Last updated: 2024-02-05
Checks: 7 0
Knit directory: Cardiotoxicity/
This reproducible R Markdown analysis was created with workflowr (version 1.7.1). The Checks tab describes the reproducibility checks that were applied when the results were created. The Past versions tab lists the development history.
Great! Since the R Markdown file has been committed to the Git repository, you know the exact version of the code that produced these results.
Great job! The global environment was empty. Objects defined in the global environment can affect the analysis in your R Markdown file in unknown ways. For reproduciblity it’s best to always run the code in an empty environment.
The command set.seed(20230109)
was run prior to running
the code in the R Markdown file. Setting a seed ensures that any results
that rely on randomness, e.g. subsampling or permutations, are
reproducible.
Great job! Recording the operating system, R version, and package versions is critical for reproducibility.
Nice! There were no cached chunks for this analysis, so you can be confident that you successfully produced the results during this run.
Great job! Using relative paths to the files within your workflowr project makes it easier to run your code on other machines.
Great! You are using Git for version control. Tracking code development and connecting the code version to the results is critical for reproducibility.
The results in this page were generated with repository version df08393. See the Past versions tab to see a history of the changes made to the R Markdown and HTML files.
Note that you need to be careful to ensure that all relevant files for
the analysis have been committed to Git prior to generating the results
(you can use wflow_publish
or
wflow_git_commit
). workflowr only checks the R Markdown
file, but you know if there are other scripts or data files that it
depends on. Below is the status of the Git repository when the results
were generated:
Ignored files:
Ignored: .RData
Ignored: .Rhistory
Ignored: .Rproj.user/
Ignored: analysis/variance_values by gene.png
Ignored: data/41588_2018_171_MOESM3_ESMeQTL_ST2_for paper.csv
Ignored: data/Arr_GWAS.txt
Ignored: data/Arr_geneset.RDS
Ignored: data/BC_cell_lines.csv
Ignored: data/BurridgeDOXTOX.RDS
Ignored: data/CADGWASgene_table.csv
Ignored: data/CAD_geneset.RDS
Ignored: data/CALIMA_Data/
Ignored: data/CMD04_75DRCviability.csv
Ignored: data/CMD04_87DRCviability.csv
Ignored: data/CMD05_75DRCviability.csv
Ignored: data/CMD05_87DRCviability.csv
Ignored: data/Clamp_Summary.csv
Ignored: data/Cormotif_24_k1-5_raw.RDS
Ignored: data/Counts_RNA_ERMatthews.txt
Ignored: data/DAgostres24.RDS
Ignored: data/DAtable1.csv
Ignored: data/DDEMresp_list.csv
Ignored: data/DDE_reQTL.txt
Ignored: data/DDEresp_list.csv
Ignored: data/DEG-GO/
Ignored: data/DEG_cormotif.RDS
Ignored: data/DF_Plate_Peak.csv
Ignored: data/DRC48hoursdata.csv
Ignored: data/Da24counts.txt
Ignored: data/Dx24counts.txt
Ignored: data/Dx_reQTL_specific.txt
Ignored: data/EPIstorelist24.RDS
Ignored: data/Ep24counts.txt
Ignored: data/FC_necela.RDS
Ignored: data/FC_necela_names.RDS
Ignored: data/Full_LD_rep.csv
Ignored: data/GOIsig.csv
Ignored: data/GOplots.R
Ignored: data/GTEX_setsimple.csv
Ignored: data/GTEX_sig24.RDS
Ignored: data/GTEx_gene_list.csv
Ignored: data/HFGWASgene_table.csv
Ignored: data/HF_geneset.RDS
Ignored: data/Heart_Left_Ventricle.v8.egenes.txt
Ignored: data/Heatmap_mat.RDS
Ignored: data/Heatmap_sig.RDS
Ignored: data/Hf_GWAS.txt
Ignored: data/K_cluster
Ignored: data/K_cluster_kisthree.csv
Ignored: data/K_cluster_kistwo.csv
Ignored: data/Knowles_log2cpm_real.RDS
Ignored: data/Knowles_variation_data.RDS
Ignored: data/Knowles_variation_data_conc.RDS
Ignored: data/Knowlesvarlist.RDS
Ignored: data/LD50_05via.csv
Ignored: data/LDH48hoursdata.csv
Ignored: data/Mt24counts.txt
Ignored: data/NoRespDEG_final.csv
Ignored: data/RINsamplelist.txt
Ignored: data/RNA_seq_trial.RDS
Ignored: data/Schneider_GWAS.txt
Ignored: data/Seonane2019supp1.txt
Ignored: data/Sup_replicate_values.csv
Ignored: data/TMMnormed_x.RDS
Ignored: data/TOP2Bi-24hoursGO_analysis.csv
Ignored: data/TR24counts.txt
Ignored: data/TableS10.csv
Ignored: data/TableS11.csv
Ignored: data/TableS9.csv
Ignored: data/Top2_expression.RDS
Ignored: data/Top2biresp_cluster24h.csv
Ignored: data/Var_test_list.RDS
Ignored: data/Var_test_list24.RDS
Ignored: data/Var_test_list24alt.RDS
Ignored: data/Var_test_list3.RDS
Ignored: data/Vargenes.RDS
Ignored: data/Viabilitylistfull.csv
Ignored: data/allexpressedgenes.txt
Ignored: data/allfinal3hour.RDS
Ignored: data/allgenes.txt
Ignored: data/allmatrix.RDS
Ignored: data/allmymatrix.RDS
Ignored: data/annotation_data_frame.RDS
Ignored: data/averageviabilitytable.RDS
Ignored: data/averageviabilitytable.csv
Ignored: data/avgLD50.RDS
Ignored: data/avg_LD50.RDS
Ignored: data/avg_via_table.csv
Ignored: data/backGL.txt
Ignored: data/burr_genes.RDS
Ignored: data/calcium_data.RDS
Ignored: data/clamp_summary.RDS
Ignored: data/cormotif_3hk1-8.RDS
Ignored: data/cormotif_initalK5.RDS
Ignored: data/cormotif_initialK5.RDS
Ignored: data/cormotif_initialall.RDS
Ignored: data/cormotifprobs.csv
Ignored: data/counts24hours.RDS
Ignored: data/cpmcount.RDS
Ignored: data/cpmnorm_counts.csv
Ignored: data/crispr_genes.csv
Ignored: data/ctnnt_results.txt
Ignored: data/cvd_GWAS.txt
Ignored: data/dat_cpm.RDS
Ignored: data/data_outline.txt
Ignored: data/drug_noveh1.csv
Ignored: data/efit2.RDS
Ignored: data/efit2_final.RDS
Ignored: data/efit2results.RDS
Ignored: data/ensembl_backup.RDS
Ignored: data/ensgtotal.txt
Ignored: data/filcpm_counts.RDS
Ignored: data/filenameonly.txt
Ignored: data/filtered_cpm_counts.csv
Ignored: data/filtered_raw_counts.csv
Ignored: data/filtermatrix_x.RDS
Ignored: data/folder_05top/
Ignored: data/framefun24.RDS
Ignored: data/geneDoxonlyQTL.csv
Ignored: data/gene_corr_df.RDS
Ignored: data/gene_corr_frame.RDS
Ignored: data/gene_prob_tran3h.RDS
Ignored: data/gene_probabilityk5.RDS
Ignored: data/geneset_24.RDS
Ignored: data/gostresTop2bi_ER.RDS
Ignored: data/gostresTop2bi_LR
Ignored: data/gostresTop2bi_LR.RDS
Ignored: data/gostresTop2bi_TI.RDS
Ignored: data/gostrescoNR
Ignored: data/gtex/
Ignored: data/heartgenes.csv
Ignored: data/highly_var_genelist.RDS
Ignored: data/hsa_kegg_anno.RDS
Ignored: data/individualDRCfile.RDS
Ignored: data/individual_DRC48.RDS
Ignored: data/individual_LDH48.RDS
Ignored: data/indv_noveh1.csv
Ignored: data/kegglistDEG.RDS
Ignored: data/kegglistDEG24.RDS
Ignored: data/kegglistDEG3.RDS
Ignored: data/knowfig4.csv
Ignored: data/knowfig5.csv
Ignored: data/label_list.RDS
Ignored: data/ld50_table.csv
Ignored: data/mean_vardrug1.csv
Ignored: data/mean_varframe.csv
Ignored: data/mymatrix.RDS
Ignored: data/new_ld50avg.RDS
Ignored: data/nonresponse_cluster24h.csv
Ignored: data/norm_LDH.csv
Ignored: data/norm_counts.csv
Ignored: data/old_sets/
Ignored: data/organized_drugframe.csv
Ignored: data/pca_all_anno.csv
Ignored: data/plan2plot.png
Ignored: data/plot_intv_list.RDS
Ignored: data/plot_list_DRC.RDS
Ignored: data/qval24hr.RDS
Ignored: data/qval3hr.RDS
Ignored: data/qvalueEPItemp.RDS
Ignored: data/raw_counts.csv
Ignored: data/response_cluster24h.csv
Ignored: data/sampsettrz.RDS
Ignored: data/schneider_closest_output.RDS
Ignored: data/sigVDA24.txt
Ignored: data/sigVDA3.txt
Ignored: data/sigVDX24.txt
Ignored: data/sigVDX3.txt
Ignored: data/sigVEP24.txt
Ignored: data/sigVEP3.txt
Ignored: data/sigVMT24.txt
Ignored: data/sigVMT3.txt
Ignored: data/sigVTR24.txt
Ignored: data/sigVTR3.txt
Ignored: data/siglist.RDS
Ignored: data/siglist_final.RDS
Ignored: data/siglist_old.RDS
Ignored: data/slope_table.csv
Ignored: data/supp10_24hlist.RDS
Ignored: data/supp10_3hlist.RDS
Ignored: data/supp_normLDH48.RDS
Ignored: data/supp_pca_all_anno.RDS
Ignored: data/supp_viadata.csv
Ignored: data/table3a.omar
Ignored: data/test_run_sample_list.txt
Ignored: data/testlist.txt
Ignored: data/toplistall.RDS
Ignored: data/trtonly_24h_genes.RDS
Ignored: data/trtonly_3h_genes.RDS
Ignored: data/tvl24hour.txt
Ignored: data/tvl24hourw.txt
Ignored: data/venn_code.R
Ignored: data/viability.RDS
Untracked files:
Untracked: .RDataTmp
Untracked: .RDataTmp1
Untracked: .RDataTmp2
Untracked: .RDataTmp3
Untracked: 3hr all.pdf
Untracked: Code_files_list.csv
Untracked: Data_files_list.csv
Untracked: Doxorubicin_vehicle_3_24.csv
Untracked: Doxtoplist.csv
Untracked: EPIqvalue_analysis.Rmd
Untracked: Final.sup.pdf
Untracked: GWAS_list_of_interest.xlsx
Untracked: KEGGpathwaylist.R
Untracked: NA
Untracked: OmicNavigator_learn.R
Untracked: SNP_egenes_allfiles.RDS
Untracked: SNP_frame_pdf
Untracked: SNP_frame_pdf.pdf
Untracked: SigDoxtoplist.csv
Untracked: analysis/DRC_viability_check.Rmd
Untracked: analysis/New_code_dec-23.R
Untracked: analysis/cellcycle_kegg_genes.R
Untracked: analysis/ciFIT.R
Untracked: analysis/export_to_excel.R
Untracked: analysis/featureCountsPLAY.R
Untracked: cleanupfiles_script.R
Untracked: code/biomart_gene_names.R
Untracked: code/constantcode.R
Untracked: code/corMotifcustom.R
Untracked: code/cpm_boxplot.R
Untracked: code/extracting_ggplot_data.R
Untracked: code/movingfilesto_ppl.R
Untracked: code/pearson_extract_func.R
Untracked: code/pearson_tox_extract.R
Untracked: code/plot1C.fun.R
Untracked: code/spearman_extract_func.R
Untracked: code/venndiagramcolor_control.R
Untracked: cormotif_p.post.list_4.csv
Untracked: figS1024h.pdf
Untracked: final.pdf
Untracked: individual-legenddark2.png
Untracked: installed_old.rda
Untracked: listoftranscripts
Untracked: motif_ER.txt
Untracked: motif_LR.txt
Untracked: motif_NR.txt
Untracked: motif_TI.txt
Untracked: output/ABHD8_dif_values.RDS
Untracked: output/C3orf18_dif_values.RDS
Untracked: output/Cardiotox_dif_values.RDS
Untracked: output/DNR_DEGlist.csv
Untracked: output/DNRvenn.RDS
Untracked: output/DOX_DEGlist.csv
Untracked: output/DOX_de_goi.csv
Untracked: output/DOXvenn.RDS
Untracked: output/EEF1B2_dif_values.RDS
Untracked: output/EEIG1_dif_values.RDS
Untracked: output/EPI_DEGlist.csv
Untracked: output/EPIvenn.RDS
Untracked: output/ESGN_rds.RDS
Untracked: output/FC_necela.RDS
Untracked: output/FC_necela_names.RDS
Untracked: output/FRS2_dif_values.RDS
Untracked: output/Figures/
Untracked: output/GTEXv8_gene_median_tpm.RDS
Untracked: output/GTEXv8_gene_tpm_heart_left_ventricle.RDS
Untracked: output/HDDC2_dif_values.RDS
Untracked: output/HER2_gene.RDS
Untracked: output/KEGGcellcyclegenes.RDS
Untracked: output/Knowles_S13.csv
Untracked: output/Knowles_log2cpm.csv
Untracked: output/Knowles_supp13.csv
Untracked: output/LD50tox_table.RDS
Untracked: output/MTX_DEGlist.csv
Untracked: output/MTXvenn.RDS
Untracked: output/PEX16_dif_values.RDS
Untracked: output/RASIP1_dif_values.RDS
Untracked: output/RMI1_dif_values.RDS
Untracked: output/RSID_QTL_list_full.txt
Untracked: output/SETA_analysis_reyes.RDS
Untracked: output/SGWAS_top50_order.csv
Untracked: output/SLC27A1_dif_values.RDS
Untracked: output/SLC28A3_dif_values.RDS
Untracked: output/SNP_egenes_allfiles.RDS
Untracked: output/SNP_list_ID.RDS
Untracked: output/SNP_list_full.txt
Untracked: output/SNP_supp.RDS
Untracked: output/TGFBR3L_dif_values.RDS
Untracked: output/TNS2_dif_values.RDS
Untracked: output/TOP_50SNPreffile.csv
Untracked: output/TRZ_DEGlist.csv
Untracked: output/TableS8.csv
Untracked: output/Volcanoplot_10
Untracked: output/Volcanoplot_10.RDS
Untracked: output/ZNF740_dif_values.RDS
Untracked: output/allfinal_sup10.RDS
Untracked: output/counts_v8_heart_left_ventricle_gct.RDS
Untracked: output/crisprfoldchange.RDS
Untracked: output/endocytosisgenes.csv
Untracked: output/expre7k.csv
Untracked: output/expressed_egenes_by_RSID.csv
Untracked: output/gene_corr_fig9.RDS
Untracked: output/genes.RDS
Untracked: output/legend_b.RDS
Untracked: output/motif_ERrep.RDS
Untracked: output/motif_LRrep.RDS
Untracked: output/motif_NRrep.RDS
Untracked: output/motif_TI_rep.RDS
Untracked: output/near_genes_SNP1.RDS
Untracked: output/necela_list_test.RDS
Untracked: output/necela_val_genes.RDS
Untracked: output/output-old/
Untracked: output/rank24genes.csv
Untracked: output/rank3genes.csv
Untracked: output/sequencinginformationforsupp.csv
Untracked: output/sequencinginformationforsupp.prn
Untracked: output/sigVDA24.txt
Untracked: output/sigVDA3.txt
Untracked: output/sigVDX24.txt
Untracked: output/sigVDX3.txt
Untracked: output/sigVEP24.txt
Untracked: output/sigVEP3.txt
Untracked: output/sigVMT24.txt
Untracked: output/sigVMT3.txt
Untracked: output/sigVTR24.txt
Untracked: output/sigVTR3.txt
Untracked: output/supplementary_motif_list_GO.RDS
Untracked: output/test_biomart_run.RDS
Untracked: output/toptablebydrug.RDS
Untracked: output/trop_knowles_fun.csv
Untracked: output/tvl24hour.txt
Untracked: output/x_counts.RDS
Untracked: reneebasecode.R
Unstaged changes:
Modified: analysis/DRC_analysis.Rmd
Modified: analysis/GOI_plots.Rmd
Modified: analysis/GTEx_genes.Rmd
Deleted: analysis/Knowles2019.Rmd
Modified: output/daplot.RDS
Modified: output/dxplot.RDS
Modified: output/epplot.RDS
Modified: output/mtplot.RDS
Modified: output/plan2plot.png
Modified: output/trplot.RDS
Modified: output/veplot.RDS
Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.
These are the previous versions of the repository in which changes were
made to the R Markdown (analysis/RNAseqanalysis.Rmd
) and
HTML (docs/RNAseqanalysis.html
) files. If you’ve configured
a remote Git repository (see ?wflow_git_remote
), click on
the hyperlinks in the table below to view the files as they were in that
past version.
File | Version | Author | Date | Message |
---|---|---|---|---|
Rmd | df08393 | reneeisnowhere | 2024-02-05 | updates to scripts |
Rmd | f4bd5e1 | reneeisnowhere | 2023-06-27 | checking code changes overtime |
html | c2db62c | reneeisnowhere | 2023-06-16 | Build site. |
Rmd | d27d788 | reneeisnowhere | 2023-06-16 | updates |
Rmd | 575fd81 | reneeisnowhere | 2023-04-11 | updating cormotif |
Rmd | 4e52216 | reneeisnowhere | 2023-03-31 | End of week updates |
Rmd | 3a26d52 | reneeisnowhere | 2023-03-22 | Wed poster analysis changes |
Rmd | 945460e | reneeisnowhere | 2023-03-19 | Updating go plot with reorder |
Rmd | 9cbe858 | reneeisnowhere | 2023-03-10 | Codescramble update |
Rmd | f31edb7 | reneeisnowhere | 2023-03-03 | altered script to significance of 0.05 to generate the sig05 files |
Rmd | 28fb31f | reneeisnowhere | 2023-02-24 | Friday-updates |
html | 64c9be0 | reneeisnowhere | 2023-02-10 | Build site. |
Rmd | 7a6d5d5 | reneeisnowhere | 2023-02-10 | updates for the week part 500 |
html | cdd9374 | reneeisnowhere | 2023-02-10 | Build site. |
Rmd | 40fb340 | reneeisnowhere | 2023-02-10 | updates for the week |
Rmd | accc241 | reneeisnowhere | 2023-02-10 | updates for the week |
Rmd | 1fc5c19 | reneeisnowhere | 2023-02-09 | Git update |
Hello! I am first loading all the beautiful libraries I will need.
#library(Biobase)
library(edgeR)#
library(limma)#
library(RColorBrewer)
# library(mixOmics)
#library(VennDiagram)
#library(HTSFilter)
library(gridExtra)#
library(reshape2)#
library(devtools)
library(AnnotationHub)
library(tidyverse)
library(scales)
library(biomaRt)#
library(Homo.sapiens)
library(cowplot)#
library(ggrepel)#
library(corrplot)
library(Hmisc)
The next step is to load all the data I will be using. Currently, I am not posting the raw data, but I will release in the future.
This is how I retrieved the gene symbols.
###now we add genenames to the geneid###
geneid <- rownames(mymatrix) ### pulls the names we have in the counts file
genes <- select(Homo.sapiens, keys=geneid, columns=c("SYMBOL"),
keytype="ENTREZID")
genes <- genes[!duplicated(genes$ENTREZID),]
mymatrix$genes <- genes
Filtering the genes that are lowly expressed using several methods.
First method, removing only those rows with zero counts across all samples.
#
# old.par <- par(mar = c(0, 0, 0, 0))
# par(old.par)
# boxplot(data =RNAseqreads, total~Sample, main = "Boxplots of total reads",xaxt = "n", xlab= "")
# x_axis_labels(labels = samplenames, every_nth = 1, adj=1, srt =90, cex =0.4)
# ggplot(RNAseqreads, x = Sample, y = total)+
# geom_boxplot()
table(rowSums(mymatrix$counts==0)==72)
FALSE TRUE
26487 1908
This filtering would leave 24931 genes and remove 3464, That is too many leftover genes!
So now to try something a little more stringent using the built in function from the edgeR package.
keep <- filterByExpr.DGEList(mymatrix, group = group)
filter_test <- mymatrix[keep, , keep.lib.sizes=FALSE]
dim(filter_test)
[1] 17189 72
This method effectively uses a cutoff off that leaves 14448 genes.
The cutoff is determined by keeping genes that have a count-per-million
(CPM) above 10, (the default minimum set) in 6 samples. A set is
determined using the design matrix.
For my design, I grouped my 72 samples into sets of 6, one set includes
each individual + a specific treatment + a specific time.
The beginning cutoff-standard in our lab is to start by using the rowMeans >0 cutoff on the log10 of cpm.
cpm <- cpm(mymatrix)
lcpm <- cpm(mymatrix, log=TRUE) ### for determining the basic cutoffs
dim(lcpm)
[1] 28395 72
L <- mean(mymatrix$samples$lib.size) * 1e-6
M <- median(mymatrix$samples$lib.size) * 1e-6
c(L, M)
[1] 21.77031 19.77884
filcpm_matrix <- subset(lcpm, (rowMeans(lcpm)>0))
write.csv(filcpm_matrix, "data/filtered_cpm_counts.csv")
dim(filcpm_matrix)
[1] 14084 72
##method 2 with rowMeans
row_means <- rowMeans(lcpm)
x <- mymatrix[row_means > 0,]
dim(x)
[1] 14084 72
write.csv(x$counts, "data/raw_counts.csv")
saveRDS(x,"data/filtermatrix_x.RDS")
Both of the above methods leave 14823 genes from 28,395. I prefer the second method, which keeps the DGEList format of the data.
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
now I will produce the RIN x sample plots:###
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
PCA was done using code adopted from J. Blischak.
### Vehicle
### Daunorubicin
### Doxorubicin
### Epirubicin
### Mitoxantrone
### Trastuzumab
Warning: `qplot()` was deprecated in ggplot2 3.4.0.
This warning is displayed once every 8 hours.
Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
generated.
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
samplenames indv drug time RIN group PC1
Da.1.3h MCW_RM_R_11_S72 1 Daunorubicin 3h 9.3 1 -18.801867
Do.1.3h MCW_RM_R_12_S1_ 1 Doxorubicin 3h 9.8 2 -12.477726
Ep.1.3h MCW_RM_R_13_S2_ 1 Epirubicin 3h 9.8 3 -12.502827
Mi.1.3h MCW_RM_R_14_S3_ 1 Mitoxantrone 3h 10 4 -10.669231
Tr.1.3h MCW_RM_R_15_S4_ 1 Trastuzumab 3h 9.6 5 -11.883176
Ve.1.3h MCW_RM_R_16_S5_ 1 Vehicle 3h 9.9 6 -14.354941
Da.1.24h MCW_RM_R_17_S6_ 1 Daunorubicin 24h 7.8 7 133.112599
Do.1.24h MCW_RM_R_18_S7_ 1 Doxorubicin 24h 8.7 8 127.043322
Ep.1.24h MCW_RM_R_19_S8_ 1 Epirubicin 24h 8.6 9 140.502625
Mi.1.24h MCW_RM_R_20_S9_ 1 Mitoxantrone 24h 9.1 10 33.538711
Tr.1.24h MCW_RM_R_21_S10 1 Trastuzumab 24h 9.4 11 -8.639401
Ve.1.24h MCW_RM_R_22_S11 1 Vehicle 24h 9.3 12 -10.980966
Da.2.3h MCW_RM_R_23_S12 2 Daunorubicin 3h 9.4 1 -56.228403
Do.2.3h MCW_RM_R_24_S13 2 Doxorubicin 3h 9.6 2 -54.025883
Ep.2.3h MCW_RM_R_25_S14 2 Epirubicin 3h 9.9 3 -52.539005
Mi.2.3h MCW_RM_R_26_S15 2 Mitoxantrone 3h 9.4 4 -46.610204
Tr.2.3h MCW_RM_R_27_S16 2 Trastuzumab 3h 9.9 5 -56.868667
Ve.2.3h MCW_RM_R_28_S17 2 Vehicle 3h 9.8 6 -56.481720
Da.2.24h MCW_RM_R_29_S18 2 Daunorubicin 24h 9.5 7 116.277807
Do.2.24h MCW_RM_R_30_S19 2 Doxorubicin 24h 9.9 8 132.058008
Ep.2.24h MCW_RM_R_31_S20 2 Epirubicin 24h 9.6 9 38.091266
Mi.2.24h MCW_RM_R_32_S21 2 Mitoxantrone 24h 9.9 10 -24.495348
Tr.2.24h MCW_RM_R_33_S22 2 Trastuzumab 24h 8.8 11 -57.574004
Ve.2.24h MCW_RM_R_34_S23 2 Vehicle 24h 9.5 12 -62.681169
Da.3.3h MCW_RM_R_35_S60 3 Daunorubicin 3h 9.3 1 -39.816800
Do.3.3h MCW_RM_R_36_S61 3 Doxorubicin 3h 10 2 -37.633581
Ep.3.3h MCW_RM_R_37_S62 3 Epirubicin 3h 9.3 3 -45.111289
Mi.3.3h MCW_RM_R_38_S63 3 Mitoxantrone 3h 9.6 4 -48.565611
Tr.3.3h MCW_RM_R_39_S64 3 Trastuzumab 3h 9.7 5 -45.188098
Ve.3.3h MCW_RM_R_40_S65 3 Vehicle 3h 9.4 6 -51.171067
Da.3.24h MCW_RM_R_41_S66 3 Daunorubicin 24h 8.9 7 106.948600
Do.3.24h MCW_RM_R_42_S67 3 Doxorubicin 24h 7.5 8 108.983709
Ep.3.24h MCW_RM_R_43_S68 3 Epirubicin 24h 8.6 9 130.765696
Mi.3.24h MCW_RM_R_44_S69 3 Mitoxantrone 24h 8.5 10 -6.504792
Tr.3.24h MCW_RM_R_45_S70 3 Trastuzumab 24h 8.6 11 -52.538480
Ve.3.24h MCW_RM_R_46_S71 3 Vehicle 24h 9.3 12 -60.196789
Da.4.3h MCW_RM_R_47_S24 4 Daunorubicin 3h 9.6 1 -25.797717
Do.4.3h MCW_RM_R_48_S25 4 Doxorubicin 3h 9.6 2 -31.029147
Ep.4.3h MCW_RM_R_49_S26 4 Epirubicin 3h 9.4 3 -27.951634
Mi.4.3h MCW_RM_R_50_S27 4 Mitoxantrone 3h 9.7 4 -27.542076
Tr.4.3h MCW_RM_R_51_S28 4 Trastuzumab 3h 9.9 5 -33.226852
Ve.4.3h MCW_RM_R_52_S29 4 Vehicle 3h 10 6 -28.909159
Da.4.24h MCW_RM_R_53_S30 4 Daunorubicin 24h 9.4 7 116.151811
Do.4.24h MCW_RM_R_54_S31 4 Doxorubicin 24h 9.6 8 119.226876
Ep.4.24h MCW_RM_R_55_S32 4 Epirubicin 24h 9.4 9 111.579718
Mi.4.24h MCW_RM_R_56_S33 4 Mitoxantrone 24h 9.5 10 7.516338
Tr.4.24h MCW_RM_R_57_S34 4 Trastuzumab 24h 9.8 11 -27.393690
Ve.4.24h MCW_RM_R_58_S35 4 Vehicle 24h 9.5 12 -26.107083
Da.5.3h MCW_RM_R_59_S36 5 Daunorubicin 3h 9.6 1 -24.048107
Do.5.3h MCW_RM_R_60_S37 5 Doxorubicin 3h 9.7 2 -24.634225
Ep.5.3h MCW_RM_R_61_S38 5 Epirubicin 3h 9.6 3 -29.927845
Mi.5.3h MCW_RM_R_62_S39 5 Mitoxantrone 3h 9.9 4 -33.906761
Tr.5.3h MCW_RM_R_63_S40 5 Trastuzumab 3h 9.6 5 -39.325444
Ve.5.3h MCW_RM_R_64_S41 5 Vehicle 3h 10 6 -36.648464
Da.5.24h MCW_RM_R_65_S42 5 Daunorubicin 24h 8.3 7 91.009431
Do.5.24h MCW_RM_R_66_S43 5 Doxorubicin 24h 8.4 8 88.675805
Ep.5.24h MCW_RM_R_67_S44 5 Epirubicin 24h 9.4 9 70.928861
Mi.5.24h MCW_RM_R_68_S45 5 Mitoxantrone 24h 9.7 10 10.795178
Tr.5.24h MCW_RM_R_69_S46 5 Trastuzumab 24h 10 11 -39.481396
Ve.5.24h MCW_RM_R_70_S47 5 Vehicle 24h 10 12 -37.407749
Da.6.3h MCW_RM_R_71_S48 6 Daunorubicin 3h 9.6 1 -38.123104
Do.6.3h MCW_RM_R_72_S49 6 Doxorubicin 3h 9.6 2 -43.857325
Ep.6.3h MCW_RM_R_73_S50 6 Epirubicin 3h 9.7 3 -42.874754
Mi.6.3h MCW_RM_R_74_S51 6 Mitoxantrone 3h 9.5 4 -43.386618
Tr.6.3h MCW_RM_R_75_S52 6 Trastuzumab 3h 9.8 5 -52.613108
Ve.6.3h MCW_RM_R_76_S53 6 Vehicle 3h 9.5 6 -49.957975
Da.6.24h MCW_RM_R_77_S54 6 Daunorubicin 24h 9.8 7 88.506102
Do.6.24h MCW_RM_R_78_S55 6 Doxorubicin 24h 8.6 8 32.474305
Ep.6.24h MCW_RM_R_79_S56 6 Epirubicin 24h 8.9 9 28.195264
Mi.6.24h MCW_RM_R_80_S57 6 Mitoxantrone 24h 9.1 10 -16.793355
Tr.6.24h MCW_RM_R_81_S58 6 Trastuzumab 24h 9.3 11 -48.426347
Ve.6.24h MCW_RM_R_82_S59 6 Vehicle 24h 9.6 12 -48.471055
PC2 PC3 PC4 PC5 PC6
Da.1.3h -61.6492431 40.7087307 -5.3120903 24.4018905 -35.4444449
Do.1.3h -73.1898070 27.3505327 3.8688884 -18.1052473 -19.4252416
Ep.1.3h -66.3749523 32.9124408 1.2376582 18.0762710 -42.4344457
Mi.1.3h -72.8150505 23.0530849 10.2568266 -7.4645061 -24.6681542
Tr.1.3h -79.0376832 10.2595124 17.2423744 -31.9316183 -11.3241836
Ve.1.3h -75.2963086 17.7279049 2.3341441 -37.4209985 -16.5916909
Da.1.24h -41.0164141 20.2282172 23.5191002 -23.7072969 9.6461308
Do.1.24h -45.1152922 10.9557441 9.0092013 -36.6981861 3.6743944
Ep.1.24h -34.9090068 0.9833687 32.7871174 -18.3866562 6.3054880
Mi.1.24h -82.2447484 -12.9914585 19.1613846 -42.6209357 -0.5124787
Tr.1.24h -82.6021742 -10.6353249 39.5323823 -40.0857874 12.0923404
Ve.1.24h -91.3265517 1.2672540 26.2234796 -43.8615491 18.6989015
Da.2.3h 63.1090955 28.9080209 3.5356043 -13.9094355 -37.6027975
Do.2.3h 67.9737849 17.2141258 -2.6490686 -47.7487786 -32.9519498
Ep.2.3h 59.3094530 21.1733532 11.0106949 -7.3427097 -50.1148519
Mi.2.3h 58.4795045 12.2405645 26.9640588 -21.4948193 -38.7602209
Tr.2.3h 77.4375391 8.0171252 -5.8523566 -44.2040959 -52.5268371
Ve.2.3h 61.3972180 -1.6863081 -4.8373428 -59.2576074 -13.2879881
Da.2.24h 65.8074456 17.9008114 12.0888708 -18.9646667 2.2138918
Do.2.24h 72.0883536 50.9110380 45.1772733 -37.0334774 36.5553703
Ep.2.24h 106.5998472 193.0345778 56.4013289 9.7790075 50.7488558
Mi.2.24h 52.7566106 -31.5414202 -12.7817910 -35.7989480 -29.3531796
Tr.2.24h 64.0812894 -15.2488653 2.3747760 -32.7440413 -23.4879717
Ve.2.24h 78.5170669 -1.3572652 -24.6341113 -37.7581165 -28.0481219
Da.3.3h 19.9614084 5.9239374 14.7281591 47.6112169 28.9324932
Do.3.3h 7.8253191 -9.6686889 6.4248512 -2.7634404 33.5284259
Ep.3.3h 20.3229898 2.9691142 -0.2989686 59.6256134 6.2421183
Mi.3.3h 30.5500277 3.7254904 -16.1973158 50.0678336 12.9540941
Tr.3.3h 13.7059119 -22.5964128 -6.9278698 0.9766313 25.8637186
Ve.3.3h 25.4232524 -24.6889608 -8.3115384 31.5316688 27.6523982
Da.3.24h 28.7329100 -32.9778627 -20.1118961 21.2387101 -0.6978308
Do.3.24h 51.0044839 -18.4055828 -60.2700910 -5.8025793 29.1942407
Ep.3.24h 43.1433685 -27.5808293 -7.4292516 17.9027540 15.1888979
Mi.3.24h 15.2518542 -42.0134510 -29.6856072 -4.1874824 19.1703708
Tr.3.24h 22.9564059 -23.9195218 -27.9962855 -22.7737881 41.6145547
Ve.3.24h 31.6224811 -17.7337474 -17.5317764 -14.3245894 40.2255084
Da.4.3h -53.1831700 45.7406998 -14.2156228 25.0384043 -7.0049852
Do.4.3h -43.0362921 30.8573073 -30.8666478 17.6141940 -4.3506028
Ep.4.3h -47.4041166 37.4960667 -20.6051516 21.4717734 -12.4520530
Mi.4.3h -41.3609174 22.1618279 -17.6614901 16.7612270 -6.2533150
Tr.4.3h -46.1382580 11.3959103 -17.5965024 6.1668565 0.1074265
Ve.4.3h -54.6024392 9.0981483 -1.8320771 0.5903865 -0.8654210
Da.4.24h -6.5592155 11.9169585 -25.0294562 20.9353047 -22.1662891
Do.4.24h -17.4354106 1.0574558 -17.2682872 12.7199549 -17.3123361
Ep.4.24h -5.5299043 19.1272634 -44.6945761 28.9163739 -28.6026630
Mi.4.24h -50.4387048 -10.7922412 -26.5694163 -7.6309107 -5.4701739
Tr.4.24h -50.2752526 -8.5039610 13.3415638 1.3534998 9.9142568
Ve.4.24h -60.8006128 -1.8945272 -1.5736303 -12.8309227 29.0580385
Da.5.3h 6.7933390 0.3645790 59.8524822 60.1356890 4.0877223
Do.5.3h -2.7541279 -20.3012559 47.0771995 24.9288013 2.8323205
Ep.5.3h 9.9981745 -17.4706010 52.8916850 68.3392347 -22.9182749
Mi.5.3h 11.1139154 -6.3407268 39.3129692 49.1209884 -16.2227417
Tr.5.3h 13.8155816 -38.8645667 45.6772161 23.2817072 0.3146050
Ve.5.3h 6.8356950 -42.9513097 77.7804805 6.9769513 -12.7166830
Da.5.24h 29.0409819 -43.2641481 51.8032440 9.9729007 -13.9267843
Do.5.24h 33.2312625 -44.8981540 -6.0575706 23.5915280 -15.6351533
Ep.5.24h 9.0876488 -64.3124744 23.9367591 14.6739001 -7.8888171
Mi.5.24h -0.4314044 -55.0248994 29.8297633 0.7353230 -15.3129313
Tr.5.24h 9.9668118 -45.1903867 58.1663438 -3.0260323 20.4266376
Ve.5.24h 3.8399573 -40.2520754 58.0660245 -27.7372162 28.3329415
Da.6.3h 2.6713745 31.0169972 -23.2336363 26.7462346 -5.4957742
Do.6.3h -6.5062072 6.7747938 -21.7962449 5.1281970 18.5941625
Ep.6.3h -9.1255573 18.6282730 -33.2849032 3.4916878 15.2108681
Mi.6.3h -5.7918813 18.9820913 -28.7073388 16.2047006 8.0850111
Tr.6.3h -3.3827229 -2.0195844 -31.6912000 10.3689165 27.8768091
Ve.6.3h -13.1731992 0.9808383 -25.0286675 5.7323649 24.0399987
Da.6.24h 15.5774947 -17.6292725 -30.3731789 11.1195258 -7.4914720
Do.6.24h 18.1399729 -19.0900355 -77.7657390 7.4723735 -17.0806294
Ep.6.24h 11.5482092 -8.6985621 -69.5770292 9.8454710 -9.1505919
Mi.6.24h 2.5146436 -20.0503952 -55.3810406 -12.3708239 13.3173502
Tr.6.24h 2.7562782 -9.8261236 -24.0267721 -34.9929863 59.9114486
Ve.6.24h -1.4823356 -2.6431594 -25.9503651 -5.6658178 22.9382905
PC7 PC8 PC9 PC10 PC11
Da.1.3h 0.1170394 -21.5353752 21.6919896 -9.6709753 21.5344659
Do.1.3h -3.5441132 -11.3852137 8.2628842 -12.0376119 3.3545955
Ep.1.3h 5.6388639 -31.8311101 4.8278739 7.0515874 28.0686564
Mi.1.3h 2.8080430 -12.7515596 5.2245798 -9.8263165 13.5584165
Tr.1.3h 6.8138544 -7.2326192 4.1070361 -9.0248653 11.4270568
Ve.1.3h 3.7807028 1.3987773 -1.4189018 -14.2131906 -5.1999564
Da.1.24h -20.8369171 6.3162442 51.5703829 4.5982064 -20.7987596
Do.1.24h -15.3444622 0.4502778 45.6241207 2.6079680 -33.9218741
Ep.1.24h -13.6013881 -17.5661872 42.4626064 16.5832746 -6.3210058
Mi.1.24h 30.7767426 -9.0164273 10.1886232 -37.4956946 0.9747284
Tr.1.24h 5.5518555 -13.4696666 7.0983699 -9.7840799 14.0424422
Ve.1.24h -4.7165160 -7.0015962 6.7896916 -19.0941142 0.5784218
Da.2.3h -25.8830442 -22.1882433 17.4084838 -0.1517254 1.1027410
Do.2.3h -24.8615080 11.3844625 1.3878642 -9.8452520 -24.6140049
Ep.2.3h -30.3761213 -16.8647153 -5.0176761 0.4567520 -5.6018652
Mi.2.3h -20.6491889 0.3014943 3.1060737 -10.5876876 -6.6374538
Tr.2.3h -14.0864183 2.7833936 -9.6222374 6.0124637 -10.7044041
Ve.2.3h -11.9817739 6.4377882 -5.4049382 5.6331056 -13.7885213
Da.2.24h -17.6575868 28.1543116 -10.6453726 -10.2114160 55.5842987
Do.2.24h -45.5341892 40.0335778 -43.9678262 -23.0148194 50.6970956
Ep.2.24h 94.2114564 -26.6242234 -12.4261175 2.2905854 -24.1070264
Mi.2.24h 35.2521902 -12.6861693 -4.4350681 -21.5712309 19.0941449
Tr.2.24h 8.1979259 -16.0503145 13.5261003 20.9710354 15.1029169
Ve.2.24h 12.6381003 2.5000711 20.6270428 14.1573377 4.3161170
Da.3.3h -34.5444999 -16.5384215 20.5687021 -36.8546299 -17.3299702
Do.3.3h -36.1029916 -20.6615819 -19.4210472 -26.9165025 -22.9828679
Ep.3.3h -19.5832512 -36.4882195 19.0694744 -9.0744564 0.3048177
Mi.3.3h -18.6350463 -24.7268373 21.2960403 -24.1298302 -7.9236249
Tr.3.3h -19.7571697 -29.0918214 -36.7311933 -7.8835722 -17.0091409
Ve.3.3h -7.9313613 -18.8120108 6.3646311 -10.5201155 -9.1086368
Da.3.24h -4.8288374 -26.9041123 2.2983270 -9.9658512 16.0796859
Do.3.24h -19.1328884 -10.3983894 2.3236123 -17.6351489 -3.2058427
Ep.3.24h -29.9269122 -28.6405930 -16.1878829 5.3571665 22.6782995
Mi.3.24h 31.6402572 -29.7957202 -17.1969316 -34.8710162 11.9380476
Tr.3.24h -6.8540337 -15.0597484 -8.5861332 -7.2545019 -10.6498157
Ve.3.24h -14.2977985 -35.5353222 0.7258584 29.8598768 -2.2384838
Da.4.3h -17.4585740 1.0090664 -19.3200580 3.2162208 -1.5784595
Do.4.3h -11.4699855 11.2621027 -21.8766782 5.6247673 -8.3618864
Ep.4.3h -11.1103534 7.0910910 -16.5360500 6.8284173 0.8305291
Mi.4.3h -6.5541138 13.1326026 -25.4240012 2.5039160 -2.5463646
Tr.4.3h -5.7669176 9.8742145 -36.7045010 14.1635724 -6.5136477
Ve.4.3h -8.6334875 13.5484680 -41.4887827 9.3516750 -6.5958534
Da.4.24h -8.1497598 3.0134625 -13.0059721 31.5624015 -14.0055485
Do.4.24h -14.3530122 -4.8270299 -24.4225919 27.4747007 -27.1507484
Ep.4.24h 1.8200936 -9.9303025 -8.2339292 43.7066532 -4.6335427
Mi.4.24h 28.7710774 -11.3599319 -34.8719823 -7.7745476 -7.9013568
Tr.4.24h -3.5938779 -7.5125099 -28.9998165 19.1488547 2.6672936
Ve.4.24h -8.4208960 5.8121401 -28.5529042 6.8133957 -6.5770969
Da.5.3h -3.4683796 16.2131144 21.8436721 -10.7794698 8.0513781
Do.5.3h -2.9814041 -5.4014449 -11.7097658 8.8971159 2.8975872
Ep.5.3h 1.9905498 3.6882549 3.5885525 5.7382159 16.1967051
Mi.5.3h 3.4627076 16.6716270 12.4149943 -8.8799241 1.4665003
Tr.5.3h 20.7521502 24.0736453 10.3831163 9.0115592 -2.4700071
Ve.5.3h 12.9816464 41.3090701 -15.9096519 -0.5923424 -35.4268136
Da.5.24h 8.3252350 44.3907541 -12.2936837 -22.8940789 -46.8637043
Do.5.24h 23.1917830 5.8402807 10.9827866 5.3150865 2.8716810
Ep.5.24h 24.6753959 -11.3799922 -11.9321605 -3.3768807 -11.0662669
Mi.5.24h 50.0744730 -10.5682712 -23.7317959 -3.9869769 25.3598379
Tr.5.24h 13.0080654 -17.5042752 8.2197640 46.6782600 19.6567640
Ve.5.24h 8.0032150 0.9724445 1.4356235 44.5737085 3.7459216
Da.6.3h 1.2462335 29.8301651 17.5741271 0.5367939 16.7199084
Do.6.3h -0.1278696 32.8616213 22.3055098 8.2433217 14.1982251
Ep.6.3h -4.1460081 21.9357183 11.8860094 17.1803230 10.9100336
Mi.6.3h -1.6100333 43.3929000 17.4476559 -7.9590669 8.3105164
Tr.6.3h 3.8117053 36.1279841 13.8065453 9.6655799 9.3857878
Ve.6.3h -4.6767237 42.0799653 7.9790754 -1.1084916 5.0673132
Da.6.24h 11.2308478 16.5507088 5.9440387 -1.1385956 0.3164799
Do.6.24h 42.4976242 -2.0421154 -1.6736118 3.5038426 -9.0793912
Ep.6.24h 31.9741430 16.8216386 13.4058132 -13.1181855 -10.0317483
Mi.6.24h 39.5264403 21.8503525 11.4329537 -27.5917996 1.9391117
Tr.6.24h 6.1797058 -5.9645868 26.6703687 38.2863700 2.1295711
Ve.6.24h 2.2392897 26.2328680 13.8782873 7.2308531 -0.2124027
PC12 PC13 PC14 PC15 PC16
Da.1.3h -12.0359096 9.8876923 7.6518665 -13.2430614 6.69416396
Do.1.3h -23.8244799 3.7976315 -8.3851977 -12.0107715 11.61011482
Ep.1.3h -17.9188729 13.5336131 -5.7930514 -16.2614148 -2.21524566
Mi.1.3h -14.7765375 9.7795742 -11.0850106 -11.4175219 2.67310566
Tr.1.3h -15.1041879 22.2595172 -12.6465083 -2.1551794 -3.41212766
Ve.1.3h -18.7191239 16.5561711 -19.0046585 -9.7195961 10.71986577
Da.1.24h 27.0365686 -13.8731868 -5.3559718 3.9235917 -5.42531156
Do.1.24h 12.1139639 -18.9593531 -9.7292431 -0.5409027 11.64351058
Ep.1.24h 20.8705973 -1.9148919 -14.0050132 6.2201227 -17.53522801
Mi.1.24h 21.2620250 -18.4253759 7.4530965 -3.9987426 2.52430718
Tr.1.24h -2.0204443 17.5473999 4.9803293 10.2400566 -18.18965083
Ve.1.24h -6.3529153 13.1764879 10.1864384 15.5826527 -3.18587377
Da.2.3h -11.5334311 -14.9490861 26.4163395 10.0774146 1.86886405
Do.2.3h -4.4142625 -16.7809816 -6.7833796 3.7650910 6.11822380
Ep.2.3h -5.7557806 -17.8199562 11.0658545 -3.9780401 -17.24673830
Mi.2.3h 2.0672282 -5.0114372 6.2921514 2.8953213 -10.53277679
Tr.2.3h 2.6537151 7.4313103 -8.6849920 -0.3598908 -19.70020078
Ve.2.3h -5.9404973 -0.2007403 -18.8294766 10.1078816 7.30117862
Da.2.24h 11.5763943 12.9944225 2.5272159 8.6218795 4.63461401
Do.2.24h 7.0831385 -13.9420677 3.5539703 -31.7491703 9.53917177
Ep.2.24h -7.8377660 8.4834062 -5.1427754 8.3493295 -7.55558089
Mi.2.24h 24.2280437 -6.5996752 9.5726568 -0.6495081 7.49059548
Tr.2.24h 19.0162396 14.4118328 7.7061648 4.6038013 0.41185000
Ve.2.24h 23.7464711 28.0762103 3.3729797 15.0728663 9.72269708
Da.3.3h 13.4792520 -6.9541494 21.8203497 -7.3136791 -4.41973131
Do.3.3h -20.5453791 -24.6435358 -18.0295768 4.3336864 -5.76059312
Ep.3.3h 11.5243993 8.6738052 11.3631175 -18.6595222 1.76657047
Mi.3.3h 16.5972229 4.5371821 1.1662840 -12.3460391 7.59461054
Tr.3.3h -5.5242233 -1.5068247 -32.7610945 -4.0941517 -18.12158267
Ve.3.3h 25.2549640 26.6443050 -12.2961454 -12.4570493 -5.00812582
Da.3.24h -17.3889843 15.8287912 -0.1751952 17.2741185 -6.10777066
Do.3.24h -23.6311927 19.5336433 -6.0078243 16.3359054 38.13474982
Ep.3.24h -10.0208437 22.8994760 -6.6161994 -2.3306804 -15.24737680
Mi.3.24h 19.2518471 -10.2039597 -1.7846500 -1.9246445 0.59543325
Tr.3.24h 3.3687640 4.3051223 -15.2997183 13.8184503 10.45914512
Ve.3.24h -8.7715454 7.6754613 6.9368238 -17.2126152 8.07419972
Da.4.3h -5.5642281 -12.0660202 24.0918320 10.6425414 12.64094972
Do.4.3h 1.1680866 -4.2991392 6.2061231 5.7347161 19.33178677
Ep.4.3h -3.0971024 -4.0700775 14.3882614 10.1978359 14.13421384
Mi.4.3h 10.9343469 -0.5818526 -0.3010829 5.8936173 6.88861644
Tr.4.3h 11.0680515 7.4975186 -2.5603188 1.4826829 -0.61413260
Ve.4.3h 5.9590872 7.1887328 -0.7982364 4.6995249 -9.54864822
Da.4.24h 22.2035919 -9.0422486 -0.9342270 -9.0923250 -0.01243867
Do.4.24h 11.4159156 -10.2205713 0.3678659 -12.0402517 -2.88236535
Ep.4.24h 24.5675600 7.2390676 -11.3755643 -0.6181898 10.62605485
Mi.4.24h 29.0812413 -16.3812141 13.7143678 -0.6933072 10.53721899
Tr.4.24h 17.5147392 12.6845366 19.4708195 11.7261386 -16.59891087
Ve.4.24h 13.9660039 7.8367970 21.8995020 30.8811756 -8.98041683
Da.5.3h 3.2705198 -11.4830458 5.3339302 18.1264350 13.55908587
Do.5.3h -22.5064622 -24.8001101 -28.7435712 20.5730927 6.61907946
Ep.5.3h 7.2909099 -0.5980779 -11.6325159 6.8327993 -11.54747250
Mi.5.3h 9.4931677 -10.6066524 -8.2694244 6.9881321 12.91661768
Tr.5.3h 22.4202869 14.7560032 -21.0892939 1.4580018 12.40771001
Ve.5.3h 5.6133918 26.0586520 -12.1643908 -32.0491050 13.47949904
Da.5.24h -32.2825917 35.1508693 38.6280321 -11.7903099 -0.70911963
Do.5.24h -24.3587501 10.3250505 3.7183812 27.9732305 11.44571883
Ep.5.24h -32.9100844 -22.0340282 12.5472189 11.1401270 -10.85998538
Mi.5.24h 12.2013331 -33.8334419 -8.5314966 -11.4339849 0.31888986
Tr.5.24h -8.1049783 -8.3095460 9.1711008 -0.8553153 6.65532329
Ve.5.24h -18.7206319 -17.5379554 9.6627785 -8.1859156 12.29396319
Da.6.3h -13.3600057 -9.9936692 -2.7197693 -2.5586773 -8.25482760
Do.6.3h -13.2371245 -7.2519578 -8.2922512 2.0268822 -5.14942509
Ep.6.3h -25.6989257 -16.1733436 -8.2948595 -4.8753530 2.49393062
Mi.6.3h -0.5592047 -7.8992610 -10.3036038 4.3308712 -7.79165706
Tr.6.3h 7.4540628 7.3339233 -13.2499037 0.4894876 -11.12035507
Ve.6.3h -0.8159929 4.8550120 -7.7307718 6.4604407 -19.44605523
Da.6.24h -17.0696802 -10.0288153 9.5719509 -6.2154570 -32.33020453
Do.6.24h -24.3597428 -8.9069930 -8.9714085 -20.7606069 -5.09509712
Ep.6.24h -10.6522855 -2.0387434 4.0266899 0.2099668 -4.46701430
Mi.6.24h 16.6031419 -9.6342128 6.4707955 -3.1429867 -0.99763858
Tr.6.24h -14.5651930 -6.6378929 27.6911903 -23.8900812 5.66337923
Ve.6.24h 6.6230884 7.2548730 15.3518933 -8.4658208 -15.51933011
PC17 PC18 PC19 PC20 PC21
Da.1.3h -1.4457388 14.5274119 -8.30956126 2.1659929 -3.871476e+00
Do.1.3h 6.1630656 -0.9786024 2.72981288 -0.5396085 2.580660e+00
Ep.1.3h -1.4051470 9.7020848 0.13154728 7.9308190 -9.464397e-04
Mi.1.3h 1.4952968 -6.8300186 7.25335659 8.7924890 1.471791e+00
Tr.1.3h 3.2648828 -4.9970175 5.29576603 -7.3443284 1.842296e+00
Ve.1.3h 10.1362151 -6.7253423 6.07296588 -3.8899103 2.554046e+00
Da.1.24h -13.2303009 13.8433121 10.70284466 -8.5670488 9.041299e+00
Do.1.24h -0.4413679 -1.9238424 -8.79160784 -4.0117196 -1.650210e+01
Ep.1.24h -9.7073028 2.1828191 -13.13990199 1.2608495 -1.783118e+01
Mi.1.24h -7.1092736 -13.5359086 2.37341544 3.7962391 6.118096e+00
Tr.1.24h 9.0202412 3.3955355 -3.11841073 -2.3232014 5.304028e+00
Ve.1.24h 15.0956978 0.3074195 1.83560834 8.0471567 -1.798597e+00
Da.2.3h -4.3005109 13.4115862 -13.60780245 6.4942196 2.574837e+00
Do.2.3h 6.4452220 -15.8069778 -0.54348144 -8.6103096 7.413235e+00
Ep.2.3h 2.7635815 -3.0429670 -11.84211117 2.1768583 3.371037e-01
Mi.2.3h -8.4032584 -16.7624680 5.40720379 6.7492554 4.833274e+00
Tr.2.3h 7.7658334 -17.3986860 8.16963561 5.8683063 3.444400e+00
Ve.2.3h -1.8756817 -1.6364694 3.47758593 -10.5005444 3.940730e+00
Da.2.24h -5.9695671 8.5347893 21.94519319 -13.7137811 1.452502e+01
Do.2.24h 27.9900996 10.0421858 -4.37934103 2.0988741 -1.666742e+01
Ep.2.24h -3.4789811 -5.2161336 -1.69340271 -1.2648911 6.921258e-01
Mi.2.24h -15.4848610 16.0306613 -6.31239455 -5.8668761 -9.529556e+00
Tr.2.24h -1.3445665 14.3966737 -2.72154868 -1.4267506 -1.083445e+01
Ve.2.24h 6.2087597 7.4697409 2.10357392 3.8300415 -9.209219e+00
Da.3.3h 11.5015533 -6.9942740 4.33735348 -12.4960362 2.091796e+00
Do.3.3h -3.0239513 19.5024338 5.22778161 -1.5263586 6.099803e+00
Ep.3.3h 1.8975342 3.8324601 4.94204438 -13.0057393 -4.880663e+00
Mi.3.3h 7.9458440 -16.6776501 18.99805077 1.6303162 -4.418965e+00
Tr.3.3h -1.7463724 19.0117446 6.03295862 9.1207056 -3.606434e+00
Ve.3.3h 3.8629712 -2.4453184 7.67857209 -15.6381686 -5.132658e+00
Da.3.24h -21.2065654 -6.4605282 -1.10567086 -11.9263902 1.687899e+01
Do.3.24h -0.7191666 -20.7583197 -17.83025180 6.6818684 8.677014e+00
Ep.3.24h -13.1049378 -24.7547052 -29.96437369 10.5764917 -1.280137e+00
Mi.3.24h -17.6953008 2.6493251 1.25618797 9.1399515 5.893184e+00
Tr.3.24h -0.9308667 25.9970216 -3.42189909 14.7458669 -5.499005e+00
Ve.3.24h -11.8333670 0.9190118 14.41476335 -0.7675895 -5.557428e+00
Da.4.3h -13.8605417 6.9180531 -8.62429195 -5.3272467 -3.735885e+00
Do.4.3h -5.2574647 -0.1438763 -3.29022825 -10.9209860 -3.492784e+00
Ep.4.3h -12.4920384 4.3430703 -5.32614004 -10.5456270 -2.710507e+00
Mi.4.3h -6.3802889 -12.0143938 3.93947423 -7.8076542 -4.832566e+00
Tr.4.3h -2.4165804 -7.0716998 -0.39511606 -12.7632984 -4.957258e+00
Ve.4.3h -5.2778470 -8.6996586 -1.67526788 -16.0540249 -4.529476e+00
Da.4.24h -0.1915080 7.3932311 12.08105677 2.4944000 1.737008e+01
Do.4.24h 6.1401274 -1.7289484 -4.32384592 11.1251173 -3.676729e-01
Ep.4.24h 8.5530278 3.3043264 15.05538130 16.0189546 1.036654e+00
Mi.4.24h 4.5124224 -5.6960840 -0.12092046 10.7617021 5.921398e+00
Tr.4.24h 7.6376578 3.8855468 -3.49392667 1.4306458 2.360297e+00
Ve.4.24h 12.5500494 1.2265171 -1.66166047 5.6915294 3.583318e+00
Da.5.3h 3.7570661 7.6277870 -8.99638747 3.3763405 7.551910e+00
Do.5.3h 9.5456587 12.6204773 4.56162699 9.2795926 9.369056e+00
Ep.5.3h 12.2313284 0.5521917 -5.83429995 6.0452030 3.801795e+00
Mi.5.3h 13.5060320 -16.8037473 0.33346878 18.1283101 2.611704e+00
Tr.5.3h 13.2924163 2.4556119 -13.51678970 -10.3699082 8.453857e+00
Ve.5.3h -17.9155783 8.6225759 -23.41928153 -5.5044288 8.274227e+00
Da.5.24h -17.9708498 12.8795781 20.34668298 21.0778564 -6.100288e+00
Do.5.24h 12.5932479 0.4489559 17.23649913 -9.3633576 -1.468552e+01
Ep.5.24h 11.0626435 -9.4566184 1.01802944 -11.9517075 -3.003258e+01
Mi.5.24h -18.9807500 -15.7445409 9.84645113 -1.2922661 -8.707177e+00
Tr.5.24h 5.7799287 -3.0989749 5.43265364 3.2704281 5.132900e+00
Ve.5.24h -2.7821055 -8.0206777 -0.87822475 -11.6857399 5.713533e+00
Da.6.3h -17.0705647 6.7723779 -4.30119827 5.3749129 -1.546160e+00
Do.6.3h -11.8720163 1.4090294 4.21560285 -3.9377319 1.767073e-01
Ep.6.3h -15.5602011 1.7212873 6.41994849 5.0010429 -5.334953e+00
Mi.6.3h -11.3392134 -15.8264275 8.92650828 13.7909869 -1.050280e+01
Tr.6.3h -4.8091088 -1.6408851 -2.22431542 0.8276443 -7.482424e+00
Ve.6.3h -6.1307303 -4.2099554 -2.62364579 6.2171292 -7.610385e+00
Da.6.24h 5.5052345 7.2968405 -0.05636913 -14.7615192 2.397664e+01
Do.6.24h 21.3436294 10.6042632 -12.81416413 -11.1836935 -2.395516e+00
Ep.6.24h 24.2153271 9.4023564 -1.32821681 -4.4782772 1.667448e+00
Mi.6.24h 5.5233706 4.0559644 -10.32524367 6.9538701 1.070625e+01
Tr.6.24h 7.4397296 -10.0251528 0.27414247 9.1686679 1.331712e+01
Ve.6.24h 8.0187772 -6.1693885 -8.06245469 4.2260837 -1.694446e+00
PC22 PC23 PC24 PC25 PC26
Da.1.3h 0.83844774 -9.71962739 14.33418601 -1.0406108 9.2574629
Do.1.3h -2.04551898 0.77991399 5.12919558 -2.1946085 -1.6526893
Ep.1.3h 6.38516471 0.93659877 1.50802179 -0.3205125 -3.1942256
Mi.1.3h -5.28265914 -5.88996623 -8.31051017 -10.2748142 0.7342194
Tr.1.3h 0.85823138 1.80524818 -0.03870608 -1.3618708 -4.1318739
Ve.1.3h -7.29061870 -3.53579185 7.25601190 -3.0655909 -2.0452662
Da.1.24h 13.78606683 -18.40215240 6.60497063 6.9827022 -3.3200186
Do.1.24h -0.91436016 -3.17539349 -4.01736353 1.0525898 -7.5326951
Ep.1.24h 16.44640381 8.32364323 -8.92134784 -15.8349740 2.8635797
Mi.1.24h -1.45681885 12.12331550 -5.57858941 16.3782581 -0.7981441
Tr.1.24h -1.69023803 2.32023552 -4.68892399 -0.6065746 7.3265560
Ve.1.24h -10.79282692 5.47202913 0.67211146 14.9278922 5.3081538
Da.2.3h -1.91005140 7.71835432 5.99786233 0.4737518 15.0960743
Do.2.3h 4.96201006 8.09431107 3.87179158 0.9603996 4.0507437
Ep.2.3h 6.21814904 6.27757287 0.95842807 9.3494837 7.8643178
Mi.2.3h -3.54034101 5.40153886 -20.09906718 -4.5593179 3.4521282
Tr.2.3h 15.01999636 -15.46336846 15.25022222 4.1638621 -8.7353334
Ve.2.3h -2.65549417 6.13822990 2.85795777 -9.3132972 -6.5911907
Da.2.24h 11.32124512 9.91136366 -11.67499387 4.1363885 15.7547545
Do.2.24h -2.47817364 -5.30552092 1.98407288 -0.5228760 -7.4662896
Ep.2.24h -2.85410532 -0.38717032 2.34433748 0.6961883 0.5784496
Mi.2.24h -16.63925409 -1.24223415 4.05197392 -14.1265631 -9.7283645
Tr.2.24h -16.24544238 -0.22728360 -4.03336223 0.4888865 -10.8218935
Ve.2.24h -0.16409120 -3.63248611 -8.93310319 6.0981233 -8.2253023
Da.3.3h -8.26789568 5.08681164 3.29192204 2.2830477 -1.5613907
Do.3.3h -9.11606652 6.32992727 3.81519442 -10.6191407 2.7229129
Ep.3.3h -0.04361201 7.73429217 5.05020325 5.8327494 -7.1815933
Mi.3.3h -4.13480031 -5.36598863 -8.98318427 -12.1418080 6.2099409
Tr.3.3h 5.06019751 -1.17004831 -2.52839193 0.5187929 3.8005108
Ve.3.3h 3.58676861 6.60162600 4.97661114 1.6629718 -1.5979081
Da.3.24h -14.64872344 -3.62865764 -4.34401466 5.7187557 -7.9362681
Do.3.24h 0.39438014 -4.93121619 6.67749017 8.9445941 -4.6016500
Ep.3.24h 3.68497326 3.81566091 1.83472811 -6.5627476 2.2829711
Mi.3.24h 9.06402224 -6.06188919 2.41187209 -4.6392254 -2.3740659
Tr.3.24h 2.09705908 -14.43947560 -5.41382058 6.0392405 10.4315736
Ve.3.24h 5.43568687 -12.80333188 -4.67890920 11.9986345 3.3023506
Da.4.3h 8.30469824 -6.30536048 -2.80653295 -0.3539695 3.7810573
Do.4.3h 10.80605449 0.05747227 -0.11839623 1.0260600 -2.6996732
Ep.4.3h 8.41486104 -1.76991337 -0.13873691 -3.3751075 -0.2199279
Mi.4.3h 4.46983721 -5.43977300 -12.41698889 -9.0080583 0.3874756
Tr.4.3h 7.32962483 0.47668734 -0.78669163 -0.3384197 -2.0229639
Ve.4.3h 1.95099080 -2.58829015 -1.88726819 -1.1294451 -4.3703533
Da.4.24h -15.23873771 -4.90959903 9.73936726 3.2448614 3.3723281
Do.4.24h -19.59309812 2.29708051 3.10827679 -0.3294521 -3.8654567
Ep.4.24h -6.47510700 17.61719158 2.40867532 1.5181606 10.6130981
Mi.4.24h 0.45680913 9.90382700 -0.92057296 1.0114440 -5.6222415
Tr.4.24h -4.51492966 -3.24626627 -1.37587562 -4.0003949 -3.8394723
Ve.4.24h -2.64320429 -0.83084263 0.24589996 -3.5688127 -0.6695244
Da.5.3h -3.01066882 1.89774697 -7.35390137 4.7184042 -12.2354758
Do.5.3h 9.84473706 9.47189679 -1.28516969 1.6926590 -11.8198304
Ep.5.3h 14.26029866 0.48979226 1.56316855 9.8726337 -14.5298436
Mi.5.3h -1.96747237 -20.47747978 -8.46353713 -8.6975440 3.7494300
Tr.5.3h 1.46583556 6.81475135 10.25297695 -12.5189189 13.1866762
Ve.5.3h -8.46083236 3.63941347 -8.08433206 11.6442545 8.7555749
Da.5.24h 12.25144472 3.64586842 1.72764737 -7.5187073 -7.2352899
Do.5.24h 3.70965855 4.74064147 10.99344897 -4.5166035 6.1469696
Ep.5.24h -7.63764312 0.20219332 3.32761195 2.9470588 7.1047779
Mi.5.24h 8.36553616 1.29595685 9.89203896 9.6652037 4.9870850
Tr.5.24h -3.00319106 -8.67762376 -1.23981290 -0.2884478 0.2152390
Ve.5.24h -4.81089665 -14.85928909 2.02973816 -3.3884677 7.9790585
Da.6.3h -4.13878012 -1.18598364 0.90802556 -0.9598823 0.8574955
Do.6.3h -10.08948762 11.44777369 7.56503648 -7.2352492 -7.9995315
Ep.6.3h -4.52807795 12.75794825 -1.13106712 5.6645804 -7.4280030
Mi.6.3h -13.50493225 -8.65674910 -8.14286416 1.8417479 7.0497932
Tr.6.3h -2.08914933 9.54811332 3.08152125 4.4513435 4.5822845
Ve.6.3h -5.57024672 -0.68815234 8.55199071 8.2663902 0.5999482
Da.6.24h -7.82452003 -14.22938387 -4.49903080 -5.7931538 -2.8169747
Do.6.24h 7.25252554 -1.87381356 -25.15933159 3.8336493 -2.5995267
Ep.6.24h 6.12019377 0.11407211 -7.68910644 7.5211865 5.6938413
Mi.6.24h 10.41084259 -2.38800274 12.74466664 -12.9682654 4.0459833
Tr.6.24h 12.84877558 17.84728096 -4.32846404 -10.1867181 -5.9221330
Ve.6.24h 3.85054048 -5.62825575 11.05271308 5.7331998 1.2475686
PC27 PC28 PC29 PC30 PC31
Da.1.3h -4.681671895 -5.282165835 0.4751454 0.6369371 2.3055324
Do.1.3h -3.636060820 4.747138238 -5.5988365 4.5600608 2.8057880
Ep.1.3h -5.807194359 2.398714135 0.5207237 1.6382293 3.5308816
Mi.1.3h -8.605955432 0.294584489 -0.4456016 3.0352939 1.3935090
Tr.1.3h 5.610482458 4.173156040 3.3879612 -4.4912450 -8.3307288
Ve.1.3h 1.153327515 0.627417724 -8.2994052 2.3173469 -3.5601678
Da.1.24h -14.630198462 -10.721305087 4.5852125 7.2278052 12.8855374
Do.1.24h 3.985143581 -0.002934811 -0.5409393 1.3653569 -9.7325225
Ep.1.24h 9.744082295 1.775564870 -4.7129836 -1.1751084 0.9733127
Mi.1.24h 8.189737394 -0.080733610 6.7099986 -9.1883044 -12.1723736
Tr.1.24h 4.995811815 7.109842933 6.0685750 -9.9776689 2.7576024
Ve.1.24h -2.648740559 -3.634344216 -5.1693951 -0.2195497 7.5506093
Da.2.3h -0.194410928 -11.036427381 7.0973780 -5.1656904 -10.1263645
Do.2.3h -3.075766876 7.452271671 -7.1308887 -6.2661419 12.3544659
Ep.2.3h -7.268023387 -1.294478804 1.1599269 -4.7074649 1.6677012
Mi.2.3h -3.753180977 -5.394931218 5.5452383 -2.4687623 3.7612470
Tr.2.3h 13.486031868 2.949600479 1.5501864 8.9028731 -6.3269973
Ve.2.3h -3.667309537 -11.335666273 -5.7057453 -10.1012804 -0.8079462
Da.2.24h -1.985351656 1.640094759 -15.2744586 13.2075916 -10.6407145
Do.2.24h 1.660921853 -3.633469034 10.2200175 -7.3807647 3.5458457
Ep.2.24h -0.856880131 -0.538882531 -0.5744913 0.6568753 -0.2894577
Mi.2.24h -3.472332061 -6.706007510 -14.1631650 4.5360885 -0.5462716
Tr.2.24h 0.068783898 -1.396795788 11.4627590 5.6314383 -3.1006024
Ve.2.24h -1.089577685 20.777769005 2.3018806 6.1042255 7.5554506
Da.3.3h 3.778386764 15.956077688 -3.3867822 5.6594654 6.9350786
Do.3.3h 7.057245430 5.273668463 -1.0735327 8.5343027 1.3912015
Ep.3.3h 6.821954766 -3.897012948 -0.7671128 1.4087992 2.0798803
Mi.3.3h 2.964339610 -8.693129470 5.7616911 2.1508677 3.0038210
Tr.3.3h -3.676717210 -0.491186723 3.9630882 4.5013741 -7.7971289
Ve.3.3h -1.956213708 -3.460261478 6.5716926 -2.8359399 -8.4442103
Da.3.24h -1.963807930 -4.076340076 9.9539220 -1.0071593 -2.7986896
Do.3.24h -0.193136363 -3.375965806 7.6775712 1.0539824 2.3268763
Ep.3.24h 1.933893322 3.351221882 -7.2404361 4.6334574 7.0992451
Mi.3.24h 0.585957484 -0.017490659 -9.3502024 -9.5138133 4.6024650
Tr.3.24h -3.448678481 13.148435503 4.4256423 -4.4558745 -4.6762025
Ve.3.24h 0.673628124 -5.058101847 -16.6304071 -15.4431433 -0.5329054
Da.4.3h 3.731682362 3.682067323 3.7632711 3.2993807 -4.9443540
Do.4.3h -2.634426297 1.769618424 -0.8252300 0.1755315 1.9465567
Ep.4.3h 6.835676467 2.311551165 3.2233531 -0.8705862 -1.4208476
Mi.4.3h -3.761989544 2.040537047 5.8727837 -0.8276540 -0.8542813
Tr.4.3h -3.423918432 -2.132157223 2.9948533 -1.9438679 -2.7442364
Ve.4.3h 2.294153087 -1.980692810 1.4123473 -2.2184597 -3.1613070
Da.4.24h -9.100871117 6.849766180 -0.1461614 -3.9608260 -0.5666347
Do.4.24h -3.014447707 7.258923683 -5.4040137 -4.6554132 -8.3625317
Ep.4.24h 15.082587453 -1.917832127 -1.9079119 -1.7680897 3.6327429
Mi.4.24h -1.306143577 -4.825908730 1.1249295 4.1459272 -0.1313090
Tr.4.24h 0.004282254 -4.109368602 -0.3639432 3.6004151 5.8790355
Ve.4.24h -1.322295907 -7.245164155 -5.9006782 3.9351748 11.1786451
Da.5.3h -3.484119911 8.788612255 -11.5120431 -8.1781001 -3.6230164
Do.5.3h 1.438204128 -4.221002321 6.8892011 8.9788787 1.5178217
Ep.5.3h -0.093266810 -2.458501613 -9.5559769 -5.6232532 -5.0999407
Mi.5.3h -3.722409711 -6.260947050 -5.3631200 0.5587999 -8.4822073
Tr.5.3h -8.162900489 2.770021318 8.0304412 -11.3633040 4.2846681
Ve.5.3h 3.057863521 -4.908983908 -1.2464356 15.9510049 0.8291806
Da.5.24h 1.630261395 0.518851669 2.7836058 -8.6371763 3.4155859
Do.5.24h -3.413999882 2.489448906 2.2898005 -2.2501678 -3.8612210
Ep.5.24h -12.024032760 0.198629743 -3.9603009 9.2752654 -5.2059307
Mi.5.24h -3.214110697 8.828095903 9.0282424 2.5414329 10.8035780
Tr.5.24h 9.921492189 -7.031409360 7.7188894 2.3222436 3.5965811
Ve.5.24h 15.036868996 3.264343419 -5.4710963 -2.8845927 1.2372235
Da.6.3h 10.040197830 10.338419235 2.8484835 -2.4940298 0.7260408
Do.6.3h 7.993195931 -1.845560492 0.2486814 -2.1833711 5.0919756
Ep.6.3h 0.421039681 -3.994345644 -2.0188270 1.4369426 4.5854799
Mi.6.3h -0.094735065 2.268344679 3.1448088 4.1163319 2.1757283
Tr.6.3h -11.031243272 -2.927802301 3.4038874 -6.8508191 1.1414144
Ve.6.3h -3.574154355 -8.604119146 -5.7560367 -1.6263509 -3.3892613
Da.6.24h -0.783984345 5.023340447 4.6395740 -5.2158376 -3.2747471
Do.6.24h -4.111744917 -1.426776737 -2.6366651 -5.0777105 8.0229519
Ep.6.24h 17.759668783 -11.373095726 -0.9520102 4.9678736 5.0209136
Mi.6.24h 6.045283246 -0.609919252 0.6519764 3.6796269 -4.4461187
Tr.6.24h -17.380405566 5.198871091 3.8699678 9.4071279 -9.1609968
Ve.6.24h -1.735776681 2.726217936 -4.2928744 6.8731922 -6.9999489
PC32 PC33 PC34 PC35 PC36
Da.1.3h 0.9306414 -5.56457451 -4.07438100 -14.251764831 5.21456704
Do.1.3h -0.8493857 3.78545061 0.88455564 0.866118782 2.99760042
Ep.1.3h -3.7224851 -2.14971993 5.78342112 -4.789687821 3.01321997
Mi.1.3h 0.9682018 -0.79309631 2.70351629 -1.152796487 4.01798204
Tr.1.3h 5.9019661 -6.27920624 1.09431977 9.959182559 -6.18478156
Ve.1.3h 6.2579064 0.75596686 5.08025163 11.434519743 0.70225567
Da.1.24h 1.9747416 2.24989207 -9.11937213 7.177500035 -0.54234938
Do.1.24h -0.9166763 6.19715120 13.88950354 -6.511680463 -3.30221459
Ep.1.24h -4.1565253 -8.07620884 4.73496803 0.765475648 1.93433062
Mi.1.24h 0.4856429 9.07926808 -8.16930584 -3.215739312 9.98447395
Tr.1.24h -3.1906994 -0.37109305 -7.92815566 -4.127060867 -12.35363812
Ve.1.24h -1.7025730 1.52549777 -5.65698112 0.082146861 -3.65673655
Da.2.3h 4.4858284 -2.08862366 10.70173583 10.019569868 -0.74336592
Do.2.3h -0.8104843 -0.49047990 -1.79998821 0.273851315 -1.42975928
Ep.2.3h 4.6953652 8.97260152 3.54663033 3.346628433 -5.32642308
Mi.2.3h -2.4449196 -7.19265247 -0.58344071 -1.950957494 -3.34546946
Tr.2.3h -17.2412438 -3.08218172 -1.76395067 -8.034478975 3.13860256
Ve.2.3h 3.2967363 -11.73726903 -8.37000659 -10.307008870 5.78442419
Da.2.24h 2.3082565 7.34334289 6.18648161 -10.998076957 -1.58825621
Do.2.24h -4.8857932 -5.40979486 0.19821409 6.669413234 2.81383886
Ep.2.24h 0.3538267 1.82137510 0.02071197 -0.604126563 -0.87928632
Mi.2.24h 2.0471484 4.30065095 -6.38473822 3.109999873 -8.52174902
Tr.2.24h 4.5071863 8.26843080 -10.78551911 -1.554700424 -0.99031576
Ve.2.24h 8.1814867 -0.17979578 8.50863210 6.063512883 10.68828838
Da.3.3h 5.8232327 -3.33485645 2.31420722 0.841217846 0.03035415
Do.3.3h -3.1539690 7.55819819 -2.51383985 0.583065994 1.55430265
Ep.3.3h -1.5696030 2.70807919 1.50523306 -2.878863142 -2.91203636
Mi.3.3h -1.3451468 0.56434610 1.49743078 -3.154830560 -3.49136829
Tr.3.3h 2.3540169 2.46006522 -0.78798340 -0.878535717 2.58208954
Ve.3.3h 4.9507254 -5.14145464 -0.94206180 -3.469390641 -0.08743440
Da.3.24h -11.1521719 -3.47644911 6.47912085 7.526126041 8.80453589
Do.3.24h 1.4032846 0.75955242 3.54010647 -8.065269492 -10.63175492
Ep.3.24h 9.2807485 7.51572091 -13.34437099 2.649866392 7.15203930
Mi.3.24h 0.2815304 -6.85656089 9.42679596 6.881637638 -1.88658114
Tr.3.24h -6.7632093 -0.71005268 -5.61677828 -3.349237923 -3.40452074
Ve.3.24h -6.2425964 1.78168498 1.26812157 7.834065452 6.12294057
Da.4.3h -0.4970756 -2.25794636 -5.22157014 1.004488932 2.51492804
Do.4.3h 0.9502061 2.40807734 -3.45472892 -0.641806878 0.97565448
Ep.4.3h -0.8338176 -0.01389859 -2.63123405 2.768312182 -1.01812361
Mi.4.3h 2.6687010 1.43149304 -5.40924837 0.862563395 -0.61088635
Tr.4.3h 3.4405922 1.66657066 -0.04219099 0.002193181 0.01620168
Ve.4.3h 4.9010808 -0.03328198 1.40667613 3.241606803 -3.12653993
Da.4.24h 0.6937997 -1.69468576 -3.05931052 -1.182139163 -2.04149852
Do.4.24h 4.1945231 2.24960289 4.21924398 -6.330105655 -4.28081446
Ep.4.24h 0.1179870 -9.28971769 -7.78180486 6.448011811 -1.58738651
Mi.4.24h -6.3095654 3.03951434 5.62372139 -1.121797672 10.16472926
Tr.4.24h -6.5321298 2.04165116 4.86796457 -2.044117746 -4.88937088
Ve.4.24h -6.0704929 -1.86028854 10.30206809 -2.950067242 1.43658774
Da.5.3h -0.5841446 -16.17776785 -6.27654779 -5.113374514 5.50933902
Do.5.3h 14.0527761 -3.38911243 3.30896085 2.496903073 0.48792090
Ep.5.3h -3.8593962 9.98025901 -2.80849435 4.655067090 -7.82216760
Mi.5.3h -2.8815205 6.28335135 -5.03378163 4.047670660 -2.25107916
Tr.5.3h -7.6182845 15.04452010 5.44066159 1.627604843 12.85645943
Ve.5.3h -9.0137166 -10.02515831 1.04481877 4.961721425 -5.04481873
Da.5.24h 7.0679902 6.37580029 0.20050013 -4.447709526 1.85630807
Do.5.24h -7.5874404 -0.68006026 -0.85330026 8.370861063 -9.67440651
Ep.5.24h -5.3321423 -6.23968276 -3.09201045 -1.920332477 9.52446351
Mi.5.24h 1.6105609 -4.83337758 1.56647970 -1.791168044 -7.22153957
Tr.5.24h 8.8276865 -0.92221050 6.16988532 -8.014820494 0.45245456
Ve.5.24h 7.5276438 3.11776445 -0.39259172 -2.939073018 1.39695906
Da.6.3h -7.5707837 0.16811186 2.00385478 -0.955037167 -1.65112627
Do.6.3h -10.8830156 6.56970106 -0.97936340 -1.978348110 -3.30771164
Ep.6.3h -4.5375145 7.16317679 0.82515951 -0.405808874 1.17637154
Mi.6.3h 2.9616300 1.61611755 0.82016840 4.724166839 0.51034681
Tr.6.3h 4.9313861 -2.57709185 2.71398140 -6.621501197 2.33127727
Ve.6.3h 7.9412356 -6.24227813 4.48381854 -0.790481950 0.42016380
Da.6.24h 3.5669271 -2.15280957 1.07197051 1.045991186 2.44167063
Do.6.24h -0.5960328 2.93669813 2.92418885 -6.286896651 -7.80510245
Ep.6.24h 2.8349318 0.43336992 -7.92405167 4.872986321 9.40714331
Mi.6.24h 5.3493929 -4.63320327 0.64214604 -1.689559227 -2.51694824
Tr.6.24h -7.3929889 -4.63114291 -6.82400828 6.360295823 -2.74178460
Ve.6.24h 4.1200200 0.41472964 0.62488459 2.944008920 -1.14547881
PC37 PC38 PC39 PC40 PC41
Da.1.3h 5.28105146 1.341398824 1.23513980 -9.35791896 -3.643339318
Do.1.3h 0.91086274 2.001903814 -2.67899704 1.01490401 2.364475203
Ep.1.3h 5.04731851 5.580897431 -0.04291028 4.44028786 -1.889790268
Mi.1.3h 1.55406483 1.789369875 0.72941746 1.99585440 -1.471918891
Tr.1.3h -9.25749611 -0.336624851 -3.29650310 2.30309044 -0.099324600
Ve.1.3h -7.64338594 -3.541585917 -5.83454050 1.36306396 5.887492415
Da.1.24h -5.12515369 -5.257196397 -2.26828290 8.63847969 -5.546881675
Do.1.24h 0.00648092 5.218779313 5.80790659 -7.08866027 2.673610274
Ep.1.24h 2.97872584 2.377144297 -3.05200820 -1.98881617 3.637048783
Mi.1.24h 6.68630059 -7.972227451 -1.31947232 -1.24985351 -4.251992062
Tr.1.24h 3.94203473 1.352071648 3.57209469 3.42163304 0.144362806
Ve.1.24h -1.90369651 -1.698481419 8.16040213 -2.80561801 0.761490131
Da.2.3h -7.37841741 -8.542645528 2.19014592 6.44120396 5.834617304
Do.2.3h 4.34396773 7.922756344 -11.48925468 -7.56266888 -4.060222432
Ep.2.3h 2.74291101 4.175212338 -1.52837589 0.67849294 -2.493721821
Mi.2.3h -0.84932829 6.002796843 -1.02202101 2.32983360 -3.462778067
Tr.2.3h -10.47292136 -4.896257477 7.74411428 -1.39953775 -3.172615254
Ve.2.3h 7.83630228 -6.053006320 1.32388893 -0.63352071 6.762236618
Da.2.24h -2.95017987 0.047340810 -0.99480331 0.80611939 1.627026882
Do.2.24h 2.70805751 -0.082551176 -0.62762454 -0.65054192 -1.847392842
Ep.2.24h 0.52921155 0.335364217 -0.55068671 -0.62122332 0.244348160
Mi.2.24h -5.17964553 4.778600422 6.54493423 -6.15563410 -1.944962000
Tr.2.24h -0.04419422 3.027069544 -1.58822435 1.31299777 2.638478484
Ve.2.24h 8.56165558 -5.318541976 1.23592522 5.90619847 -0.976228656
Da.3.3h -4.68389079 -0.729700365 3.84794146 -3.75230753 -0.102492843
Do.3.3h 3.00478294 -0.068775400 3.62300158 0.92677265 -5.020652419
Ep.3.3h -1.73264634 -6.197099512 -8.17577116 -4.15426503 -0.411697924
Mi.3.3h 2.57560566 -6.814019115 -2.73187173 2.07732416 7.614134775
Tr.3.3h -1.10217111 1.682461862 4.89868189 2.01208940 -5.326647311
Ve.3.3h 3.72729336 6.732607609 4.23657466 8.30814121 -2.860217729
Da.3.24h 0.40319247 3.073043184 -5.33334128 -12.98466511 -2.191647782
Do.3.24h -0.34873106 5.647890372 5.17308484 8.81158801 0.243244213
Ep.3.24h -1.68678739 -8.299197827 -0.96385356 0.86464842 2.110193012
Mi.3.24h -2.92475691 5.647368323 1.79459404 1.80096459 -10.022474429
Tr.3.24h -6.53267541 -0.142610876 -16.90661406 -6.84666529 7.392020147
Ve.3.24h 7.81540337 -0.410544981 7.35624919 1.68965765 7.183204970
Da.4.3h 0.70525663 0.675263909 7.88181420 -0.89206416 -2.059182352
Do.4.3h 1.23475088 0.831026440 -3.38953035 -3.57709430 1.496506310
Ep.4.3h 0.04168979 -1.348078469 -0.87650688 -1.87311789 0.005550194
Mi.4.3h 0.99051992 2.377153339 3.14596030 -0.75381822 -0.324736356
Tr.4.3h -2.85598752 1.127290809 -1.13252813 0.51536399 0.144753992
Ve.4.3h -4.34559378 -0.608725113 -3.05064531 1.36640467 -0.429612270
Da.4.24h 1.11586354 2.586506014 -1.37963099 3.52102046 2.904713058
Do.4.24h 1.32406768 3.411451512 0.04115751 3.91830581 0.508070569
Ep.4.24h -4.65177229 -3.246620434 2.15285393 -5.67914106 -4.668487304
Mi.4.24h 1.24847256 -3.538859966 -5.25290092 4.52515339 -3.670254509
Tr.4.24h 0.88271528 0.249431241 -2.59853067 -0.04518158 1.876061391
Ve.4.24h 2.69816104 -2.211211743 2.56413592 1.09113055 4.633608251
Da.5.3h -10.62450258 -1.374851502 2.88889854 5.05603588 -0.697705191
Do.5.3h 7.00511079 -3.367365737 5.45775405 -6.86086157 3.656426794
Ep.5.3h 6.02008904 6.455759401 -5.53001209 2.41195182 0.859952884
Mi.5.3h 1.50218291 -3.596265457 0.29969423 -2.19996929 3.136999339
Tr.5.3h -9.46650005 2.151900196 7.97846340 -2.99129694 0.468923567
Ve.5.3h 7.79095518 -2.447348833 -0.56442927 1.16580928 -0.065413110
Da.5.24h -3.96906670 0.677796447 -0.67458198 -2.81139923 1.502414252
Do.5.24h 11.47693332 -5.304672822 1.70029622 -1.79902072 -9.443769933
Ep.5.24h -2.81025350 1.157773933 -7.03396248 9.68542184 0.020829070
Mi.5.24h -2.67899091 -0.253049025 6.30136625 -3.24597613 16.798466295
Tr.5.24h -6.34580865 3.749438059 -9.08638854 -3.44796673 -6.120042908
Ve.5.24h 1.94087010 0.116044898 0.19445617 4.42186281 -9.318269074
Da.6.3h 0.57119220 -0.014666070 1.15504211 9.47992462 0.532660910
Do.6.3h -0.02539650 -3.122919235 -2.67376318 6.36128516 3.576048308
Ep.6.3h -2.08207952 -1.694574430 -2.47635101 1.98082184 2.152265726
Mi.6.3h 1.35507342 3.339893994 3.08763480 -3.20915695 -6.864415485
Tr.6.3h -2.50200323 -0.007009004 -0.34945838 -0.31929708 -3.203233441
Ve.6.3h -2.55193416 -0.833420787 -1.62479200 -5.65184531 -2.797548883
Da.6.24h 6.51816413 -2.236895905 3.43215567 -3.05759395 8.203321826
Do.6.24h -7.39122829 -15.663786986 3.36856796 -2.54247952 -6.883697428
Ep.6.24h -3.62198715 20.432539940 1.55977479 2.82934892 7.726686371
Mi.6.24h 8.02082847 -3.651836370 -9.33038582 5.84883020 0.088692026
Tr.6.24h -3.35604507 4.963552632 2.85028271 -3.61687678 -0.171906390
Ve.6.24h 5.99710791 -2.153675359 1.89514897 -9.49596291 0.104337648
PC42 PC43 PC44 PC45 PC46
Da.1.3h -0.10582757 -6.24562170 3.10624765 3.59539885 0.45886826
Do.1.3h -0.34912201 0.17100001 -0.59540194 -4.84457823 -4.80810669
Ep.1.3h -3.92723914 0.21062126 -0.04805682 2.10673156 -0.68572945
Mi.1.3h -5.89656198 2.06423461 2.94329931 1.81840647 -4.25040082
Tr.1.3h 1.77902451 3.32863061 -2.14064319 5.48750252 -0.10860546
Ve.1.3h -1.70256272 -2.37473599 -3.26625495 -6.81423232 8.27730103
Da.1.24h -0.29007073 -0.23622330 0.57162448 2.91261524 1.67432048
Do.1.24h -3.68405707 1.42881605 0.41456855 5.04385165 1.88154825
Ep.1.24h 1.39520522 -3.22558070 -3.14480232 -9.15175716 -3.03771805
Mi.1.24h -3.36329982 -1.54595764 5.79639054 -0.66266493 0.32995948
Tr.1.24h 7.12233752 2.60311970 -2.04631689 5.37444004 1.51265248
Ve.1.24h 7.19141250 3.10266758 -0.77080747 -6.32581071 -2.62214443
Da.2.3h -1.27457748 -4.94669242 6.79253568 5.14760215 -1.88602148
Do.2.3h 1.58565847 -0.97706458 -0.57737965 0.96042329 5.71558521
Ep.2.3h -1.69029898 3.22799354 -6.74663077 -10.74948804 -4.17336789
Mi.2.3h -4.44265068 5.56515758 -3.15270629 6.42006682 -3.24796588
Tr.2.3h -0.05135975 5.98732644 2.05044609 -0.95540639 -2.38988665
Ve.2.3h 2.20296355 -6.58102019 4.30222254 1.16848911 8.70419805
Da.2.24h 1.14414239 -0.03120077 -0.31685778 1.28835494 1.83751436
Do.2.24h 1.01521878 0.01637179 0.15151892 -0.05758551 -0.82038802
Ep.2.24h -0.32892265 0.45026138 0.13958830 0.04659657 -0.62387225
Mi.2.24h 2.62011291 4.54050070 0.69930223 -4.02890083 -2.16022002
Tr.2.24h -6.06815760 -1.39981031 -7.19202379 -1.35994827 3.74756932
Ve.2.24h 7.57045214 -4.80889692 4.86456257 0.92369602 -5.24999881
Da.3.3h -4.25479681 -2.47168569 3.53895408 -0.18003649 4.24058583
Do.3.3h -1.59302155 -8.95955787 -5.51622125 3.92191409 -7.97120985
Ep.3.3h -1.79092355 3.25122042 1.46051515 3.79897653 1.50562334
Mi.3.3h 7.82948698 3.68477721 0.22649823 -2.34220140 -0.72569589
Tr.3.3h -1.53254947 -7.41797295 -1.99931962 -4.72001762 4.71383424
Ve.3.3h 3.40852209 2.78950913 1.83462908 -5.49794586 -1.27709094
Da.3.24h 10.10907331 -5.19505459 -7.52101883 2.06216268 -1.79572388
Do.3.24h -1.49998188 -3.11235127 -1.80834757 -4.34624048 -2.01738277
Ep.3.24h -4.87754525 4.09275452 3.63249338 4.04363613 3.38214440
Mi.3.24h 2.00149181 3.52740913 10.20214186 2.19205151 0.59863877
Tr.3.24h -4.00973963 5.15880770 7.06932916 -0.24404444 -2.23657423
Ve.3.24h -4.15174949 4.81108649 -9.74468438 3.47625034 2.00958232
Da.4.3h 8.38043706 4.84425176 0.03085585 -6.90643457 8.96974935
Do.4.3h 0.79450461 2.50316535 0.39971153 -2.36615383 -5.10719861
Ep.4.3h 4.26522783 1.60315463 1.20137241 -0.22660319 -0.51420947
Mi.4.3h -4.01931435 2.51138387 1.69525978 4.95380467 -5.54935999
Tr.4.3h -3.00898929 -2.74028297 -1.37328991 -0.85159185 -3.15724584
Ve.4.3h -2.54516249 -7.25572212 -0.34231817 2.87531892 -1.56980426
Da.4.24h 4.20665236 0.69279743 -1.78476233 2.20626817 -0.60430501
Do.4.24h 4.11854417 3.84955865 4.12704087 6.82360902 2.52435396
Ep.4.24h 1.45321234 -1.95143050 -1.70491820 -4.03696303 -3.75826631
Mi.4.24h -4.85383401 -0.33466421 -4.05379820 -2.82476639 2.05871783
Tr.4.24h -5.07010629 -2.20358656 -0.30675081 4.44827240 6.11208702
Ve.4.24h -2.13650355 -1.46603512 2.65519137 -2.34625333 0.94212576
Da.5.3h -9.64878109 -0.57065438 -9.44771893 -0.65746840 -3.15203856
Do.5.3h 4.48173184 12.89263177 -0.22639316 5.69076903 1.52383485
Ep.5.3h 6.17895457 -6.41845982 6.10308364 -1.42610989 1.75735979
Mi.5.3h 3.98812153 -8.33104085 0.06774726 -1.28293643 -3.30257918
Tr.5.3h 1.72197601 5.85445694 -1.91576496 2.30597664 3.23106076
Ve.5.3h -2.41300218 2.23301857 3.90044654 -1.09677150 0.07292879
Da.5.24h 2.97778055 -2.53719978 -1.98603431 -0.64487540 -0.43710580
Do.5.24h -15.60160621 0.89754343 2.65117383 -0.01870588 2.97371723
Ep.5.24h 9.23212632 4.60894855 0.13889856 1.58118416 -0.26380899
Mi.5.24h -2.11963895 -8.51524267 -2.39624019 0.76929736 -0.96787654
Tr.5.24h -2.36369379 0.64148128 0.03302582 -5.96563385 4.34307449
Ve.5.24h 2.95477022 -2.86734702 2.46410627 0.14478344 -6.83429913
Da.6.3h 2.81928250 -2.69846004 -2.85733450 -0.14640113 12.04032943
Do.6.3h 0.64903875 -1.32539022 4.98201504 1.76109083 -7.41475045
Ep.6.3h -0.45113518 8.35707601 1.66614406 -2.50731886 -1.80764187
Mi.6.3h -1.66975522 0.02246397 -0.31753015 -0.81968624 10.29243152
Tr.6.3h -0.20320618 -0.36191138 -0.28327698 -3.21359856 -4.41019521
Ve.6.3h 0.67766370 -1.13943283 3.13106321 0.15205789 -2.70067574
Da.6.24h -7.81842260 5.47229412 7.13397674 -12.86207694 -2.89291136
Do.6.24h 4.08624000 -4.11611663 -3.10874113 1.76972749 1.70573417
Ep.6.24h -3.59307909 -2.63931212 3.85039187 6.14035129 -0.13807792
Mi.6.24h 1.85751443 5.29713824 -13.86681464 1.53061747 0.34810773
Tr.6.24h 2.60516230 -5.21755796 4.93382736 -0.51606669 2.56934644
Ve.6.24h -0.02279701 -0.07435637 -8.40303971 8.05497928 -5.38443123
PC47 PC48 PC49 PC50 PC51
Da.1.3h 6.64629557 2.33570569 1.336797654 1.11992329 -3.55203678
Do.1.3h 0.40940222 -2.71976212 3.919397284 4.09475414 1.40802263
Ep.1.3h -3.49059667 2.88640662 -3.291898593 1.59379619 -0.04676964
Mi.1.3h -2.58958952 -3.38195959 -4.927283788 0.26623243 4.25838545
Tr.1.3h 3.27832674 5.05671135 -2.376703000 -4.48409641 -4.67153186
Ve.1.3h 0.87868791 -1.80870186 2.766224283 2.38063673 2.08783280
Da.1.24h 0.13750718 0.30932512 -1.966219019 1.13830129 -0.94669882
Do.1.24h 2.67187104 -2.52791992 8.370728616 1.12604270 -7.86205996
Ep.1.24h -3.27528454 3.10673884 -5.313725601 -1.58466872 8.59094400
Mi.1.24h 1.46033054 -0.32333494 -5.481342036 -0.49538742 0.89168698
Tr.1.24h -0.75159804 -1.07709979 0.980614793 -2.62209172 3.22032309
Ve.1.24h -4.69806336 -0.58961510 5.228147488 -2.26233589 -2.78791450
Da.2.3h -5.14073789 -5.36608152 -0.421938096 3.03913079 3.85599157
Do.2.3h -1.69096284 -8.02993509 -0.329636805 1.14465031 -1.17426177
Ep.2.3h 1.02772594 8.09886007 5.235333369 -4.22013158 1.56489880
Mi.2.3h 4.58395505 -0.41722661 -4.140166017 4.96853453 -9.08259627
Tr.2.3h -1.75412434 -0.02291070 0.750687116 0.20226322 2.27513093
Ve.2.3h -1.56402693 5.65647880 0.840567305 -3.84636623 4.04421193
Da.2.24h 1.92774328 0.03488489 1.008070338 0.11520100 1.73044867
Do.2.24h -0.67228168 -0.15816405 -0.037742116 0.22691578 -0.49198292
Ep.2.24h 0.10653351 -0.13347931 0.063168277 -0.07737358 -0.12076381
Mi.2.24h -6.69929643 0.88024782 -10.489005789 0.75529400 -4.95329535
Tr.2.24h 9.68248101 1.47129870 7.704833567 3.56252378 9.50165489
Ve.2.24h 0.53092903 -1.70483551 -0.916628710 -5.81269898 -6.79329235
Da.3.3h 4.27839544 12.22964055 -6.188316319 9.59992777 2.91056238
Do.3.3h 4.52756233 -7.06122647 1.027447198 -3.01493477 -0.78304234
Ep.3.3h -6.50172763 -8.13276791 -4.415797104 -13.25102448 2.83527486
Mi.3.3h 0.86965684 7.94606770 5.035960770 -5.81673824 -4.14707307
Tr.3.3h -2.88805232 3.40563069 -2.314101551 -6.85765152 -5.51851719
Ve.3.3h -7.96892183 -10.87938217 5.035937420 14.18226818 -0.12546230
Da.3.24h -5.61870769 2.81117359 3.262490669 3.59007746 -0.67061051
Do.3.24h 4.03784320 0.16647975 -10.667796050 -3.55335225 4.69291896
Ep.3.24h -2.04995548 -1.83774057 6.367344987 1.95042040 -5.82023293
Mi.3.24h 8.25492172 1.44687193 12.320603705 -4.14798732 8.46652634
Tr.3.24h -2.65606000 2.58055930 -2.078056073 5.76365628 -0.27703201
Ve.3.24h 6.12468187 -2.34009405 -5.153753378 2.24134545 -1.70742990
Da.4.3h 2.70393047 -1.10354559 1.335023632 -0.33422086 -4.78033110
Do.4.3h -0.31129640 -2.49638803 1.996583786 -0.76139486 2.22746022
Ep.4.3h 1.46979857 -3.26069712 -0.486219136 -1.37005457 0.06900698
Mi.4.3h -1.04453529 0.99067181 -0.245100910 -0.21877404 6.35806981
Tr.4.3h -0.91738321 1.94547079 0.918099031 -0.33072415 -0.26734577
Ve.4.3h 2.67613680 2.92402404 -1.776529535 -1.46359215 -3.86125159
Da.4.24h -3.94095088 3.48382243 2.363315174 -2.50816315 2.61072294
Do.4.24h -2.52360759 0.33901249 0.517815754 -2.16646016 -1.16445219
Ep.4.24h 7.86366550 -3.60031615 -3.480170831 3.35724467 -0.17618506
Mi.4.24h -2.98354907 4.77818393 -0.273904243 3.51047171 -0.37428878
Tr.4.24h -1.55215671 -3.99492325 -2.490066252 -0.24581108 1.49824400
Ve.4.24h -0.25370842 -1.17558449 0.930530386 3.36902188 -1.04755988
Da.5.3h -3.65804568 -2.62692073 5.558138563 -5.22163601 -1.10459698
Do.5.3h 0.05495726 1.73089696 -2.275461653 4.81415958 3.99939451
Ep.5.3h 4.31652132 -0.44551362 -4.021587519 2.58683989 -1.73456513
Mi.5.3h -1.06212565 -1.00367617 1.975124541 1.78681864 -0.05536315
Tr.5.3h 3.22670071 1.07992104 -4.437667791 -2.83492634 0.15407368
Ve.5.3h 2.03548210 1.41989672 1.965640149 -1.95920592 0.79413055
Da.5.24h -0.90454658 -0.76102690 0.020376238 1.55571375 1.65237210
Do.5.24h -4.56541435 4.76237797 4.169489771 -0.77521397 -4.08104654
Ep.5.24h 7.90180027 -2.50571083 -3.990372734 -1.19006846 3.68865546
Mi.5.24h -2.37023714 -3.41790896 1.436758793 -0.15543901 -2.77875108
Tr.5.24h 3.18608851 -4.07318878 1.220733621 -3.57777530 -3.48730266
Ve.5.24h -8.96845656 6.23286431 -0.424586179 4.54575977 1.12737159
Da.6.3h -2.66673129 3.21214920 -1.346519680 4.17651333 -1.60356067
Do.6.3h 7.17534589 -0.81767447 3.522799717 2.44747861 -0.67572909
Ep.6.3h -5.28709433 5.68814308 0.971378023 -1.70398777 -0.39926897
Mi.6.3h -4.11633000 -7.41722579 -1.802050194 -3.32615536 8.03785301
Tr.6.3h -0.57999439 0.90908871 1.224930308 -0.47100339 -1.44448876
Ve.6.3h 4.40305748 1.24557313 -3.886653959 1.25021920 -3.92459607
Da.6.24h 4.83975261 -5.67191230 -3.014995785 -3.27502449 -1.70797408
Do.6.24h -0.33206319 -1.55220785 0.861250415 5.47303641 2.37476594
Ep.6.24h -5.30063229 3.51646755 2.432567777 -3.15702597 -1.31593075
Mi.6.24h 0.36829067 -2.00846942 -0.742378666 1.01610989 -5.36215933
Tr.6.24h 0.72939309 -0.48733262 0.538518618 -2.21728615 -1.95541342
Ve.6.24h -1.03692543 2.25081473 -0.009054026 -1.64050078 7.90783024
PC52 PC53 PC54 PC55 PC56
Da.1.3h -6.8780193 -8.00516922 -0.39838458 -1.04864917 -0.514600698
Do.1.3h -0.1818470 3.07594948 -3.14842431 0.04172312 4.759478225
Ep.1.3h 4.7516591 -0.16527150 1.20834916 1.33770633 2.555809789
Mi.1.3h 1.9732429 7.68037372 2.93973776 -0.50282055 -4.433737443
Tr.1.3h 0.7669524 -5.76182996 -9.60187112 12.74517928 8.225724887
Ve.1.3h 0.7909570 -0.98214301 0.16274332 -9.15053776 -10.610382858
Da.1.24h 1.8294034 -0.40607418 -0.76146308 -0.62859385 -0.480781117
Do.1.24h 3.4363849 -5.11282702 7.39763752 2.72098853 -0.789465055
Ep.1.24h -4.3452044 4.18840190 -4.56344562 -1.70562529 1.702294165
Mi.1.24h -1.7453633 1.39802034 -5.76347379 -2.19486644 -2.263046233
Tr.1.24h -3.0217787 -0.92456839 6.75173708 -0.22693442 1.404922363
Ve.1.24h 1.1471487 5.03347811 6.61423878 -2.01482196 0.884813845
Da.2.3h -3.1675920 1.53108226 3.16746246 -2.62866050 5.899505275
Do.2.3h -3.7251551 -2.82103755 -2.51715862 -3.09175818 9.373105479
Ep.2.3h -0.1992500 -3.95920620 -1.26399285 8.43715489 -11.398138213
Mi.2.3h 7.8850652 1.87556003 -2.55612448 -5.50932755 -4.663586478
Tr.2.3h -5.5265924 1.96722496 1.21168081 -0.49422065 0.001851310
Ve.2.3h 8.6428963 2.22401734 3.14544987 5.80790854 -2.201841433
Da.2.24h -0.2743380 -0.59487973 -0.09330981 0.47044833 -0.002537996
Do.2.24h 0.1217745 0.40637424 0.02967994 -0.02360910 -0.400725098
Ep.2.24h -0.1925718 0.25682954 0.06625155 0.07137899 0.049708291
Mi.2.24h -3.2678966 -1.47570033 -0.97123657 -0.20363537 0.542127721
Tr.2.24h -0.4559112 0.23163768 -2.00324859 -2.98735679 3.677495067
Ve.2.24h -0.5154090 -0.04898404 1.35054041 0.57535882 -1.625372093
Da.3.3h -0.5219122 6.35081251 5.90635243 4.96632927 1.587622536
Do.3.3h 0.4082138 1.84249600 -2.51034930 0.40131096 1.750583453
Ep.3.3h 3.2386596 -2.23238199 1.58192069 3.14833714 -6.517952446
Mi.3.3h -3.9551904 -3.98391892 -4.83722731 -10.30025143 3.837287463
Tr.3.3h 2.3076499 -0.09047194 1.07539100 -2.25370044 1.275850469
Ve.3.3h 3.2686981 -2.08479523 -3.77485374 3.35103761 -0.015700623
Da.3.24h -0.8192321 1.55050170 2.45395044 -0.12853822 -2.605694445
Do.3.24h 0.6560134 -1.89908899 -1.35796588 -1.18154071 0.750543325
Ep.3.24h -0.4048026 -0.24857145 0.17548966 1.65973362 0.793453718
Mi.3.24h 3.2376199 0.01436570 1.40629996 -1.82028917 0.544134467
Tr.3.24h 2.1271197 -2.24751243 -0.62101484 0.81772561 -3.397200462
Ve.3.24h -6.7554753 2.23880301 0.86542951 2.20823523 0.864490146
Da.4.3h 3.9479872 5.32423564 -6.15802391 -0.75711329 0.112797592
Do.4.3h -2.0900357 2.91071733 0.71105465 -1.16317885 0.634552153
Ep.4.3h 4.6366151 3.53002844 -2.06366273 1.79706056 -2.032925471
Mi.4.3h -1.0293772 0.59376906 5.88489045 0.02470292 -1.860900782
Tr.4.3h -4.2221886 -0.75479914 5.08227616 -0.90815046 2.302597368
Ve.4.3h -4.5212579 -1.52025676 5.70949325 -4.36313578 0.965054111
Da.4.24h -4.1337015 3.74539829 -2.80234647 3.11442868 0.605481889
Do.4.24h -2.7008776 6.41907996 -4.92238225 -3.19018496 -1.429548506
Ep.4.24h 6.2094248 -6.30622517 5.71127899 -0.06208719 -1.106816743
Mi.4.24h -1.1968162 -4.82522646 0.85581644 2.58946241 5.288145983
Tr.4.24h 0.5963298 -3.15204635 -1.22834237 -0.72000323 -0.891234739
Ve.4.24h 1.5581338 -4.85724990 -7.58841111 3.91504412 -2.122962992
Da.5.3h -2.0906929 -3.43812387 -2.07581289 -3.68566497 -0.522984453
Do.5.3h -7.2913185 -3.63923495 -0.97035190 -1.30584248 -2.715822673
Ep.5.3h 1.5256205 0.36465015 3.36147596 -4.98319107 1.242482099
Mi.5.3h 2.5451019 1.59492228 1.06485912 10.45128528 3.214705728
Tr.5.3h 3.1681610 0.36935075 -1.08488594 -1.49688663 -0.826253952
Ve.5.3h -2.3680105 1.17221869 0.79747956 1.29782607 1.533881038
Da.5.24h -0.2805207 -1.58953278 0.46357035 1.01799485 0.154582416
Do.5.24h -1.3206720 4.77961932 -2.54503418 -1.80976242 -0.102641401
Ep.5.24h 1.6168520 -3.73530072 3.07706225 0.92030265 -0.121545205
Mi.5.24h 2.6457722 0.95757559 -2.37917323 -0.00977928 -1.116438882
Tr.5.24h 0.2359172 11.91087733 0.85599632 2.93776379 3.564783751
Ve.5.24h 2.0357209 -8.88104012 -0.60748362 -3.71368249 -3.705796379
Da.6.3h 2.3951696 -2.00615189 1.34969230 -2.65259384 -1.421652516
Do.6.3h -4.2627099 1.95495016 -3.86631248 4.34140349 -6.798546998
Ep.6.3h 7.6037653 -1.53440470 5.52433394 -0.88315796 9.595086192
Mi.6.3h -5.8105771 -6.01077304 0.16365024 4.81793084 -0.621862378
Tr.6.3h -5.1214341 1.46363872 1.65516620 -0.56330406 2.001240277
Ve.6.3h -1.2840556 4.88371392 -4.73773394 -1.37367140 -2.130017336
Da.6.24h 2.5895984 -5.60544415 2.71279706 -1.57229617 4.519676056
Do.6.24h -0.6647211 2.62212383 -3.89392075 0.73263138 -0.076961937
Ep.6.24h -1.6270984 2.57375116 -2.32550431 0.56495242 -2.049606076
Mi.6.24h -1.9628549 4.26151418 8.82357725 2.49363092 -2.594229328
Tr.6.24h -3.6723490 -2.51340893 0.64157250 -0.20603769 -3.891339810
Ve.6.24h 13.7051821 0.11558764 -5.96345879 -6.26151486 3.844982602
PC57 PC58 PC59 PC60 PC61
Da.1.3h -5.0176582 -3.5661348 8.336996e+00 5.12157066 3.08464028
Do.1.3h 0.5128667 1.1612208 -9.343601e+00 -6.02282375 6.15525053
Ep.1.3h 4.9395848 2.4802122 -7.232061e+00 -1.62279204 2.83660561
Mi.1.3h 0.7172074 2.7836297 -1.779731e-01 -1.55149795 -11.74354627
Tr.1.3h -4.5846444 1.6741397 3.410919e+00 -2.29814499 -1.71494823
Ve.1.3h 0.2587333 -0.6758582 5.967159e+00 4.97225366 0.06217548
Da.1.24h 2.1157145 -0.4101931 -3.727152e-01 -0.62595143 1.62574656
Do.1.24h 2.4311156 3.5343658 -1.155852e+00 -2.95052577 -3.79245216
Ep.1.24h -3.9879027 -3.8468701 1.518554e+00 2.38065519 2.25956884
Mi.1.24h 3.2320262 4.4028268 -3.728132e-01 5.36656061 -1.15400984
Tr.1.24h 5.6656184 0.1697151 -1.153249e+00 2.26453500 -1.41838160
Ve.1.24h -5.2980203 -6.7050783 1.236662e+00 -4.54189220 3.22413002
Da.2.3h -0.8314310 1.5867241 1.726763e+00 -2.54018207 -0.65644224
Do.2.3h 2.3851032 -3.1029767 6.304268e-02 1.31503254 -7.90174536
Ep.2.3h 5.2482158 2.7662966 2.313072e-01 1.88295018 1.98448903
Mi.2.3h -6.9604250 -5.3601185 1.215431e+00 -0.14671092 3.81897543
Tr.2.3h -0.7654477 2.1647363 -8.151810e-01 0.89588463 0.36536355
Ve.2.3h 1.0795254 2.7380019 -9.241734e-01 -4.06516015 4.63673754
Da.2.24h -0.1689449 -1.4115333 -3.710883e-01 -0.29601109 0.67098294
Do.2.24h -0.1993941 0.7517837 6.483318e-05 0.33050136 -0.32301228
Ep.2.24h -0.0374983 0.1305521 2.102847e-03 -0.22718480 0.05369490
Mi.2.24h 6.1487510 1.8818534 1.991177e+00 -0.37771777 0.28834194
Tr.2.24h -7.3368254 -0.9850691 -6.133359e+00 0.52887864 -4.60728260
Ve.2.24h 0.9451316 -1.0232908 2.025192e+00 2.57683348 1.54824528
Da.3.3h -1.2176443 0.6747078 6.961751e-01 -0.20735564 -0.94286987
Do.3.3h 0.7110620 5.5313596 -3.560090e-01 3.51828519 5.78558611
Ep.3.3h -5.4986450 -6.7836875 -4.931664e+00 0.14262718 -2.43762737
Mi.3.3h 4.8445532 6.4412332 -1.716751e+00 -3.29327371 0.11662076
Tr.3.3h -2.7042134 -3.7084858 3.621754e+00 -3.81003265 -8.66836474
Ve.3.3h 1.7424755 -0.8682916 3.069675e+00 4.21755084 3.19376987
Da.3.24h -0.6325083 1.9696778 -1.210004e-02 -0.49543820 -0.88746675
Do.3.24h 0.3347110 -1.5493123 1.837425e-01 0.99138221 0.06427518
Ep.3.24h 1.3909571 1.3806904 4.884828e-01 -1.24008874 -0.63759657
Mi.3.24h -0.3399976 -2.7838249 -1.863984e+00 2.15136427 -0.30183922
Tr.3.24h 1.1421660 0.2632412 -7.113833e-01 -1.84125191 3.47334148
Ve.3.24h 0.5026603 -0.6965614 5.866082e-01 -0.18824346 0.33974541
Da.4.3h -2.0516823 -1.3466158 -2.423308e+00 -1.37297490 -3.74383374
Do.4.3h -1.9954948 0.8298698 1.733865e+00 -1.33283167 -1.38892274
Ep.4.3h 1.9283441 2.1197218 -2.172219e+00 -2.05207138 1.26271050
Mi.4.3h -0.5036366 3.8911189 9.076706e+00 -0.16125131 0.23616430
Tr.4.3h 0.7115816 -2.6036717 3.436080e-01 0.60685899 -1.11757294
Ve.4.3h 2.9819965 -4.6475073 -6.869613e+00 4.05123283 7.75350691
Da.4.24h -1.3784749 3.0093917 1.782194e+00 2.36152469 -3.62803847
Do.4.24h -3.5407235 -3.7395183 1.724872e-01 0.74602507 5.73258525
Ep.4.24h 3.0887527 2.4294269 -1.801432e+00 -0.92563311 -1.65478690
Mi.4.24h 1.0216165 -8.0171166 2.411034e+00 -8.54633773 2.62379595
Tr.4.24h 4.4535333 1.3366607 -2.185493e+00 2.58736667 -0.44816959
Ve.4.24h -4.8408913 7.2306947 1.194999e+00 4.07924076 -4.51054796
Da.5.3h 2.1605354 2.4854400 7.555385e-01 -0.32139031 0.08840873
Do.5.3h 2.8486525 -4.8650917 -1.880245e+00 1.02112613 -0.43236195
Ep.5.3h -6.1667736 8.3258588 4.239787e+00 -6.59560075 1.03419051
Mi.5.3h 1.9662671 -9.8113846 -4.077851e+00 8.39099949 -2.32188266
Tr.5.3h -2.2072003 0.1153823 -1.666235e+00 0.44346649 2.77083663
Ve.5.3h 0.8816587 1.5423983 6.174138e-01 0.06169704 -0.64241682
Da.5.24h 0.5167687 0.3724242 -2.686338e-01 -0.50884708 -0.55979136
Do.5.24h -0.6275354 -0.5655578 -6.145990e-01 0.72650300 0.83944625
Ep.5.24h 2.3370641 0.5761364 5.487870e-01 0.46019091 -1.38891185
Mi.5.24h -3.0514184 0.6254223 -6.285316e-01 -0.46955971 0.03014470
Tr.5.24h 7.1548460 1.7618419 7.552050e+00 0.29507932 3.87003768
Ve.5.24h -6.6489504 0.1824649 -4.582801e+00 -3.41426321 -3.31156452
Da.6.3h 7.4051053 -4.0743639 -1.793605e-01 2.17339484 -1.78364595
Do.6.3h 2.7132632 -8.2048884 6.549315e+00 -7.28234789 -3.18356682
Ep.6.3h -5.7238718 3.2066818 3.469951e+00 13.96515356 1.46060380
Mi.6.3h -4.7872015 4.2320847 2.783108e-01 -6.43417695 8.49620242
Tr.6.3h 3.0417877 1.2380040 -2.571191e+00 -3.12463496 -5.69444601
Ve.6.3h -0.5534063 1.6929255 -9.849188e+00 2.29789828 -1.63837445
Da.6.24h -0.6987422 -3.6393203 -3.974154e-01 -1.53763604 0.79078962
Do.6.24h -1.5531481 1.7315653 7.968576e-01 0.21023107 0.65512547
Ep.6.24h 1.4190623 -0.5363061 -1.023606e+00 0.62734971 -0.20543487
Mi.6.24h -7.5956581 4.2440881 -1.643676e+00 0.49595384 -0.41018593
Tr.6.24h -0.4363278 0.8326196 -2.175188e+00 1.63413828 1.22210828
Ve.6.24h 6.9633232 -2.9705625 6.759831e+00 -3.47046039 0.79709690
PC62 PC63 PC64 PC65 PC66
Da.1.3h 0.15681915 1.66983587 0.65864616 -0.56746540 -0.339554928
Do.1.3h 2.37248263 -6.05961102 11.55212342 -0.41951906 1.611223257
Ep.1.3h -2.84899266 -6.49515904 -5.58936815 2.26484587 2.651536029
Mi.1.3h -6.21200799 10.57469614 -1.87116148 -4.38750931 -6.066132296
Tr.1.3h -0.42873964 1.55505041 -3.35165650 2.20082737 -0.617777295
Ve.1.3h 5.93972927 -0.32381369 0.80388577 2.40603707 0.379756456
Da.1.24h -2.35768468 1.83226316 0.83607421 4.29223683 -0.092545345
Do.1.24h 2.08675080 -0.72067195 -0.47130204 -3.12794042 0.217251819
Ep.1.24h 1.00477753 0.01406533 -0.98977694 -1.55839930 0.061645984
Mi.1.24h -2.20832239 -5.94793068 0.01359406 -0.15075878 0.020426622
Tr.1.24h 6.03433390 5.07886293 8.74186052 0.55275360 1.936292552
Ve.1.24h -3.27174439 -2.24064848 -10.79823044 -1.43444208 0.139340714
Da.2.3h -0.33277690 -0.74664563 1.12498251 -0.65982829 0.969354833
Do.2.3h -5.16757776 0.14018870 -2.70761355 0.13976136 1.304706011
Ep.2.3h -2.93303094 3.34782881 0.32901901 0.38634853 0.421413944
Mi.2.3h 7.14367167 -4.65394145 2.36607951 -1.51481429 -1.346358117
Tr.2.3h 0.94156671 0.26457833 -0.25930718 1.08537080 -0.847500557
Ve.2.3h 0.20738010 1.59668062 0.65826936 0.08363599 -0.708071332
Da.2.24h -1.10702679 0.93823052 -0.54591730 0.70249200 0.405660895
Do.2.24h 0.23906212 -0.44193211 0.38197616 -0.09305300 0.097720948
Ep.2.24h 0.07003761 0.13656541 0.01355287 0.04817386 0.127313514
Mi.2.24h 0.88186666 -1.89835810 0.96183768 -0.01513606 -1.276749863
Tr.2.24h -1.24200457 0.22503667 -3.44313174 1.09684214 -0.309113808
Ve.2.24h 1.17297602 1.20274810 1.77035979 -0.71435944 1.239113371
Da.3.3h -0.57708510 -1.13077387 1.88266712 1.04357130 0.913545797
Do.3.3h 5.16373398 5.36937465 -5.00076706 1.85579406 -3.846999741
Ep.3.3h 3.93114693 -0.98603355 0.83311346 0.29622684 -3.104202956
Mi.3.3h -2.16580997 1.23826579 -2.23195203 -0.35310951 1.064897195
Tr.3.3h -3.22223878 -6.87348454 4.52367920 -0.69737764 6.580380982
Ve.3.3h -2.14494650 2.24810349 -1.18862558 -2.64676412 0.962641063
Da.3.24h -2.57328696 0.66354777 1.94208678 2.97202454 0.572782903
Do.3.24h 0.49177808 -0.03521155 0.21601865 -1.04707074 0.174854482
Ep.3.24h 1.99608486 -0.67952921 -0.86095509 -1.77416766 -0.399852885
Mi.3.24h 0.30622192 -1.79338305 -0.25464662 -0.30112587 -0.773488682
Tr.3.24h -1.25436109 1.59373024 -0.16058884 -1.08577472 -2.512280522
Ve.3.24h -0.03327675 0.36291992 -0.25171553 1.01128958 -0.344096887
Da.4.3h -1.12239698 5.91344258 7.49906847 -2.18124512 -3.725586937
Do.4.3h 3.33669932 -1.31360435 -1.22560440 2.54068092 5.269705147
Ep.4.3h 1.85180560 -3.41147412 -7.39841487 1.01226220 1.548538546
Mi.4.3h 0.87684549 -1.86114103 -2.59050622 4.00484675 6.272775897
Tr.4.3h 1.56495041 -1.94883486 0.89088430 2.31897697 -3.035591505
Ve.4.3h -8.82876321 -0.76155076 0.30690119 -9.06186218 -7.317710837
Da.4.24h 8.32184858 -5.70885422 -2.01220908 -13.48989562 -1.329663126
Do.4.24h -7.03105953 3.36284109 1.14441667 11.74829763 0.014047497
Ep.4.24h -3.07652319 0.51327154 2.02902789 1.82149483 0.287279238
Mi.4.24h 7.11389041 10.29741256 -1.32736928 -1.56062465 0.556342778
Tr.4.24h 0.00700678 1.17727864 2.37531867 0.24378173 9.004581284
Ve.4.24h -2.28384956 -5.93932973 0.52495439 2.04767461 -6.440513402
Da.5.3h -3.54165154 0.69572191 1.38035274 -0.82879639 2.050376050
Do.5.3h 0.44789721 -1.77385732 -0.67263114 -0.95078930 -1.482184435
Ep.5.3h 2.22590945 2.43012300 -0.17890022 -1.11280095 -3.030325643
Mi.5.3h 1.28812175 -1.96651722 0.60508347 3.14991190 0.329660950
Tr.5.3h -1.74946807 0.33539271 -0.68329114 -1.49353661 1.239359672
Ve.5.3h -0.40733830 -0.14621785 -0.22224320 0.87484080 -0.225627452
Da.5.24h -0.16649519 0.27739562 0.03685670 -0.46133809 -0.012728846
Do.5.24h 1.00941609 0.67438692 0.35130209 -0.01381281 -0.522616765
Ep.5.24h 0.21879836 -2.25573163 -0.59106773 -0.63919985 0.298298357
Mi.5.24h -0.94552400 2.86438417 0.53156947 1.55772494 0.504816465
Tr.5.24h 0.41256677 -1.54098444 -0.20873786 -0.56217913 -0.650766342
Ve.5.24h 0.59887878 0.57819945 -0.45808874 0.72568158 1.136962398
Da.6.3h 3.01172748 -1.91774866 -7.97132403 2.18910953 -2.631884750
Do.6.3h -6.35632289 -1.98207743 3.66548033 -3.14072433 3.093301417
Ep.6.3h -1.75463717 3.07400892 4.68462755 -1.45084936 1.292772666
Mi.6.3h -1.94831828 -1.20697866 2.20914297 -2.50139106 -0.704998005
Tr.6.3h 7.55319276 -2.52317637 1.99654466 9.58911344 -9.991278755
Ve.6.3h 4.74661449 7.24442745 -3.73227492 -3.10567387 11.055046902
Da.6.24h 0.59164219 0.85343724 -1.92031154 1.65387819 0.480740138
Do.6.24h -0.17509747 -0.31531768 -0.39627823 -2.10398601 0.273354178
Ep.6.24h 0.73760516 0.99874363 1.04290643 0.73786444 -0.824816261
Mi.6.24h -5.03143640 -2.44105297 0.66722004 0.50655566 1.097781307
Tr.6.24h 0.09722504 -0.08740788 -2.08372755 -0.05048241 0.005068316
Ve.6.24h -1.65326641 -1.21405522 2.09821191 -1.90312443 -3.151650301
PC67 PC68 PC69 PC70 PC71
Da.1.3h -0.609100729 -3.104194155 0.063107204 1.897333184 -0.332510045
Do.1.3h -10.093667994 -5.309186037 -0.971235343 3.437902608 -0.174125817
Ep.1.3h 7.408261452 10.661236546 -1.829366078 -4.447055408 1.270942265
Mi.1.3h -0.765044846 -5.879411054 2.124253285 0.571909021 0.219221375
Tr.1.3h -1.857053389 -0.164861925 3.606579372 0.530580948 -0.962972853
Ve.1.3h 5.021836860 3.904666001 -1.810208607 -0.165283722 -0.842720808
Da.1.24h -0.319381732 -0.701694183 -0.673357342 -0.761331164 0.243388303
Do.1.24h 0.241287078 0.440202244 0.203063305 -0.201021803 -0.187237961
Ep.1.24h 0.117111664 0.522851041 0.490172054 1.100211046 -0.078665933
Mi.1.24h -0.282110963 0.391894513 2.156169601 0.479840692 0.639965929
Tr.1.24h 3.373779920 -1.902422700 -5.840027954 -5.751599785 0.268587363
Ve.1.24h -1.787410112 1.544293151 2.804653093 2.801511942 0.304013294
Da.2.3h -0.188952198 0.767185421 0.197132998 -0.862485053 0.053256424
Do.2.3h -0.021392815 2.355171967 -2.975388790 1.243323683 0.147549696
Ep.2.3h -1.417365377 -1.359712802 0.617807956 0.587897249 -0.277106223
Mi.2.3h 1.638633989 -1.256272632 1.852246137 -0.623057019 0.401327864
Tr.2.3h 0.750659290 -0.077474971 0.019481047 0.230460586 -0.892141276
Ve.2.3h -0.587121228 -0.003174709 2.035573307 -0.116842354 0.337360971
Da.2.24h 0.089093694 -0.166356681 -0.186579175 0.152886845 -0.129601276
Do.2.24h 0.179905330 -0.021181674 0.041724961 -0.033203606 0.042808557
Ep.2.24h 0.127194020 -0.018236786 -0.033352130 0.003159153 -0.026823285
Mi.2.24h -0.219456349 -0.244652648 -0.329947314 -1.187088361 0.297471901
Tr.2.24h 0.153030451 -0.126809872 -1.668887179 -0.863850576 -0.415493973
Ve.2.24h -0.043265564 -0.016911557 0.463271085 0.853352091 0.484453043
Da.3.3h 3.078617469 -0.658305051 0.490155472 0.209992996 -0.195663380
Do.3.3h 0.401514819 3.208518645 1.860533060 0.064546930 0.985679202
Ep.3.3h -4.338630328 1.983517793 -2.165335335 -1.042619909 0.143321582
Mi.3.3h 0.814579780 -0.238530062 0.395800372 -0.145448438 0.841660904
Tr.3.3h 0.689930808 -3.965923355 -2.648111769 -0.894489355 -1.885821960
Ve.3.3h 0.216312271 -1.044849561 0.259939506 0.121180969 -0.705510163
Da.3.24h -0.552665746 -0.256990748 -0.105242965 -0.378337203 0.048874182
Do.3.24h 0.003556331 0.431149365 0.180809664 1.102864006 -0.001529806
Ep.3.24h 0.445804098 0.053489068 -0.156479322 -0.589150269 -0.020525282
Mi.3.24h -0.365064827 -0.345043302 1.738602104 0.652384048 0.341319563
Tr.3.24h -0.117636312 1.519220825 0.201429422 0.371893030 0.922203097
Ve.3.24h 0.019474040 -0.599382212 -0.702249075 0.500407863 -0.570136363
Da.4.3h -0.313815446 10.167295489 1.609425694 1.589172398 0.667424545
Do.4.3h 2.208580340 -4.444870751 11.123355653 -13.916976946 -4.610119753
Ep.4.3h 9.602311778 -11.416027185 -8.727990321 7.508143748 -0.955582048
Mi.4.3h -11.104612158 7.728826899 -6.438956915 3.568379726 -3.117592282
Tr.4.3h 0.523343641 -1.244063613 2.774597365 1.009849481 17.388951287
Ve.4.3h -0.633549611 0.364925124 -1.244753051 -1.957634103 -6.633387685
Da.4.24h 0.682633390 1.705517651 0.546921861 1.293856536 -0.163544561
Do.4.24h 0.315073814 -2.121593595 -1.472085876 -1.007321816 0.096806605
Ep.4.24h -1.616221013 -0.190633158 0.905411781 -0.829277445 0.164307136
Mi.4.24h 0.969095691 -0.330482264 -4.312549655 -0.849982421 -1.746404357
Tr.4.24h 1.504121269 0.174855059 11.567705888 10.526979372 -1.980995273
Ve.4.24h -2.969416202 -1.333825355 -5.795643581 -5.925571846 0.495061139
Da.5.3h 0.786682206 -0.703955244 -1.051468331 0.243077483 0.715534684
Do.5.3h -0.411211178 -0.607881606 0.679629268 1.111295290 0.122384167
Ep.5.3h -0.656132212 0.221878179 0.088980952 0.955365858 0.042002955
Mi.5.3h 1.976611721 1.027394624 0.098139192 -0.399717750 -0.783387600
Tr.5.3h -0.545614116 -0.491488965 0.146905910 -0.950636551 0.343136733
Ve.5.3h -0.076744300 0.071360688 -0.606768914 -0.156329498 0.053037801
Da.5.24h -0.037499341 0.704187659 -0.005802818 0.173160690 0.026272467
Do.5.24h -0.234989123 -0.495433685 0.021368717 -0.132722430 -0.069600783
Ep.5.24h -0.078032982 -0.122891160 0.516444596 -0.034676949 0.166275288
Mi.5.24h 0.302123450 -0.129609988 -0.479290606 0.112855184 -0.294976214
Tr.5.24h -2.078133093 -0.124029420 -1.019170001 -2.091790018 0.430097917
Ve.5.24h 1.097003868 0.848614707 1.000333906 0.840585178 -0.336650593
Da.6.3h -11.083495736 -4.827534417 2.853381501 -2.295126737 0.482301423
Do.6.3h 3.483057671 3.515917526 -0.551233088 -0.217747981 1.099145871
Ep.6.3h 2.431498288 -1.376415725 -0.819416547 2.015417937 -0.338382729
Mi.6.3h 4.436785669 -0.690837765 0.783826536 -1.873757926 1.510313414
Tr.6.3h 3.467012512 2.453850808 2.124526689 5.673782772 -6.355405174
Ve.6.3h -3.564476708 1.080215399 -4.348694709 -2.708929966 2.334389293
Da.6.24h 0.389550553 0.153900367 -0.182601990 -0.355521386 -0.022744615
Do.6.24h 0.056376925 0.554261975 -0.109833779 0.219247802 0.427123857
Ep.6.24h 0.594547275 -0.242502441 0.083953505 0.476920130 -0.337737628
Mi.6.24h -0.097789243 0.815483909 0.939823002 1.254019929 0.276164997
Tr.6.24h -0.711330489 -0.722744743 -0.436394560 -0.537946275 0.129831286
Ve.6.24h 0.181390033 -0.293482886 0.031186095 -1.181216336 0.481129320
PC72
Da.1.3h -6.651229e-14
Do.1.3h -4.489259e-14
Ep.1.3h -9.254712e-14
Mi.1.3h -1.628912e-13
Tr.1.3h -1.385861e-13
Ve.1.3h -1.559786e-13
Da.1.24h 1.348112e-13
Do.1.24h -3.666718e-13
Ep.1.24h -2.127344e-13
Mi.1.24h -1.530603e-13
Tr.1.24h -1.327780e-13
Ve.1.24h -6.613611e-14
Da.2.3h 2.174891e-13
Do.2.3h 1.314039e-13
Ep.2.3h -4.111564e-14
Mi.2.3h 1.927072e-13
Tr.2.3h 8.026929e-14
Ve.2.3h 7.455985e-14
Da.2.24h -2.085120e-13
Do.2.24h -1.400767e-13
Ep.2.24h -2.269504e-13
Mi.2.24h 1.164443e-13
Tr.2.24h 1.717236e-13
Ve.2.24h 1.082040e-13
Da.3.3h 5.683559e-14
Do.3.3h -1.338923e-14
Ep.3.3h 1.053792e-14
Mi.3.3h 1.030323e-13
Tr.3.3h 1.818786e-13
Ve.3.3h 2.986194e-14
Da.3.24h -5.555761e-14
Do.3.24h -1.135552e-13
Ep.3.24h -2.581390e-13
Mi.3.24h -4.964779e-15
Tr.3.24h 1.111992e-13
Ve.3.24h 9.766046e-14
Da.4.3h -8.011418e-14
Do.4.3h -8.794967e-15
Ep.4.3h -8.694526e-14
Mi.4.3h -9.490188e-14
Tr.4.3h 7.359714e-14
Ve.4.3h -2.669925e-14
Da.4.24h -5.633543e-13
Do.4.24h -2.208718e-13
Ep.4.24h -1.101381e-13
Mi.4.24h -7.260077e-14
Tr.4.24h 1.473639e-14
Ve.4.24h -2.136728e-14
Da.5.3h 8.228456e-14
Do.5.3h 5.982603e-14
Ep.5.3h 1.444372e-13
Mi.5.3h 6.829189e-14
Tr.5.3h 1.645843e-13
Ve.5.3h 1.453787e-13
Da.5.24h 8.805031e-14
Do.5.24h 5.840459e-14
Ep.5.24h -2.688076e-14
Mi.5.24h 2.896994e-14
Tr.5.24h 1.365049e-13
Ve.5.24h 1.668764e-13
Da.6.3h -6.140879e-14
Do.6.3h -1.924612e-14
Ep.6.3h -6.040741e-15
Mi.6.3h 5.698397e-14
Tr.6.3h 8.373978e-14
Ve.6.3h 1.407447e-13
Da.6.24h -1.038608e-13
Do.6.24h -2.735874e-14
Ep.6.24h -9.366458e-14
Mi.6.24h 1.902084e-14
Tr.6.24h 6.407533e-14
Ve.6.24h 3.958598e-14
function(pca) {
# x: class == prcomp
pca.var <- pca$sdev^2
pca.prop <- pca.var / sum(pca.var)
var.plot <- qplot(PC, prop, data = data.frame(PC = 1:length(pca.prop),
prop = pca.prop)) +
labs(title = 'Variance contributed by each PC',
x = 'PC', y = 'Proportion of variance')
}
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Warning: Using shapes for an ordinal variable is not advised
Version | Author | Date |
---|---|---|
c2db62c | reneeisnowhere | 2023-06-16 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Length Class Mode
coefficients 140840 -none- numeric
stdev.unscaled 140840 -none- numeric
sigma 14084 -none- numeric
df.residual 14084 -none- numeric
cov.coefficients 100 -none- numeric
pivot 12 -none- numeric
rank 1 -none- numeric
genes 2 data.frame list
Amean 14084 -none- numeric
method 1 -none- character
design 864 -none- numeric
contrasts 120 -none- numeric
df.prior 1 -none- numeric
s2.prior 1 -none- numeric
var.prior 10 -none- numeric
proportion 1 -none- numeric
s2.post 14084 -none- numeric
t 140840 -none- numeric
df.total 14084 -none- numeric
p.value 140840 -none- numeric
lods 140840 -none- numeric
F 14084 -none- numeric
F.p.value 14084 -none- numeric
mm2 <- model.matrix(~0 + group1)
##made the matrix model using the interaction between Treatment and Time
colnames(mm2) <- c("A3", "X3", "E3","M3","T3", "V3","A24", "X24", "E24","M24","T24", "V24")
y2 <- voom(x, mm2)
corfit2 <- duplicateCorrelation(y2, mm2, block = indv)
v2 <- voom(x, mm2, block = indv, correlation = corfit2$consensus)
fit2 <- lmFit(v2, mm2, block = indv, correlation = corfit2$consensus)
vfit2 <- lmFit(v2, mm2)
vfit2<- contrasts.fit(vfit2, contrasts=cm2)
efit2 <- eBayes(vfit2)
V.DA.top= topTable(efit2, coef=1, adjust="BH", number=Inf, sort.by="p")
### sorting all top expressed genes for the Vehicle and Daunorubicin 3 hour treatments
sigVDA3 = V.DA.top[V.DA.top$adj.P.Val < .1 , ]
### this helped pull only those files that were at an adjusted p value of less than 0.1
### This p-value was used as the beginning examination of the data, considering I will run multiple runs of this RNA seq library.
This is the example code I used to process my data. I used two model matrix initially, one set up was /~0 +drug +time and the second was /~0+group1, then blocking by individual. That is why you see the number 2 in the code above.
#DEG summary
Importance of components:
PC1 PC2 PC3 PC4 PC5 PC6
Standard deviation 62.4366 46.4535 34.03056 32.38995 28.09502 24.20110
Proportion of Variance 0.2768 0.1532 0.08223 0.07449 0.05604 0.04159
Cumulative Proportion 0.2768 0.4300 0.51224 0.58673 0.64277 0.68436
PC7 PC8 PC9 PC10 PC11 PC12
Standard deviation 22.20405 20.69847 19.78302 18.00510 17.09551 16.2307
Proportion of Variance 0.03501 0.03042 0.02779 0.02302 0.02075 0.0187
Cumulative Proportion 0.71936 0.74978 0.77757 0.80059 0.82134 0.8400
PC13 PC14 PC15 PC16 PC17 PC18
Standard deviation 14.42210 13.35826 12.24616 11.57513 10.76393 10.45848
Proportion of Variance 0.01477 0.01267 0.01065 0.00951 0.00823 0.00777
Cumulative Proportion 0.85481 0.86748 0.87813 0.88764 0.89587 0.90363
PC19 PC20 PC21 PC22 PC23 PC24 PC25
Standard deviation 9.40687 8.97456 8.75212 8.20930 7.94130 7.34670 6.96962
Proportion of Variance 0.00628 0.00572 0.00544 0.00479 0.00448 0.00383 0.00345
Cumulative Proportion 0.90992 0.91564 0.92107 0.92586 0.93034 0.93417 0.93762
PC26 PC27 PC28 PC29 PC30 PC31 PC32
Standard deviation 6.65895 6.54610 6.13447 6.10142 6.01330 5.71516 5.57713
Proportion of Variance 0.00315 0.00304 0.00267 0.00264 0.00257 0.00232 0.00221
Cumulative Proportion 0.94077 0.94381 0.94648 0.94913 0.95169 0.95401 0.95622
PC33 PC34 PC35 PC36 PC37 PC38 PC39
Standard deviation 5.50168 5.35324 5.21994 5.15023 4.8971 4.86687 4.71568
Proportion of Variance 0.00215 0.00203 0.00193 0.00188 0.0017 0.00168 0.00158
Cumulative Proportion 0.95837 0.96040 0.96234 0.96422 0.9659 0.96761 0.96919
PC40 PC41 PC42 PC43 PC44 PC45 PC46
Standard deviation 4.65993 4.53939 4.50666 4.29982 4.25872 4.15079 4.07068
Proportion of Variance 0.00154 0.00146 0.00144 0.00131 0.00129 0.00122 0.00118
Cumulative Proportion 0.97073 0.97219 0.97363 0.97495 0.97623 0.97746 0.97863
PC47 PC48 PC49 PC50 PC51 PC52 PC53
Standard deviation 4.03193 3.98075 3.95315 3.90338 3.85976 3.81543 3.7552
Proportion of Variance 0.00115 0.00113 0.00111 0.00108 0.00106 0.00103 0.0010
Cumulative Proportion 0.97979 0.98091 0.98202 0.98310 0.98416 0.98520 0.9862
PC54 PC55 PC56 PC57 PC58 PC59 PC60
Standard deviation 3.68512 3.65754 3.62646 3.58982 3.5642 3.49341 3.46598
Proportion of Variance 0.00096 0.00095 0.00093 0.00091 0.0009 0.00087 0.00085
Cumulative Proportion 0.98716 0.98811 0.98904 0.98996 0.9909 0.99173 0.99258
PC61 PC62 PC63 PC64 PC65 PC66 PC67
Standard deviation 3.40572 3.33298 3.27132 3.23877 3.1490 3.09861 3.07446
Proportion of Variance 0.00082 0.00079 0.00076 0.00074 0.0007 0.00068 0.00067
Cumulative Proportion 0.99340 0.99419 0.99495 0.99570 0.9964 0.99708 0.99775
PC68 PC69 PC70 PC71 PC72
Standard deviation 2.97300 2.88995 2.84338 2.51996 4.02e-14
Proportion of Variance 0.00063 0.00059 0.00057 0.00045 0.00e+00
Cumulative Proportion 0.99838 0.99898 0.99955 1.00000 1.00e+00
V.DA V.DX V.EP V.MT V.TR V.DA24 V.DX24 V.EP24 V.MT24 V.TR24
Down 109 3 30 24 0 3540 3336 3105 428 0
NotSig 13552 14065 13874 14009 14084 7067 7439 7756 12969 14084
Up 423 16 180 51 0 3477 3309 3223 687 0
I then created a counts table for each set of genes. Luckily, the counts are stored in the y2 object, which is an EList class object. I can ‘simplify’ this process because I kept the DEGList format initially. I first made an object called ‘countstotal’ from the EList y2. For ggploting later, I subsetted ‘countstotal’ by treatments.
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
library(cowplot)
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
Version | Author | Date |
---|---|---|
cdd9374 | reneeisnowhere | 2023-02-10 |
R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.utf8
[2] LC_CTYPE=English_United States.utf8
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C
[5] LC_TIME=English_United States.utf8
time zone: America/Chicago
tzcode source: internal
attached base packages:
[1] stats4 stats graphics grDevices utils datasets methods
[8] base
other attached packages:
[1] pheatmap_1.0.12
[2] ggfortify_0.4.16
[3] Hmisc_5.1-1
[4] corrplot_0.92
[5] ggrepel_0.9.4
[6] cowplot_1.1.1
[7] Homo.sapiens_1.3.1
[8] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
[9] org.Hs.eg.db_3.17.0
[10] GO.db_3.17.0
[11] OrganismDbi_1.42.0
[12] GenomicFeatures_1.52.2
[13] GenomicRanges_1.52.1
[14] GenomeInfoDb_1.36.4
[15] AnnotationDbi_1.62.2
[16] IRanges_2.34.1
[17] S4Vectors_0.38.2
[18] Biobase_2.60.0
[19] biomaRt_2.56.1
[20] scales_1.3.0
[21] lubridate_1.9.3
[22] forcats_1.0.0
[23] stringr_1.5.0
[24] dplyr_1.1.3
[25] purrr_1.0.2
[26] readr_2.1.4
[27] tidyr_1.3.0
[28] tibble_3.2.1
[29] ggplot2_3.4.4
[30] tidyverse_2.0.0
[31] AnnotationHub_3.8.0
[32] BiocFileCache_2.8.0
[33] dbplyr_2.4.0
[34] BiocGenerics_0.46.0
[35] devtools_2.4.5
[36] usethis_2.2.2
[37] reshape2_1.4.4
[38] gridExtra_2.3
[39] RColorBrewer_1.1-3
[40] edgeR_3.42.4
[41] limma_3.56.2
[42] workflowr_1.7.1
loaded via a namespace (and not attached):
[1] later_1.3.1 BiocIO_1.10.0
[3] bitops_1.0-7 filelock_1.0.3
[5] graph_1.78.0 rpart_4.1.23
[7] XML_3.99-0.16.1 lifecycle_1.0.4
[9] rprojroot_2.0.4 vroom_1.6.5
[11] processx_3.8.2 lattice_0.22-5
[13] backports_1.4.1 magrittr_2.0.3
[15] sass_0.4.7 rmarkdown_2.25
[17] jquerylib_0.1.4 yaml_2.3.7
[19] remotes_2.4.2.1 httpuv_1.6.12
[21] sessioninfo_1.2.2 pkgbuild_1.4.3
[23] DBI_1.2.1 abind_1.4-5
[25] pkgload_1.3.4 zlibbioc_1.46.0
[27] RCurl_1.98-1.14 nnet_7.3-19
[29] rappdirs_0.3.3 git2r_0.32.0
[31] GenomeInfoDbData_1.2.10 codetools_0.2-19
[33] DelayedArray_0.26.7 xml2_1.3.5
[35] tidyselect_1.2.0 farver_2.1.1
[37] base64enc_0.1-3 matrixStats_1.1.0
[39] GenomicAlignments_1.36.0 jsonlite_1.8.7
[41] ellipsis_0.3.2 Formula_1.2-5
[43] tools_4.3.1 progress_1.2.3
[45] Rcpp_1.0.11 glue_1.6.2
[47] xfun_0.41 MatrixGenerics_1.12.3
[49] withr_3.0.0 BiocManager_1.30.22
[51] fastmap_1.1.1 fansi_1.0.5
[53] callr_3.7.3 digest_0.6.33
[55] timechange_0.2.0 R6_2.5.1
[57] mime_0.12 colorspace_2.1-0
[59] RSQLite_2.3.5 utf8_1.2.4
[61] generics_0.1.3 data.table_1.14.8
[63] rtracklayer_1.60.1 prettyunits_1.2.0
[65] httr_1.4.7 htmlwidgets_1.6.4
[67] S4Arrays_1.0.6 whisker_0.4.1
[69] pkgconfig_2.0.3 gtable_0.3.4
[71] blob_1.2.4 XVector_0.40.0
[73] htmltools_0.5.7 profvis_0.3.8
[75] RBGL_1.76.0 png_0.1-8
[77] knitr_1.45 rstudioapi_0.15.0
[79] tzdb_0.4.0 rjson_0.2.21
[81] checkmate_2.3.1 curl_5.2.0
[83] cachem_1.0.8 BiocVersion_3.17.1
[85] parallel_4.3.1 miniUI_0.1.1.1
[87] foreign_0.8-86 restfulr_0.0.15
[89] pillar_1.9.0 grid_4.3.1
[91] vctrs_0.6.4 urlchecker_1.0.1
[93] promises_1.2.1 cluster_2.1.4
[95] xtable_1.8-4 htmlTable_2.4.2
[97] evaluate_0.23 cli_3.6.1
[99] locfit_1.5-9.8 compiler_4.3.1
[101] Rsamtools_2.16.0 rlang_1.1.2
[103] crayon_1.5.2 labeling_0.4.3
[105] ps_1.7.5 getPass_0.2-2
[107] plyr_1.8.9 fs_1.6.3
[109] stringi_1.7.12 viridisLite_0.4.2
[111] BiocParallel_1.34.2 munsell_0.5.0
[113] Biostrings_2.68.1 Matrix_1.6-2
[115] hms_1.1.3 bit64_4.0.5
[117] statmod_1.5.0 KEGGREST_1.40.1
[119] shiny_1.8.0 highr_0.10
[121] SummarizedExperiment_1.30.2 interactiveDisplayBase_1.38.0
[123] memoise_2.0.1 bslib_0.6.1
[125] bit_4.0.5