation of gamma-delta T cell differentiation | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0045682 | regulation of epidermis development | 2 | 45 | 2.92e-01 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | 4 | 179 | 2.92e-01 |
| GO:BP | GO:1902949 | positive regulation of tau-protein kinase activity | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0001568 | blood vessel development | 8 | 534 | 2.92e-01 |
| GO:BP | GO:2000677 | regulation of transcription regulatory region DNA binding | 2 | 43 | 2.92e-01 |
| GO:BP | GO:0090130 | tissue migration | 5 | 256 | 2.92e-01 |
| GO:BP | GO:1905710 | positive regulation of membrane permeability | 2 | 45 | 2.92e-01 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12 | 937 | 2.92e-01 |
| GO:BP | GO:0001649 | osteoblast differentiation | 4 | 179 | 2.92e-01 |
| GO:BP | GO:0032324 | molybdopterin cofactor biosynthetic process | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0019720 | Mo-molybdopterin cofactor metabolic process | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0051189 | prosthetic group metabolic process | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0048518 | positive regulation of biological process | 42 | 4579 | 2.92e-01 |
| GO:BP | GO:0099562 | maintenance of postsynaptic density structure | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0003278 | apoptotic process involved in heart morphogenesis | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0051101 | regulation of DNA binding | 3 | 104 | 2.92e-01 |
| GO:BP | GO:0046643 | regulation of gamma-delta T cell activation | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0006356 | regulation of transcription by RNA polymerase I | 2 | 45 | 2.92e-01 |
| GO:BP | GO:0051049 | regulation of transport | 15 | 1267 | 2.92e-01 |
| GO:BP | GO:0060075 | regulation of resting membrane potential | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0120182 | regulation of focal adhesion disassembly | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0043545 | molybdopterin cofactor metabolic process | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0035794 | positive regulation of mitochondrial membrane permeability | 2 | 43 | 2.92e-01 |
| GO:BP | GO:0043009 | chordate embryonic development | 8 | 534 | 2.92e-01 |
| GO:BP | GO:0060710 | chorio-allantoic fusion | 1 | 6 | 2.92e-01 |
| GO:BP | GO:1901525 | negative regulation of mitophagy | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0061343 | cell adhesion involved in heart morphogenesis | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0038146 | chemokine (C-X-C motif) ligand 12 signaling pathway | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0006984 | ER-nucleus signaling pathway | 2 | 45 | 2.92e-01 |
| GO:BP | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | 1 | 6 | 2.92e-01 |
| GO:BP | GO:0030098 | lymphocyte differentiation | 5 | 260 | 2.92e-01 |
| GO:BP | GO:0012501 | programmed cell death | 17 | 1479 | 2.92e-01 |
| GO:BP | GO:0042789 | mRNA transcription by RNA polymerase II | 2 | 45 | 2.92e-01 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 5 | 265 | 2.97e-01 |
| GO:BP | GO:0003197 | endocardial cushion development | 2 | 46 | 2.97e-01 |
| GO:BP | GO:0043392 | negative regulation of DNA binding | 2 | 46 | 2.97e-01 |
| GO:BP | GO:0040011 | locomotion | 12 | 954 | 2.97e-01 |
| GO:BP | GO:0010823 | negative regulation of mitochondrion organization | 2 | 46 | 2.97e-01 |
| GO:BP | GO:0002244 | hematopoietic progenitor cell differentiation | 3 | 109 | 3.02e-01 |
| GO:BP | GO:0030217 | T cell differentiation | 4 | 185 | 3.07e-01 |
| GO:BP | GO:0050708 | regulation of protein secretion | 4 | 185 | 3.07e-01 |
| GO:BP | GO:0046146 | tetrahydrobiopterin metabolic process | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0042492 | gamma-delta T cell differentiation | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0046543 | development of secondary female sexual characteristics | 1 | 7 | 3.08e-01 |
| GO:BP | GO:2000171 | negative regulation of dendrite development | 1 | 7 | 3.08e-01 |
| GO:BP | GO:1903147 | negative regulation of autophagy of mitochondrion | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0048870 | cell motility | 14 | 1182 | 3.08e-01 |
| GO:BP | GO:0035967 | cellular response to topologically incorrect protein | 3 | 111 | 3.08e-01 |
| GO:BP | GO:0009396 | folic acid-containing compound biosynthetic process | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0097152 | mesenchymal cell apoptotic process | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0009404 | toxin metabolic process | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0006398 | mRNA 3’-end processing by stem-loop binding and cleavage | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0061312 | BMP signaling pathway involved in heart development | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0031329 | regulation of cellular catabolic process | 8 | 555 | 3.08e-01 |
| GO:BP | GO:0006729 | tetrahydrobiopterin biosynthetic process | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0090649 | response to oxygen-glucose deprivation | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0030097 | hemopoiesis | 9 | 656 | 3.08e-01 |
| GO:BP | GO:0019083 | viral transcription | 2 | 48 | 3.08e-01 |
| GO:BP | GO:0045472 | response to ether | 1 | 7 | 3.08e-01 |
| GO:BP | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0003357 | noradrenergic neuron differentiation | 1 | 7 | 3.08e-01 |
| GO:BP | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0060548 | negative regulation of cell death | 10 | 756 | 3.08e-01 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 8 | 551 | 3.08e-01 |
| GO:BP | GO:1900246 | positive regulation of RIG-I signaling pathway | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0006370 | 7-methylguanosine mRNA capping | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0033131 | regulation of glucokinase activity | 1 | 7 | 3.08e-01 |
| GO:BP | GO:0009299 | mRNA transcription | 2 | 50 | 3.14e-01 |
| GO:BP | GO:0001944 | vasculature development | 8 | 559 | 3.14e-01 |
| GO:BP | GO:0072132 | mesenchyme morphogenesis | 2 | 50 | 3.14e-01 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 11 | 870 | 3.14e-01 |
| GO:BP | GO:0035239 | tube morphogenesis | 9 | 663 | 3.18e-01 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | 7 | 464 | 3.19e-01 |
| GO:BP | GO:0042149 | cellular response to glucose starvation | 2 | 51 | 3.22e-01 |
| GO:BP | GO:1902510 | regulation of apoptotic DNA fragmentation | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0120181 | focal adhesion disassembly | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0042416 | dopamine biosynthetic process | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0035878 | nail development | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0120180 | cell-substrate junction disassembly | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0045607 | regulation of inner ear auditory receptor cell differentiation | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0032344 | regulation of aldosterone metabolic process | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0032347 | regulation of aldosterone biosynthetic process | 1 | 8 | 3.24e-01 |
| GO:BP | GO:1902947 | regulation of tau-protein kinase activity | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0045631 | regulation of mechanoreceptor differentiation | 1 | 8 | 3.24e-01 |
| GO:BP | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0009452 | 7-methylguanosine RNA capping | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0034393 | positive regulation of smooth muscle cell apoptotic process | 1 | 8 | 3.24e-01 |
| GO:BP | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 6 | 373 | 3.24e-01 |
| GO:BP | GO:0036353 | histone H2A-K119 monoubiquitination | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0071287 | cellular response to manganese ion | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0090394 | negative regulation of excitatory postsynaptic potential | 1 | 8 | 3.24e-01 |
| GO:BP | GO:2000980 | regulation of inner ear receptor cell differentiation | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0071499 | cellular response to laminar fluid shear stress | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0051028 | mRNA transport | 3 | 117 | 3.24e-01 |
| GO:BP | GO:1903299 | regulation of hexokinase activity | 1 | 8 | 3.24e-01 |
| GO:BP | GO:0000271 | polysaccharide biosynthetic process | 2 | 53 | 3.24e-01 |
| GO:BP | GO:0001501 | skeletal system development | 6 | 377 | 3.25e-01 |
| GO:BP | GO:1902966 | positive regulation of protein localization to early endosome | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 24 | 2412 | 3.32e-01 |
| GO:BP | GO:0097064 | ncRNA export from nucleus | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0046629 | gamma-delta T cell activation | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0034214 | protein hexamerization | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | 10 | 787 | 3.32e-01 |
| GO:BP | GO:0060352 | cell adhesion molecule production | 1 | 9 | 3.32e-01 |
| GO:BP | GO:2001214 | positive regulation of vasculogenesis | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0007021 | tubulin complex assembly | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0006705 | mineralocorticoid biosynthetic process | 1 | 9 | 3.32e-01 |
| GO:BP | GO:1903036 | positive regulation of response to wounding | 2 | 55 | 3.32e-01 |
| GO:BP | GO:0030509 | BMP signaling pathway | 3 | 123 | 3.32e-01 |
| GO:BP | GO:1902965 | regulation of protein localization to early endosome | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | 7 | 479 | 3.32e-01 |
| GO:BP | GO:0045836 | positive regulation of meiotic nuclear division | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0045669 | positive regulation of osteoblast differentiation | 2 | 54 | 3.32e-01 |
| GO:BP | GO:0051338 | regulation of transferase activity | 9 | 679 | 3.32e-01 |
| GO:BP | GO:0045136 | development of secondary sexual characteristics | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0090161 | Golgi ribbon formation | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0046902 | regulation of mitochondrial membrane permeability | 2 | 54 | 3.32e-01 |
| GO:BP | GO:1905459 | regulation of vascular associated smooth muscle cell apoptotic process | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0003129 | heart induction | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0048757 | pigment granule maturation | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0031953 | negative regulation of protein autophosphorylation | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0032342 | aldosterone biosynthetic process | 1 | 9 | 3.32e-01 |
| GO:BP | GO:1905288 | vascular associated smooth muscle cell apoptotic process | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0061043 | regulation of vascular wound healing | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 13 | 1111 | 3.32e-01 |
| GO:BP | GO:0048519 | negative regulation of biological process | 37 | 4045 | 3.32e-01 |
| GO:BP | GO:0002521 | leukocyte differentiation | 6 | 382 | 3.32e-01 |
| GO:BP | GO:0002407 | dendritic cell chemotaxis | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0035646 | endosome to melanosome transport | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | 2 | 56 | 3.32e-01 |
| GO:BP | GO:0043485 | endosome to pigment granule transport | 1 | 9 | 3.32e-01 |
| GO:BP | GO:0098880 | maintenance of postsynaptic specialization structure | 1 | 9 | 3.32e-01 |
| GO:BP | GO:1903201 | regulation of oxidative stress-induced cell death | 2 | 56 | 3.32e-01 |
| GO:BP | GO:0061180 | mammary gland epithelium development | 2 | 57 | 3.37e-01 |
| GO:BP | GO:0001525 | angiogenesis | 6 | 390 | 3.39e-01 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 3 | 128 | 3.45e-01 |
| GO:BP | GO:0031124 | mRNA 3’-end processing | 2 | 58 | 3.45e-01 |
| GO:BP | GO:0008544 | epidermis development | 4 | 210 | 3.46e-01 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | 6 | 393 | 3.46e-01 |
| GO:BP | GO:0042481 | regulation of odontogenesis | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0001514 | selenocysteine incorporation | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0060174 | limb bud formation | 1 | 10 | 3.48e-01 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 3 | 129 | 3.48e-01 |
| GO:BP | GO:0033690 | positive regulation of osteoblast proliferation | 1 | 10 | 3.48e-01 |
| GO:BP | GO:1903624 | regulation of DNA catabolic process | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0006283 | transcription-coupled nucleotide-excision repair | 1 | 10 | 3.48e-01 |
| GO:BP | GO:1902415 | regulation of mRNA binding | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0002328 | pro-B cell differentiation | 1 | 10 | 3.48e-01 |
| GO:BP | GO:2000826 | regulation of heart morphogenesis | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0006451 | translational readthrough | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0003211 | cardiac ventricle formation | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0008212 | mineralocorticoid metabolic process | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0048194 | Golgi vesicle budding | 1 | 10 | 3.48e-01 |
| GO:BP | GO:1903069 | regulation of ER-associated ubiquitin-dependent protein catabolic process | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0007423 | sensory organ development | 6 | 396 | 3.48e-01 |
| GO:BP | GO:0050965 | detection of temperature stimulus involved in sensory perception of pain | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0032341 | aldosterone metabolic process | 1 | 10 | 3.48e-01 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 17 | 1602 | 3.48e-01 |
| GO:BP | GO:0010657 | muscle cell apoptotic process | 2 | 60 | 3.48e-01 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | 6 | 399 | 3.49e-01 |
| GO:BP | GO:0045619 | regulation of lymphocyte differentiation | 3 | 132 | 3.52e-01 |
| GO:BP | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 1 | 11 | 3.56e-01 |
| GO:BP | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration | 1 | 11 | 3.56e-01 |
| GO:BP | GO:1902946 | protein localization to early endosome | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 37 | 4099 | 3.56e-01 |
| GO:BP | GO:0090280 | positive regulation of calcium ion import | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0010508 | positive regulation of autophagy | 3 | 133 | 3.56e-01 |
| GO:BP | GO:1905165 | regulation of lysosomal protein catabolic process | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0006396 | RNA processing | 11 | 929 | 3.56e-01 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 6 | 407 | 3.56e-01 |
| GO:BP | GO:0051100 | negative regulation of binding | 3 | 135 | 3.56e-01 |
| GO:BP | GO:2000303 | regulation of ceramide biosynthetic process | 1 | 11 | 3.56e-01 |
| GO:BP | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0051549 | positive regulation of keratinocyte migration | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0043482 | cellular pigment accumulation | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0071044 | histone mRNA catabolic process | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0016567 | protein ubiquitination | 9 | 717 | 3.56e-01 |
| GO:BP | GO:0051657 | maintenance of organelle location | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0009713 | catechol-containing compound biosynthetic process | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | 3 | 134 | 3.56e-01 |
| GO:BP | GO:0070307 | lens fiber cell development | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0001562 | response to protozoan | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0006360 | transcription by RNA polymerase I | 2 | 62 | 3.56e-01 |
| GO:BP | GO:0043476 | pigment accumulation | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 4 | 220 | 3.56e-01 |
| GO:BP | GO:0050665 | hydrogen peroxide biosynthetic process | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0042423 | catecholamine biosynthetic process | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0030007 | intracellular potassium ion homeostasis | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0043922 | negative regulation by host of viral transcription | 1 | 11 | 3.56e-01 |
| GO:BP | GO:1901533 | negative regulation of hematopoietic progenitor cell differentiation | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0003183 | mitral valve morphogenesis | 1 | 11 | 3.56e-01 |
| GO:BP | GO:0065008 | regulation of biological quality | 21 | 2102 | 3.59e-01 |
| GO:BP | GO:0001503 | ossification | 5 | 313 | 3.59e-01 |
| GO:BP | GO:0010506 | regulation of autophagy | 5 | 313 | 3.59e-01 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 4 | 222 | 3.60e-01 |
| GO:BP | GO:0005977 | glycogen metabolic process | 2 | 64 | 3.60e-01 |
| GO:BP | GO:0090559 | regulation of membrane permeability | 2 | 64 | 3.60e-01 |
| GO:BP | GO:0044042 | glucan metabolic process | 2 | 64 | 3.60e-01 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 14 | 1278 | 3.60e-01 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 7 | 513 | 3.64e-01 |
| GO:BP | GO:0034309 | primary alcohol biosynthetic process | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0050884 | neuromuscular process controlling posture | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0071248 | cellular response to metal ion | 3 | 139 | 3.65e-01 |
| GO:BP | GO:1905038 | regulation of membrane lipid metabolic process | 1 | 12 | 3.65e-01 |
| GO:BP | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0007214 | gamma-aminobutyric acid signaling pathway | 1 | 12 | 3.65e-01 |
| GO:BP | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0090153 | regulation of sphingolipid biosynthetic process | 1 | 12 | 3.65e-01 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 7 | 517 | 3.65e-01 |
| GO:BP | GO:0051177 | meiotic sister chromatid cohesion | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0098869 | cellular oxidant detoxification | 2 | 65 | 3.65e-01 |
| GO:BP | GO:2000009 | negative regulation of protein localization to cell surface | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0042559 | pteridine-containing compound biosynthetic process | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0051098 | regulation of binding | 5 | 317 | 3.65e-01 |
| GO:BP | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0010035 | response to inorganic substance | 6 | 414 | 3.65e-01 |
| GO:BP | GO:0003174 | mitral valve development | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 4 | 227 | 3.65e-01 |
| GO:BP | GO:0061029 | eyelid development in camera-type eye | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0050961 | detection of temperature stimulus involved in sensory perception | 1 | 12 | 3.65e-01 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 4 | 227 | 3.65e-01 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 33 | 3625 | 3.67e-01 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 2 | 67 | 3.70e-01 |
| GO:BP | GO:0070167 | regulation of biomineral tissue development | 2 | 67 | 3.70e-01 |
| GO:BP | GO:0035542 | regulation of SNARE complex assembly | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0016048 | detection of temperature stimulus | 1 | 13 | 3.70e-01 |
| GO:BP | GO:1905214 | regulation of RNA binding | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0031290 | retinal ganglion cell axon guidance | 1 | 13 | 3.70e-01 |
| GO:BP | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death | 1 | 13 | 3.70e-01 |
| GO:BP | GO:1904350 | regulation of protein catabolic process in the vacuole | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0006309 | apoptotic DNA fragmentation | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0034248 | regulation of amide metabolic process | 6 | 424 | 3.70e-01 |
| GO:BP | GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 2 | 69 | 3.70e-01 |
| GO:BP | GO:0003281 | ventricular septum development | 2 | 69 | 3.70e-01 |
| GO:BP | GO:1905668 | positive regulation of protein localization to endosome | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0006109 | regulation of carbohydrate metabolic process | 3 | 144 | 3.70e-01 |
| GO:BP | GO:0051547 | regulation of keratinocyte migration | 1 | 13 | 3.70e-01 |
| GO:BP | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0001682 | tRNA 5’-leader removal | 1 | 13 | 3.70e-01 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 6 | 421 | 3.70e-01 |
| GO:BP | GO:1990253 | cellular response to leucine starvation | 1 | 13 | 3.70e-01 |
| GO:BP | GO:2001212 | regulation of vasculogenesis | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0050951 | sensory perception of temperature stimulus | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0006750 | glutathione biosynthetic process | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0045820 | negative regulation of glycolytic process | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0046500 | S-adenosylmethionine metabolic process | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0050658 | RNA transport | 3 | 144 | 3.70e-01 |
| GO:BP | GO:1901524 | regulation of mitophagy | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0010594 | regulation of endothelial cell migration | 3 | 143 | 3.70e-01 |
| GO:BP | GO:0098876 | vesicle-mediated transport to the plasma membrane | 3 | 143 | 3.70e-01 |
| GO:BP | GO:0042104 | positive regulation of activated T cell proliferation | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0048714 | positive regulation of oligodendrocyte differentiation | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0050657 | nucleic acid transport | 3 | 144 | 3.70e-01 |
| GO:BP | GO:1901032 | negative regulation of response to reactive oxygen species | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0042474 | middle ear morphogenesis | 1 | 13 | 3.70e-01 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | 4 | 234 | 3.73e-01 |
| GO:BP | GO:0030968 | endoplasmic reticulum unfolded protein response | 2 | 70 | 3.74e-01 |
| GO:BP | GO:0051236 | establishment of RNA localization | 3 | 147 | 3.74e-01 |
| GO:BP | GO:0006813 | potassium ion transport | 3 | 147 | 3.74e-01 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 6 | 429 | 3.77e-01 |
| GO:BP | GO:0003207 | cardiac chamber formation | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0006349 | regulation of gene expression by genomic imprinting | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0099505 | regulation of presynaptic membrane potential | 1 | 14 | 3.78e-01 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 4 | 236 | 3.78e-01 |
| GO:BP | GO:0014819 | regulation of skeletal muscle contraction | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0051000 | positive regulation of nitric-oxide synthase activity | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | 3 | 149 | 3.78e-01 |
| GO:BP | GO:0046184 | aldehyde biosynthetic process | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0046653 | tetrahydrofolate metabolic process | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0048485 | sympathetic nervous system development | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0060644 | mammary gland epithelial cell differentiation | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0003159 | morphogenesis of an endothelium | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0035966 | response to topologically incorrect protein | 3 | 150 | 3.78e-01 |
| GO:BP | GO:0051645 | Golgi localization | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0010310 | regulation of hydrogen peroxide metabolic process | 1 | 14 | 3.78e-01 |
| GO:BP | GO:1905666 | regulation of protein localization to endosome | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0060021 | roof of mouth development | 2 | 71 | 3.78e-01 |
| GO:BP | GO:0023019 | signal transduction involved in regulation of gene expression | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0034616 | response to laminar fluid shear stress | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0061154 | endothelial tube morphogenesis | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 12 | 1088 | 3.78e-01 |
| GO:BP | GO:0071732 | cellular response to nitric oxide | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0003085 | negative regulation of systemic arterial blood pressure | 1 | 14 | 3.78e-01 |
| GO:BP | GO:0070301 | cellular response to hydrogen peroxide | 2 | 73 | 3.82e-01 |
| GO:BP | GO:0006112 | energy reserve metabolic process | 2 | 73 | 3.82e-01 |
| GO:BP | GO:0099587 | inorganic ion import across plasma membrane | 2 | 73 | 3.82e-01 |
| GO:BP | GO:0098659 | inorganic cation import across plasma membrane | 2 | 73 | 3.82e-01 |
| GO:BP | GO:0043266 | regulation of potassium ion transport | 2 | 73 | 3.82e-01 |
| GO:BP | GO:0016051 | carbohydrate biosynthetic process | 3 | 155 | 3.86e-01 |
| GO:BP | GO:0019184 | nonribosomal peptide biosynthetic process | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0060349 | bone morphogenesis | 2 | 74 | 3.86e-01 |
| GO:BP | GO:1903861 | positive regulation of dendrite extension | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0062149 | detection of stimulus involved in sensory perception of pain | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0016973 | poly(A)+ mRNA export from nucleus | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 12 | 1101 | 3.86e-01 |
| GO:BP | GO:2000637 | positive regulation of miRNA-mediated gene silencing | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 3 | 155 | 3.86e-01 |
| GO:BP | GO:0090030 | regulation of steroid hormone biosynthetic process | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0051546 | keratinocyte migration | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 6 | 440 | 3.86e-01 |
| GO:BP | GO:0036336 | dendritic cell migration | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0010042 | response to manganese ion | 1 | 15 | 3.86e-01 |
| GO:BP | GO:1902036 | regulation of hematopoietic stem cell differentiation | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0010942 | positive regulation of cell death | 6 | 441 | 3.86e-01 |
| GO:BP | GO:0036473 | cell death in response to oxidative stress | 2 | 75 | 3.86e-01 |
| GO:BP | GO:0043583 | ear development | 3 | 153 | 3.86e-01 |
| GO:BP | GO:0034390 | smooth muscle cell apoptotic process | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0006474 | N-terminal protein amino acid acetylation | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0034391 | regulation of smooth muscle cell apoptotic process | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0043217 | myelin maintenance | 1 | 15 | 3.86e-01 |
| GO:BP | GO:0045582 | positive regulation of T cell differentiation | 2 | 74 | 3.86e-01 |
| GO:BP | GO:0009790 | embryo development | 10 | 875 | 3.86e-01 |
| GO:BP | GO:0060148 | positive regulation of post-transcriptional gene silencing | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0043278 | response to morphine | 1 | 16 | 3.92e-01 |
| GO:BP | GO:1902170 | cellular response to reactive nitrogen species | 1 | 16 | 3.92e-01 |
| GO:BP | GO:2000042 | negative regulation of double-strand break repair via homologous recombination | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0010226 | response to lithium ion | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0006044 | N-acetylglucosamine metabolic process | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0071731 | response to nitric oxide | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0010566 | regulation of ketone biosynthetic process | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0035269 | protein O-linked mannosylation | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0042633 | hair cycle | 2 | 78 | 3.92e-01 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 10 | 881 | 3.92e-01 |
| GO:BP | GO:0042303 | molting cycle | 2 | 78 | 3.92e-01 |
| GO:BP | GO:1904294 | positive regulation of ERAD pathway | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0003128 | heart field specification | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0060716 | labyrinthine layer blood vessel development | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0072359 | circulatory system development | 10 | 884 | 3.92e-01 |
| GO:BP | GO:0009636 | response to toxic substance | 3 | 158 | 3.92e-01 |
| GO:BP | GO:0099116 | tRNA 5’-end processing | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0009084 | glutamine family amino acid biosynthetic process | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0050901 | leukocyte tethering or rolling | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0009612 | response to mechanical stimulus | 3 | 158 | 3.92e-01 |
| GO:BP | GO:0014072 | response to isoquinoline alkaloid | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0051446 | positive regulation of meiotic cell cycle | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0002098 | tRNA wobble uridine modification | 1 | 16 | 3.92e-01 |
| GO:BP | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator | 1 | 16 | 3.92e-01 |
| GO:BP | GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 6 | 448 | 3.92e-01 |
| GO:BP | GO:1990748 | cellular detoxification | 2 | 76 | 3.92e-01 |
| GO:BP | GO:0001701 | in utero embryonic development | 5 | 344 | 3.92e-01 |
| GO:BP | GO:1900370 | positive regulation of post-transcriptional gene silencing by RNA | 1 | 16 | 3.92e-01 |
| GO:BP | GO:1903828 | negative regulation of protein localization | 3 | 160 | 3.93e-01 |
| GO:BP | GO:0030308 | negative regulation of cell growth | 3 | 160 | 3.93e-01 |
| GO:BP | GO:0048265 | response to pain | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0035795 | negative regulation of mitochondrial membrane permeability | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0003215 | cardiac right ventricle morphogenesis | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0097284 | hepatocyte apoptotic process | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0002320 | lymphoid progenitor cell differentiation | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0032456 | endocytic recycling | 2 | 80 | 3.98e-01 |
| GO:BP | GO:1903859 | regulation of dendrite extension | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0001759 | organ induction | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0055119 | relaxation of cardiac muscle | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0035115 | embryonic forelimb morphogenesis | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0061042 | vascular wound healing | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0060996 | dendritic spine development | 2 | 80 | 3.98e-01 |
| GO:BP | GO:0120255 | olefinic compound biosynthetic process | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0060713 | labyrinthine layer morphogenesis | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0031338 | regulation of vesicle fusion | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0060575 | intestinal epithelial cell differentiation | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0051050 | positive regulation of transport | 8 | 667 | 3.98e-01 |
| GO:BP | GO:0035116 | embryonic hindlimb morphogenesis | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0005976 | polysaccharide metabolic process | 2 | 80 | 3.98e-01 |
| GO:BP | GO:0039535 | regulation of RIG-I signaling pathway | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0015693 | magnesium ion transport | 1 | 17 | 3.98e-01 |
| GO:BP | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0006817 | phosphate ion transport | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0006700 | C21-steroid hormone biosynthetic process | 1 | 17 | 3.98e-01 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | 10 | 898 | 4.02e-01 |
| GO:BP | GO:0001558 | regulation of cell growth | 5 | 357 | 4.05e-01 |
| GO:BP | GO:0030282 | bone mineralization | 2 | 82 | 4.07e-01 |
| GO:BP | GO:0097237 | cellular response to toxic substance | 2 | 82 | 4.07e-01 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 5 | 358 | 4.07e-01 |
| GO:BP | GO:0002089 | lens morphogenesis in camera-type eye | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 19 | 1974 | 4.07e-01 |
| GO:BP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0006607 | NLS-bearing protein import into nucleus | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0010575 | positive regulation of vascular endothelial growth factor production | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0106030 | neuron projection fasciculation | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0007413 | axonal fasciculation | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0045947 | negative regulation of translational initiation | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0045185 | maintenance of protein location | 2 | 83 | 4.07e-01 |
| GO:BP | GO:0051963 | regulation of synapse assembly | 2 | 83 | 4.07e-01 |
| GO:BP | GO:0086013 | membrane repolarization during cardiac muscle cell action potential | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0043923 | positive regulation by host of viral transcription | 1 | 18 | 4.07e-01 |
| GO:BP | GO:1902883 | negative regulation of response to oxidative stress | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 12 | 1133 | 4.07e-01 |
| GO:BP | GO:0021522 | spinal cord motor neuron differentiation | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0071280 | cellular response to copper ion | 1 | 18 | 4.07e-01 |
| GO:BP | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 1 | 18 | 4.07e-01 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | 4 | 262 | 4.08e-01 |
| GO:BP | GO:0035592 | establishment of protein localization to extracellular region | 4 | 262 | 4.08e-01 |
| GO:BP | GO:0009306 | protein secretion | 4 | 262 | 4.08e-01 |
| GO:BP | GO:0071692 | protein localization to extracellular region | 4 | 266 | 4.15e-01 |
| GO:BP | GO:1903319 | positive regulation of protein maturation | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0035162 | embryonic hemopoiesis | 1 | 19 | 4.15e-01 |
| GO:BP | GO:1903204 | negative regulation of oxidative stress-induced neuron death | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0002027 | regulation of heart rate | 2 | 86 | 4.15e-01 |
| GO:BP | GO:0010001 | glial cell differentiation | 3 | 170 | 4.15e-01 |
| GO:BP | GO:0035518 | histone H2A monoubiquitination | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0006448 | regulation of translational elongation | 1 | 19 | 4.15e-01 |
| GO:BP | GO:1905146 | lysosomal protein catabolic process | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0001774 | microglial cell activation | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0002097 | tRNA wobble base modification | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0060341 | regulation of cellular localization | 9 | 798 | 4.15e-01 |
| GO:BP | GO:1905709 | negative regulation of membrane permeability | 1 | 19 | 4.15e-01 |
| GO:BP | GO:1901071 | glucosamine-containing compound metabolic process | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0045621 | positive regulation of lymphocyte differentiation | 2 | 86 | 4.15e-01 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 4 | 265 | 4.15e-01 |
| GO:BP | GO:0040020 | regulation of meiotic nuclear division | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 2 | 86 | 4.15e-01 |
| GO:BP | GO:0071498 | cellular response to fluid shear stress | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0006308 | DNA catabolic process | 1 | 19 | 4.15e-01 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 8 | 691 | 4.17e-01 |
| GO:BP | GO:0008037 | cell recognition | 2 | 87 | 4.21e-01 |
| GO:BP | GO:0061484 | hematopoietic stem cell homeostasis | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0036260 | RNA capping | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0010574 | regulation of vascular endothelial growth factor production | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0010661 | positive regulation of muscle cell apoptotic process | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0035137 | hindlimb morphogenesis | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0034312 | diol biosynthetic process | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0150146 | cell junction disassembly | 1 | 20 | 4.26e-01 |
| GO:BP | GO:1903205 | regulation of hydrogen peroxide-induced cell death | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0050974 | detection of mechanical stimulus involved in sensory perception | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0022038 | corpus callosum development | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0030262 | apoptotic nuclear changes | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0003156 | regulation of animal organ formation | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0032770 | positive regulation of monooxygenase activity | 1 | 20 | 4.26e-01 |
| GO:BP | GO:0043267 | negative regulation of potassium ion transport | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0010460 | positive regulation of heart rate | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0086012 | membrane depolarization during cardiac muscle cell action potential | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | 3 | 178 | 4.28e-01 |
| GO:BP | GO:0034504 | protein localization to nucleus | 4 | 276 | 4.28e-01 |
| GO:BP | GO:0035640 | exploration behavior | 1 | 21 | 4.28e-01 |
| GO:BP | GO:1903076 | regulation of protein localization to plasma membrane | 2 | 90 | 4.28e-01 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 2 | 91 | 4.28e-01 |
| GO:BP | GO:0002269 | leukocyte activation involved in inflammatory response | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 5 | 376 | 4.28e-01 |
| GO:BP | GO:1900048 | positive regulation of hemostasis | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0060561 | apoptotic process involved in morphogenesis | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | 1 | 21 | 4.28e-01 |
| GO:BP | GO:1902455 | negative regulation of stem cell population maintenance | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0035268 | protein mannosylation | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 5 | 375 | 4.28e-01 |
| GO:BP | GO:0050773 | regulation of dendrite development | 2 | 90 | 4.28e-01 |
| GO:BP | GO:0035020 | regulation of Rac protein signal transduction | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0035136 | forelimb morphogenesis | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 4 | 275 | 4.28e-01 |
| GO:BP | GO:0034620 | cellular response to unfolded protein | 2 | 91 | 4.28e-01 |
| GO:BP | GO:0006468 | protein phosphorylation | 12 | 1167 | 4.28e-01 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 24 | 2646 | 4.28e-01 |
| GO:BP | GO:0046006 | regulation of activated T cell proliferation | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0030194 | positive regulation of blood coagulation | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0051291 | protein heterooligomerization | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0046885 | regulation of hormone biosynthetic process | 1 | 21 | 4.28e-01 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 6 | 485 | 4.28e-01 |
| GO:BP | GO:0098754 | detoxification | 2 | 91 | 4.28e-01 |
| GO:BP | GO:0008637 | apoptotic mitochondrial changes | 2 | 90 | 4.28e-01 |
| GO:BP | GO:0031331 | positive regulation of cellular catabolic process | 4 | 277 | 4.31e-01 |
| GO:BP | GO:0048565 | digestive tract development | 2 | 92 | 4.34e-01 |
| GO:BP | GO:0046700 | heterocycle catabolic process | 5 | 381 | 4.35e-01 |
| GO:BP | GO:0032880 | regulation of protein localization | 8 | 710 | 4.36e-01 |
| GO:BP | GO:0055075 | potassium ion homeostasis | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0060669 | embryonic placenta morphogenesis | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0030900 | forebrain development | 4 | 281 | 4.36e-01 |
| GO:BP | GO:0039529 | RIG-I signaling pathway | 1 | 22 | 4.36e-01 |
| GO:BP | GO:2000352 | negative regulation of endothelial cell apoptotic process | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0035493 | SNARE complex assembly | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0060563 | neuroepithelial cell differentiation | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0030182 | neuron differentiation | 11 | 1061 | 4.36e-01 |
| GO:BP | GO:0000966 | RNA 5’-end processing | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0006403 | RNA localization | 3 | 182 | 4.36e-01 |
| GO:BP | GO:0086011 | membrane repolarization during action potential | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0006760 | folic acid-containing compound metabolic process | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0007039 | protein catabolic process in the vacuole | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0043542 | endothelial cell migration | 3 | 182 | 4.36e-01 |
| GO:BP | GO:1904292 | regulation of ERAD pathway | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0042634 | regulation of hair cycle | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | 1 | 22 | 4.36e-01 |
| GO:BP | GO:0010595 | positive regulation of endothelial cell migration | 2 | 94 | 4.37e-01 |
| GO:BP | GO:0001824 | blastocyst development | 2 | 94 | 4.37e-01 |
| GO:BP | GO:0071900 | regulation of protein serine/threonine kinase activity | 4 | 282 | 4.38e-01 |
| GO:BP | GO:0051259 | protein complex oligomerization | 3 | 185 | 4.41e-01 |
| GO:BP | GO:1904752 | regulation of vascular associated smooth muscle cell migration | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0036474 | cell death in response to hydrogen peroxide | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0019080 | viral gene expression | 2 | 96 | 4.41e-01 |
| GO:BP | GO:0061900 | glial cell activation | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0009888 | tissue development | 14 | 1425 | 4.41e-01 |
| GO:BP | GO:0010573 | vascular endothelial growth factor production | 1 | 23 | 4.41e-01 |
| GO:BP | GO:1904385 | cellular response to angiotensin | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0032006 | regulation of TOR signaling | 2 | 96 | 4.41e-01 |
| GO:BP | GO:0071218 | cellular response to misfolded protein | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0051220 | cytoplasmic sequestering of protein | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0098703 | calcium ion import across plasma membrane | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0033688 | regulation of osteoblast proliferation | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0050820 | positive regulation of coagulation | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0042417 | dopamine metabolic process | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0061041 | regulation of wound healing | 2 | 95 | 4.41e-01 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | 6 | 494 | 4.41e-01 |
| GO:BP | GO:0021952 | central nervous system projection neuron axonogenesis | 1 | 23 | 4.41e-01 |
| GO:BP | GO:0046822 | regulation of nucleocytoplasmic transport | 2 | 97 | 4.47e-01 |
| GO:BP | GO:0046777 | protein autophosphorylation | 3 | 188 | 4.48e-01 |
| GO:BP | GO:0055123 | digestive system development | 2 | 100 | 4.49e-01 |
| GO:BP | GO:0060055 | angiogenesis involved in wound healing | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0033028 | myeloid cell apoptotic process | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0050821 | protein stabilization | 3 | 191 | 4.49e-01 |
| GO:BP | GO:0071276 | cellular response to cadmium ion | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0048261 | negative regulation of receptor-mediated endocytosis | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0040008 | regulation of growth | 6 | 501 | 4.49e-01 |
| GO:BP | GO:0009057 | macromolecule catabolic process | 12 | 1199 | 4.49e-01 |
| GO:BP | GO:0050798 | activated T cell proliferation | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0010962 | regulation of glucan biosynthetic process | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0051788 | response to misfolded protein | 1 | 25 | 4.49e-01 |
| GO:BP | GO:1990776 | response to angiotensin | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0021515 | cell differentiation in spinal cord | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0048513 | animal organ development | 20 | 2189 | 4.49e-01 |
| GO:BP | GO:0021517 | ventral spinal cord development | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0006541 | glutamine metabolic process | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0042401 | biogenic amine biosynthetic process | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0034470 | ncRNA processing | 5 | 400 | 4.49e-01 |
| GO:BP | GO:1905606 | regulation of presynapse assembly | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0099174 | regulation of presynapse organization | 1 | 25 | 4.49e-01 |
| GO:BP | GO:1901796 | regulation of signal transduction by p53 class mediator | 2 | 101 | 4.49e-01 |
| GO:BP | GO:0014912 | negative regulation of smooth muscle cell migration | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 2 | 100 | 4.49e-01 |
| GO:BP | GO:0001841 | neural tube formation | 2 | 101 | 4.49e-01 |
| GO:BP | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0090279 | regulation of calcium ion import | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0099558 | maintenance of synapse structure | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0045732 | positive regulation of protein catabolic process | 3 | 192 | 4.49e-01 |
| GO:BP | GO:0009309 | amine biosynthetic process | 1 | 25 | 4.49e-01 |
| GO:BP | GO:1904738 | vascular associated smooth muscle cell migration | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0036075 | replacement ossification | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0003279 | cardiac septum development | 2 | 101 | 4.49e-01 |
| GO:BP | GO:0001958 | endochondral ossification | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0010664 | negative regulation of striated muscle cell apoptotic process | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0048729 | tissue morphogenesis | 6 | 504 | 4.49e-01 |
| GO:BP | GO:2000737 | negative regulation of stem cell differentiation | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0061311 | cell surface receptor signaling pathway involved in heart development | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0048713 | regulation of oligodendrocyte differentiation | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0060964 | regulation of miRNA-mediated gene silencing | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0003272 | endocardial cushion formation | 1 | 24 | 4.49e-01 |
| GO:BP | GO:0061036 | positive regulation of cartilage development | 1 | 25 | 4.49e-01 |
| GO:BP | GO:2000027 | regulation of animal organ morphogenesis | 2 | 101 | 4.49e-01 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | 7 | 616 | 4.49e-01 |
| GO:BP | GO:1903203 | regulation of oxidative stress-induced neuron death | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0050999 | regulation of nitric-oxide synthase activity | 1 | 25 | 4.49e-01 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 2 | 100 | 4.49e-01 |
| GO:BP | GO:0005979 | regulation of glycogen biosynthetic process | 1 | 25 | 4.49e-01 |
| GO:BP | GO:1904019 | epithelial cell apoptotic process | 2 | 98 | 4.49e-01 |
| GO:BP | GO:0031123 | RNA 3’-end processing | 2 | 100 | 4.49e-01 |
| GO:BP | GO:0015931 | nucleobase-containing compound transport | 3 | 194 | 4.50e-01 |
| GO:BP | GO:0035909 | aorta morphogenesis | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0030224 | monocyte differentiation | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0034311 | diol metabolic process | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0010092 | specification of animal organ identity | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0010614 | negative regulation of cardiac muscle hypertrophy | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0035994 | response to muscle stretch | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0050931 | pigment cell differentiation | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0031128 | developmental induction | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0006914 | autophagy | 6 | 513 | 4.54e-01 |
| GO:BP | GO:0042542 | response to hydrogen peroxide | 2 | 103 | 4.54e-01 |
| GO:BP | GO:0060674 | placenta blood vessel development | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 8 | 742 | 4.54e-01 |
| GO:BP | GO:0042398 | cellular modified amino acid biosynthetic process | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0051223 | regulation of protein transport | 5 | 404 | 4.54e-01 |
| GO:BP | GO:0007431 | salivary gland development | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0046326 | positive regulation of glucose import | 1 | 26 | 4.54e-01 |
| GO:BP | GO:0061919 | process utilizing autophagic mechanism | 6 | 513 | 4.54e-01 |
| GO:BP | GO:0110110 | positive regulation of animal organ morphogenesis | 1 | 26 | 4.54e-01 |
| GO:BP | GO:1901361 | organic cyclic compound catabolic process | 5 | 406 | 4.57e-01 |
| GO:BP | GO:0015698 | inorganic anion transport | 2 | 104 | 4.59e-01 |
| GO:BP | GO:0043153 | entrainment of circadian clock by photoperiod | 1 | 27 | 4.61e-01 |
| GO:BP | GO:1900368 | regulation of post-transcriptional gene silencing by RNA | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0071466 | cellular response to xenobiotic stimulus | 2 | 105 | 4.61e-01 |
| GO:BP | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0033687 | osteoblast proliferation | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0097484 | dendrite extension | 1 | 27 | 4.61e-01 |
| GO:BP | GO:1903532 | positive regulation of secretion by cell | 3 | 199 | 4.61e-01 |
| GO:BP | GO:0014741 | negative regulation of muscle hypertrophy | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0062208 | positive regulation of pattern recognition receptor signaling pathway | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0034067 | protein localization to Golgi apparatus | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0010518 | positive regulation of phospholipase activity | 1 | 27 | 4.61e-01 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | 3 | 199 | 4.61e-01 |
| GO:BP | GO:0061756 | leukocyte adhesion to vascular endothelial cell | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0009048 | dosage compensation by inactivation of X chromosome | 1 | 27 | 4.61e-01 |
| GO:BP | GO:0042558 | pteridine-containing compound metabolic process | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0034063 | stress granule assembly | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0036475 | neuron death in response to oxidative stress | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0050905 | neuromuscular process | 2 | 107 | 4.63e-01 |
| GO:BP | GO:0033522 | histone H2A ubiquitination | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0086010 | membrane depolarization during action potential | 1 | 28 | 4.63e-01 |
| GO:BP | GO:1901798 | positive regulation of signal transduction by p53 class mediator | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0048483 | autonomic nervous system development | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0070098 | chemokine-mediated signaling pathway | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0060306 | regulation of membrane repolarization | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0060317 | cardiac epithelial to mesenchymal transition | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0000470 | maturation of LSU-rRNA | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0046676 | negative regulation of insulin secretion | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0009648 | photoperiodism | 1 | 28 | 4.63e-01 |
| GO:BP | GO:1900181 | negative regulation of protein localization to nucleus | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0031365 | N-terminal protein amino acid modification | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0046189 | phenol-containing compound biosynthetic process | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0060325 | face morphogenesis | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0060147 | regulation of post-transcriptional gene silencing | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0030879 | mammary gland development | 2 | 106 | 4.63e-01 |
| GO:BP | GO:0016358 | dendrite development | 3 | 202 | 4.63e-01 |
| GO:BP | GO:0021537 | telencephalon development | 3 | 201 | 4.63e-01 |
| GO:BP | GO:0008207 | C21-steroid hormone metabolic process | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0070873 | regulation of glycogen metabolic process | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0045687 | positive regulation of glial cell differentiation | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0006515 | protein quality control for misfolded or incompletely synthesized proteins | 1 | 28 | 4.63e-01 |
| GO:BP | GO:0009611 | response to wounding | 5 | 415 | 4.63e-01 |
| GO:BP | GO:0120178 | steroid hormone biosynthetic process | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | 5 | 418 | 4.63e-01 |
| GO:BP | GO:0016049 | cell growth | 5 | 418 | 4.63e-01 |
| GO:BP | GO:0060047 | heart contraction | 3 | 205 | 4.63e-01 |
| GO:BP | GO:0045580 | regulation of T cell differentiation | 2 | 110 | 4.63e-01 |
| GO:BP | GO:0007549 | dosage compensation | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0042743 | hydrogen peroxide metabolic process | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0045926 | negative regulation of growth | 3 | 206 | 4.63e-01 |
| GO:BP | GO:0060966 | regulation of gene silencing by RNA | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0048699 | generation of neurons | 11 | 1119 | 4.63e-01 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | 2 | 110 | 4.63e-01 |
| GO:BP | GO:0060914 | heart formation | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 3 | 204 | 4.63e-01 |
| GO:BP | GO:0046165 | alcohol biosynthetic process | 2 | 110 | 4.63e-01 |
| GO:BP | GO:0042491 | inner ear auditory receptor cell differentiation | 1 | 29 | 4.63e-01 |
| GO:BP | GO:1903426 | regulation of reactive oxygen species biosynthetic process | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 2 | 109 | 4.63e-01 |
| GO:BP | GO:0001889 | liver development | 2 | 110 | 4.63e-01 |
| GO:BP | GO:0150117 | positive regulation of cell-substrate junction organization | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0006730 | one-carbon metabolic process | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 2 | 108 | 4.63e-01 |
| GO:BP | GO:0034260 | negative regulation of GTPase activity | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0046688 | response to copper ion | 1 | 29 | 4.63e-01 |
| GO:BP | GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0000902 | cell morphogenesis | 8 | 761 | 4.63e-01 |
| GO:BP | GO:0090075 | relaxation of muscle | 1 | 29 | 4.63e-01 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 10 | 994 | 4.63e-01 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 10 | 993 | 4.63e-01 |
| GO:BP | GO:0007272 | ensheathment of neurons | 2 | 113 | 4.63e-01 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | 3 | 213 | 4.63e-01 |
| GO:BP | GO:0008366 | axon ensheathment | 2 | 113 | 4.63e-01 |
| GO:BP | GO:0042110 | T cell activation | 4 | 313 | 4.63e-01 |
| GO:BP | GO:0099622 | cardiac muscle cell membrane repolarization | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0048701 | embryonic cranial skeleton morphogenesis | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0003009 | skeletal muscle contraction | 1 | 31 | 4.63e-01 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 9 | 893 | 4.63e-01 |
| GO:BP | GO:0046825 | regulation of protein export from nucleus | 1 | 30 | 4.63e-01 |
| GO:BP | GO:1904375 | regulation of protein localization to cell periphery | 2 | 113 | 4.63e-01 |
| GO:BP | GO:0045910 | negative regulation of DNA recombination | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0048546 | digestive tract morphogenesis | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0070306 | lens fiber cell differentiation | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0048568 | embryonic organ development | 4 | 316 | 4.63e-01 |
| GO:BP | GO:0070201 | regulation of establishment of protein localization | 5 | 428 | 4.63e-01 |
| GO:BP | GO:0051154 | negative regulation of striated muscle cell differentiation | 1 | 31 | 4.63e-01 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 10 | 1014 | 4.63e-01 |
| GO:BP | GO:0061008 | hepaticobiliary system development | 2 | 112 | 4.63e-01 |
| GO:BP | GO:0061448 | connective tissue development | 3 | 208 | 4.63e-01 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 6 | 539 | 4.63e-01 |
| GO:BP | GO:0023056 | positive regulation of signaling | 12 | 1256 | 4.63e-01 |
| GO:BP | GO:0002792 | negative regulation of peptide secretion | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0042552 | myelination | 2 | 111 | 4.63e-01 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 12 | 1255 | 4.63e-01 |
| GO:BP | GO:0021955 | central nervous system neuron axonogenesis | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0061842 | microtubule organizing center localization | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0090278 | negative regulation of peptide hormone secretion | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0097106 | postsynaptic density organization | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0032350 | regulation of hormone metabolic process | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0035107 | appendage morphogenesis | 2 | 114 | 4.63e-01 |
| GO:BP | GO:0032885 | regulation of polysaccharide biosynthetic process | 1 | 31 | 4.63e-01 |
| GO:BP | GO:1901381 | positive regulation of potassium ion transmembrane transport | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0060218 | hematopoietic stem cell differentiation | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0009649 | entrainment of circadian clock | 1 | 31 | 4.63e-01 |
| GO:BP | GO:2000758 | positive regulation of peptidyl-lysine acetylation | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0010390 | histone monoubiquitination | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0003231 | cardiac ventricle development | 2 | 114 | 4.63e-01 |
| GO:BP | GO:0120161 | regulation of cold-induced thermogenesis | 2 | 112 | 4.63e-01 |
| GO:BP | GO:0009712 | catechol-containing compound metabolic process | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0010828 | positive regulation of glucose transmembrane transport | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0001775 | cell activation | 7 | 655 | 4.63e-01 |
| GO:BP | GO:0006359 | regulation of transcription by RNA polymerase III | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0034405 | response to fluid shear stress | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0090505 | epiboly involved in wound healing | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0035108 | limb morphogenesis | 2 | 114 | 4.63e-01 |
| GO:BP | GO:0006584 | catecholamine metabolic process | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0106106 | cold-induced thermogenesis | 2 | 113 | 4.63e-01 |
| GO:BP | GO:0051642 | centrosome localization | 1 | 31 | 4.63e-01 |
| GO:BP | GO:2000780 | negative regulation of double-strand break repair | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0090504 | epiboly | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0007006 | mitochondrial membrane organization | 2 | 114 | 4.63e-01 |
| GO:BP | GO:0033674 | positive regulation of kinase activity | 4 | 317 | 4.63e-01 |
| GO:BP | GO:1902742 | apoptotic process involved in development | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0044319 | wound healing, spreading of cells | 1 | 30 | 4.63e-01 |
| GO:BP | GO:0051051 | negative regulation of transport | 4 | 318 | 4.63e-01 |
| GO:BP | GO:0031214 | biomineral tissue development | 2 | 111 | 4.63e-01 |
| GO:BP | GO:0016310 | phosphorylation | 13 | 1372 | 4.63e-01 |
| GO:BP | GO:1990573 | potassium ion import across plasma membrane | 1 | 31 | 4.63e-01 |
| GO:BP | GO:0010720 | positive regulation of cell development | 4 | 317 | 4.63e-01 |
| GO:BP | GO:0045766 | positive regulation of angiogenesis | 2 | 115 | 4.64e-01 |
| GO:BP | GO:1904018 | positive regulation of vasculature development | 2 | 115 | 4.64e-01 |
| GO:BP | GO:0031929 | TOR signaling | 2 | 115 | 4.64e-01 |
| GO:BP | GO:0008217 | regulation of blood pressure | 2 | 115 | 4.64e-01 |
| GO:BP | GO:0042060 | wound healing | 4 | 320 | 4.64e-01 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 4 | 320 | 4.64e-01 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | 7 | 660 | 4.65e-01 |
| GO:BP | GO:0050796 | regulation of insulin secretion | 2 | 116 | 4.65e-01 |
| GO:BP | GO:0009913 | epidermal cell differentiation | 2 | 116 | 4.65e-01 |
| GO:BP | GO:0050853 | B cell receptor signaling pathway | 1 | 32 | 4.65e-01 |
| GO:BP | GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 1 | 32 | 4.65e-01 |
| GO:BP | GO:0031018 | endocrine pancreas development | 1 | 32 | 4.65e-01 |
| GO:BP | GO:0045738 | negative regulation of DNA repair | 1 | 32 | 4.65e-01 |
| GO:BP | GO:0010543 | regulation of platelet activation | 1 | 32 | 4.65e-01 |
| GO:BP | GO:0003015 | heart process | 3 | 216 | 4.65e-01 |
| GO:BP | GO:0045823 | positive regulation of heart contraction | 1 | 32 | 4.65e-01 |
| GO:BP | GO:0097502 | mannosylation | 1 | 32 | 4.65e-01 |
| GO:BP | GO:1903524 | positive regulation of blood circulation | 1 | 32 | 4.65e-01 |
| GO:BP | GO:0050982 | detection of mechanical stimulus | 1 | 32 | 4.65e-01 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | 5 | 433 | 4.65e-01 |
| GO:BP | GO:0001838 | embryonic epithelial tube formation | 2 | 116 | 4.65e-01 |
| GO:BP | GO:0051047 | positive regulation of secretion | 3 | 215 | 4.65e-01 |
| GO:BP | GO:0006402 | mRNA catabolic process | 3 | 216 | 4.65e-01 |
| GO:BP | GO:0016071 | mRNA metabolic process | 7 | 665 | 4.69e-01 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 2 | 118 | 4.72e-01 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 2 | 118 | 4.72e-01 |
| GO:BP | GO:1902930 | regulation of alcohol biosynthetic process | 1 | 33 | 4.74e-01 |
| GO:BP | GO:0003161 | cardiac conduction system development | 1 | 33 | 4.74e-01 |
| GO:BP | GO:0150076 | neuroinflammatory response | 1 | 33 | 4.74e-01 |
| GO:BP | GO:0010665 | regulation of cardiac muscle cell apoptotic process | 1 | 33 | 4.74e-01 |
| GO:BP | GO:0003180 | aortic valve morphogenesis | 1 | 33 | 4.74e-01 |
| GO:BP | GO:0060323 | head morphogenesis | 1 | 33 | 4.74e-01 |
| GO:BP | GO:0006040 | amino sugar metabolic process | 1 | 33 | 4.74e-01 |
| GO:BP | GO:0007399 | nervous system development | 17 | 1904 | 4.76e-01 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 2 | 121 | 4.76e-01 |
| GO:BP | GO:0007283 | spermatogenesis | 4 | 330 | 4.76e-01 |
| GO:BP | GO:0048813 | dendrite morphogenesis | 2 | 120 | 4.76e-01 |
| GO:BP | GO:1901532 | regulation of hematopoietic progenitor cell differentiation | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0009966 | regulation of signal transduction | 20 | 2285 | 4.76e-01 |
| GO:BP | GO:0043507 | positive regulation of JUN kinase activity | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0045321 | leukocyte activation | 6 | 554 | 4.76e-01 |
| GO:BP | GO:0016242 | negative regulation of macroautophagy | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0014037 | Schwann cell differentiation | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0060193 | positive regulation of lipase activity | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0019748 | secondary metabolic process | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0032881 | regulation of polysaccharide metabolic process | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0006364 | rRNA processing | 3 | 221 | 4.76e-01 |
| GO:BP | GO:0032768 | regulation of monooxygenase activity | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0000956 | nuclear-transcribed mRNA catabolic process | 2 | 120 | 4.76e-01 |
| GO:BP | GO:1903034 | regulation of response to wounding | 2 | 121 | 4.76e-01 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 3 | 221 | 4.76e-01 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | 2 | 120 | 4.76e-01 |
| GO:BP | GO:0030501 | positive regulation of bone mineralization | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0035315 | hair cell differentiation | 1 | 34 | 4.76e-01 |
| GO:BP | GO:1905898 | positive regulation of response to endoplasmic reticulum stress | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0035272 | exocrine system development | 1 | 34 | 4.76e-01 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | 4 | 331 | 4.78e-01 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 8 | 796 | 4.81e-01 |
| GO:BP | GO:0030866 | cortical actin cytoskeleton organization | 1 | 35 | 4.82e-01 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 2 | 123 | 4.82e-01 |
| GO:BP | GO:2000351 | regulation of endothelial cell apoptotic process | 1 | 35 | 4.82e-01 |
| GO:BP | GO:0010656 | negative regulation of muscle cell apoptotic process | 1 | 35 | 4.82e-01 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | 7 | 678 | 4.82e-01 |
| GO:BP | GO:0032501 | multicellular organismal process | 39 | 4794 | 4.82e-01 |
| GO:BP | GO:0034660 | ncRNA metabolic process | 6 | 561 | 4.82e-01 |
| GO:BP | GO:0010463 | mesenchymal cell proliferation | 1 | 35 | 4.82e-01 |
| GO:BP | GO:0060711 | labyrinthine layer development | 1 | 35 | 4.82e-01 |
| GO:BP | GO:0007095 | mitotic G2 DNA damage checkpoint signaling | 1 | 35 | 4.82e-01 |
| GO:BP | GO:0048538 | thymus development | 1 | 35 | 4.82e-01 |
| GO:BP | GO:0000209 | protein polyubiquitination | 3 | 226 | 4.85e-01 |
| GO:BP | GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 2 | 124 | 4.86e-01 |
| GO:BP | GO:0000460 | maturation of 5.8S rRNA | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0050775 | positive regulation of dendrite morphogenesis | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0086091 | regulation of heart rate by cardiac conduction | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0043268 | positive regulation of potassium ion transport | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0050890 | cognition | 3 | 227 | 4.87e-01 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0023051 | regulation of signaling | 22 | 2565 | 4.87e-01 |
| GO:BP | GO:1903409 | reactive oxygen species biosynthetic process | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0022008 | neurogenesis | 12 | 1294 | 4.87e-01 |
| GO:BP | GO:0048066 | developmental pigmentation | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0099084 | postsynaptic specialization organization | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0010659 | cardiac muscle cell apoptotic process | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0006397 | mRNA processing | 5 | 450 | 4.87e-01 |
| GO:BP | GO:0010662 | regulation of striated muscle cell apoptotic process | 1 | 36 | 4.87e-01 |
| GO:BP | GO:0010769 | regulation of cell morphogenesis involved in differentiation | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0010770 | positive regulation of cell morphogenesis involved in differentiation | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0097178 | ruffle assembly | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | 2 | 126 | 4.89e-01 |
| GO:BP | GO:0001825 | blastocyst formation | 1 | 37 | 4.89e-01 |
| GO:BP | GO:1990868 | response to chemokine | 1 | 37 | 4.89e-01 |
| GO:BP | GO:1903146 | regulation of autophagy of mitochondrion | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0008360 | regulation of cell shape | 2 | 126 | 4.89e-01 |
| GO:BP | GO:1990869 | cellular response to chemokine | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0045663 | positive regulation of myoblast differentiation | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0045727 | positive regulation of translation | 2 | 126 | 4.89e-01 |
| GO:BP | GO:0045747 | positive regulation of Notch signaling pathway | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0000423 | mitophagy | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0030832 | regulation of actin filament length | 2 | 127 | 4.89e-01 |
| GO:BP | GO:2000008 | regulation of protein localization to cell surface | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0070509 | calcium ion import | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0003176 | aortic valve development | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0010517 | regulation of phospholipase activity | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0072175 | epithelial tube formation | 2 | 127 | 4.89e-01 |
| GO:BP | GO:0042181 | ketone biosynthetic process | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0043001 | Golgi to plasma membrane protein transport | 1 | 37 | 4.89e-01 |
| GO:BP | GO:0010646 | regulation of cell communication | 22 | 2573 | 4.89e-01 |
| GO:BP | GO:0008033 | tRNA processing | 2 | 128 | 4.92e-01 |
| GO:BP | GO:0006986 | response to unfolded protein | 2 | 128 | 4.92e-01 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 14 | 1555 | 4.92e-01 |
| GO:BP | GO:0035556 | intracellular signal transduction | 18 | 2065 | 4.93e-01 |
| GO:BP | GO:0048232 | male gamete generation | 4 | 343 | 4.93e-01 |
| GO:BP | GO:0065009 | regulation of molecular function | 17 | 1939 | 4.95e-01 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 2 | 129 | 4.95e-01 |
| GO:BP | GO:0051785 | positive regulation of nuclear division | 1 | 38 | 4.96e-01 |
| GO:BP | GO:0045454 | cell redox homeostasis | 1 | 38 | 4.96e-01 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 3 | 234 | 4.96e-01 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | 2 | 130 | 4.99e-01 |
| GO:BP | GO:0042063 | gliogenesis | 3 | 235 | 4.99e-01 |
| GO:BP | GO:0042311 | vasodilation | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0036294 | cellular response to decreased oxygen levels | 2 | 131 | 5.00e-01 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0031952 | regulation of protein autophosphorylation | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0010658 | striated muscle cell apoptotic process | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 2 | 131 | 5.00e-01 |
| GO:BP | GO:0043010 | camera-type eye development | 3 | 236 | 5.00e-01 |
| GO:BP | GO:0009066 | aspartate family amino acid metabolic process | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0030838 | positive regulation of actin filament polymerization | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0045604 | regulation of epidermal cell differentiation | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0099054 | presynapse assembly | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0006378 | mRNA polyadenylation | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0050906 | detection of stimulus involved in sensory perception | 1 | 39 | 5.00e-01 |
| GO:BP | GO:0001659 | temperature homeostasis | 2 | 132 | 5.02e-01 |
| GO:BP | GO:0090276 | regulation of peptide hormone secretion | 2 | 132 | 5.02e-01 |
| GO:BP | GO:0048839 | inner ear development | 2 | 132 | 5.02e-01 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | 2 | 132 | 5.02e-01 |
| GO:BP | GO:0060412 | ventricular septum morphogenesis | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0045022 | early endosome to late endosome transport | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0120163 | negative regulation of cold-induced thermogenesis | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0042446 | hormone biosynthetic process | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0039531 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0045778 | positive regulation of ossification | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0010596 | negative regulation of endothelial cell migration | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0014009 | glial cell proliferation | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0098739 | import across plasma membrane | 2 | 133 | 5.02e-01 |
| GO:BP | GO:0007275 | multicellular organism development | 28 | 3386 | 5.02e-01 |
| GO:BP | GO:0034331 | cell junction maintenance | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0072577 | endothelial cell apoptotic process | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0009266 | response to temperature stimulus | 2 | 133 | 5.02e-01 |
| GO:BP | GO:0046649 | lymphocyte activation | 5 | 465 | 5.02e-01 |
| GO:BP | GO:0002376 | immune system process | 13 | 1447 | 5.02e-01 |
| GO:BP | GO:0098815 | modulation of excitatory postsynaptic potential | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0006110 | regulation of glycolytic process | 1 | 40 | 5.02e-01 |
| GO:BP | GO:0030010 | establishment of cell polarity | 2 | 134 | 5.03e-01 |
| GO:BP | GO:0030041 | actin filament polymerization | 2 | 134 | 5.03e-01 |
| GO:BP | GO:0046890 | regulation of lipid biosynthetic process | 2 | 134 | 5.03e-01 |
| GO:BP | GO:0002791 | regulation of peptide secretion | 2 | 134 | 5.03e-01 |
| GO:BP | GO:0046686 | response to cadmium ion | 1 | 41 | 5.03e-01 |
| GO:BP | GO:1905314 | semi-lunar valve development | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0050881 | musculoskeletal movement | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0035196 | miRNA processing | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0060612 | adipose tissue development | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0086009 | membrane repolarization | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0048013 | ephrin receptor signaling pathway | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0043631 | RNA polyadenylation | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0050879 | multicellular organismal movement | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0030520 | intracellular estrogen receptor signaling pathway | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0051222 | positive regulation of protein transport | 3 | 242 | 5.03e-01 |
| GO:BP | GO:0035329 | hippo signaling | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0043525 | positive regulation of neuron apoptotic process | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0046324 | regulation of glucose import | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0030307 | positive regulation of cell growth | 2 | 135 | 5.03e-01 |
| GO:BP | GO:1901985 | positive regulation of protein acetylation | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0006749 | glutathione metabolic process | 1 | 41 | 5.03e-01 |
| GO:BP | GO:0051260 | protein homooligomerization | 2 | 136 | 5.05e-01 |
| GO:BP | GO:0051726 | regulation of cell cycle | 9 | 956 | 5.05e-01 |
| GO:BP | GO:0090087 | regulation of peptide transport | 2 | 136 | 5.05e-01 |
| GO:BP | GO:0051289 | protein homotetramerization | 1 | 42 | 5.10e-01 |
| GO:BP | GO:0099172 | presynapse organization | 1 | 42 | 5.10e-01 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 1 | 42 | 5.10e-01 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | 4 | 358 | 5.10e-01 |
| GO:BP | GO:0031103 | axon regeneration | 1 | 42 | 5.10e-01 |
| GO:BP | GO:0098927 | vesicle-mediated transport between endosomal compartments | 1 | 42 | 5.10e-01 |
| GO:BP | GO:0016601 | Rac protein signal transduction | 1 | 42 | 5.10e-01 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | 2 | 138 | 5.12e-01 |
| GO:BP | GO:0035148 | tube formation | 2 | 138 | 5.12e-01 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | 3 | 246 | 5.12e-01 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 24 | 2890 | 5.16e-01 |
| GO:BP | GO:1904036 | negative regulation of epithelial cell apoptotic process | 1 | 43 | 5.17e-01 |
| GO:BP | GO:0051353 | positive regulation of oxidoreductase activity | 1 | 43 | 5.17e-01 |
| GO:BP | GO:0032008 | positive regulation of TOR signaling | 1 | 43 | 5.17e-01 |
| GO:BP | GO:0098900 | regulation of action potential | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0051489 | regulation of filopodium assembly | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0001961 | positive regulation of cytokine-mediated signaling pathway | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 3 | 249 | 5.20e-01 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | 3 | 249 | 5.20e-01 |
| GO:BP | GO:0036211 | protein modification process | 24 | 2901 | 5.20e-01 |
| GO:BP | GO:0045123 | cellular extravasation | 1 | 44 | 5.20e-01 |
| GO:BP | GO:1902459 | positive regulation of stem cell population maintenance | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0043388 | positive regulation of DNA binding | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0030073 | insulin secretion | 2 | 141 | 5.20e-01 |
| GO:BP | GO:0022029 | telencephalon cell migration | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0001954 | positive regulation of cell-matrix adhesion | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0060485 | mesenchyme development | 3 | 249 | 5.20e-01 |
| GO:BP | GO:0048731 | system development | 24 | 2901 | 5.20e-01 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 12 | 1345 | 5.20e-01 |
| GO:BP | GO:0051965 | positive regulation of synapse assembly | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0050709 | negative regulation of protein secretion | 1 | 44 | 5.20e-01 |
| GO:BP | GO:0060173 | limb development | 2 | 142 | 5.22e-01 |
| GO:BP | GO:0048736 | appendage development | 2 | 142 | 5.22e-01 |
| GO:BP | GO:0031099 | regeneration | 2 | 142 | 5.22e-01 |
| GO:BP | GO:0009101 | glycoprotein biosynthetic process | 3 | 252 | 5.24e-01 |
| GO:BP | GO:0014015 | positive regulation of gliogenesis | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0051445 | regulation of meiotic cell cycle | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0031529 | ruffle organization | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0010498 | proteasomal protein catabolic process | 5 | 486 | 5.24e-01 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0060324 | face development | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0030514 | negative regulation of BMP signaling pathway | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0010171 | body morphogenesis | 1 | 45 | 5.24e-01 |
| GO:BP | GO:0050870 | positive regulation of T cell activation | 2 | 144 | 5.26e-01 |
| GO:BP | GO:0044248 | cellular catabolic process | 11 | 1229 | 5.26e-01 |
| GO:BP | GO:0071453 | cellular response to oxygen levels | 2 | 144 | 5.26e-01 |
| GO:BP | GO:0006417 | regulation of translation | 4 | 370 | 5.28e-01 |
| GO:BP | GO:0098609 | cell-cell adhesion | 6 | 609 | 5.28e-01 |
| GO:BP | GO:0046888 | negative regulation of hormone secretion | 1 | 46 | 5.30e-01 |
| GO:BP | GO:0014823 | response to activity | 1 | 46 | 5.30e-01 |
| GO:BP | GO:0016574 | histone ubiquitination | 1 | 46 | 5.30e-01 |
| GO:BP | GO:0061462 | protein localization to lysosome | 1 | 46 | 5.30e-01 |
| GO:BP | GO:0021885 | forebrain cell migration | 1 | 46 | 5.30e-01 |
| GO:BP | GO:0006401 | RNA catabolic process | 3 | 256 | 5.30e-01 |
| GO:BP | GO:0016072 | rRNA metabolic process | 3 | 258 | 5.30e-01 |
| GO:BP | GO:0032007 | negative regulation of TOR signaling | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0008015 | blood circulation | 4 | 374 | 5.30e-01 |
| GO:BP | GO:0060113 | inner ear receptor cell differentiation | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0046173 | polyol biosynthetic process | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0043470 | regulation of carbohydrate catabolic process | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0033365 | protein localization to organelle | 8 | 859 | 5.30e-01 |
| GO:BP | GO:0006606 | protein import into nucleus | 2 | 147 | 5.30e-01 |
| GO:BP | GO:0031102 | neuron projection regeneration | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 4 | 372 | 5.30e-01 |
| GO:BP | GO:0045685 | regulation of glial cell differentiation | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0021915 | neural tube development | 2 | 146 | 5.30e-01 |
| GO:BP | GO:1903351 | cellular response to dopamine | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0070918 | regulatory ncRNA processing | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 1 | 47 | 5.30e-01 |
| GO:BP | GO:0042102 | positive regulation of T cell proliferation | 1 | 47 | 5.30e-01 |
| GO:BP | GO:1904951 | positive regulation of establishment of protein localization | 3 | 258 | 5.30e-01 |
| GO:BP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 2 | 147 | 5.30e-01 |
| GO:BP | GO:0060998 | regulation of dendritic spine development | 1 | 48 | 5.34e-01 |
| GO:BP | GO:1903350 | response to dopamine | 1 | 48 | 5.34e-01 |
| GO:BP | GO:0051235 | maintenance of location | 3 | 260 | 5.34e-01 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | 1 | 48 | 5.34e-01 |
| GO:BP | GO:0048856 | anatomical structure development | 33 | 4128 | 5.34e-01 |
| GO:BP | GO:0045860 | positive regulation of protein kinase activity | 3 | 260 | 5.34e-01 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | 1 | 48 | 5.34e-01 |
| GO:BP | GO:0003205 | cardiac chamber development | 2 | 149 | 5.34e-01 |
| GO:BP | GO:0019827 | stem cell population maintenance | 2 | 149 | 5.34e-01 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 1 | 48 | 5.34e-01 |
| GO:BP | GO:0040007 | growth | 7 | 742 | 5.34e-01 |
| GO:BP | GO:0050435 | amyloid-beta metabolic process | 1 | 48 | 5.34e-01 |
| GO:BP | GO:0019233 | sensory perception of pain | 1 | 48 | 5.34e-01 |
| GO:BP | GO:0034198 | cellular response to amino acid starvation | 1 | 48 | 5.34e-01 |
| GO:BP | GO:0044270 | cellular nitrogen compound catabolic process | 4 | 378 | 5.34e-01 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 10 | 1123 | 5.36e-01 |
| GO:BP | GO:0043506 | regulation of JUN kinase activity | 1 | 49 | 5.36e-01 |
| GO:BP | GO:0098727 | maintenance of cell number | 2 | 151 | 5.36e-01 |
| GO:BP | GO:0071300 | cellular response to retinoic acid | 1 | 49 | 5.36e-01 |
| GO:BP | GO:1905475 | regulation of protein localization to membrane | 2 | 150 | 5.36e-01 |
| GO:BP | GO:0006006 | glucose metabolic process | 2 | 151 | 5.36e-01 |
| GO:BP | GO:0001655 | urogenital system development | 1 | 49 | 5.36e-01 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | 1 | 49 | 5.36e-01 |
| GO:BP | GO:0007005 | mitochondrion organization | 5 | 500 | 5.36e-01 |
| GO:BP | GO:0007596 | blood coagulation | 2 | 150 | 5.36e-01 |
| GO:BP | GO:0051099 | positive regulation of binding | 2 | 150 | 5.36e-01 |
| GO:BP | GO:0042490 | mechanoreceptor differentiation | 1 | 49 | 5.36e-01 |
| GO:BP | GO:1901605 | alpha-amino acid metabolic process | 2 | 151 | 5.36e-01 |
| GO:BP | GO:0051216 | cartilage development | 2 | 151 | 5.36e-01 |
| GO:BP | GO:0060760 | positive regulation of response to cytokine stimulus | 1 | 49 | 5.36e-01 |
| GO:BP | GO:0016241 | regulation of macroautophagy | 2 | 151 | 5.36e-01 |
| GO:BP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 2 | 153 | 5.37e-01 |
| GO:BP | GO:0035019 | somatic stem cell population maintenance | 1 | 50 | 5.37e-01 |
| GO:BP | GO:1903530 | regulation of secretion by cell | 4 | 382 | 5.37e-01 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 12 | 1380 | 5.37e-01 |
| GO:BP | GO:1903078 | positive regulation of protein localization to plasma membrane | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0006941 | striated muscle contraction | 2 | 152 | 5.37e-01 |
| GO:BP | GO:1900046 | regulation of hemostasis | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0009267 | cellular response to starvation | 2 | 152 | 5.37e-01 |
| GO:BP | GO:0050865 | regulation of cell activation | 4 | 384 | 5.37e-01 |
| GO:BP | GO:1903317 | regulation of protein maturation | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0002067 | glandular epithelial cell differentiation | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0010038 | response to metal ion | 3 | 264 | 5.37e-01 |
| GO:BP | GO:0044818 | mitotic G2/M transition checkpoint | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0035904 | aorta development | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0030193 | regulation of blood coagulation | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0060997 | dendritic spine morphogenesis | 1 | 50 | 5.37e-01 |
| GO:BP | GO:0044770 | cell cycle phase transition | 5 | 504 | 5.37e-01 |
| GO:BP | GO:0007599 | hemostasis | 2 | 153 | 5.37e-01 |
| GO:BP | GO:0007416 | synapse assembly | 2 | 152 | 5.37e-01 |
| GO:BP | GO:0050817 | coagulation | 2 | 153 | 5.37e-01 |
| GO:BP | GO:0051170 | import into nucleus | 2 | 152 | 5.37e-01 |
| GO:BP | GO:0007507 | heart development | 5 | 506 | 5.40e-01 |
| GO:BP | GO:0045165 | cell fate commitment | 2 | 155 | 5.40e-01 |
| GO:BP | GO:1904888 | cranial skeletal system development | 1 | 51 | 5.40e-01 |
| GO:BP | GO:0019439 | aromatic compound catabolic process | 4 | 387 | 5.40e-01 |
| GO:BP | GO:0006809 | nitric oxide biosynthetic process | 1 | 51 | 5.40e-01 |
| GO:BP | GO:0099173 | postsynapse organization | 2 | 155 | 5.40e-01 |
| GO:BP | GO:1990928 | response to amino acid starvation | 1 | 51 | 5.40e-01 |
| GO:BP | GO:0048645 | animal organ formation | 1 | 51 | 5.40e-01 |
| GO:BP | GO:0042733 | embryonic digit morphogenesis | 1 | 51 | 5.40e-01 |
| GO:BP | GO:0043270 | positive regulation of monoatomic ion transport | 2 | 154 | 5.40e-01 |
| GO:BP | GO:1903829 | positive regulation of protein localization | 4 | 386 | 5.40e-01 |
| GO:BP | GO:0050810 | regulation of steroid biosynthetic process | 1 | 51 | 5.40e-01 |
| GO:BP | GO:1902476 | chloride transmembrane transport | 1 | 51 | 5.40e-01 |
| GO:BP | GO:0046605 | regulation of centrosome cycle | 1 | 51 | 5.40e-01 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 3 | 270 | 5.44e-01 |
| GO:BP | GO:0002064 | epithelial cell development | 2 | 156 | 5.44e-01 |
| GO:BP | GO:0006081 | cellular aldehyde metabolic process | 1 | 52 | 5.44e-01 |
| GO:BP | GO:0051148 | negative regulation of muscle cell differentiation | 1 | 52 | 5.44e-01 |
| GO:BP | GO:0007062 | sister chromatid cohesion | 1 | 52 | 5.44e-01 |
| GO:BP | GO:0002011 | morphogenesis of an epithelial sheet | 1 | 52 | 5.44e-01 |
| GO:BP | GO:1902074 | response to salt | 3 | 271 | 5.44e-01 |
| GO:BP | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 1 | 52 | 5.44e-01 |
| GO:BP | GO:0050877 | nervous system process | 6 | 634 | 5.44e-01 |
| GO:BP | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 1 | 52 | 5.44e-01 |
| GO:BP | GO:0060191 | regulation of lipase activity | 1 | 52 | 5.44e-01 |
| GO:BP | GO:0007155 | cell adhesion | 9 | 1012 | 5.44e-01 |
| GO:BP | GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 2 | 157 | 5.44e-01 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 4 | 391 | 5.45e-01 |
| GO:BP | GO:0070482 | response to oxygen levels | 3 | 272 | 5.45e-01 |
| GO:BP | GO:0001654 | eye development | 3 | 272 | 5.45e-01 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 7 | 763 | 5.46e-01 |
| GO:BP | GO:0097194 | execution phase of apoptosis | 1 | 53 | 5.46e-01 |
| GO:BP | GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 1 | 53 | 5.46e-01 |
| GO:BP | GO:0030500 | regulation of bone mineralization | 1 | 53 | 5.46e-01 |
| GO:BP | GO:0031016 | pancreas development | 1 | 53 | 5.46e-01 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | 2 | 158 | 5.46e-01 |
| GO:BP | GO:0150063 | visual system development | 3 | 273 | 5.46e-01 |
| GO:BP | GO:0010633 | negative regulation of epithelial cell migration | 1 | 53 | 5.46e-01 |
| GO:BP | GO:0046323 | glucose import | 1 | 53 | 5.46e-01 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | 3 | 273 | 5.46e-01 |
| GO:BP | GO:0046513 | ceramide biosynthetic process | 1 | 53 | 5.46e-01 |
| GO:BP | GO:0009615 | response to virus | 3 | 275 | 5.49e-01 |
| GO:BP | GO:0048880 | sensory system development | 3 | 275 | 5.49e-01 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 10 | 1147 | 5.49e-01 |
| GO:BP | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 2 | 160 | 5.50e-01 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | 2 | 160 | 5.50e-01 |
| GO:BP | GO:0061035 | regulation of cartilage development | 1 | 54 | 5.50e-01 |
| GO:BP | GO:0051123 | RNA polymerase II preinitiation complex assembly | 1 | 54 | 5.50e-01 |
| GO:BP | GO:2000243 | positive regulation of reproductive process | 1 | 54 | 5.50e-01 |
| GO:BP | GO:0042246 | tissue regeneration | 1 | 54 | 5.50e-01 |
| GO:BP | GO:0006383 | transcription by RNA polymerase III | 1 | 54 | 5.50e-01 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | 2 | 161 | 5.52e-01 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | 2 | 161 | 5.52e-01 |
| GO:BP | GO:0035195 | miRNA-mediated gene silencing | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0006611 | protein export from nucleus | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0048704 | embryonic skeletal system morphogenesis | 1 | 55 | 5.54e-01 |
| GO:BP | GO:1990874 | vascular associated smooth muscle cell proliferation | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 3 | 278 | 5.54e-01 |
| GO:BP | GO:0050818 | regulation of coagulation | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0046209 | nitric oxide metabolic process | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0030865 | cortical cytoskeleton organization | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0042475 | odontogenesis of dentin-containing tooth | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0010827 | regulation of glucose transmembrane transport | 1 | 55 | 5.54e-01 |
| GO:BP | GO:0009410 | response to xenobiotic stimulus | 3 | 279 | 5.54e-01 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 3 | 279 | 5.54e-01 |
| GO:BP | GO:0051347 | positive regulation of transferase activity | 4 | 400 | 5.55e-01 |
| GO:BP | GO:0009895 | negative regulation of catabolic process | 3 | 280 | 5.56e-01 |
| GO:BP | GO:0030163 | protein catabolic process | 8 | 901 | 5.56e-01 |
| GO:BP | GO:2001057 | reactive nitrogen species metabolic process | 1 | 56 | 5.57e-01 |
| GO:BP | GO:0045806 | negative regulation of endocytosis | 1 | 56 | 5.57e-01 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 3 | 281 | 5.57e-01 |
| GO:BP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 1 | 56 | 5.57e-01 |
| GO:BP | GO:0032024 | positive regulation of insulin secretion | 1 | 56 | 5.57e-01 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 1 | 56 | 5.57e-01 |
| GO:BP | GO:0033077 | T cell differentiation in thymus | 1 | 56 | 5.57e-01 |
| GO:BP | GO:0046847 | filopodium assembly | 1 | 56 | 5.57e-01 |
| GO:BP | GO:0033554 | cellular response to stress | 14 | 1681 | 5.60e-01 |
| GO:BP | GO:0007623 | circadian rhythm | 2 | 165 | 5.60e-01 |
| GO:BP | GO:0017148 | negative regulation of translation | 2 | 165 | 5.60e-01 |
| GO:BP | GO:0033555 | multicellular organismal response to stress | 1 | 57 | 5.60e-01 |
| GO:BP | GO:0098657 | import into cell | 2 | 166 | 5.60e-01 |
| GO:BP | GO:0044057 | regulation of system process | 4 | 405 | 5.60e-01 |
| GO:BP | GO:0061614 | miRNA transcription | 1 | 57 | 5.60e-01 |
| GO:BP | GO:1904377 | positive regulation of protein localization to cell periphery | 1 | 57 | 5.60e-01 |
| GO:BP | GO:0042116 | macrophage activation | 1 | 57 | 5.60e-01 |
| GO:BP | GO:2000756 | regulation of peptidyl-lysine acetylation | 1 | 57 | 5.60e-01 |
| GO:BP | GO:0030072 | peptide hormone secretion | 2 | 166 | 5.60e-01 |
| GO:BP | GO:0006576 | biogenic amine metabolic process | 1 | 57 | 5.60e-01 |
| GO:BP | GO:0002088 | lens development in camera-type eye | 1 | 57 | 5.60e-01 |
| GO:BP | GO:0043523 | regulation of neuron apoptotic process | 2 | 167 | 5.63e-01 |
| GO:BP | GO:1901215 | negative regulation of neuron death | 2 | 167 | 5.63e-01 |
| GO:BP | GO:0032271 | regulation of protein polymerization | 2 | 168 | 5.64e-01 |
| GO:BP | GO:0048844 | artery morphogenesis | 1 | 58 | 5.64e-01 |
| GO:BP | GO:0048814 | regulation of dendrite morphogenesis | 1 | 58 | 5.64e-01 |
| GO:BP | GO:0014910 | regulation of smooth muscle cell migration | 1 | 58 | 5.64e-01 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 2 | 168 | 5.64e-01 |
| GO:BP | GO:0032507 | maintenance of protein location in cell | 1 | 58 | 5.64e-01 |
| GO:BP | GO:0046883 | regulation of hormone secretion | 2 | 168 | 5.64e-01 |
| GO:BP | GO:0006821 | chloride transport | 1 | 58 | 5.64e-01 |
| GO:BP | GO:0033059 | cellular pigmentation | 1 | 58 | 5.64e-01 |
| GO:BP | GO:0071260 | cellular response to mechanical stimulus | 1 | 59 | 5.68e-01 |
| GO:BP | GO:0015980 | energy derivation by oxidation of organic compounds | 3 | 288 | 5.68e-01 |
| GO:BP | GO:0061951 | establishment of protein localization to plasma membrane | 1 | 59 | 5.68e-01 |
| GO:BP | GO:1901607 | alpha-amino acid biosynthetic process | 1 | 59 | 5.68e-01 |
| GO:BP | GO:0043954 | cellular component maintenance | 1 | 59 | 5.68e-01 |
| GO:BP | GO:0021510 | spinal cord development | 1 | 59 | 5.68e-01 |
| GO:BP | GO:0032502 | developmental process | 35 | 4494 | 5.68e-01 |
| GO:BP | GO:0051651 | maintenance of location in cell | 2 | 170 | 5.69e-01 |
| GO:BP | GO:0060348 | bone development | 2 | 170 | 5.69e-01 |
| GO:BP | GO:0002790 | peptide secretion | 2 | 170 | 5.69e-01 |
| GO:BP | GO:0031647 | regulation of protein stability | 3 | 290 | 5.71e-01 |
| GO:BP | GO:0071868 | cellular response to monoamine stimulus | 1 | 60 | 5.71e-01 |
| GO:BP | GO:0051899 | membrane depolarization | 1 | 60 | 5.71e-01 |
| GO:BP | GO:0035194 | ncRNA-mediated post-transcriptional gene silencing | 1 | 60 | 5.71e-01 |
| GO:BP | GO:0071870 | cellular response to catecholamine stimulus | 1 | 60 | 5.71e-01 |
| GO:BP | GO:0006893 | Golgi to plasma membrane transport | 1 | 60 | 5.71e-01 |
| GO:BP | GO:0009064 | glutamine family amino acid metabolic process | 1 | 60 | 5.71e-01 |
| GO:BP | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 1 | 60 | 5.71e-01 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | 2 | 172 | 5.72e-01 |
| GO:BP | GO:1901617 | organic hydroxy compound biosynthetic process | 2 | 172 | 5.72e-01 |
| GO:BP | GO:0051924 | regulation of calcium ion transport | 2 | 172 | 5.72e-01 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 2 | 172 | 5.72e-01 |
| GO:BP | GO:0008016 | regulation of heart contraction | 2 | 173 | 5.74e-01 |
| GO:BP | GO:0018958 | phenol-containing compound metabolic process | 1 | 61 | 5.74e-01 |
| GO:BP | GO:0034308 | primary alcohol metabolic process | 1 | 61 | 5.74e-01 |
| GO:BP | GO:0021954 | central nervous system neuron development | 1 | 61 | 5.74e-01 |
| GO:BP | GO:0030032 | lamellipodium assembly | 1 | 61 | 5.74e-01 |
| GO:BP | GO:0033143 | regulation of intracellular steroid hormone receptor signaling pathway | 1 | 61 | 5.74e-01 |
| GO:BP | GO:0042391 | regulation of membrane potential | 3 | 293 | 5.74e-01 |
| GO:BP | GO:0034394 | protein localization to cell surface | 1 | 61 | 5.74e-01 |
| GO:BP | GO:0045661 | regulation of myoblast differentiation | 1 | 61 | 5.74e-01 |
| GO:BP | GO:2000036 | regulation of stem cell population maintenance | 1 | 62 | 5.76e-01 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 3 | 295 | 5.76e-01 |
| GO:BP | GO:0008380 | RNA splicing | 4 | 419 | 5.76e-01 |
| GO:BP | GO:1902750 | negative regulation of cell cycle G2/M phase transition | 1 | 62 | 5.76e-01 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 4 | 418 | 5.76e-01 |
| GO:BP | GO:0051046 | regulation of secretion | 4 | 418 | 5.76e-01 |
| GO:BP | GO:0003208 | cardiac ventricle morphogenesis | 1 | 62 | 5.76e-01 |
| GO:BP | GO:0003073 | regulation of systemic arterial blood pressure | 1 | 62 | 5.76e-01 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 3 | 295 | 5.76e-01 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 16 | 1974 | 5.76e-01 |
| GO:BP | GO:0071869 | response to catecholamine | 1 | 62 | 5.76e-01 |
| GO:BP | GO:0043588 | skin development | 2 | 175 | 5.76e-01 |
| GO:BP | GO:0071867 | response to monoamine | 1 | 62 | 5.76e-01 |
| GO:BP | GO:0051249 | regulation of lymphocyte activation | 3 | 296 | 5.77e-01 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 5 | 547 | 5.80e-01 |
| GO:BP | GO:0048488 | synaptic vesicle endocytosis | 1 | 63 | 5.81e-01 |
| GO:BP | GO:0046889 | positive regulation of lipid biosynthetic process | 1 | 63 | 5.81e-01 |
| GO:BP | GO:0048661 | positive regulation of smooth muscle cell proliferation | 1 | 63 | 5.81e-01 |
| GO:BP | GO:0032922 | circadian regulation of gene expression | 1 | 63 | 5.81e-01 |
| GO:BP | GO:0010569 | regulation of double-strand break repair via homologous recombination | 1 | 63 | 5.81e-01 |
| GO:BP | GO:0009605 | response to external stimulus | 14 | 1719 | 5.82e-01 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 2 | 178 | 5.84e-01 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | 1 | 64 | 5.84e-01 |
| GO:BP | GO:0051262 | protein tetramerization | 1 | 64 | 5.84e-01 |
| GO:BP | GO:0042326 | negative regulation of phosphorylation | 3 | 300 | 5.84e-01 |
| GO:BP | GO:0008652 | amino acid biosynthetic process | 1 | 64 | 5.84e-01 |
| GO:BP | GO:0042594 | response to starvation | 2 | 178 | 5.84e-01 |
| GO:BP | GO:0048678 | response to axon injury | 1 | 64 | 5.84e-01 |
| GO:BP | GO:1901379 | regulation of potassium ion transmembrane transport | 1 | 64 | 5.84e-01 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 3 | 300 | 5.84e-01 |
| GO:BP | GO:0044283 | small molecule biosynthetic process | 4 | 425 | 5.84e-01 |
| GO:BP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 4 | 427 | 5.85e-01 |
| GO:BP | GO:0014909 | smooth muscle cell migration | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0060395 | SMAD protein signal transduction | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 3 | 302 | 5.85e-01 |
| GO:BP | GO:0015833 | peptide transport | 2 | 179 | 5.85e-01 |
| GO:BP | GO:0022411 | cellular component disassembly | 4 | 427 | 5.85e-01 |
| GO:BP | GO:0042254 | ribosome biogenesis | 3 | 301 | 5.85e-01 |
| GO:BP | GO:0006414 | translational elongation | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0006487 | protein N-linked glycosylation | 1 | 65 | 5.85e-01 |
| GO:BP | GO:2000144 | positive regulation of DNA-templated transcription initiation | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0140238 | presynaptic endocytosis | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0008306 | associative learning | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0016441 | post-transcriptional gene silencing | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0071230 | cellular response to amino acid stimulus | 1 | 65 | 5.85e-01 |
| GO:BP | GO:0065003 | protein-containing complex assembly | 11 | 1335 | 5.88e-01 |
| GO:BP | GO:0006954 | inflammatory response | 4 | 429 | 5.88e-01 |
| GO:BP | GO:0080134 | regulation of response to stress | 9 | 1075 | 5.90e-01 |
| GO:BP | GO:0098661 | inorganic anion transmembrane transport | 1 | 66 | 5.91e-01 |
| GO:BP | GO:0009582 | detection of abiotic stimulus | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0050807 | regulation of synapse organization | 2 | 184 | 5.91e-01 |
| GO:BP | GO:0019318 | hexose metabolic process | 2 | 185 | 5.91e-01 |
| GO:BP | GO:0006094 | gluconeogenesis | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0051851 | modulation by host of symbiont process | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0062207 | regulation of pattern recognition receptor signaling pathway | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | 1 | 68 | 5.91e-01 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0051707 | response to other organism | 7 | 820 | 5.91e-01 |
| GO:BP | GO:0009581 | detection of external stimulus | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0001570 | vasculogenesis | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0001942 | hair follicle development | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0030001 | metal ion transport | 5 | 562 | 5.91e-01 |
| GO:BP | GO:0051153 | regulation of striated muscle cell differentiation | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0065004 | protein-DNA complex assembly | 2 | 185 | 5.91e-01 |
| GO:BP | GO:0051341 | regulation of oxidoreductase activity | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0048709 | oligodendrocyte differentiation | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0097061 | dendritic spine organization | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0070897 | transcription preinitiation complex assembly | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0009308 | amine metabolic process | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0071277 | cellular response to calcium ion | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0007422 | peripheral nervous system development | 1 | 67 | 5.91e-01 |
| GO:BP | GO:0006839 | mitochondrial transport | 2 | 185 | 5.91e-01 |
| GO:BP | GO:0043207 | response to external biotic stimulus | 7 | 820 | 5.91e-01 |
| GO:BP | GO:0010822 | positive regulation of mitochondrion organization | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0014013 | regulation of gliogenesis | 1 | 68 | 5.91e-01 |
| GO:BP | GO:2001233 | regulation of apoptotic signaling pathway | 3 | 307 | 5.91e-01 |
| GO:BP | GO:0043279 | response to alkaloid | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0002753 | cytosolic pattern recognition receptor signaling pathway | 1 | 68 | 5.91e-01 |
| GO:BP | GO:0090257 | regulation of muscle system process | 2 | 184 | 5.91e-01 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 15 | 1869 | 5.91e-01 |
| GO:BP | GO:0022402 | cell cycle process | 9 | 1086 | 5.92e-01 |
| GO:BP | GO:0120162 | positive regulation of cold-induced thermogenesis | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0090277 | positive regulation of peptide hormone secretion | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0006493 | protein O-linked glycosylation | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0022405 | hair cycle process | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0006399 | tRNA metabolic process | 2 | 186 | 5.92e-01 |
| GO:BP | GO:0048562 | embryonic organ morphogenesis | 2 | 187 | 5.92e-01 |
| GO:BP | GO:1901983 | regulation of protein acetylation | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0022404 | molting cycle process | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0034249 | negative regulation of amide metabolic process | 2 | 186 | 5.92e-01 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 2 | 187 | 5.92e-01 |
| GO:BP | GO:0043413 | macromolecule glycosylation | 2 | 187 | 5.92e-01 |
| GO:BP | GO:1901566 | organonitrogen compound biosynthetic process | 12 | 1484 | 5.92e-01 |
| GO:BP | GO:0006486 | protein glycosylation | 2 | 187 | 5.92e-01 |
| GO:BP | GO:0019218 | regulation of steroid metabolic process | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0030901 | midbrain development | 1 | 69 | 5.92e-01 |
| GO:BP | GO:0030154 | cell differentiation | 23 | 2958 | 5.92e-01 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 1 | 70 | 5.92e-01 |
| GO:BP | GO:0097306 | cellular response to alcohol | 1 | 70 | 5.92e-01 |
| GO:BP | GO:1901216 | positive regulation of neuron death | 1 | 70 | 5.92e-01 |
| GO:BP | GO:0002793 | positive regulation of peptide secretion | 1 | 70 | 5.92e-01 |
| GO:BP | GO:0043412 | macromolecule modification | 24 | 3090 | 5.92e-01 |
| GO:BP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 1 | 70 | 5.92e-01 |
| GO:BP | GO:0060079 | excitatory postsynaptic potential | 1 | 70 | 5.92e-01 |
| GO:BP | GO:0022409 | positive regulation of cell-cell adhesion | 2 | 189 | 5.92e-01 |
| GO:BP | GO:0006096 | glycolytic process | 1 | 70 | 5.92e-01 |
| GO:BP | GO:0048534 | hematopoietic or lymphoid organ development | 1 | 70 | 5.92e-01 |
| GO:BP | GO:1901698 | response to nitrogen compound | 7 | 830 | 5.92e-01 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 2 | 189 | 5.92e-01 |
| GO:BP | GO:0016239 | positive regulation of macroautophagy | 1 | 70 | 5.92e-01 |
| GO:BP | GO:0019319 | hexose biosynthetic process | 1 | 70 | 5.92e-01 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 10 | 1223 | 5.92e-01 |
| GO:BP | GO:2000736 | regulation of stem cell differentiation | 1 | 71 | 5.95e-01 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | 8 | 963 | 5.95e-01 |
| GO:BP | GO:0098656 | monoatomic anion transmembrane transport | 1 | 71 | 5.95e-01 |
| GO:BP | GO:0071229 | cellular response to acid chemical | 1 | 71 | 5.95e-01 |
| GO:BP | GO:1904035 | regulation of epithelial cell apoptotic process | 1 | 71 | 5.95e-01 |
| GO:BP | GO:0062014 | negative regulation of small molecule metabolic process | 1 | 71 | 5.95e-01 |
| GO:BP | GO:0046620 | regulation of organ growth | 1 | 71 | 5.95e-01 |
| GO:BP | GO:0001892 | embryonic placenta development | 1 | 71 | 5.95e-01 |
| GO:BP | GO:0009100 | glycoprotein metabolic process | 3 | 316 | 5.95e-01 |
| GO:BP | GO:0006473 | protein acetylation | 2 | 190 | 5.95e-01 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | 2 | 191 | 5.95e-01 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 2 | 191 | 5.95e-01 |
| GO:BP | GO:0043933 | protein-containing complex organization | 12 | 1496 | 5.97e-01 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | 3 | 318 | 5.97e-01 |
| GO:BP | GO:0051603 | proteolysis involved in protein catabolic process | 6 | 706 | 5.97e-01 |
| GO:BP | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 1 | 72 | 5.97e-01 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 1 | 72 | 5.97e-01 |
| GO:BP | GO:0072665 | protein localization to vacuole | 1 | 72 | 5.97e-01 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 15 | 1898 | 5.97e-01 |
| GO:BP | GO:0050671 | positive regulation of lymphocyte proliferation | 1 | 72 | 5.97e-01 |
| GO:BP | GO:0003013 | circulatory system process | 4 | 447 | 5.99e-01 |
| GO:BP | GO:0006446 | regulation of translational initiation | 1 | 73 | 6.00e-01 |
| GO:BP | GO:0042471 | ear morphogenesis | 1 | 73 | 6.00e-01 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | 2 | 194 | 6.00e-01 |
| GO:BP | GO:0042273 | ribosomal large subunit biogenesis | 1 | 73 | 6.00e-01 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 1 | 73 | 6.00e-01 |
| GO:BP | GO:2001234 | negative regulation of apoptotic signaling pathway | 2 | 194 | 6.00e-01 |
| GO:BP | GO:0060993 | kidney morphogenesis | 1 | 73 | 6.00e-01 |
| GO:BP | GO:0036465 | synaptic vesicle recycling | 1 | 73 | 6.00e-01 |
| GO:BP | GO:0009987 | cellular process | 84 | 11336 | 6.01e-01 |
| GO:BP | GO:0014896 | muscle hypertrophy | 1 | 74 | 6.05e-01 |
| GO:BP | GO:0001938 | positive regulation of endothelial cell proliferation | 1 | 74 | 6.05e-01 |
| GO:BP | GO:0010507 | negative regulation of autophagy | 1 | 74 | 6.05e-01 |
| GO:BP | GO:0048869 | cellular developmental process | 23 | 2984 | 6.05e-01 |
| GO:BP | GO:0022613 | ribonucleoprotein complex biogenesis | 4 | 453 | 6.08e-01 |
| GO:BP | GO:0099565 | chemical synaptic transmission, postsynaptic | 1 | 75 | 6.08e-01 |
| GO:BP | GO:0051865 | protein autoubiquitination | 1 | 75 | 6.08e-01 |
| GO:BP | GO:0043535 | regulation of blood vessel endothelial cell migration | 1 | 75 | 6.08e-01 |
| GO:BP | GO:0033673 | negative regulation of kinase activity | 2 | 197 | 6.08e-01 |
| GO:BP | GO:0032946 | positive regulation of mononuclear cell proliferation | 1 | 75 | 6.08e-01 |
| GO:BP | GO:0048863 | stem cell differentiation | 2 | 197 | 6.08e-01 |
| GO:BP | GO:0030216 | keratinocyte differentiation | 1 | 75 | 6.08e-01 |
| GO:BP | GO:2000142 | regulation of DNA-templated transcription initiation | 1 | 76 | 6.08e-01 |
| GO:BP | GO:0031397 | negative regulation of protein ubiquitination | 1 | 76 | 6.08e-01 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 6 | 719 | 6.08e-01 |
| GO:BP | GO:0009607 | response to biotic stimulus | 7 | 850 | 6.08e-01 |
| GO:BP | GO:0106027 | neuron projection organization | 1 | 76 | 6.08e-01 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 2 | 198 | 6.08e-01 |
| GO:BP | GO:0045927 | positive regulation of growth | 2 | 199 | 6.08e-01 |
| GO:BP | GO:0014812 | muscle cell migration | 1 | 76 | 6.08e-01 |
| GO:BP | GO:0032273 | positive regulation of protein polymerization | 1 | 76 | 6.08e-01 |
| GO:BP | GO:0006900 | vesicle budding from membrane | 1 | 76 | 6.08e-01 |
| GO:BP | GO:0051251 | positive regulation of lymphocyte activation | 2 | 199 | 6.08e-01 |
| GO:BP | GO:1905897 | regulation of response to endoplasmic reticulum stress | 1 | 76 | 6.08e-01 |
| GO:BP | GO:0006282 | regulation of DNA repair | 2 | 198 | 6.08e-01 |
| GO:BP | GO:1903522 | regulation of blood circulation | 2 | 198 | 6.08e-01 |
| GO:BP | GO:0051402 | neuron apoptotic process | 2 | 200 | 6.11e-01 |
| GO:BP | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 1 | 77 | 6.13e-01 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | 1 | 77 | 6.13e-01 |
| GO:BP | GO:0043255 | regulation of carbohydrate biosynthetic process | 1 | 77 | 6.13e-01 |
| GO:BP | GO:0007420 | brain development | 5 | 591 | 6.14e-01 |
| GO:BP | GO:0032092 | positive regulation of protein binding | 1 | 78 | 6.16e-01 |
| GO:BP | GO:0007276 | gamete generation | 4 | 461 | 6.16e-01 |
| GO:BP | GO:0048706 | embryonic skeletal system development | 1 | 78 | 6.16e-01 |
| GO:BP | GO:0097581 | lamellipodium organization | 1 | 78 | 6.16e-01 |
| GO:BP | GO:0070085 | glycosylation | 2 | 202 | 6.16e-01 |
| GO:BP | GO:0008593 | regulation of Notch signaling pathway | 1 | 78 | 6.16e-01 |
| GO:BP | GO:0051702 | biological process involved in interaction with symbiont | 1 | 78 | 6.16e-01 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 6 | 726 | 6.16e-01 |
| GO:BP | GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 2 | 203 | 6.17e-01 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 2 | 203 | 6.17e-01 |
| GO:BP | GO:0007049 | cell cycle | 12 | 1529 | 6.18e-01 |
| GO:BP | GO:0071824 | protein-DNA complex subunit organization | 2 | 204 | 6.19e-01 |
| GO:BP | GO:0006289 | nucleotide-excision repair | 1 | 79 | 6.19e-01 |
| GO:BP | GO:0046364 | monosaccharide biosynthetic process | 1 | 79 | 6.19e-01 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 5 | 597 | 6.20e-01 |
| GO:BP | GO:0003012 | muscle system process | 3 | 334 | 6.20e-01 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 5 | 597 | 6.20e-01 |
| GO:BP | GO:0003006 | developmental process involved in reproduction | 5 | 598 | 6.21e-01 |
| GO:BP | GO:0071310 | cellular response to organic substance | 11 | 1399 | 6.21e-01 |
| GO:BP | GO:1901342 | regulation of vasculature development | 2 | 206 | 6.21e-01 |
| GO:BP | GO:0006334 | nucleosome assembly | 1 | 80 | 6.21e-01 |
| GO:BP | GO:0045995 | regulation of embryonic development | 1 | 80 | 6.21e-01 |
| GO:BP | GO:0006513 | protein monoubiquitination | 1 | 80 | 6.21e-01 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 2 | 206 | 6.21e-01 |
| GO:BP | GO:0006672 | ceramide metabolic process | 1 | 80 | 6.21e-01 |
| GO:BP | GO:0010817 | regulation of hormone levels | 3 | 336 | 6.21e-01 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | 4 | 468 | 6.22e-01 |
| GO:BP | GO:0044773 | mitotic DNA damage checkpoint signaling | 1 | 81 | 6.23e-01 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | 2 | 207 | 6.23e-01 |
| GO:BP | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 1 | 81 | 6.23e-01 |
| GO:BP | GO:0009628 | response to abiotic stimulus | 7 | 868 | 6.23e-01 |
| GO:BP | GO:0010586 | miRNA metabolic process | 1 | 81 | 6.23e-01 |
| GO:BP | GO:1904659 | glucose transmembrane transport | 1 | 81 | 6.23e-01 |
| GO:BP | GO:0007267 | cell-cell signaling | 9 | 1138 | 6.26e-01 |
| GO:BP | GO:1901890 | positive regulation of cell junction assembly | 1 | 82 | 6.26e-01 |
| GO:BP | GO:0051928 | positive regulation of calcium ion transport | 1 | 82 | 6.26e-01 |
| GO:BP | GO:0043406 | positive regulation of MAP kinase activity | 1 | 82 | 6.26e-01 |
| GO:BP | GO:0019751 | polyol metabolic process | 1 | 82 | 6.26e-01 |
| GO:BP | GO:0060284 | regulation of cell development | 5 | 605 | 6.26e-01 |
| GO:BP | GO:0050900 | leukocyte migration | 2 | 209 | 6.26e-01 |
| GO:BP | GO:0060078 | regulation of postsynaptic membrane potential | 1 | 82 | 6.26e-01 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | 2 | 209 | 6.26e-01 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 3 | 340 | 6.26e-01 |
| GO:BP | GO:0014706 | striated muscle tissue development | 2 | 210 | 6.27e-01 |
| GO:BP | GO:0046879 | hormone secretion | 2 | 210 | 6.27e-01 |
| GO:BP | GO:0034341 | response to type II interferon | 1 | 83 | 6.28e-01 |
| GO:BP | GO:0030433 | ubiquitin-dependent ERAD pathway | 1 | 83 | 6.28e-01 |
| GO:BP | GO:0006820 | monoatomic anion transport | 1 | 83 | 6.28e-01 |
| GO:BP | GO:0009056 | catabolic process | 16 | 2088 | 6.28e-01 |
| GO:BP | GO:0060840 | artery development | 1 | 83 | 6.28e-01 |
| GO:BP | GO:0070665 | positive regulation of leukocyte proliferation | 1 | 83 | 6.28e-01 |
| GO:BP | GO:0070371 | ERK1 and ERK2 cascade | 2 | 211 | 6.28e-01 |
| GO:BP | GO:1903037 | regulation of leukocyte cell-cell adhesion | 2 | 211 | 6.28e-01 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 4 | 475 | 6.28e-01 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | 3 | 344 | 6.28e-01 |
| GO:BP | GO:0008645 | hexose transmembrane transport | 1 | 84 | 6.28e-01 |
| GO:BP | GO:0030278 | regulation of ossification | 1 | 84 | 6.28e-01 |
| GO:BP | GO:0009408 | response to heat | 1 | 84 | 6.28e-01 |
| GO:BP | GO:0016032 | viral process | 3 | 344 | 6.28e-01 |
| GO:BP | GO:1905477 | positive regulation of protein localization to membrane | 1 | 84 | 6.28e-01 |
| GO:BP | GO:0120254 | olefinic compound metabolic process | 1 | 84 | 6.28e-01 |
| GO:BP | GO:0050852 | T cell receptor signaling pathway | 1 | 84 | 6.28e-01 |
| GO:BP | GO:0021782 | glial cell development | 1 | 84 | 6.28e-01 |
| GO:BP | GO:1990830 | cellular response to leukemia inhibitory factor | 1 | 84 | 6.28e-01 |
| GO:BP | GO:0015749 | monosaccharide transmembrane transport | 1 | 85 | 6.30e-01 |
| GO:BP | GO:0044774 | mitotic DNA integrity checkpoint signaling | 1 | 85 | 6.30e-01 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 1 | 85 | 6.30e-01 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | 3 | 345 | 6.30e-01 |
| GO:BP | GO:0051716 | cellular response to stimulus | 37 | 4953 | 6.30e-01 |
| GO:BP | GO:0032526 | response to retinoic acid | 1 | 85 | 6.30e-01 |
| GO:BP | GO:1903050 | regulation of proteolysis involved in protein catabolic process | 2 | 214 | 6.30e-01 |
| GO:BP | GO:0050921 | positive regulation of chemotaxis | 1 | 85 | 6.30e-01 |
| GO:BP | GO:1990823 | response to leukemia inhibitory factor | 1 | 85 | 6.30e-01 |
| GO:BP | GO:0034644 | cellular response to UV | 1 | 86 | 6.32e-01 |
| GO:BP | GO:0035270 | endocrine system development | 1 | 86 | 6.32e-01 |
| GO:BP | GO:0006511 | ubiquitin-dependent protein catabolic process | 5 | 615 | 6.32e-01 |
| GO:BP | GO:0009914 | hormone transport | 2 | 215 | 6.32e-01 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | 3 | 348 | 6.32e-01 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 1 | 86 | 6.32e-01 |
| GO:BP | GO:0010906 | regulation of glucose metabolic process | 1 | 86 | 6.32e-01 |
| GO:BP | GO:1901655 | cellular response to ketone | 1 | 86 | 6.32e-01 |
| GO:BP | GO:0042476 | odontogenesis | 1 | 86 | 6.32e-01 |
| GO:BP | GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 1 | 86 | 6.32e-01 |
| GO:BP | GO:0002694 | regulation of leukocyte activation | 3 | 348 | 6.32e-01 |
| GO:BP | GO:0050863 | regulation of T cell activation | 2 | 216 | 6.32e-01 |
| GO:BP | GO:0048259 | regulation of receptor-mediated endocytosis | 1 | 87 | 6.35e-01 |
| GO:BP | GO:0098773 | skin epidermis development | 1 | 87 | 6.35e-01 |
| GO:BP | GO:0050728 | negative regulation of inflammatory response | 1 | 87 | 6.35e-01 |
| GO:BP | GO:0044092 | negative regulation of molecular function | 6 | 755 | 6.38e-01 |
| GO:BP | GO:0061337 | cardiac conduction | 1 | 88 | 6.40e-01 |
| GO:BP | GO:0030148 | sphingolipid biosynthetic process | 1 | 88 | 6.40e-01 |
| GO:BP | GO:0031668 | cellular response to extracellular stimulus | 2 | 219 | 6.40e-01 |
| GO:BP | GO:0033043 | regulation of organelle organization | 8 | 1028 | 6.41e-01 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | 1 | 89 | 6.41e-01 |
| GO:BP | GO:0045445 | myoblast differentiation | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0043467 | regulation of generation of precursor metabolites and energy | 1 | 89 | 6.41e-01 |
| GO:BP | GO:0006400 | tRNA modification | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0001843 | neural tube closure | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0043271 | negative regulation of monoatomic ion transport | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0043500 | muscle adaptation | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0002696 | positive regulation of leukocyte activation | 2 | 222 | 6.41e-01 |
| GO:BP | GO:1901575 | organic substance catabolic process | 13 | 1712 | 6.41e-01 |
| GO:BP | GO:0045446 | endothelial cell differentiation | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0019941 | modification-dependent protein catabolic process | 5 | 625 | 6.41e-01 |
| GO:BP | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | 1 | 89 | 6.41e-01 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 1 | 89 | 6.41e-01 |
| GO:BP | GO:0031644 | regulation of nervous system process | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0046887 | positive regulation of hormone secretion | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 1 | 89 | 6.41e-01 |
| GO:BP | GO:0006520 | amino acid metabolic process | 2 | 222 | 6.41e-01 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 1 | 89 | 6.41e-01 |
| GO:BP | GO:0061912 | selective autophagy | 1 | 90 | 6.41e-01 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 1 | 89 | 6.41e-01 |
| GO:BP | GO:0051960 | regulation of nervous system development | 3 | 357 | 6.42e-01 |
| GO:BP | GO:0044403 | biological process involved in symbiotic interaction | 2 | 223 | 6.43e-01 |
| GO:BP | GO:0060606 | tube closure | 1 | 91 | 6.44e-01 |
| GO:BP | GO:0031399 | regulation of protein modification process | 9 | 1173 | 6.44e-01 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 1 | 91 | 6.44e-01 |
| GO:BP | GO:0051224 | negative regulation of protein transport | 1 | 91 | 6.44e-01 |
| GO:BP | GO:0030168 | platelet activation | 1 | 91 | 6.44e-01 |
| GO:BP | GO:0000422 | autophagy of mitochondrion | 1 | 92 | 6.45e-01 |
| GO:BP | GO:0061726 | mitochondrion disassembly | 1 | 92 | 6.45e-01 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | 4 | 496 | 6.45e-01 |
| GO:BP | GO:0048144 | fibroblast proliferation | 1 | 92 | 6.45e-01 |
| GO:BP | GO:0034219 | carbohydrate transmembrane transport | 1 | 92 | 6.45e-01 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | 5 | 631 | 6.45e-01 |
| GO:BP | GO:0043473 | pigmentation | 1 | 92 | 6.45e-01 |
| GO:BP | GO:0019953 | sexual reproduction | 5 | 631 | 6.45e-01 |
| GO:BP | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 1 | 92 | 6.45e-01 |
| GO:BP | GO:0060322 | head development | 5 | 633 | 6.47e-01 |
| GO:BP | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 2 | 227 | 6.48e-01 |
| GO:BP | GO:0006090 | pyruvate metabolic process | 1 | 93 | 6.48e-01 |
| GO:BP | GO:0006518 | peptide metabolic process | 6 | 771 | 6.48e-01 |
| GO:BP | GO:0071333 | cellular response to glucose stimulus | 1 | 93 | 6.48e-01 |
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | 1 | 93 | 6.48e-01 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | 2 | 227 | 6.48e-01 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 2 | 228 | 6.50e-01 |
| GO:BP | GO:0043543 | protein acylation | 2 | 228 | 6.50e-01 |
| GO:BP | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 1 | 94 | 6.50e-01 |
| GO:BP | GO:0014020 | primary neural tube formation | 1 | 94 | 6.50e-01 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | 5 | 637 | 6.50e-01 |
| GO:BP | GO:0071331 | cellular response to hexose stimulus | 1 | 94 | 6.50e-01 |
| GO:BP | GO:0050867 | positive regulation of cell activation | 2 | 229 | 6.51e-01 |
| GO:BP | GO:0006811 | monoatomic ion transport | 6 | 775 | 6.51e-01 |
| GO:BP | GO:0043604 | amide biosynthetic process | 6 | 775 | 6.51e-01 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | 2 | 229 | 6.51e-01 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 5 | 640 | 6.51e-01 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | 2 | 230 | 6.51e-01 |
| GO:BP | GO:0042129 | regulation of T cell proliferation | 1 | 95 | 6.51e-01 |
| GO:BP | GO:1904950 | negative regulation of establishment of protein localization | 1 | 95 | 6.51e-01 |
| GO:BP | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 1 | 95 | 6.51e-01 |
| GO:BP | GO:0043200 | response to amino acid | 1 | 95 | 6.51e-01 |
| GO:BP | GO:0071326 | cellular response to monosaccharide stimulus | 1 | 95 | 6.51e-01 |
| GO:BP | GO:0016197 | endosomal transport | 2 | 231 | 6.53e-01 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 15 | 2011 | 6.53e-01 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | 2 | 232 | 6.54e-01 |
| GO:BP | GO:0006091 | generation of precursor metabolites and energy | 3 | 369 | 6.54e-01 |
| GO:BP | GO:0006575 | cellular modified amino acid metabolic process | 1 | 96 | 6.54e-01 |
| GO:BP | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 1 | 96 | 6.54e-01 |
| GO:BP | GO:0045088 | regulation of innate immune response | 2 | 232 | 6.54e-01 |
| GO:BP | GO:0007059 | chromosome segregation | 3 | 369 | 6.54e-01 |
| GO:BP | GO:0031175 | neuron projection development | 6 | 780 | 6.54e-01 |
| GO:BP | GO:0034446 | substrate adhesion-dependent cell spreading | 1 | 97 | 6.55e-01 |
| GO:BP | GO:0043534 | blood vessel endothelial cell migration | 1 | 97 | 6.55e-01 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 6 | 782 | 6.55e-01 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 1 | 97 | 6.55e-01 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | 1 | 97 | 6.55e-01 |
| GO:BP | GO:0051348 | negative regulation of transferase activity | 2 | 234 | 6.57e-01 |
| GO:BP | GO:0034728 | nucleosome organization | 1 | 98 | 6.59e-01 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 1 | 98 | 6.59e-01 |
| GO:BP | GO:0010565 | regulation of cellular ketone metabolic process | 1 | 98 | 6.59e-01 |
| GO:BP | GO:0042886 | amide transport | 2 | 235 | 6.59e-01 |
| GO:BP | GO:0008584 | male gonad development | 1 | 99 | 6.59e-01 |
| GO:BP | GO:0097746 | blood vessel diameter maintenance | 1 | 99 | 6.59e-01 |
| GO:BP | GO:1903531 | negative regulation of secretion by cell | 1 | 99 | 6.59e-01 |
| GO:BP | GO:0071482 | cellular response to light stimulus | 1 | 99 | 6.59e-01 |
| GO:BP | GO:0035296 | regulation of tube diameter | 1 | 99 | 6.59e-01 |
| GO:BP | GO:1904064 | positive regulation of cation transmembrane transport | 1 | 99 | 6.59e-01 |
| GO:BP | GO:0090630 | activation of GTPase activity | 1 | 99 | 6.59e-01 |
| GO:BP | GO:0035150 | regulation of tube size | 1 | 99 | 6.59e-01 |
| GO:BP | GO:0050878 | regulation of body fluid levels | 2 | 236 | 6.59e-01 |
| GO:BP | GO:0048511 | rhythmic process | 2 | 237 | 6.60e-01 |
| GO:BP | GO:0001666 | response to hypoxia | 2 | 237 | 6.60e-01 |
| GO:BP | GO:0042177 | negative regulation of protein catabolic process | 1 | 100 | 6.62e-01 |
| GO:BP | GO:0033135 | regulation of peptidyl-serine phosphorylation | 1 | 100 | 6.62e-01 |
| GO:BP | GO:0046546 | development of primary male sexual characteristics | 1 | 100 | 6.62e-01 |
| GO:BP | GO:0007417 | central nervous system development | 6 | 792 | 6.63e-01 |
| GO:BP | GO:0000904 | cell morphogenesis involved in differentiation | 4 | 516 | 6.64e-01 |
| GO:BP | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 1 | 101 | 6.64e-01 |
| GO:BP | GO:0021987 | cerebral cortex development | 1 | 101 | 6.64e-01 |
| GO:BP | GO:0030856 | regulation of epithelial cell differentiation | 1 | 101 | 6.64e-01 |
| GO:BP | GO:0000018 | regulation of DNA recombination | 1 | 101 | 6.64e-01 |
| GO:BP | GO:0051258 | protein polymerization | 2 | 241 | 6.68e-01 |
| GO:BP | GO:0071674 | mononuclear cell migration | 1 | 102 | 6.68e-01 |
| GO:BP | GO:0001936 | regulation of endothelial cell proliferation | 1 | 102 | 6.68e-01 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | 2 | 242 | 6.70e-01 |
| GO:BP | GO:1902749 | regulation of cell cycle G2/M phase transition | 1 | 103 | 6.70e-01 |
| GO:BP | GO:0031047 | RNA-mediated gene silencing | 1 | 103 | 6.70e-01 |
| GO:BP | GO:0006892 | post-Golgi vesicle-mediated transport | 1 | 103 | 6.70e-01 |
| GO:BP | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 1 | 103 | 6.70e-01 |
| GO:BP | GO:0022904 | respiratory electron transport chain | 1 | 104 | 6.74e-01 |
| GO:BP | GO:0003158 | endothelium development | 1 | 104 | 6.74e-01 |
| GO:BP | GO:0006906 | vesicle fusion | 1 | 104 | 6.74e-01 |
| GO:BP | GO:0043043 | peptide biosynthetic process | 5 | 666 | 6.76e-01 |
| GO:BP | GO:0001101 | response to acid chemical | 1 | 105 | 6.76e-01 |
| GO:BP | GO:1901214 | regulation of neuron death | 2 | 246 | 6.76e-01 |
| GO:BP | GO:0006952 | defense response | 7 | 944 | 6.76e-01 |
| GO:BP | GO:0001508 | action potential | 1 | 105 | 6.76e-01 |
| GO:BP | GO:0009416 | response to light stimulus | 2 | 246 | 6.76e-01 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 5 | 665 | 6.76e-01 |
| GO:BP | GO:0071322 | cellular response to carbohydrate stimulus | 1 | 105 | 6.76e-01 |
| GO:BP | GO:0050851 | antigen receptor-mediated signaling pathway | 1 | 106 | 6.78e-01 |
| GO:BP | GO:0090174 | organelle membrane fusion | 1 | 106 | 6.78e-01 |
| GO:BP | GO:0048660 | regulation of smooth muscle cell proliferation | 1 | 106 | 6.78e-01 |
| GO:BP | GO:0036503 | ERAD pathway | 1 | 106 | 6.78e-01 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 4 | 529 | 6.78e-01 |
| GO:BP | GO:0006935 | chemotaxis | 3 | 389 | 6.78e-01 |
| GO:BP | GO:0006812 | monoatomic cation transport | 5 | 669 | 6.78e-01 |
| GO:BP | GO:0042330 | taxis | 3 | 389 | 6.78e-01 |
| GO:BP | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 1 | 107 | 6.80e-01 |
| GO:BP | GO:0046718 | viral entry into host cell | 1 | 107 | 6.80e-01 |
| GO:BP | GO:0061024 | membrane organization | 5 | 671 | 6.80e-01 |
| GO:BP | GO:0031398 | positive regulation of protein ubiquitination | 1 | 108 | 6.82e-01 |
| GO:BP | GO:0045834 | positive regulation of lipid metabolic process | 1 | 108 | 6.82e-01 |
| GO:BP | GO:0019216 | regulation of lipid metabolic process | 2 | 250 | 6.82e-01 |
| GO:BP | GO:2001235 | positive regulation of apoptotic signaling pathway | 1 | 108 | 6.82e-01 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | 6 | 816 | 6.86e-01 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 1 | 109 | 6.86e-01 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 3 | 395 | 6.88e-01 |
| GO:BP | GO:0051606 | detection of stimulus | 1 | 110 | 6.88e-01 |
| GO:BP | GO:0001678 | intracellular glucose homeostasis | 1 | 110 | 6.88e-01 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | 1 | 110 | 6.88e-01 |
| GO:BP | GO:0008283 | cell population proliferation | 10 | 1378 | 6.88e-01 |
| GO:BP | GO:0048609 | multicellular organismal reproductive process | 4 | 538 | 6.89e-01 |
| GO:BP | GO:0051048 | negative regulation of secretion | 1 | 111 | 6.90e-01 |
| GO:BP | GO:1901800 | positive regulation of proteasomal protein catabolic process | 1 | 111 | 6.90e-01 |
| GO:BP | GO:0008643 | carbohydrate transport | 1 | 111 | 6.90e-01 |
| GO:BP | GO:0030048 | actin filament-based movement | 1 | 112 | 6.92e-01 |
| GO:BP | GO:0050954 | sensory perception of mechanical stimulus | 1 | 112 | 6.92e-01 |
| GO:BP | GO:0043401 | steroid hormone mediated signaling pathway | 1 | 112 | 6.92e-01 |
| GO:BP | GO:0018108 | peptidyl-tyrosine phosphorylation | 2 | 256 | 6.92e-01 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 4 | 541 | 6.92e-01 |
| GO:BP | GO:0051053 | negative regulation of DNA metabolic process | 1 | 112 | 6.92e-01 |
| GO:BP | GO:0048592 | eye morphogenesis | 1 | 113 | 6.94e-01 |
| GO:BP | GO:0051592 | response to calcium ion | 1 | 113 | 6.94e-01 |
| GO:BP | GO:0018212 | peptidyl-tyrosine modification | 2 | 258 | 6.94e-01 |
| GO:BP | GO:0044409 | entry into host | 1 | 113 | 6.94e-01 |
| GO:BP | GO:0048638 | regulation of developmental growth | 2 | 258 | 6.94e-01 |
| GO:BP | GO:0006950 | response to stress | 20 | 2780 | 6.96e-01 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 1 | 114 | 6.97e-01 |
| GO:BP | GO:0046661 | male sex differentiation | 1 | 114 | 6.97e-01 |
| GO:BP | GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 1 | 114 | 6.97e-01 |
| GO:BP | GO:0002221 | pattern recognition receptor signaling pathway | 1 | 115 | 6.99e-01 |
| GO:BP | GO:0030595 | leukocyte chemotaxis | 1 | 115 | 6.99e-01 |
| GO:BP | GO:0007612 | learning | 1 | 115 | 6.99e-01 |
| GO:BP | GO:0007568 | aging | 1 | 115 | 6.99e-01 |
| GO:BP | GO:0097553 | calcium ion transmembrane import into cytosol | 1 | 115 | 6.99e-01 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 6 | 834 | 7.01e-01 |
| GO:BP | GO:0001935 | endothelial cell proliferation | 1 | 116 | 7.01e-01 |
| GO:BP | GO:0051783 | regulation of nuclear division | 1 | 116 | 7.01e-01 |
| GO:BP | GO:0010033 | response to organic substance | 14 | 1957 | 7.01e-01 |
| GO:BP | GO:0006413 | translational initiation | 1 | 116 | 7.01e-01 |
| GO:BP | GO:0007009 | plasma membrane organization | 1 | 116 | 7.01e-01 |
| GO:BP | GO:1903047 | mitotic cell cycle process | 5 | 694 | 7.02e-01 |
| GO:BP | GO:1900180 | regulation of protein localization to nucleus | 1 | 117 | 7.02e-01 |
| GO:BP | GO:0001959 | regulation of cytokine-mediated signaling pathway | 1 | 117 | 7.02e-01 |
| GO:BP | GO:0001890 | placenta development | 1 | 117 | 7.02e-01 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 1 | 117 | 7.02e-01 |
| GO:BP | GO:0048468 | cell development | 14 | 1963 | 7.04e-01 |
| GO:BP | GO:0006066 | alcohol metabolic process | 2 | 265 | 7.04e-01 |
| GO:BP | GO:0051147 | regulation of muscle cell differentiation | 1 | 118 | 7.05e-01 |
| GO:BP | GO:0000165 | MAPK cascade | 4 | 556 | 7.07e-01 |
| GO:BP | GO:0032504 | multicellular organism reproduction | 4 | 556 | 7.07e-01 |
| GO:BP | GO:1903311 | regulation of mRNA metabolic process | 2 | 267 | 7.07e-01 |
| GO:BP | GO:0006936 | muscle contraction | 2 | 267 | 7.07e-01 |
| GO:BP | GO:0042098 | T cell proliferation | 1 | 120 | 7.08e-01 |
| GO:BP | GO:0043524 | negative regulation of neuron apoptotic process | 1 | 120 | 7.08e-01 |
| GO:BP | GO:0104004 | cellular response to environmental stimulus | 2 | 268 | 7.08e-01 |
| GO:BP | GO:0071214 | cellular response to abiotic stimulus | 2 | 268 | 7.08e-01 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 3 | 414 | 7.08e-01 |
| GO:BP | GO:0051225 | spindle assembly | 1 | 120 | 7.08e-01 |
| GO:BP | GO:0140013 | meiotic nuclear division | 1 | 120 | 7.08e-01 |
| GO:BP | GO:0016052 | carbohydrate catabolic process | 1 | 120 | 7.08e-01 |
| GO:BP | GO:0006816 | calcium ion transport | 2 | 269 | 7.09e-01 |
| GO:BP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 1 | 121 | 7.10e-01 |
| GO:BP | GO:2000779 | regulation of double-strand break repair | 1 | 121 | 7.10e-01 |
| GO:BP | GO:0051983 | regulation of chromosome segregation | 1 | 121 | 7.10e-01 |
| GO:BP | GO:0000077 | DNA damage checkpoint signaling | 1 | 121 | 7.10e-01 |
| GO:BP | GO:0006694 | steroid biosynthetic process | 1 | 121 | 7.10e-01 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 4 | 563 | 7.11e-01 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | 3 | 418 | 7.11e-01 |
| GO:BP | GO:0019722 | calcium-mediated signaling | 1 | 122 | 7.11e-01 |
| GO:BP | GO:0050792 | regulation of viral process | 1 | 122 | 7.11e-01 |
| GO:BP | GO:0002758 | innate immune response-activating signaling pathway | 1 | 122 | 7.11e-01 |
| GO:BP | GO:0044272 | sulfur compound biosynthetic process | 1 | 122 | 7.11e-01 |
| GO:BP | GO:0043603 | amide metabolic process | 7 | 993 | 7.11e-01 |
| GO:BP | GO:0002253 | activation of immune response | 2 | 272 | 7.11e-01 |
| GO:BP | GO:0071456 | cellular response to hypoxia | 1 | 123 | 7.12e-01 |
| GO:BP | GO:0003002 | regionalization | 2 | 273 | 7.12e-01 |
| GO:BP | GO:0051896 | regulation of protein kinase B signaling | 1 | 123 | 7.12e-01 |
| GO:BP | GO:0002274 | myeloid leukocyte activation | 1 | 123 | 7.12e-01 |
| GO:BP | GO:0046467 | membrane lipid biosynthetic process | 1 | 124 | 7.15e-01 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 1 | 124 | 7.15e-01 |
| GO:BP | GO:0032940 | secretion by cell | 4 | 569 | 7.17e-01 |
| GO:BP | GO:0019725 | cellular homeostasis | 4 | 569 | 7.17e-01 |
| GO:BP | GO:0010950 | positive regulation of endopeptidase activity | 1 | 126 | 7.19e-01 |
| GO:BP | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 1 | 126 | 7.19e-01 |
| GO:BP | GO:0050670 | regulation of lymphocyte proliferation | 1 | 126 | 7.19e-01 |
| GO:BP | GO:0060759 | regulation of response to cytokine stimulus | 1 | 126 | 7.19e-01 |
| GO:BP | GO:0001933 | negative regulation of protein phosphorylation | 2 | 277 | 7.19e-01 |
| GO:BP | GO:1901565 | organonitrogen compound catabolic process | 8 | 1145 | 7.19e-01 |
| GO:BP | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 1 | 127 | 7.21e-01 |
| GO:BP | GO:0007098 | centrosome cycle | 1 | 127 | 7.21e-01 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 1 | 127 | 7.21e-01 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 8 | 1149 | 7.21e-01 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 15 | 2139 | 7.21e-01 |
| GO:BP | GO:2000241 | regulation of reproductive process | 1 | 128 | 7.24e-01 |
| GO:BP | GO:0007165 | signal transduction | 27 | 3818 | 7.25e-01 |
| GO:BP | GO:0031570 | DNA integrity checkpoint signaling | 1 | 129 | 7.26e-01 |
| GO:BP | GO:0032944 | regulation of mononuclear cell proliferation | 1 | 129 | 7.26e-01 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | 1 | 130 | 7.29e-01 |
| GO:BP | GO:0002684 | positive regulation of immune system process | 4 | 581 | 7.30e-01 |
| GO:BP | GO:0035265 | organ growth | 1 | 131 | 7.31e-01 |
| GO:BP | GO:0006665 | sphingolipid metabolic process | 1 | 131 | 7.31e-01 |
| GO:BP | GO:0070997 | neuron death | 2 | 286 | 7.34e-01 |
| GO:BP | GO:0048666 | neuron development | 6 | 877 | 7.35e-01 |
| GO:BP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 1 | 133 | 7.35e-01 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 15 | 2161 | 7.35e-01 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 1 | 133 | 7.35e-01 |
| GO:BP | GO:0042445 | hormone metabolic process | 1 | 133 | 7.35e-01 |
| GO:BP | GO:0001764 | neuron migration | 1 | 133 | 7.35e-01 |
| GO:BP | GO:0002682 | regulation of immune system process | 6 | 877 | 7.35e-01 |
| GO:BP | GO:0046907 | intracellular transport | 10 | 1453 | 7.35e-01 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | 3 | 439 | 7.36e-01 |
| GO:BP | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 2 | 289 | 7.36e-01 |
| GO:BP | GO:0000398 | mRNA splicing, via spliceosome | 2 | 289 | 7.36e-01 |
| GO:BP | GO:0010952 | positive regulation of peptidase activity | 1 | 135 | 7.38e-01 |
| GO:BP | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 1 | 135 | 7.38e-01 |
| GO:BP | GO:0048284 | organelle fusion | 1 | 135 | 7.38e-01 |
| GO:BP | GO:0006955 | immune response | 6 | 882 | 7.38e-01 |
| GO:BP | GO:1903046 | meiotic cell cycle process | 1 | 135 | 7.38e-01 |
| GO:BP | GO:0032386 | regulation of intracellular transport | 2 | 292 | 7.41e-01 |
| GO:BP | GO:0090501 | RNA phosphodiester bond hydrolysis | 1 | 136 | 7.41e-01 |
| GO:BP | GO:1903008 | organelle disassembly | 1 | 137 | 7.41e-01 |
| GO:BP | GO:0000375 | RNA splicing, via transesterification reactions | 2 | 293 | 7.41e-01 |
| GO:BP | GO:0009749 | response to glucose | 1 | 137 | 7.41e-01 |
| GO:BP | GO:0031023 | microtubule organizing center organization | 1 | 137 | 7.41e-01 |
| GO:BP | GO:0061025 | membrane fusion | 1 | 137 | 7.41e-01 |
| GO:BP | GO:0002831 | regulation of response to biotic stimulus | 2 | 293 | 7.41e-01 |
| GO:BP | GO:0045664 | regulation of neuron differentiation | 1 | 137 | 7.41e-01 |
| GO:BP | GO:0007030 | Golgi organization | 1 | 137 | 7.41e-01 |
| GO:BP | GO:0044000 | movement in host | 1 | 138 | 7.43e-01 |
| GO:BP | GO:0009746 | response to hexose | 1 | 138 | 7.43e-01 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | 2 | 295 | 7.43e-01 |
| GO:BP | GO:0031347 | regulation of defense response | 3 | 448 | 7.44e-01 |
| GO:BP | GO:0009755 | hormone-mediated signaling pathway | 1 | 139 | 7.44e-01 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 1 | 139 | 7.44e-01 |
| GO:BP | GO:0021543 | pallium development | 1 | 139 | 7.44e-01 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | 1 | 139 | 7.44e-01 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 5 | 748 | 7.46e-01 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | 1 | 140 | 7.46e-01 |
| GO:BP | GO:0051052 | regulation of DNA metabolic process | 3 | 452 | 7.47e-01 |
| GO:BP | GO:0043405 | regulation of MAP kinase activity | 1 | 141 | 7.47e-01 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 2 | 299 | 7.47e-01 |
| GO:BP | GO:0009411 | response to UV | 1 | 141 | 7.47e-01 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | 1 | 141 | 7.47e-01 |
| GO:BP | GO:0070663 | regulation of leukocyte proliferation | 1 | 141 | 7.47e-01 |
| GO:BP | GO:0003008 | system process | 8 | 1189 | 7.47e-01 |
| GO:BP | GO:0050920 | regulation of chemotaxis | 1 | 142 | 7.47e-01 |
| GO:BP | GO:0022900 | electron transport chain | 1 | 142 | 7.47e-01 |
| GO:BP | GO:0034284 | response to monosaccharide | 1 | 142 | 7.47e-01 |
| GO:BP | GO:0002218 | activation of innate immune response | 1 | 142 | 7.47e-01 |
| GO:BP | GO:1902075 | cellular response to salt | 1 | 142 | 7.47e-01 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 4 | 604 | 7.47e-01 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 2 | 301 | 7.47e-01 |
| GO:BP | GO:0051668 | localization within membrane | 4 | 605 | 7.47e-01 |
| GO:BP | GO:0034097 | response to cytokine | 4 | 607 | 7.50e-01 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 2 | 303 | 7.50e-01 |
| GO:BP | GO:0098542 | defense response to other organism | 4 | 608 | 7.51e-01 |
| GO:BP | GO:0002520 | immune system development | 1 | 144 | 7.51e-01 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 6 | 906 | 7.52e-01 |
| GO:BP | GO:0032535 | regulation of cellular component size | 2 | 305 | 7.53e-01 |
| GO:BP | GO:0140352 | export from cell | 4 | 611 | 7.54e-01 |
| GO:BP | GO:0007389 | pattern specification process | 2 | 306 | 7.54e-01 |
| GO:BP | GO:0043491 | protein kinase B signaling | 1 | 146 | 7.55e-01 |
| GO:BP | GO:0007219 | Notch signaling pathway | 1 | 146 | 7.55e-01 |
| GO:BP | GO:0030324 | lung development | 1 | 146 | 7.55e-01 |
| GO:BP | GO:0043488 | regulation of mRNA stability | 1 | 147 | 7.56e-01 |
| GO:BP | GO:1901654 | response to ketone | 1 | 147 | 7.56e-01 |
| GO:BP | GO:0016236 | macroautophagy | 2 | 308 | 7.56e-01 |
| GO:BP | GO:1990138 | neuron projection extension | 1 | 148 | 7.59e-01 |
| GO:BP | GO:0030099 | myeloid cell differentiation | 2 | 310 | 7.59e-01 |
| GO:BP | GO:0000724 | double-strand break repair via homologous recombination | 1 | 149 | 7.61e-01 |
| GO:BP | GO:0030323 | respiratory tube development | 1 | 150 | 7.63e-01 |
| GO:BP | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 1 | 151 | 7.65e-01 |
| GO:BP | GO:0015031 | protein transport | 9 | 1361 | 7.65e-01 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 1 | 151 | 7.65e-01 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 1 | 151 | 7.65e-01 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 1 | 152 | 7.67e-01 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 7 | 1074 | 7.68e-01 |
| GO:BP | GO:0010564 | regulation of cell cycle process | 4 | 626 | 7.68e-01 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | 1 | 153 | 7.68e-01 |
| GO:BP | GO:0000725 | recombinational repair | 1 | 153 | 7.68e-01 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 2 | 317 | 7.68e-01 |
| GO:BP | GO:0022414 | reproductive process | 6 | 927 | 7.68e-01 |
| GO:BP | GO:0023057 | negative regulation of signaling | 7 | 1076 | 7.69e-01 |
| GO:BP | GO:0051701 | biological process involved in interaction with host | 1 | 154 | 7.69e-01 |
| GO:BP | GO:0071356 | cellular response to tumor necrosis factor | 1 | 155 | 7.71e-01 |
| GO:BP | GO:0071478 | cellular response to radiation | 1 | 156 | 7.71e-01 |
| GO:BP | GO:0051641 | cellular localization | 19 | 2810 | 7.71e-01 |
| GO:BP | GO:0016050 | vesicle organization | 2 | 320 | 7.71e-01 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 1 | 156 | 7.71e-01 |
| GO:BP | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 1 | 155 | 7.71e-01 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | 3 | 478 | 7.71e-01 |
| GO:BP | GO:0010628 | positive regulation of gene expression | 5 | 783 | 7.71e-01 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 4 | 632 | 7.71e-01 |
| GO:BP | GO:0050679 | positive regulation of epithelial cell proliferation | 1 | 155 | 7.71e-01 |
| GO:BP | GO:0023061 | signal release | 2 | 321 | 7.71e-01 |
| GO:BP | GO:0000003 | reproduction | 6 | 934 | 7.71e-01 |
| GO:BP | GO:0010629 | negative regulation of gene expression | 5 | 785 | 7.71e-01 |
| GO:BP | GO:0006974 | DNA damage response | 5 | 785 | 7.71e-01 |
| GO:BP | GO:0033002 | muscle cell proliferation | 1 | 157 | 7.72e-01 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 3 | 482 | 7.73e-01 |
| GO:BP | GO:0008406 | gonad development | 1 | 158 | 7.73e-01 |
| GO:BP | GO:0042180 | cellular ketone metabolic process | 1 | 158 | 7.73e-01 |
| GO:BP | GO:0031348 | negative regulation of defense response | 1 | 159 | 7.75e-01 |
| GO:BP | GO:0097305 | response to alcohol | 1 | 159 | 7.75e-01 |
| GO:BP | GO:0043487 | regulation of RNA stability | 1 | 159 | 7.75e-01 |
| GO:BP | GO:0050776 | regulation of immune response | 3 | 484 | 7.75e-01 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 2 | 326 | 7.76e-01 |
| GO:BP | GO:0018394 | peptidyl-lysine acetylation | 1 | 160 | 7.76e-01 |
| GO:BP | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 1 | 162 | 7.76e-01 |
| GO:BP | GO:0071702 | organic substance transport | 14 | 2116 | 7.76e-01 |
| GO:BP | GO:0019538 | protein metabolic process | 29 | 4241 | 7.76e-01 |
| GO:BP | GO:0071705 | nitrogen compound transport | 11 | 1684 | 7.76e-01 |
| GO:BP | GO:0009743 | response to carbohydrate | 1 | 161 | 7.76e-01 |
| GO:BP | GO:0045087 | innate immune response | 3 | 488 | 7.76e-01 |
| GO:BP | GO:0031334 | positive regulation of protein-containing complex assembly | 1 | 161 | 7.76e-01 |
| GO:BP | GO:0046651 | lymphocyte proliferation | 1 | 162 | 7.76e-01 |
| GO:BP | GO:0055082 | intracellular chemical homeostasis | 3 | 486 | 7.76e-01 |
| GO:BP | GO:0045137 | development of primary sexual characteristics | 1 | 161 | 7.76e-01 |
| GO:BP | GO:0060326 | cell chemotaxis | 1 | 162 | 7.76e-01 |
| GO:BP | GO:0009451 | RNA modification | 1 | 162 | 7.76e-01 |
| GO:BP | GO:0016482 | cytosolic transport | 1 | 161 | 7.76e-01 |
| GO:BP | GO:0050896 | response to stimulus | 40 | 5770 | 7.77e-01 |
| GO:BP | GO:0046903 | secretion | 4 | 645 | 7.77e-01 |
| GO:BP | GO:0060541 | respiratory system development | 1 | 163 | 7.77e-01 |
| GO:BP | GO:0099504 | synaptic vesicle cycle | 1 | 163 | 7.77e-01 |
| GO:BP | GO:0006412 | translation | 4 | 646 | 7.77e-01 |
| GO:BP | GO:0043484 | regulation of RNA splicing | 1 | 164 | 7.79e-01 |
| GO:BP | GO:0051179 | localization | 27 | 3969 | 7.79e-01 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | 1 | 165 | 7.80e-01 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 1 | 165 | 7.80e-01 |
| GO:BP | GO:0031330 | negative regulation of cellular catabolic process | 1 | 165 | 7.80e-01 |
| GO:BP | GO:0042221 | response to chemical | 17 | 2559 | 7.80e-01 |
| GO:BP | GO:0008104 | protein localization | 14 | 2129 | 7.81e-01 |
| GO:BP | GO:1901991 | negative regulation of mitotic cell cycle phase transition | 1 | 166 | 7.81e-01 |
| GO:BP | GO:0071383 | cellular response to steroid hormone stimulus | 1 | 166 | 7.81e-01 |
| GO:BP | GO:0046578 | regulation of Ras protein signal transduction | 1 | 166 | 7.81e-01 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 1 | 167 | 7.83e-01 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 5 | 809 | 7.83e-01 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | 2 | 337 | 7.83e-01 |
| GO:BP | GO:0032943 | mononuclear cell proliferation | 1 | 168 | 7.83e-01 |
| GO:BP | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 1 | 168 | 7.83e-01 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | 2 | 338 | 7.83e-01 |
| GO:BP | GO:0042593 | glucose homeostasis | 1 | 168 | 7.83e-01 |
| GO:BP | GO:0070727 | cellular macromolecule localization | 14 | 2138 | 7.83e-01 |
| GO:BP | GO:2000116 | regulation of cysteine-type endopeptidase activity | 1 | 169 | 7.84e-01 |
| GO:BP | GO:0033500 | carbohydrate homeostasis | 1 | 169 | 7.84e-01 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 2 | 341 | 7.87e-01 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 2 | 342 | 7.88e-01 |
| GO:BP | GO:0060537 | muscle tissue development | 2 | 343 | 7.88e-01 |
| GO:BP | GO:0044085 | cellular component biogenesis | 18 | 2724 | 7.88e-01 |
| GO:BP | GO:0043393 | regulation of protein binding | 1 | 172 | 7.88e-01 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 4 | 662 | 7.88e-01 |
| GO:BP | GO:0023052 | signaling | 28 | 4141 | 7.88e-01 |
| GO:BP | GO:0034329 | cell junction assembly | 2 | 344 | 7.89e-01 |
| GO:BP | GO:0006643 | membrane lipid metabolic process | 1 | 173 | 7.89e-01 |
| GO:BP | GO:0006810 | transport | 22 | 3298 | 7.89e-01 |
| GO:BP | GO:0033036 | macromolecule localization | 16 | 2450 | 7.95e-01 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 3 | 512 | 7.96e-01 |
| GO:BP | GO:0000278 | mitotic cell cycle | 5 | 827 | 7.97e-01 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 2 | 351 | 7.98e-01 |
| GO:BP | GO:0032496 | response to lipopolysaccharide | 1 | 178 | 7.99e-01 |
| GO:BP | GO:0009314 | response to radiation | 2 | 352 | 7.99e-01 |
| GO:BP | GO:0006469 | negative regulation of protein kinase activity | 1 | 179 | 7.99e-01 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 1 | 179 | 7.99e-01 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 3 | 517 | 7.99e-01 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | 1 | 179 | 7.99e-01 |
| GO:BP | GO:0031667 | response to nutrient levels | 2 | 353 | 7.99e-01 |
| GO:BP | GO:0099003 | vesicle-mediated transport in synapse | 1 | 180 | 8.00e-01 |
| GO:BP | GO:0030003 | intracellular monoatomic cation homeostasis | 2 | 357 | 8.03e-01 |
| GO:BP | GO:0045089 | positive regulation of innate immune response | 1 | 182 | 8.03e-01 |
| GO:BP | GO:0048589 | developmental growth | 3 | 522 | 8.03e-01 |
| GO:BP | GO:0140694 | non-membrane-bounded organelle assembly | 2 | 357 | 8.03e-01 |
| GO:BP | GO:0061136 | regulation of proteasomal protein catabolic process | 1 | 183 | 8.04e-01 |
| GO:BP | GO:0072657 | protein localization to membrane | 3 | 523 | 8.04e-01 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | 1 | 183 | 8.04e-01 |
| GO:BP | GO:0006897 | endocytosis | 3 | 527 | 8.08e-01 |
| GO:BP | GO:0007411 | axon guidance | 1 | 185 | 8.08e-01 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 3 | 527 | 8.08e-01 |
| GO:BP | GO:0006873 | intracellular monoatomic ion homeostasis | 2 | 362 | 8.08e-01 |
| GO:BP | GO:0097485 | neuron projection guidance | 1 | 186 | 8.08e-01 |
| GO:BP | GO:0045444 | fat cell differentiation | 1 | 187 | 8.10e-01 |
| GO:BP | GO:0002237 | response to molecule of bacterial origin | 1 | 187 | 8.10e-01 |
| GO:BP | GO:0051321 | meiotic cell cycle | 1 | 188 | 8.10e-01 |
| GO:BP | GO:0070661 | leukocyte proliferation | 1 | 188 | 8.10e-01 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 3 | 531 | 8.10e-01 |
| GO:BP | GO:0050808 | synapse organization | 2 | 365 | 8.10e-01 |
| GO:BP | GO:0007051 | spindle organization | 1 | 188 | 8.10e-01 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 3 | 532 | 8.10e-01 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 6 | 1006 | 8.10e-01 |
| GO:BP | GO:0045184 | establishment of protein localization | 9 | 1462 | 8.11e-01 |
| GO:BP | GO:0006281 | DNA repair | 3 | 534 | 8.11e-01 |
| GO:BP | GO:0030162 | regulation of proteolysis | 3 | 535 | 8.12e-01 |
| GO:BP | GO:0019932 | second-messenger-mediated signaling | 1 | 191 | 8.13e-01 |
| GO:BP | GO:0007548 | sex differentiation | 1 | 191 | 8.13e-01 |
| GO:BP | GO:0050778 | positive regulation of immune response | 2 | 369 | 8.13e-01 |
| GO:BP | GO:0006457 | protein folding | 1 | 192 | 8.14e-01 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | 1 | 192 | 8.14e-01 |
| GO:BP | GO:0048588 | developmental cell growth | 1 | 192 | 8.14e-01 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 4 | 701 | 8.15e-01 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | 3 | 540 | 8.15e-01 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 3 | 540 | 8.15e-01 |
| GO:BP | GO:0007015 | actin filament organization | 2 | 373 | 8.15e-01 |
| GO:BP | GO:0007154 | cell communication | 28 | 4226 | 8.17e-01 |
| GO:BP | GO:0051276 | chromosome organization | 3 | 543 | 8.17e-01 |
| GO:BP | GO:0006898 | receptor-mediated endocytosis | 1 | 196 | 8.18e-01 |
| GO:BP | GO:1901137 | carbohydrate derivative biosynthetic process | 3 | 544 | 8.18e-01 |
| GO:BP | GO:1901615 | organic hydroxy compound metabolic process | 2 | 376 | 8.18e-01 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 2 | 377 | 8.19e-01 |
| GO:BP | GO:0033157 | regulation of intracellular protein transport | 1 | 197 | 8.19e-01 |
| GO:BP | GO:0006338 | chromatin remodeling | 2 | 378 | 8.19e-01 |
| GO:BP | GO:0003018 | vascular process in circulatory system | 1 | 198 | 8.20e-01 |
| GO:BP | GO:0006874 | intracellular calcium ion homeostasis | 1 | 200 | 8.23e-01 |
| GO:BP | GO:0032990 | cell part morphogenesis | 3 | 551 | 8.23e-01 |
| GO:BP | GO:0006325 | chromatin organization | 3 | 551 | 8.23e-01 |
| GO:BP | GO:0140546 | defense response to symbiont | 1 | 202 | 8.25e-01 |
| GO:BP | GO:0007611 | learning or memory | 1 | 202 | 8.25e-01 |
| GO:BP | GO:0051607 | defense response to virus | 1 | 202 | 8.25e-01 |
| GO:BP | GO:0022618 | ribonucleoprotein complex assembly | 1 | 203 | 8.26e-01 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 1 | 204 | 8.27e-01 |
| GO:BP | GO:0008202 | steroid metabolic process | 1 | 204 | 8.27e-01 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 2 | 389 | 8.30e-01 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 7 | 1201 | 8.33e-01 |
| GO:BP | GO:0090068 | positive regulation of cell cycle process | 1 | 209 | 8.35e-01 |
| GO:BP | GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 1 | 211 | 8.36e-01 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | 1 | 211 | 8.36e-01 |
| GO:BP | GO:0045333 | cellular respiration | 1 | 211 | 8.36e-01 |
| GO:BP | GO:0030100 | regulation of endocytosis | 1 | 211 | 8.36e-01 |
| GO:BP | GO:0021700 | developmental maturation | 1 | 211 | 8.36e-01 |
| GO:BP | GO:0071826 | ribonucleoprotein complex subunit organization | 1 | 211 | 8.36e-01 |
| GO:BP | GO:0008150 | biological_process | 86 | 12070 | 8.36e-01 |
| GO:BP | GO:0061564 | axon development | 2 | 398 | 8.36e-01 |
| GO:BP | GO:0048608 | reproductive structure development | 1 | 212 | 8.36e-01 |
| GO:BP | GO:0050727 | regulation of inflammatory response | 1 | 212 | 8.36e-01 |
| GO:BP | GO:0051234 | establishment of localization | 22 | 3433 | 8.36e-01 |
| GO:BP | GO:0071396 | cellular response to lipid | 2 | 398 | 8.36e-01 |
| GO:BP | GO:0070588 | calcium ion transmembrane transport | 1 | 213 | 8.37e-01 |
| GO:BP | GO:0055074 | calcium ion homeostasis | 1 | 214 | 8.38e-01 |
| GO:BP | GO:0055080 | monoatomic cation homeostasis | 2 | 401 | 8.38e-01 |
| GO:BP | GO:0061458 | reproductive system development | 1 | 215 | 8.39e-01 |
| GO:BP | GO:0060627 | regulation of vesicle-mediated transport | 2 | 403 | 8.40e-01 |
| GO:BP | GO:0032886 | regulation of microtubule-based process | 1 | 217 | 8.41e-01 |
| GO:BP | GO:0000819 | sister chromatid segregation | 1 | 217 | 8.41e-01 |
| GO:BP | GO:0002250 | adaptive immune response | 1 | 218 | 8.42e-01 |
| GO:BP | GO:0050801 | monoatomic ion homeostasis | 2 | 408 | 8.44e-01 |
| GO:BP | GO:0051346 | negative regulation of hydrolase activity | 1 | 220 | 8.44e-01 |
| GO:BP | GO:0032984 | protein-containing complex disassembly | 1 | 222 | 8.46e-01 |
| GO:BP | GO:0043547 | positive regulation of GTPase activity | 1 | 222 | 8.46e-01 |
| GO:BP | GO:0030030 | cell projection organization | 7 | 1233 | 8.46e-01 |
| GO:BP | GO:0046394 | carboxylic acid biosynthetic process | 1 | 223 | 8.47e-01 |
| GO:BP | GO:0016053 | organic acid biosynthetic process | 1 | 224 | 8.48e-01 |
| GO:BP | GO:0016042 | lipid catabolic process | 1 | 225 | 8.49e-01 |
| GO:BP | GO:0033993 | response to lipid | 3 | 592 | 8.51e-01 |
| GO:BP | GO:0048872 | homeostasis of number of cells | 1 | 228 | 8.53e-01 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 2 | 420 | 8.54e-01 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 7 | 1248 | 8.54e-01 |
| GO:BP | GO:0007264 | small GTPase mediated signal transduction | 2 | 421 | 8.54e-01 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 1 | 230 | 8.54e-01 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | 2 | 422 | 8.54e-01 |
| GO:BP | GO:0072594 | establishment of protein localization to organelle | 2 | 422 | 8.54e-01 |
| GO:BP | GO:0052548 | regulation of endopeptidase activity | 1 | 232 | 8.56e-01 |
| GO:BP | GO:0030198 | extracellular matrix organization | 1 | 233 | 8.57e-01 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 1 | 233 | 8.57e-01 |
| GO:BP | GO:0043062 | extracellular structure organization | 1 | 234 | 8.57e-01 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 1 | 234 | 8.57e-01 |
| GO:BP | GO:1901988 | negative regulation of cell cycle phase transition | 1 | 235 | 8.58e-01 |
| GO:BP | GO:0016570 | histone modification | 2 | 433 | 8.63e-01 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 1 | 241 | 8.66e-01 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | 2 | 438 | 8.68e-01 |
| GO:BP | GO:0001822 | kidney development | 1 | 244 | 8.68e-01 |
| GO:BP | GO:0019058 | viral life cycle | 1 | 244 | 8.68e-01 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | 2 | 441 | 8.69e-01 |
| GO:BP | GO:0048545 | response to steroid hormone | 1 | 245 | 8.69e-01 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 1 | 247 | 8.71e-01 |
| GO:BP | GO:0006790 | sulfur compound metabolic process | 1 | 248 | 8.72e-01 |
| GO:BP | GO:0090150 | establishment of protein localization to membrane | 1 | 250 | 8.74e-01 |
| GO:BP | GO:0072001 | renal system development | 1 | 251 | 8.74e-01 |
| GO:BP | GO:0031349 | positive regulation of defense response | 1 | 251 | 8.74e-01 |
| GO:BP | GO:0006886 | intracellular protein transport | 4 | 803 | 8.75e-01 |
| GO:BP | GO:0032989 | cellular component morphogenesis | 3 | 639 | 8.80e-01 |
| GO:BP | GO:0006310 | DNA recombination | 1 | 257 | 8.80e-01 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 1 | 257 | 8.80e-01 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 2 | 457 | 8.80e-01 |
| GO:BP | GO:0051604 | protein maturation | 1 | 259 | 8.81e-01 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 2 | 459 | 8.81e-01 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 1 | 259 | 8.81e-01 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | 2 | 461 | 8.82e-01 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 2 | 463 | 8.83e-01 |
| GO:BP | GO:0006508 | proteolysis | 7 | 1318 | 8.84e-01 |
| GO:BP | GO:0051054 | positive regulation of DNA metabolic process | 1 | 265 | 8.86e-01 |
| GO:BP | GO:0030031 | cell projection assembly | 2 | 469 | 8.87e-01 |
| GO:BP | GO:0055085 | transmembrane transport | 5 | 998 | 8.87e-01 |
| GO:BP | GO:0007600 | sensory perception | 1 | 269 | 8.88e-01 |
| GO:BP | GO:0032102 | negative regulation of response to external stimulus | 1 | 269 | 8.88e-01 |
| GO:BP | GO:0006302 | double-strand break repair | 1 | 271 | 8.90e-01 |
| GO:BP | GO:0052547 | regulation of peptidase activity | 1 | 271 | 8.90e-01 |
| GO:BP | GO:0098813 | nuclear chromosome segregation | 1 | 273 | 8.91e-01 |
| GO:BP | GO:0010948 | negative regulation of cell cycle process | 1 | 273 | 8.91e-01 |
| GO:BP | GO:0019221 | cytokine-mediated signaling pathway | 1 | 274 | 8.91e-01 |
| GO:BP | GO:0045787 | positive regulation of cell cycle | 1 | 274 | 8.91e-01 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | 1 | 276 | 8.92e-01 |
| GO:BP | GO:0001819 | positive regulation of cytokine production | 1 | 276 | 8.92e-01 |
| GO:BP | GO:0007517 | muscle organ development | 1 | 277 | 8.93e-01 |
| GO:BP | GO:0048878 | chemical homeostasis | 3 | 676 | 8.98e-01 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 2 | 490 | 8.98e-01 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 2 | 490 | 8.98e-01 |
| GO:BP | GO:0051649 | establishment of localization in cell | 10 | 1836 | 8.98e-01 |
| GO:BP | GO:0048193 | Golgi vesicle transport | 1 | 285 | 8.99e-01 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | 3 | 681 | 8.99e-01 |
| GO:BP | GO:0010256 | endomembrane system organization | 2 | 496 | 8.99e-01 |
| GO:BP | GO:1901653 | cellular response to peptide | 1 | 287 | 8.99e-01 |
| GO:BP | GO:1901564 | organonitrogen compound metabolic process | 31 | 4955 | 8.99e-01 |
| GO:BP | GO:0022607 | cellular component assembly | 14 | 2466 | 8.99e-01 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 2 | 495 | 8.99e-01 |
| GO:BP | GO:0030029 | actin filament-based process | 3 | 687 | 9.01e-01 |
| GO:BP | GO:0007265 | Ras protein signal transduction | 1 | 294 | 9.03e-01 |
| GO:BP | GO:0090407 | organophosphate biosynthetic process | 2 | 506 | 9.05e-01 |
| GO:BP | GO:0043436 | oxoacid metabolic process | 3 | 696 | 9.05e-01 |
| GO:BP | GO:0044281 | small molecule metabolic process | 7 | 1389 | 9.07e-01 |
| GO:BP | GO:0099536 | synaptic signaling | 2 | 511 | 9.07e-01 |
| GO:BP | GO:0006082 | organic acid metabolic process | 3 | 700 | 9.07e-01 |
| GO:BP | GO:0006259 | DNA metabolic process | 4 | 884 | 9.08e-01 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | 1 | 308 | 9.12e-01 |
| GO:BP | GO:0009617 | response to bacterium | 1 | 321 | 9.21e-01 |
| GO:BP | GO:0043434 | response to peptide hormone | 1 | 321 | 9.21e-01 |
| GO:BP | GO:0050673 | epithelial cell proliferation | 1 | 323 | 9.22e-01 |
| GO:BP | GO:0042692 | muscle cell differentiation | 1 | 324 | 9.22e-01 |
| GO:BP | GO:0061061 | muscle structure development | 2 | 546 | 9.25e-01 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | 2 | 552 | 9.28e-01 |
| GO:BP | GO:0018205 | peptidyl-lysine modification | 1 | 336 | 9.29e-01 |
| GO:BP | GO:0008610 | lipid biosynthetic process | 2 | 560 | 9.31e-01 |
| GO:BP | GO:0000280 | nuclear division | 1 | 344 | 9.33e-01 |
| GO:BP | GO:0051301 | cell division | 2 | 570 | 9.35e-01 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 32 | 5274 | 9.36e-01 |
| GO:BP | GO:0034330 | cell junction organization | 2 | 575 | 9.37e-01 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 4 | 963 | 9.37e-01 |
| GO:BP | GO:0007409 | axonogenesis | 1 | 359 | 9.39e-01 |
| GO:BP | GO:0042592 | homeostatic process | 5 | 1159 | 9.42e-01 |
| GO:BP | GO:1901652 | response to peptide | 1 | 377 | 9.48e-01 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 2 | 612 | 9.50e-01 |
| GO:BP | GO:0048285 | organelle fission | 1 | 388 | 9.52e-01 |
| GO:BP | GO:1901987 | regulation of cell cycle phase transition | 1 | 391 | 9.52e-01 |
| GO:BP | GO:1901135 | carbohydrate derivative metabolic process | 3 | 843 | 9.57e-01 |
| GO:BP | GO:0009725 | response to hormone | 2 | 642 | 9.58e-01 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 5 | 1238 | 9.60e-01 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 2 | 665 | 9.64e-01 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | 1 | 433 | 9.65e-01 |
| GO:BP | GO:0007610 | behavior | 1 | 436 | 9.66e-01 |
| GO:BP | GO:0016043 | cellular component organization | 29 | 5076 | 9.68e-01 |
| GO:BP | GO:0001817 | regulation of cytokine production | 1 | 447 | 9.68e-01 |
| GO:BP | GO:0001816 | cytokine production | 1 | 451 | 9.69e-01 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 1 | 484 | 9.76e-01 |
| GO:BP | GO:0051640 | organelle localization | 1 | 503 | 9.79e-01 |
| GO:BP | GO:0007017 | microtubule-based process | 2 | 760 | 9.80e-01 |
| GO:BP | GO:0006629 | lipid metabolic process | 3 | 994 | 9.81e-01 |
| GO:BP | GO:0019637 | organophosphate metabolic process | 2 | 784 | 9.82e-01 |
| GO:BP | GO:0007010 | cytoskeleton organization | 4 | 1226 | 9.83e-01 |
| GO:BP | GO:0070925 | organelle assembly | 2 | 817 | 9.85e-01 |
| GO:BP | GO:0044255 | cellular lipid metabolic process | 1 | 740 | 9.97e-01 |
| GO:BP | GO:0006996 | organelle organization | 11 | 3000 | 9.99e-01 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 11 | 415 | 2.84e-02 |
| KEGG | KEGG:03260 | Virion - Human immunodeficiency virus | 1 | 1 | 4.85e-01 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 2 | 70 | 6.29e-01 |
| KEGG | KEGG:05226 | Gastric cancer | 2 | 117 | 6.29e-01 |
| KEGG | KEGG:04668 | TNF signaling pathway | 2 | 87 | 6.29e-01 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 2 | 99 | 6.29e-01 |
| KEGG | KEGG:03040 | Spliceosome | 3 | 132 | 6.29e-01 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 1 | 53 | 6.29e-01 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | 3 | 86 | 6.29e-01 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 1 | 64 | 6.29e-01 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 3 | 145 | 6.29e-01 |
| KEGG | KEGG:05224 | Breast cancer | 3 | 117 | 6.29e-01 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 1 | 84 | 6.29e-01 |
| KEGG | KEGG:01240 | Biosynthesis of cofactors | 2 | 115 | 6.29e-01 |
| KEGG | KEGG:03018 | RNA degradation | 1 | 74 | 6.29e-01 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 1 | 75 | 6.29e-01 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1 | 69 | 6.29e-01 |
| KEGG | KEGG:05321 | Inflammatory bowel disease | 1 | 22 | 6.29e-01 |
| KEGG | KEGG:03022 | Basal transcription factors | 1 | 40 | 6.29e-01 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 1 | 56 | 6.29e-01 |
| KEGG | KEGG:05323 | Rheumatoid arthritis | 1 | 43 | 6.29e-01 |
| KEGG | KEGG:01522 | Endocrine resistance | 1 | 85 | 6.29e-01 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | 1 | 56 | 6.29e-01 |
| KEGG | KEGG:03008 | Ribosome biogenesis in eukaryotes | 2 | 75 | 6.29e-01 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 1 | 72 | 6.29e-01 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | 1 | 60 | 6.29e-01 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 4 | 138 | 6.29e-01 |
| KEGG | KEGG:04934 | Cushing syndrome | 3 | 121 | 6.29e-01 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | 2 | 131 | 6.29e-01 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 1 | 82 | 6.29e-01 |
| KEGG | KEGG:05142 | Chagas disease | 1 | 75 | 6.29e-01 |
| KEGG | KEGG:05161 | Hepatitis B | 2 | 136 | 6.29e-01 |
| KEGG | KEGG:05140 | Leishmaniasis | 1 | 42 | 6.29e-01 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 1 | 84 | 6.29e-01 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 2 | 104 | 6.29e-01 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 1 | 77 | 6.29e-01 |
| KEGG | KEGG:04924 | Renin secretion | 1 | 50 | 6.29e-01 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 1 | 84 | 6.29e-01 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 2 | 115 | 6.29e-01 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 1 | 55 | 6.29e-01 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 2 | 48 | 6.29e-01 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 2 | 176 | 6.29e-01 |
| KEGG | KEGG:04971 | Gastric acid secretion | 1 | 52 | 6.29e-01 |
| KEGG | KEGG:04978 | Mineral absorption | 1 | 42 | 6.29e-01 |
| KEGG | KEGG:05132 | Salmonella infection | 2 | 214 | 6.29e-01 |
| KEGG | KEGG:04210 | Apoptosis | 2 | 118 | 6.29e-01 |
| KEGG | KEGG:05133 | Pertussis | 1 | 45 | 6.29e-01 |
| KEGG | KEGG:05131 | Shigellosis | 2 | 210 | 6.29e-01 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 2 | 150 | 6.29e-01 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 1 | 78 | 6.29e-01 |
| KEGG | KEGG:05135 | Yersinia infection | 2 | 112 | 6.29e-01 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 1 | 58 | 6.29e-01 |
| KEGG | KEGG:05030 | Cocaine addiction | 2 | 35 | 6.29e-01 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 2 | 124 | 6.29e-01 |
| KEGG | KEGG:04144 | Endocytosis | 3 | 232 | 6.29e-01 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 2 | 161 | 6.29e-01 |
| KEGG | KEGG:04137 | Mitophagy - animal | 2 | 70 | 6.29e-01 |
| KEGG | KEGG:05010 | Alzheimer disease | 3 | 315 | 6.29e-01 |
| KEGG | KEGG:05031 | Amphetamine addiction | 2 | 49 | 6.29e-01 |
| KEGG | KEGG:04360 | Axon guidance | 2 | 162 | 6.29e-01 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 2 | 87 | 6.29e-01 |
| KEGG | KEGG:04916 | Melanogenesis | 1 | 77 | 6.29e-01 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 2 | 186 | 6.29e-01 |
| KEGG | KEGG:05210 | Colorectal cancer | 1 | 84 | 6.29e-01 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 2 | 104 | 6.29e-01 |
| KEGG | KEGG:00000 | KEGG root term | 47 | 5558 | 6.29e-01 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 1 | 60 | 6.29e-01 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 1 | 76 | 6.29e-01 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 2 | 142 | 6.29e-01 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | 1 | 38 | 6.29e-01 |
| KEGG | KEGG:05215 | Prostate cancer | 1 | 86 | 6.29e-01 |
| KEGG | KEGG:00510 | N-Glycan biosynthesis | 1 | 48 | 6.29e-01 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 1 | 56 | 6.29e-01 |
| KEGG | KEGG:00515 | Mannose type O-glycan biosynthesis | 1 | 19 | 6.29e-01 |
| KEGG | KEGG:00565 | Ether lipid metabolism | 1 | 28 | 6.29e-01 |
| KEGG | KEGG:00790 | Folate biosynthesis | 1 | 18 | 6.29e-01 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 1 | 65 | 6.29e-01 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 1 | 25 | 6.29e-01 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 3 | 172 | 6.29e-01 |
| KEGG | KEGG:05200 | Pathways in cancer | 6 | 409 | 6.29e-01 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 2 | 97 | 6.29e-01 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 3 | 180 | 6.29e-01 |
| KEGG | KEGG:04122 | Sulfur relay system | 1 | 8 | 6.29e-01 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 1 | 20 | 6.29e-01 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 2 | 134 | 6.29e-01 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 2 | 98 | 6.29e-01 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 2 | 76 | 6.29e-01 |
| KEGG | KEGG:04911 | Insulin secretion | 1 | 64 | 6.29e-01 |
| KEGG | KEGG:04725 | Cholinergic synapse | 2 | 83 | 6.29e-01 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 2 | 110 | 6.29e-01 |
| KEGG | KEGG:04720 | Long-term potentiation | 1 | 55 | 6.29e-01 |
| KEGG | KEGG:04672 | Intestinal immune network for IgA production | 1 | 12 | 6.29e-01 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 1 | 78 | 6.29e-01 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 2 | 165 | 6.29e-01 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 1 | 79 | 6.29e-01 |
| KEGG | KEGG:05217 | Basal cell carcinoma | 1 | 49 | 6.29e-01 |
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | 1 | 56 | 6.29e-01 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 2 | 114 | 6.29e-01 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 3 | 153 | 6.29e-01 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 1 | 91 | 6.48e-01 |
| KEGG | KEGG:05012 | Parkinson disease | 2 | 226 | 6.49e-01 |
| KEGG | KEGG:04931 | Insulin resistance | 1 | 95 | 6.55e-01 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 1 | 98 | 6.56e-01 |
| KEGG | KEGG:05162 | Measles | 1 | 98 | 6.56e-01 |
| KEGG | KEGG:05164 | Influenza A | 1 | 103 | 6.59e-01 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 1 | 103 | 6.59e-01 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 2 | 240 | 6.59e-01 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | 3 | 385 | 6.59e-01 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 1 | 110 | 6.76e-01 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 1 | 113 | 6.82e-01 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 1 | 117 | 6.91e-01 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 1 | 121 | 6.97e-01 |
| KEGG | KEGG:05034 | Alcoholism | 1 | 122 | 6.97e-01 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 1 | 128 | 7.11e-01 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 1 | 135 | 7.15e-01 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 1 | 133 | 7.15e-01 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | 1 | 134 | 7.15e-01 |
| KEGG | KEGG:04530 | Tight junction | 1 | 137 | 7.15e-01 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | 2 | 303 | 7.27e-01 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 1 | 145 | 7.27e-01 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 1 | 153 | 7.30e-01 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 1 | 151 | 7.30e-01 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 1 | 149 | 7.30e-01 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 1 | 157 | 7.35e-01 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 1 | 162 | 7.41e-01 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 1 | 170 | 7.50e-01 |
| KEGG | KEGG:04014 | Ras signaling pathway | 1 | 171 | 7.50e-01 |
| KEGG | KEGG:04510 | Focal adhesion | 1 | 177 | 7.55e-01 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 1 | 179 | 7.55e-01 |
| KEGG | KEGG:05020 | Prion disease | 1 | 220 | 8.21e-01 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 1 | 254 | 8.60e-01 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 1 | 272 | 8.73e-01 |
| KEGG | KEGG:01100 | Metabolic pathways | 5 | 1146 | 9.28e-01 |
Dnr3_sp_DEGtable %>%
dplyr::filter(source=="KEGG") %>%
# dplyr::filter(p_value<0.05) %>%
dplyr::select(p_value,term_name,intersection_size) %>%
slice_min(., n=2 ,order_by=p_value) %>%
mutate(log_val = -log10(p_value)) %>%
# slice_max(., n=10,order_by = p_value) %>%
ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col= intersection_size)) +
geom_point(aes(size = intersection_size)) +
geom_vline(xintercept = (-log10(0.05)))+
scale_y_discrete(labels = wrap_format(30))+
scale_linetype(3)+
guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
ggtitle('DNR 3 hour specific(stringent)\n gene set KEGG terms') +
xlab(expression(" -"~log[10]~("adj. p-value")))+
ylab("KEGG pathway")+
theme_bw()+
theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(linewidth = 1.5),
axis.line = element_line(linewidth = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0),
strip.text.x = element_text(size = 12, color = "black", face = "bold"))
| Version | Author | Date |
|---|---|---|
| 454978c | reneeisnowhere | 2023-07-14 |
Mtx3_sp_DEGtable %>%
dplyr::filter(source=="GO:BP") %>%
dplyr::select(p_value,term_name,intersection_size) %>%
slice_min(., n=10 ,order_by=p_value) %>%
mutate(log_val = -log10(p_value)) %>%
# slice_max(., n=10,order_by = p_value) %>%
ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col= intersection_size)) +
geom_point(aes(size = intersection_size)) +
scale_y_discrete(labels = wrap_format(30))+
geom_vline(xintercept = (-log10(0.05)))+
guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
ggtitle('MTX 3 hour specific(stringent)\n gene set GO:BP terms') +
xlab(expression(" -"~log[10]~("adj. p-value")))+
ylab("GO: BP term")+
theme_bw()+
theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(linewidth = 1.5),
axis.line = element_line(linewidth = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0),
strip.text.x = element_text(size = 12, color = "black", face = "bold"))
| Version | Author | Date |
|---|---|---|
| 454978c | reneeisnowhere | 2023-07-14 |
Mtx3_sp_DEGtable %>%
mutate_at(.vars = 6, .funs= scientific_format()) %>%
kable(., caption= "Stringent (adj. P value of <0.01) MTX 3 hour specific genes (n = 4) enriched GO and KEGG terms") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(full_width = FALSE, position = "left",bootstrap_options = c("striped","hover")) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0006367 | transcription initiation at RNA polymerase II promoter | 2 | 93 | 2.93e-02 |
| GO:BP | GO:0060260 | regulation of transcription initiation by RNA polymerase II | 2 | 69 | 2.93e-02 |
| GO:BP | GO:2000142 | regulation of DNA-templated transcription initiation | 2 | 76 | 2.93e-02 |
| GO:BP | GO:0006352 | DNA-templated transcription initiation | 2 | 130 | 4.29e-02 |
| GO:BP | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway | 1 | 5 | 7.82e-02 |
| GO:BP | GO:0006470 | protein dephosphorylation | 2 | 214 | 7.82e-02 |
| GO:BP | GO:0016311 | dephosphorylation | 2 | 284 | 8.60e-02 |
| GO:BP | GO:0009617 | response to bacterium | 2 | 321 | 8.60e-02 |
| GO:BP | GO:0070417 | cellular response to cold | 1 | 8 | 8.60e-02 |
| GO:BP | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 1 | 10 | 8.60e-02 |
| GO:BP | GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway | 1 | 11 | 8.60e-02 |
| GO:BP | GO:0007253 | cytoplasmic sequestering of NF-kappaB | 1 | 7 | 8.60e-02 |
| GO:BP | GO:0032495 | response to muramyl dipeptide | 1 | 15 | 8.81e-02 |
| GO:BP | GO:0045746 | negative regulation of Notch signaling pathway | 1 | 31 | 8.81e-02 |
| GO:BP | GO:0043330 | response to exogenous dsRNA | 1 | 27 | 8.81e-02 |
| GO:BP | GO:0032373 | positive regulation of sterol transport | 1 | 30 | 8.81e-02 |
| GO:BP | GO:0042994 | cytoplasmic sequestering of transcription factor | 1 | 15 | 8.81e-02 |
| GO:BP | GO:0035970 | peptidyl-threonine dephosphorylation | 1 | 17 | 8.81e-02 |
| GO:BP | GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 1 | 19 | 8.81e-02 |
| GO:BP | GO:0034142 | toll-like receptor 4 signaling pathway | 1 | 24 | 8.81e-02 |
| GO:BP | GO:0010742 | macrophage derived foam cell differentiation | 1 | 22 | 8.81e-02 |
| GO:BP | GO:0010743 | regulation of macrophage derived foam cell differentiation | 1 | 18 | 8.81e-02 |
| GO:BP | GO:0032376 | positive regulation of cholesterol transport | 1 | 30 | 8.81e-02 |
| GO:BP | GO:0050853 | B cell receptor signaling pathway | 1 | 32 | 8.81e-02 |
| GO:BP | GO:0010888 | negative regulation of lipid storage | 1 | 16 | 8.81e-02 |
| GO:BP | GO:0010875 | positive regulation of cholesterol efflux | 1 | 23 | 8.81e-02 |
| GO:BP | GO:0035994 | response to muscle stretch | 1 | 26 | 8.81e-02 |
| GO:BP | GO:0010874 | regulation of cholesterol efflux | 1 | 31 | 8.81e-02 |
| GO:BP | GO:0051220 | cytoplasmic sequestering of protein | 1 | 23 | 8.81e-02 |
| GO:BP | GO:0140895 | cell surface toll-like receptor signaling pathway | 1 | 27 | 8.81e-02 |
| GO:BP | GO:0002752 | cell surface pattern recognition receptor signaling pathway | 1 | 27 | 8.81e-02 |
| GO:BP | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | 1 | 18 | 8.81e-02 |
| GO:BP | GO:0090077 | foam cell differentiation | 1 | 22 | 8.81e-02 |
| GO:BP | GO:1905953 | negative regulation of lipid localization | 1 | 32 | 8.81e-02 |
| GO:BP | GO:0043331 | response to dsRNA | 1 | 33 | 8.82e-02 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | 3 | 1914 | 8.85e-02 |
| GO:BP | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 1 | 36 | 9.10e-02 |
| GO:BP | GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 1 | 37 | 9.11e-02 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | 3 | 1995 | 9.12e-02 |
| GO:BP | GO:0010883 | regulation of lipid storage | 1 | 39 | 9.12e-02 |
| GO:BP | GO:0033344 | cholesterol efflux | 1 | 40 | 9.12e-02 |
| GO:BP | GO:0009409 | response to cold | 1 | 41 | 9.13e-02 |
| GO:BP | GO:0006306 | DNA methylation | 1 | 46 | 9.15e-02 |
| GO:BP | GO:0032374 | regulation of cholesterol transport | 1 | 45 | 9.15e-02 |
| GO:BP | GO:0006305 | DNA alkylation | 1 | 46 | 9.15e-02 |
| GO:BP | GO:0043392 | negative regulation of DNA binding | 1 | 46 | 9.15e-02 |
| GO:BP | GO:0032371 | regulation of sterol transport | 1 | 45 | 9.15e-02 |
| GO:BP | GO:0032370 | positive regulation of lipid transport | 1 | 58 | 1.07e-01 |
| GO:BP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 1 | 66 | 1.07e-01 |
| GO:BP | GO:0031507 | heterochromatin formation | 1 | 69 | 1.07e-01 |
| GO:BP | GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 1 | 69 | 1.07e-01 |
| GO:BP | GO:0050729 | positive regulation of inflammatory response | 1 | 75 | 1.07e-01 |
| GO:BP | GO:1905954 | positive regulation of lipid localization | 1 | 75 | 1.07e-01 |
| GO:BP | GO:2000144 | positive regulation of DNA-templated transcription initiation | 1 | 65 | 1.07e-01 |
| GO:BP | GO:0051707 | response to other organism | 2 | 820 | 1.07e-01 |
| GO:BP | GO:1903506 | regulation of nucleic acid-templated transcription | 3 | 2576 | 1.07e-01 |
| GO:BP | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 1 | 76 | 1.07e-01 |
| GO:BP | GO:1901222 | regulation of NIK/NF-kappaB signaling | 1 | 65 | 1.07e-01 |
| GO:BP | GO:0070828 | heterochromatin organization | 1 | 77 | 1.07e-01 |
| GO:BP | GO:0045638 | negative regulation of myeloid cell differentiation | 1 | 69 | 1.07e-01 |
| GO:BP | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II | 1 | 59 | 1.07e-01 |
| GO:BP | GO:0045814 | negative regulation of gene expression, epigenetic | 1 | 79 | 1.07e-01 |
| GO:BP | GO:0030301 | cholesterol transport | 1 | 80 | 1.07e-01 |
| GO:BP | GO:0019915 | lipid storage | 1 | 66 | 1.07e-01 |
| GO:BP | GO:0043207 | response to external biotic stimulus | 2 | 820 | 1.07e-01 |
| GO:BP | GO:0008593 | regulation of Notch signaling pathway | 1 | 78 | 1.07e-01 |
| GO:BP | GO:0009607 | response to biotic stimulus | 2 | 850 | 1.07e-01 |
| GO:BP | GO:0009628 | response to abiotic stimulus | 2 | 868 | 1.07e-01 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | 3 | 2574 | 1.07e-01 |
| GO:BP | GO:0002753 | cytosolic pattern recognition receptor signaling pathway | 1 | 68 | 1.07e-01 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | 3 | 2593 | 1.07e-01 |
| GO:BP | GO:0045185 | maintenance of protein location | 1 | 83 | 1.07e-01 |
| GO:BP | GO:0006304 | DNA modification | 1 | 89 | 1.09e-01 |
| GO:BP | GO:0097659 | nucleic acid-templated transcription | 3 | 2684 | 1.09e-01 |
| GO:BP | GO:0015918 | sterol transport | 1 | 92 | 1.09e-01 |
| GO:BP | GO:0032774 | RNA biosynthetic process | 3 | 2714 | 1.09e-01 |
| GO:BP | GO:0038061 | NIK/NF-kappaB signaling | 1 | 86 | 1.09e-01 |
| GO:BP | GO:0032368 | regulation of lipid transport | 1 | 92 | 1.09e-01 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | 2 | 963 | 1.09e-01 |
| GO:BP | GO:0006351 | DNA-templated transcription | 3 | 2683 | 1.09e-01 |
| GO:BP | GO:0051101 | regulation of DNA binding | 1 | 104 | 1.19e-01 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | 3 | 2845 | 1.19e-01 |
| GO:BP | GO:0050851 | antigen receptor-mediated signaling pathway | 1 | 106 | 1.19e-01 |
| GO:BP | GO:0071222 | cellular response to lipopolysaccharide | 1 | 110 | 1.22e-01 |
| GO:BP | GO:1905952 | regulation of lipid localization | 1 | 112 | 1.22e-01 |
| GO:BP | GO:0071219 | cellular response to molecule of bacterial origin | 1 | 114 | 1.23e-01 |
| GO:BP | GO:0002221 | pattern recognition receptor signaling pathway | 1 | 115 | 1.23e-01 |
| GO:BP | GO:0044839 | cell cycle G2/M phase transition | 1 | 149 | 1.28e-01 |
| GO:BP | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 1 | 138 | 1.28e-01 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | 3 | 3012 | 1.28e-01 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 1 | 152 | 1.28e-01 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 2 | 1147 | 1.28e-01 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | 1 | 153 | 1.28e-01 |
| GO:BP | GO:0019438 | aromatic compound biosynthetic process | 3 | 3133 | 1.28e-01 |
| GO:BP | GO:0009267 | cellular response to starvation | 1 | 152 | 1.28e-01 |
| GO:BP | GO:0051170 | import into nucleus | 1 | 152 | 1.28e-01 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | 3 | 3169 | 1.28e-01 |
| GO:BP | GO:0071216 | cellular response to biotic stimulus | 1 | 138 | 1.28e-01 |
| GO:BP | GO:0009266 | response to temperature stimulus | 1 | 133 | 1.28e-01 |
| GO:BP | GO:1901362 | organic cyclic compound biosynthetic process | 3 | 3237 | 1.28e-01 |
| GO:BP | GO:0007219 | Notch signaling pathway | 1 | 146 | 1.28e-01 |
| GO:BP | GO:0006606 | protein import into nucleus | 1 | 147 | 1.28e-01 |
| GO:BP | GO:0002758 | innate immune response-activating signaling pathway | 1 | 122 | 1.28e-01 |
| GO:BP | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 1 | 151 | 1.28e-01 |
| GO:BP | GO:0002218 | activation of innate immune response | 1 | 142 | 1.28e-01 |
| GO:BP | GO:0051100 | negative regulation of binding | 1 | 135 | 1.28e-01 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | 3 | 3070 | 1.28e-01 |
| GO:BP | GO:0000086 | G2/M transition of mitotic cell cycle | 1 | 134 | 1.28e-01 |
| GO:BP | GO:0018130 | heterocycle biosynthetic process | 3 | 3132 | 1.28e-01 |
| GO:BP | GO:0031326 | regulation of cellular biosynthetic process | 3 | 3080 | 1.28e-01 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | 3 | 3080 | 1.28e-01 |
| GO:BP | GO:0071356 | cellular response to tumor necrosis factor | 1 | 155 | 1.28e-01 |
| GO:BP | GO:0009612 | response to mechanical stimulus | 1 | 158 | 1.29e-01 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | 1 | 161 | 1.30e-01 |
| GO:BP | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 1 | 162 | 1.30e-01 |
| GO:BP | GO:0032496 | response to lipopolysaccharide | 1 | 178 | 1.37e-01 |
| GO:BP | GO:0042594 | response to starvation | 1 | 178 | 1.37e-01 |
| GO:BP | GO:0042770 | signal transduction in response to DNA damage | 1 | 178 | 1.37e-01 |
| GO:BP | GO:0034612 | response to tumor necrosis factor | 1 | 172 | 1.37e-01 |
| GO:BP | GO:0015850 | organic hydroxy compound transport | 1 | 174 | 1.37e-01 |
| GO:BP | GO:0045089 | positive regulation of innate immune response | 1 | 182 | 1.38e-01 |
| GO:BP | GO:0002237 | response to molecule of bacterial origin | 1 | 187 | 1.40e-01 |
| GO:BP | GO:0008283 | cell population proliferation | 2 | 1378 | 1.40e-01 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | 1 | 192 | 1.42e-01 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | 1 | 194 | 1.43e-01 |
| GO:BP | GO:0010468 | regulation of gene expression | 3 | 3580 | 1.49e-01 |
| GO:BP | GO:0016070 | RNA metabolic process | 3 | 3600 | 1.50e-01 |
| GO:BP | GO:0050727 | regulation of inflammatory response | 1 | 212 | 1.52e-01 |
| GO:BP | GO:0031668 | cellular response to extracellular stimulus | 1 | 219 | 1.56e-01 |
| GO:BP | GO:0044271 | cellular nitrogen compound biosynthetic process | 3 | 3750 | 1.56e-01 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | 3 | 3730 | 1.56e-01 |
| GO:BP | GO:0045088 | regulation of innate immune response | 1 | 232 | 1.56e-01 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | 1 | 227 | 1.56e-01 |
| GO:BP | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 1 | 227 | 1.56e-01 |
| GO:BP | GO:0007049 | cell cycle | 2 | 1529 | 1.56e-01 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | 1 | 230 | 1.56e-01 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | 1 | 242 | 1.62e-01 |
| GO:BP | GO:0044237 | cellular metabolic process | 4 | 6996 | 1.62e-01 |
| GO:BP | GO:0031349 | positive regulation of defense response | 1 | 251 | 1.65e-01 |
| GO:BP | GO:0043170 | macromolecule metabolic process | 4 | 7069 | 1.67e-01 |
| GO:BP | GO:0051235 | maintenance of location | 1 | 260 | 1.68e-01 |
| GO:BP | GO:0006869 | lipid transport | 1 | 272 | 1.70e-01 |
| GO:BP | GO:0033554 | cellular response to stress | 2 | 1681 | 1.70e-01 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 1 | 270 | 1.70e-01 |
| GO:BP | GO:0002253 | activation of immune response | 1 | 272 | 1.70e-01 |
| GO:BP | GO:0043414 | macromolecule methylation | 1 | 272 | 1.70e-01 |
| GO:BP | GO:0019221 | cytokine-mediated signaling pathway | 1 | 274 | 1.70e-01 |
| GO:BP | GO:0034504 | protein localization to nucleus | 1 | 276 | 1.70e-01 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 1 | 279 | 1.71e-01 |
| GO:BP | GO:0009605 | response to external stimulus | 2 | 1719 | 1.71e-01 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | 3 | 4048 | 1.74e-01 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | 1 | 295 | 1.74e-01 |
| GO:BP | GO:0051169 | nuclear transport | 1 | 295 | 1.74e-01 |
| GO:BP | GO:0002831 | regulation of response to biotic stimulus | 1 | 293 | 1.74e-01 |
| GO:BP | GO:0010876 | lipid localization | 1 | 310 | 1.80e-01 |
| GO:BP | GO:0032259 | methylation | 1 | 313 | 1.80e-01 |
| GO:BP | GO:0051098 | regulation of binding | 1 | 317 | 1.80e-01 |
| GO:BP | GO:0030099 | myeloid cell differentiation | 1 | 310 | 1.80e-01 |
| GO:BP | GO:0006807 | nitrogen compound metabolic process | 4 | 7441 | 1.80e-01 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 3 | 4174 | 1.80e-01 |
| GO:BP | GO:0019538 | protein metabolic process | 3 | 4241 | 1.84e-01 |
| GO:BP | GO:0044249 | cellular biosynthetic process | 3 | 4245 | 1.84e-01 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | 1 | 337 | 1.85e-01 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | 1 | 335 | 1.85e-01 |
| GO:BP | GO:0050794 | regulation of cellular process | 4 | 7552 | 1.85e-01 |
| GO:BP | GO:0051171 | regulation of nitrogen compound metabolic process | 3 | 4292 | 1.85e-01 |
| GO:BP | GO:0009314 | response to radiation | 1 | 352 | 1.90e-01 |
| GO:BP | GO:0031667 | response to nutrient levels | 1 | 353 | 1.90e-01 |
| GO:BP | GO:1901652 | response to peptide | 1 | 377 | 1.96e-01 |
| GO:BP | GO:0006338 | chromatin remodeling | 1 | 378 | 1.96e-01 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | 3 | 4455 | 1.96e-01 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 1 | 377 | 1.96e-01 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | 3 | 4417 | 1.96e-01 |
| GO:BP | GO:0050778 | positive regulation of immune response | 1 | 369 | 1.96e-01 |
| GO:BP | GO:0044238 | primary metabolic process | 4 | 7806 | 1.99e-01 |
| GO:BP | GO:1901576 | organic substance biosynthetic process | 3 | 4539 | 2.01e-01 |
| GO:BP | GO:0071396 | cellular response to lipid | 1 | 398 | 2.01e-01 |
| GO:BP | GO:0035556 | intracellular signal transduction | 2 | 2065 | 2.01e-01 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 1 | 407 | 2.01e-01 |
| GO:BP | GO:0006725 | cellular aromatic compound metabolic process | 3 | 4596 | 2.01e-01 |
| GO:BP | GO:0046483 | heterocycle metabolic process | 3 | 4570 | 2.01e-01 |
| GO:BP | GO:0010467 | gene expression | 3 | 4587 | 2.01e-01 |
| GO:BP | GO:0009058 | biosynthetic process | 3 | 4590 | 2.01e-01 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | 3 | 4617 | 2.02e-01 |
| GO:BP | GO:0006954 | inflammatory response | 1 | 429 | 2.02e-01 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 2 | 2139 | 2.02e-01 |
| GO:BP | GO:0072594 | establishment of protein localization to organelle | 1 | 422 | 2.02e-01 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 1 | 429 | 2.02e-01 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 1 | 421 | 2.02e-01 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | 1 | 418 | 2.02e-01 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 2 | 2161 | 2.03e-01 |
| GO:BP | GO:0050789 | regulation of biological process | 4 | 8061 | 2.06e-01 |
| GO:BP | GO:0031347 | regulation of defense response | 1 | 448 | 2.07e-01 |
| GO:BP | GO:1901360 | organic cyclic compound metabolic process | 3 | 4747 | 2.07e-01 |
| GO:BP | GO:0071704 | organic substance metabolic process | 4 | 8169 | 2.14e-01 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 1 | 482 | 2.19e-01 |
| GO:BP | GO:0050776 | regulation of immune response | 1 | 484 | 2.19e-01 |
| GO:BP | GO:0045087 | innate immune response | 1 | 488 | 2.19e-01 |
| GO:BP | GO:1901564 | organonitrogen compound metabolic process | 3 | 4955 | 2.23e-01 |
| GO:BP | GO:0044770 | cell cycle phase transition | 1 | 504 | 2.23e-01 |
| GO:BP | GO:0034641 | cellular nitrogen compound metabolic process | 3 | 4946 | 2.23e-01 |
| GO:BP | GO:0065007 | biological regulation | 4 | 8320 | 2.23e-01 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 1 | 513 | 2.24e-01 |
| GO:BP | GO:0019222 | regulation of metabolic process | 3 | 5017 | 2.28e-01 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | 1 | 540 | 2.33e-01 |
| GO:BP | GO:0006325 | chromatin organization | 1 | 551 | 2.36e-01 |
| GO:BP | GO:0008152 | metabolic process | 4 | 8518 | 2.38e-01 |
| GO:BP | GO:0002684 | positive regulation of immune system process | 1 | 581 | 2.46e-01 |
| GO:BP | GO:0033993 | response to lipid | 1 | 592 | 2.49e-01 |
| GO:BP | GO:0098542 | defense response to other organism | 1 | 608 | 2.52e-01 |
| GO:BP | GO:0060284 | regulation of cell development | 1 | 605 | 2.52e-01 |
| GO:BP | GO:0034097 | response to cytokine | 1 | 607 | 2.52e-01 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 1 | 640 | 2.63e-01 |
| GO:BP | GO:0030097 | hemopoiesis | 1 | 656 | 2.68e-01 |
| GO:BP | GO:0051050 | positive regulation of transport | 1 | 667 | 2.68e-01 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 1 | 665 | 2.68e-01 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 1 | 662 | 2.68e-01 |
| GO:BP | GO:0006950 | response to stress | 2 | 2780 | 2.75e-01 |
| GO:BP | GO:1903047 | mitotic cell cycle process | 1 | 694 | 2.76e-01 |
| GO:BP | GO:0030334 | regulation of cell migration | 1 | 706 | 2.79e-01 |
| GO:BP | GO:2000145 | regulation of cell motility | 1 | 742 | 2.90e-01 |
| GO:BP | GO:0036211 | protein modification process | 2 | 2901 | 2.90e-01 |
| GO:BP | GO:0044092 | negative regulation of molecular function | 1 | 755 | 2.92e-01 |
| GO:BP | GO:0040012 | regulation of locomotion | 1 | 763 | 2.94e-01 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 1 | 782 | 2.98e-01 |
| GO:BP | GO:0010629 | negative regulation of gene expression | 1 | 785 | 2.98e-01 |
| GO:BP | GO:0006974 | DNA damage response | 1 | 785 | 2.98e-01 |
| GO:BP | GO:0006886 | intracellular protein transport | 1 | 803 | 3.03e-01 |
| GO:BP | GO:1901698 | response to nitrogen compound | 1 | 830 | 3.09e-01 |
| GO:BP | GO:0000278 | mitotic cell cycle | 1 | 827 | 3.09e-01 |
| GO:BP | GO:0043412 | macromolecule modification | 2 | 3090 | 3.10e-01 |
| GO:BP | GO:0033365 | protein localization to organelle | 1 | 859 | 3.16e-01 |
| GO:BP | GO:0002682 | regulation of immune system process | 1 | 877 | 3.20e-01 |
| GO:BP | GO:0006259 | DNA metabolic process | 1 | 884 | 3.20e-01 |
| GO:BP | GO:0006955 | immune response | 1 | 882 | 3.20e-01 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 1 | 893 | 3.22e-01 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1 | 937 | 3.35e-01 |
| GO:BP | GO:0006952 | defense response | 1 | 944 | 3.35e-01 |
| GO:BP | GO:0040011 | locomotion | 1 | 954 | 3.37e-01 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 1 | 1006 | 3.52e-01 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 1 | 1014 | 3.53e-01 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 1 | 1074 | 3.68e-01 |
| GO:BP | GO:0080134 | regulation of response to stress | 1 | 1075 | 3.68e-01 |
| GO:BP | GO:0023057 | negative regulation of signaling | 1 | 1076 | 3.68e-01 |
| GO:BP | GO:0022402 | cell cycle process | 1 | 1086 | 3.68e-01 |
| GO:BP | GO:0016477 | cell migration | 1 | 1081 | 3.68e-01 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 2 | 3625 | 3.75e-01 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 1 | 1123 | 3.75e-01 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 1 | 1137 | 3.78e-01 |
| GO:BP | GO:0048870 | cell motility | 1 | 1182 | 3.89e-01 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 1 | 1223 | 3.99e-01 |
| GO:BP | GO:0007165 | signal transduction | 2 | 3818 | 3.99e-01 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 1 | 1248 | 4.03e-01 |
| GO:BP | GO:0051049 | regulation of transport | 1 | 1267 | 4.07e-01 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 1 | 1315 | 4.17e-01 |
| GO:BP | GO:1903508 | positive regulation of nucleic acid-templated transcription | 1 | 1315 | 4.17e-01 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 1 | 1322 | 4.17e-01 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 1 | 1345 | 4.22e-01 |
| GO:BP | GO:0048519 | negative regulation of biological process | 2 | 4045 | 4.23e-01 |
| GO:BP | GO:0015031 | protein transport | 1 | 1361 | 4.23e-01 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 2 | 4099 | 4.29e-01 |
| GO:BP | GO:0071310 | cellular response to organic substance | 1 | 1399 | 4.29e-01 |
| GO:BP | GO:0023052 | signaling | 2 | 4141 | 4.33e-01 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 1 | 1441 | 4.35e-01 |
| GO:BP | GO:0006915 | apoptotic process | 1 | 1443 | 4.35e-01 |
| GO:BP | GO:0046907 | intracellular transport | 1 | 1453 | 4.35e-01 |
| GO:BP | GO:0002376 | immune system process | 1 | 1447 | 4.35e-01 |
| GO:BP | GO:0045184 | establishment of protein localization | 1 | 1462 | 4.35e-01 |
| GO:BP | GO:0007154 | cell communication | 2 | 4226 | 4.36e-01 |
| GO:BP | GO:0012501 | programmed cell death | 1 | 1479 | 4.36e-01 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 1 | 1507 | 4.42e-01 |
| GO:BP | GO:0032879 | regulation of localization | 1 | 1555 | 4.50e-01 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 1 | 1555 | 4.50e-01 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 1 | 1564 | 4.50e-01 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 1 | 1602 | 4.55e-01 |
| GO:BP | GO:0008219 | cell death | 1 | 1596 | 4.55e-01 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 1 | 1604 | 4.55e-01 |
| GO:BP | GO:0071705 | nitrogen compound transport | 1 | 1684 | 4.72e-01 |
| GO:BP | GO:0048518 | positive regulation of biological process | 2 | 4579 | 4.73e-01 |
| GO:BP | GO:0050793 | regulation of developmental process | 1 | 1835 | 5.00e-01 |
| GO:BP | GO:0051649 | establishment of localization in cell | 1 | 1836 | 5.00e-01 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 1 | 1869 | 5.05e-01 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 1 | 1898 | 5.10e-01 |
| GO:BP | GO:0065009 | regulation of molecular function | 1 | 1939 | 5.16e-01 |
| GO:BP | GO:0048468 | cell development | 1 | 1963 | 5.16e-01 |
| GO:BP | GO:0010033 | response to organic substance | 1 | 1957 | 5.16e-01 |
| GO:BP | GO:0051716 | cellular response to stimulus | 2 | 4953 | 5.16e-01 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 1 | 1974 | 5.17e-01 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1 | 2035 | 5.27e-01 |
| GO:BP | GO:0009987 | cellular process | 4 | 11336 | 5.33e-01 |
| GO:BP | GO:0070727 | cellular macromolecule localization | 1 | 2138 | 5.38e-01 |
| GO:BP | GO:0008104 | protein localization | 1 | 2129 | 5.38e-01 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 1 | 2135 | 5.38e-01 |
| GO:BP | GO:0071702 | organic substance transport | 1 | 2116 | 5.38e-01 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 1 | 2270 | 5.61e-01 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 1 | 2293 | 5.61e-01 |
| GO:BP | GO:0009966 | regulation of signal transduction | 1 | 2285 | 5.61e-01 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 1 | 2412 | 5.81e-01 |
| GO:BP | GO:0033036 | macromolecule localization | 1 | 2450 | 5.85e-01 |
| GO:BP | GO:0042221 | response to chemical | 1 | 2559 | 5.98e-01 |
| GO:BP | GO:0023051 | regulation of signaling | 1 | 2565 | 5.98e-01 |
| GO:BP | GO:0050896 | response to stimulus | 2 | 5770 | 5.98e-01 |
| GO:BP | GO:0010646 | regulation of cell communication | 1 | 2573 | 5.98e-01 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 1 | 2646 | 6.08e-01 |
| GO:BP | GO:0051641 | cellular localization | 1 | 2810 | 6.32e-01 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 1 | 2880 | 6.40e-01 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 1 | 2890 | 6.40e-01 |
| GO:BP | GO:0008150 | biological_process | 4 | 12070 | 6.45e-01 |
| GO:BP | GO:0030154 | cell differentiation | 1 | 2958 | 6.46e-01 |
| GO:BP | GO:0048869 | cellular developmental process | 1 | 2984 | 6.47e-01 |
| GO:BP | GO:0006810 | transport | 1 | 3298 | 6.88e-01 |
| GO:BP | GO:0007275 | multicellular organism development | 1 | 3386 | 6.98e-01 |
| GO:BP | GO:0051234 | establishment of localization | 1 | 3433 | 7.01e-01 |
| GO:BP | GO:0051179 | localization | 1 | 3969 | 7.61e-01 |
| GO:BP | GO:0048856 | anatomical structure development | 1 | 4128 | 7.75e-01 |
| GO:BP | GO:0032502 | developmental process | 1 | 4494 | 8.07e-01 |
| GO:BP | GO:0032501 | multicellular organismal process | 1 | 4794 | 8.30e-01 |
| GO:BP | GO:0016043 | cellular component organization | 1 | 5076 | 8.49e-01 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 1 | 5274 | 8.60e-01 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 1 | 76 | 5.00e-02 |
| KEGG | KEGG:05135 | Yersinia infection | 1 | 112 | 5.00e-02 |
| KEGG | KEGG:05134 | Legionellosis | 1 | 39 | 5.00e-02 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 1 | 56 | 5.00e-02 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 1 | 53 | 5.00e-02 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 1 | 64 | 5.00e-02 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 1 | 113 | 5.00e-02 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | 1 | 42 | 5.00e-02 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 1 | 56 | 5.00e-02 |
| KEGG | KEGG:04668 | TNF signaling pathway | 1 | 87 | 5.00e-02 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 1 | 58 | 5.00e-02 |
| KEGG | KEGG:04936 | Alcoholic liver disease | 1 | 97 | 5.00e-02 |
| KEGG | KEGG:04931 | Insulin resistance | 1 | 95 | 5.00e-02 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 1 | 104 | 5.00e-02 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 1 | 70 | 5.00e-02 |
| KEGG | KEGG:05140 | Leishmaniasis | 1 | 42 | 5.00e-02 |
| KEGG | KEGG:05145 | Toxoplasmosis | 1 | 82 | 5.00e-02 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 1 | 51 | 5.00e-02 |
| KEGG | KEGG:05222 | Small cell lung cancer | 1 | 87 | 5.00e-02 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 1 | 75 | 5.00e-02 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1 | 69 | 5.00e-02 |
| KEGG | KEGG:05215 | Prostate cancer | 1 | 86 | 5.00e-02 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | 1 | 71 | 5.00e-02 |
| KEGG | KEGG:04115 | p53 signaling pathway | 1 | 65 | 5.00e-02 |
| KEGG | KEGG:05142 | Chagas disease | 1 | 75 | 5.00e-02 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 2 | 415 | 5.00e-02 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 1 | 87 | 5.00e-02 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 1 | 60 | 5.00e-02 |
| KEGG | KEGG:05164 | Influenza A | 1 | 103 | 5.00e-02 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 1 | 117 | 5.00e-02 |
| KEGG | KEGG:05162 | Measles | 1 | 98 | 5.00e-02 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | 1 | 49 | 5.00e-02 |
| KEGG | KEGG:05160 | Hepatitis C | 1 | 115 | 5.00e-02 |
| KEGG | KEGG:04210 | Apoptosis | 1 | 118 | 5.00e-02 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 1 | 110 | 5.00e-02 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 1 | 151 | 5.51e-02 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 1 | 153 | 5.51e-02 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 1 | 150 | 5.51e-02 |
| KEGG | KEGG:05161 | Hepatitis B | 1 | 136 | 5.51e-02 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 1 | 145 | 5.51e-02 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 1 | 153 | 5.51e-02 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 1 | 162 | 5.66e-02 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 1 | 165 | 5.66e-02 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 1 | 172 | 5.76e-02 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 1 | 176 | 5.76e-02 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 1 | 180 | 5.76e-02 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 1 | 186 | 5.82e-02 |
| KEGG | KEGG:05131 | Shigellosis | 1 | 210 | 6.41e-02 |
| KEGG | KEGG:05132 | Salmonella infection | 1 | 214 | 6.41e-02 |
| KEGG | KEGG:05200 | Pathways in cancer | 1 | 409 | 1.17e-01 |
| KEGG | KEGG:00000 | KEGG root term | 3 | 5558 | 1.90e-01 |
Mtx3_sp_DEGtable %>%
dplyr::filter(source=="KEGG") %>%
# dplyr::filter(p_value<0.05) %>%
dplyr::select(p_value,term_name,intersection_size) %>%
slice_min(., n=10 ,order_by=p_value) %>%
mutate(log_val = -log10(p_value)) %>%
# slice_max(., n=10,order_by = p_value) %>%
ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col= intersection_size)) +
geom_point(aes(size = intersection_size)) +
geom_vline(xintercept = (-log10(0.05)))+
scale_y_discrete(labels = wrap_format(30))+
guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
ggtitle('MTX 3 hour specific(stringent)\n gene set KEGG terms') +
xlab(expression(" -"~log[10]~("adj. p-value")))+
ylab("KEGG pathway")+
theme_bw()+
theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
axis.title = element_text(size = 15, color = "black"),
axis.ticks = element_line(linewidth = 1.5),
axis.line = element_line(linewidth = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0),
strip.text.x = element_text(size = 12, color = "black", face = "bold"))
| Version | Author | Date |
|---|---|---|
| 454978c | reneeisnowhere | 2023-07-14 |
toplist3hr <- toplistall %>%
mutate(id =case_match(id, "Da"~"DNR",
"Do"~"DOX",
"Ep"~"EPI",
"Mi"~"MTX",
"Tr"~"TRZ",
"Ve"~"VEH", .default = id)) %>%
mutate(id=factor(id, levels = c('DOX','EPI','DNR','MTX','TRZ','VEH'))) %>%
mutate(id = as.factor(id)) %>%
mutate(time=factor(time, levels=c("3_hours","24_hours"))) %>%
filter(time=="3_hours")
densityDOX3sp <-
toplist3hr %>%
filter(ENTREZID %in% Dox3onlyDEG) %>%
# filter(adj.P.Val<0.5) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("DOX\n n = 0")+
guides(fill=FALSE,alpha=FALSE)+
theme(
axis.title = element_text(size = 14, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
densityDNR3sp <-
toplist3hr %>%
filter(ENTREZID %in% Dnr3onlyDEG) %>%
# filter(adj.P.Val<0.5) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
# geom_histogram(aes(y = ..density.., fill = id, alpha = 0.8), bins = 120)+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("DNR-only 3 hour DEGs\n n = 322")+
guides(fill=FALSE,alpha=FALSE)+
theme(
axis.title = element_text(size = 14, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
densityEPI3sp <-
toplist3hr %>%
filter(ENTREZID %in% Epi3onlyDEG) %>%
# filter(adj.P.Val<0.5) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("EPI-only DEGs\n n = 18")+
ylim(0,50)+
guides(fill=FALSE,alpha=FALSE)+
theme(axis.title = element_text(size = 14, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
densityMTX3sp <-
toplist3hr %>%
filter(ENTREZID %in% Mtx3onlyDEG) %>%
# filter(adj.P.Val<0.5) %>%
ggplot(., aes(x=adj.P.Val))+
geom_density(aes(fill=id, alpha= 0.8))+
fill_palette(palette = drug_palc)+
theme_bw()+
ylab("MTX-only DEGs\n n = 16")+
# ylim(0,0.5)+
guides(fill=FALSE,alpha=FALSE)+
theme(axis.title = element_text(size = 14, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))Dox3Bplot <- toplist3hr %>%
group_by(time,id) %>%
dplyr::filter(ENTREZID %in% DOX3deg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("DOX n = 0")+
theme_classic()+
fill_palette(palette = drug_palc)+
guides(fill= "none")+
theme(
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
Dnr3Bplot <-
toplist3hr %>%
group_by(time,id) %>%
dplyr::filter(ENTREZID %in% DNR3deg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("DNR-spec. adj.P.V <0.01\n n = 100")+
theme_classic()+
guides(fill= "none")+
fill_palette(palette = drug_palc)+
theme(
axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
Epi3Bplot <-
toplist3hr %>%
group_by(time,id) %>%
filter(ENTREZID %in% EPI3deg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("EPI-spec.adj.P.V <0.01\n n = 0")+
theme_classic()+
guides(fill= "none")+
fill_palette(palette = drug_palc)+
theme(axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))
Mtx3Bplot <-
toplist3hr %>%
group_by(time,id) %>%
filter(time=="3_hours") %>%
filter(ENTREZID %in% MTX3deg_sp$ENTREZID) %>%
mutate(logFC=logFC*(-1)) %>%
mutate("treatment" = id) %>%
ggplot(., aes(x= treatment, y=logFC))+
geom_boxplot(aes(fill=id))+
xlab(" ")+
ylab("MTX-spec. adj.P.V <0.01\n n = 4")+
guides(fill= "none")+
theme_classic()+
fill_palette(palette = drug_palc)+
theme(axis.title = element_text(size = 10, color = "black"),
axis.ticks = element_line(size = 1.5),
axis.text = element_text(size = 10, color = "black", angle = 0))Dox3genesp_example <- "none"#cpm_boxplot(cpmcounts,GOI=101927720,"Dark2",drug_palc,
# ylab=bquote(~italic("ZNF793-AS1 ")~log[2]~"cpm "))+
# theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
Dnr3genesp_example <- cpm_boxplot_time(cpmcounts,"3h",7975 ,"Dark2",drug_palc,
ylab=bquote(~italic("MAFK")~log[2]~"cpm "))+
theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
Epi3genesp_example <- "none"#cpm_boxplot(cpmcounts,GOI=79169,"Dark2",drug_palc,
# ylab=bquote(~italic("C1orf35")~log[2]~"cpm "))+
# theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
Mtx3genesp_example <- cpm_boxplot_time(cpmcounts, "3h",GOI=284306,"Dark2",drug_palc,
ylab=bquote(~italic("ZNF547")~log[2]~"cpm "))+
theme(axis.title = element_text(size = 10, color = "black"), axis.text = element_text(size = 10, color = "black", angle = 0))
grid 3 hour
mito3pg <- plot_grid(densityMTX3sp, Mtx3Bplot, Mtx3genesp_example,
nrow = 1,
rel_heights = c(.8,2,1),
rel_widths=c(1.2,1,1.5),
scale=c(1,0.8,0.8))
Daun3pg <- plot_grid(densityDNR3sp, Dnr3Bplot, Dnr3genesp_example, nrow = 1, rel_heights = c(.8,2,1), rel_widths=c(1.2,1,1.5),scale=c(1,0.8,0.8))
Doxo3pg <- plot_grid(densityDOX3sp, Dox3Bplot, Dox3genesp_example, nrow = 1, rel_heights = c(.8,2,1), rel_widths=c(1.2,1,1.5),scale=c(1,0.8,0.8))
Epi3pg <- plot_grid(densityEPI3sp, Epi3Bplot, Epi3genesp_example, nrow = 1, rel_heights = c(.8,2,1), rel_widths=c(1.2,1,1.5),scale=c(1,0.8,0.8))
allfinal3hour <- plot_grid(Doxo3pg,Epi3pg,Daun3pg,mito3pg,nrow=4, rel_heights = c(0.5,1,1,1))
allfinal3hour
saveRDS(allfinal3hour,"data/allfinal3hour.RDS")
sessionInfo()R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.utf8
[2] LC_CTYPE=English_United States.utf8
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C
[5] LC_TIME=English_United States.utf8
time zone: America/Chicago
tzcode source: internal
attached base packages:
[1] grid stats graphics grDevices utils datasets methods
[8] base
other attached packages:
[1] gprofiler2_0.2.2 paletteer_1.5.0 ggVennDiagram_1.2.3
[4] ComplexHeatmap_2.16.0 broom_1.0.5 kableExtra_1.3.4
[7] sjmisc_2.8.9 scales_1.2.1 ggpubr_0.6.0
[10] cowplot_1.1.1 ggsignif_0.6.4 lubridate_1.9.2
[13] forcats_1.0.0 stringr_1.5.0 dplyr_1.1.3
[16] purrr_1.0.2 readr_2.1.4 tidyr_1.3.0
[19] tibble_3.2.1 ggplot2_3.4.3 tidyverse_2.0.0
[22] RColorBrewer_1.1-3 limma_3.56.2 workflowr_1.7.1
loaded via a namespace (and not attached):
[1] rstudioapi_0.15.0 jsonlite_1.8.7 shape_1.4.6
[4] magrittr_2.0.3 farver_2.1.1 rmarkdown_2.24
[7] GlobalOptions_0.1.2 fs_1.6.3 ragg_1.2.5
[10] vctrs_0.6.3 rstatix_0.7.2 webshot_0.5.5
[13] htmltools_0.5.6 lambda.r_1.2.4 sass_0.4.7
[16] KernSmooth_2.23-22 bslib_0.5.1 htmlwidgets_1.6.2
[19] futile.options_1.0.1 plotly_4.10.2 cachem_1.0.8
[22] whisker_0.4.1 mime_0.12 lifecycle_1.0.3
[25] iterators_1.0.14 pkgconfig_2.0.3 sjlabelled_1.2.0
[28] R6_2.5.1 fastmap_1.1.1 shiny_1.7.5
[31] clue_0.3-64 digest_0.6.33 colorspace_2.1-0
[34] rematch2_2.1.2 S4Vectors_0.38.1 ps_1.7.5
[37] rprojroot_2.0.3 prismatic_1.1.1 crosstalk_1.2.0
[40] textshaping_0.3.6 labeling_0.4.3 fansi_1.0.4
[43] timechange_0.2.0 httr_1.4.7 abind_1.4-5
[46] compiler_4.3.1 proxy_0.4-27 withr_2.5.0
[49] doParallel_1.0.17 backports_1.4.1 carData_3.0-5
[52] DBI_1.1.3 highr_0.10 rjson_0.2.21
[55] classInt_0.4-10 tools_4.3.1 units_0.8-4
[58] httpuv_1.6.11 glue_1.6.2 VennDiagram_1.7.3
[61] callr_3.7.3 promises_1.2.1 sf_1.0-14
[64] getPass_0.2-2 cluster_2.1.4 generics_0.1.3
[67] gtable_0.3.4 tzdb_0.4.0 class_7.3-22
[70] data.table_1.14.8 hms_1.1.3 xml2_1.3.5
[73] car_3.1-2 utf8_1.2.3 BiocGenerics_0.46.0
[76] foreach_1.5.2 pillar_1.9.0 later_1.3.1
[79] circlize_0.4.15 tidyselect_1.2.0 knitr_1.44
[82] git2r_0.32.0 IRanges_2.34.1 svglite_2.1.1
[85] stats4_4.3.1 futile.logger_1.4.3 xfun_0.40
[88] matrixStats_1.0.0 stringi_1.7.12 lazyeval_0.2.2
[91] yaml_2.3.7 evaluate_0.21 codetools_0.2-19
[94] RVenn_1.1.0 cli_3.6.1 xtable_1.8-4
[97] systemfonts_1.0.4 munsell_0.5.0 processx_3.8.2
[100] jquerylib_0.1.4 Rcpp_1.0.11 png_0.1-8
[103] parallel_4.3.1 ellipsis_0.3.2 viridisLite_0.4.2
[106] e1071_1.7-13 insight_0.19.5 crayon_1.5.2
[109] GetoptLong_1.0.5 rlang_1.1.1 rvest_1.0.3
[112] formatR_1.14