Jaspar_motif_norm

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Last updated: 2025-05-15

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Knit directory: ATAC_learning/

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These are the previous versions of the repository in which changes were made to the R Markdown (analysis/Jaspar_motif_norm.Rmd) and HTML (docs/Jaspar_motif_norm.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
html	6638b27	reneeisnowhere	2025-05-12	Build site.
Rmd	a88fc92	reneeisnowhere	2025-05-12	wflow_publish("analysis/Jaspar_motif_norm.Rmd")
html	d377357	reneeisnowhere	2025-05-12	Build site.
Rmd	fd6cfe1	reneeisnowhere	2025-05-12	added supplemental data table code
html	a3f6c4c	reneeisnowhere	2025-05-12	Build site.
html	7b1c18d	reneeisnowhere	2025-05-08	Build site.
Rmd	0fb8e8b	reneeisnowhere	2025-05-08	updates to analysis

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library(tidyverse)
library(cowplot)
library(kableExtra)
library(broom)
library(RColorBrewer)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
library(Cormotif)
library(BiocParallel)
library(ggpubr)
library(devtools)
library(JASPAR2022)
library(TFBSTools)
library(MotifDb)
library(BSgenome.Hsapiens.UCSC.hg38)
library(data.table)
library(universalmotif)
library(ggseqlogo)
library(motifmatchr)
library(gridExtra)

mrc_palette <- c(
    "EAR_open" = "#F8766D",
    "EAR_close" = "#f6483c",
    "ESR_open" = "#7CAE00",
    "ESR_close" = "#587b00",
    "ESR_C"="grey40",
     "ESR_opcl"="grey40",
    "ESR_D"="tan",
     "ESR_clop"="tan",
     "LR_open" = "#00BFC4",
     "LR_close" = "#008d91",
     "NR" = "#C77CFF"
  )

EAR_open data

EAR_open_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EAR_open_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EAR_open_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EAR_open_sea_all <- rbind(EAR_open_sea_disc, EAR_open_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EAR_open_combo <- EAR_open_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EAR_open_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ NA_character_
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EAR_open")

EAR_open_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1721.1 (ZNF93)	MEME-3	CGSSSSSSGCSSSGS	CGSSSSSSGCSSSGS	ZNF93	1.2e-28	9.74e-29	1270	28.8	16200	21.2	1.36	EAR_open
2	2	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	4.64e-27	1.89e-27	1480	33.4	19600	25.6	1.31	EAR_open
3	3	2-GCGSCGC	STREME-2	2-GCGSCGC	GCGSCGC	GCGSCGC	2.15e-26	5.82e-27	1760	39.8	24200	31.6	1.26	EAR_open
4	4	4-GCGGCC	STREME-4	4-GCGGCC	GCGGCC	GCGGCC	1.7e-24	3.46e-25	1560	35.4	21200	27.7	1.28	EAR_open
5	7	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	5.74e-24	9.32e-25	1220	27.7	15900	20.8	1.34	EAR_open
6	5	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	1.77e-23	2.4e-24	880	20	10700	14	1.43	EAR_open
7	6	5-CCCGGAG	STREME-5	5-CCCGGAG	CCCGGAG	CCCGGAG	5.54e-23	5.85e-24	1060	24	13400	17.5	1.37	EAR_open
8	7	MA1713.1 (ZNF610)	STREME-6	6-CGCTCC	CGCTCC	ZNF610	5.76e-23	5.85e-24	1360	30.9	18200	23.7	1.3	EAR_open
9	8	1-SCGGNCCGS	STREME-1	1-SCGGNCCGS	SCGGNCCGS	SCGGNCCGS	2.47e-20	2.23e-21	837	19	10300	13.5	1.41	EAR_open
10	9	MA0506.2 (Nrf1)	STREME-8	8-GCAGGCGC	GCAGGCGC	Nrf1	4.95e-20	4.02e-21	1750	39.8	24900	32.5	1.22	EAR_open
11	10	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	3.7e-19	2.73e-20	1290	29.2	17400	22.8	1.28	EAR_open
12	11	3-CCGGAGC	STREME-3	3-CCGGAGC	CCGGAGC	CCGGAGC	6.82e-19	4.62e-20	1580	35.9	22300	29.1	1.24	EAR_open
13	12	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	9.22e-18	5.76e-19	1270	28.7	17300	22.5	1.28	EAR_open
14	13	MA1990.1 (Gli1)	STREME-9	9-ACACACCACACACAC	ACACACCACACACAC	Gli1	3.81e-17	2.14e-18	65	1.47	257	0.34	4.44	EAR_open
15	1	MA1721.1 (ZNF93)	MEME-5	GGMGGSGGSGGCSGS	GGMGGSGGSGGCSGS	ZNF93	3.96e-17	2.14e-18	702	15.9	8590	11.2	1.42	EAR_open
16	14	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	6.01e-16	3.05e-17	1360	30.7	18900	24.7	1.25	EAR_open
17	10	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	8.37e-15	4e-16	1700	38.5	24700	32.2	1.19	EAR_open
18	15	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	9.74e-15	4.4e-16	2180	49.3	32800	42.8	1.15	EAR_open
19	15	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	1.59e-14	6.81e-16	1320	29.8	18500	24.1	1.24	EAR_open
20	12	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	1.49e-13	6.05e-15	774	17.6	10000	13.1	1.34	EAR_open
21	16	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	2.07e-13	8.02e-15	853	19.3	11300	14.7	1.32	EAR_open
22	17	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	3.2e-13	1.18e-14	1780	40.4	26300	34.4	1.18	EAR_open
23	18	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	7.97e-13	2.81e-14	808	18.3	10600	13.9	1.32	EAR_open
24	19	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	2.36e-12	8.01e-14	707	16	9130	11.9	1.35	EAR_open
25	20	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	8.97e-10	2.92e-11	771	17.5	10400	13.6	1.29	EAR_open
26	15	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	2.17e-09	6.78e-11	1550	35.1	23100	30.1	1.17	EAR_open
27	21	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	5.12e-09	1.5e-10	1250	28.4	18300	23.8	1.19	EAR_open
28	22	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	5.16e-09	1.5e-10	715	16.2	9640	12.6	1.29	EAR_open
29	23	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	1.36e-08	3.81e-10	1170	26.5	16900	22.1	1.2	EAR_open
30	24	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	9.21e-08	2.49e-09	429	9.73	5410	7.06	1.38	EAR_open
31	15	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	1.95e-07	5.1e-09	1970	44.8	30600	40	1.12	EAR_open
32	25	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	2.76e-07	6.79e-09	1760	39.9	27100	35.3	1.13	EAR_open
33	13	MA1107.2 (KLF9)	STREME-7	7-CATGCACACACACA	CATGCACACACACA	KLF9	2.76e-07	6.79e-09	62	1.41	417	0.54	2.62	EAR_open
34	15	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	3.55e-07	8.49e-09	977	22.2	14100	18.4	1.21	EAR_open
35	15	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	1.16e-06	2.69e-08	1520	34.6	23200	30.3	1.14	EAR_open
36	26	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	1.39e-06	3.13e-08	1540	34.8	23400	30.6	1.14	EAR_open
37	27	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	1.99e-06	4.36e-08	722	16.4	10100	13.2	1.24	EAR_open
38	28	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	2.13e-06	4.55e-08	1370	31	20600	26.9	1.15	EAR_open
39	10	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	2.97e-06	6.18e-08	675	15.3	9390	12.2	1.25	EAR_open
40	13	MA1107.2 (KLF9)	MEME-4	ACAYRCACACACACA	ACAYRCACACACACA	KLF9	3.22e-06	6.55e-08	291	6.6	3520	4.59	1.44	EAR_open
41	15	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	4.43e-06	8.79e-08	1340	30.4	20200	26.4	1.15	EAR_open
42	29	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	9.57e-06	1.85e-07	1300	29.4	19600	25.5	1.15	EAR_open
43	13	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	1.85e-05	3.49e-07	1800	40.7	28000	36.6	1.11	EAR_open
44	30	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	1.98e-05	3.66e-07	1060	24	15700	20.5	1.17	EAR_open
45	12	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	2.51e-05	4.53e-07	1720	39.1	26900	35	1.12	EAR_open
46	17	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	4.07e-05	7.19e-07	776	17.6	11200	14.6	1.21	EAR_open
47	15	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	5.06e-05	8.74e-07	1800	40.8	28200	36.8	1.11	EAR_open
48	23	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	6.65e-05	1.13e-06	1090	24.6	16300	21.2	1.16	EAR_open
49	31	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	7.58e-05	1.26e-06	278	6.3	3460	4.51	1.4	EAR_open
50	15	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	0.000128	2.08e-06	1800	40.8	28300	37	1.1	EAR_open
51	32	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	0.000186	2.96e-06	955	21.7	14200	18.5	1.17	EAR_open
52	26	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	0.00026	4.07e-06	1060	24.1	16000	20.9	1.15	EAR_open
53	12	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	0.000268	4.11e-06	528	12	7360	9.61	1.25	EAR_open
54	33	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	0.000278	4.18e-06	798	18.1	11700	15.2	1.19	EAR_open
55	13	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	0.000338	5e-06	1140	25.9	17400	22.7	1.14	EAR_open
56	34	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	0.000405	5.88e-06	1460	33	22600	29.5	1.12	EAR_open
57	15	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	0.000543	7.73e-06	3020	68.4	49700	64.8	1.06	EAR_open
58	10	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	0.000603	8.45e-06	1910	43.3	30400	39.6	1.09	EAR_open
59	35	MA1533.1	NR1I2	MA1533.1	DYGAACTSVDTGAACTC	NR1I2	0.000832	1.15e-05	1300	29.5	20100	26.2	1.13	EAR_open
60	22	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	0.000909	1.23e-05	543	12.3	7680	10	1.23	EAR_open
61	36	MA1602.1	ZSCAN29	MA1602.1	YGTCTACRCNGN	ZSCAN29	0.000933	1.24e-05	1080	24.6	16500	21.5	1.14	EAR_open
62	22	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	0.000957	1.25e-05	1470	33.4	23000	30	1.11	EAR_open
63	15	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	0.000995	1.27e-05	725	16.4	10600	13.8	1.19	EAR_open
64	10	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	0.001	1.27e-05	628	14.2	9040	11.8	1.21	EAR_open
65	15	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	0.00104	1.3e-05	372	8.44	5010	6.54	1.29	EAR_open
66	10	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	0.00111	1.36e-05	1850	41.9	29400	38.4	1.09	EAR_open
67	17	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	0.0013	1.57e-05	832	18.9	12400	16.1	1.17	EAR_open
68	17	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	0.00149	1.78e-05	1690	38.4	26800	34.9	1.1	EAR_open
69	26	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	0.0017	2e-05	1780	40.3	28200	36.9	1.09	EAR_open
70	37	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	0.00214	2.48e-05	1730	39.2	27400	35.8	1.1	EAR_open
13	13	MA1107.2 (KLF9)	MEME-1	ACACACABRCACACA	ACACACABRCACACA	KLF9	0.00226	0.000174	68	1.54	723	0.94	1.66	EAR_open
71	38	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	0.00288	3.3e-05	1180	26.7	18200	23.7	1.13	EAR_open
72	26	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	0.00339	3.83e-05	1750	39.8	27900	36.4	1.09	EAR_open
73	22	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	0.00453	5.05e-05	450	10.2	6320	8.25	1.24	EAR_open
74	39	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	0.00499	5.48e-05	933	21.2	14200	18.5	1.15	EAR_open
75	15	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	0.00567	6.15e-05	664	15.1	9760	12.7	1.18	EAR_open
76	15	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	0.00604	6.45e-05	1770	40	28200	36.8	1.09	EAR_open
77	29	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	0.00789	8.33e-05	1620	36.7	25700	33.5	1.09	EAR_open
78	32	MA0645.1	ETV6	MA0645.1	MSCGGAAGTR	ETV6	0.00855	8.82e-05	59	1.34	540	0.7	1.93	EAR_open
79	26	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	0.00867	8.82e-05	1040	23.5	15900	20.7	1.13	EAR_open
80	40	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	0.00868	8.82e-05	1950	44.2	31300	40.9	1.08	EAR_open
81	15	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	0.0143	0.000144	2380	53.8	38800	50.6	1.06	EAR_open
82	13	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	0.0149	0.000148	2250	51.1	36700	47.8	1.07	EAR_open
83	27	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	0.0188	0.000184	335	7.6	4620	6.02	1.26	EAR_open
84	26	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	0.02	0.000193	1010	22.8	15500	20.2	1.13	EAR_open
85	41	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	0.0214	0.000204	1690	38.2	27000	35.2	1.09	EAR_open
14	42	MA1125.1 (ZNF384)	MEME-2	TTTTTWTTTTTTTTT	TTTTTWTTTTTTTTT	ZNF384	14	1	127	2.88	2960	3.87	0.75	EAR_open

ER_rat <- 1.25
mrc_type <- "EAR_open"
EAR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of EAR_open-1.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

EAR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of EAR_open-2.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

EAR_close data

EAR_close_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EAR_close_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EAR_close_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EAR_close_sea_all <- rbind(EAR_close_sea_disc, EAR_close_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EAR_close_combo <- EAR_close_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EAR_close_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EAR_close")

EAR_close_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0476.1 (FOS)	STREME-1	1-VTGASTCAB	VTGASTCAB	FOS	4.82e-72	2.63e-72	1200	43.5	20700	27	1.61	EAR_close
2	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	8.33e-71	2.28e-71	1120	40.3	18700	24.3	1.66	EAR_close
3	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	3.77e-65	6.86e-66	1100	39.6	18600	24.3	1.63	EAR_close
4	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	5.26e-65	7.19e-66	1120	40.6	19300	25.2	1.61	EAR_close
5	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	8.59e-64	9.39e-65	1090	39.3	18600	24.2	1.62	EAR_close
6	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	1.15e-63	1.05e-64	1370	49.4	25400	33.2	1.49	EAR_close
7	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	2.53e-63	1.98e-64	1190	43	21000	27.5	1.57	EAR_close
8	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	6.88e-63	4.7e-64	1220	44	21800	28.4	1.55	EAR_close
9	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	9.64e-63	5.85e-64	918	33.2	14700	19.1	1.73	EAR_close
10	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	1.96e-62	1.07e-63	1040	37.4	17400	22.7	1.65	EAR_close
11	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	3.21e-62	1.6e-63	1380	49.7	25800	33.7	1.48	EAR_close
12	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	5.57e-62	2.54e-63	893	32.3	14200	18.5	1.75	EAR_close
13	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	1.38e-61	5.82e-63	941	34	15300	19.9	1.71	EAR_close
14	2	MA0036.3 (GATA2)	STREME-2	2-GWGATAA	GWGATAA	GATA2	6.53e-61	2.55e-62	1970	71.1	42300	55.2	1.29	EAR_close
15	3	MA0498.2 (MEIS1)	STREME-3	3-CTGTCAG	CTGTCAG	MEIS1	8.83e-60	3.22e-61	2680	96.8	67300	87.8	1.1	EAR_close
16	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	4.03e-59	1.38e-60	848	30.6	13400	17.4	1.76	EAR_close
17	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	9.69e-59	3.11e-60	879	31.8	14100	18.4	1.73	EAR_close
18	1	MA1988.1 (Atf3)	MEME-1	TGACTCAB	TGACTCAB	Atf3	1.19e-58	3.61e-60	753	27.2	11300	14.8	1.85	EAR_close
19	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	2.73e-58	7.85e-60	1220	43.9	22100	28.9	1.52	EAR_close
20	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	2.62e-55	7.15e-57	1460	52.6	28500	37.2	1.41	EAR_close
21	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	9.11e-55	2.37e-56	986	35.6	16900	22	1.62	EAR_close
22	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	1.14e-53	2.82e-55	1450	52.3	28500	37.2	1.41	EAR_close
23	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	1.25e-53	2.97e-55	1660	59.9	34200	44.7	1.34	EAR_close
24	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	1.7e-53	3.87e-55	756	27.3	11700	15.3	1.79	EAR_close
25	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	3.38e-53	7.38e-55	1410	50.9	27500	35.9	1.42	EAR_close
26	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	4.41e-53	9.27e-55	1300	47	24800	32.3	1.46	EAR_close
27	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	6.94e-52	1.4e-53	868	31.4	14400	18.7	1.67	EAR_close
28	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	2.95e-49	5.75e-51	714	25.8	11100	14.5	1.78	EAR_close
29	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	5.3e-44	9.99e-46	1700	61.3	36300	47.4	1.29	EAR_close
30	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	8.22e-44	1.5e-45	695	25.1	11100	14.5	1.73	EAR_close
31	4	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	2.89e-42	5.1e-44	2650	95.8	67500	88.1	1.09	EAR_close
32	2	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	5.92e-41	1.01e-42	1020	37	19100	24.9	1.49	EAR_close
33	5	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	8.35e-41	1.38e-42	2400	86.9	58400	76.2	1.14	EAR_close
34	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	1.65e-40	2.65e-42	674	24.4	10900	14.2	1.71	EAR_close
35	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	4.46e-37	6.96e-39	894	32.3	16300	21.3	1.52	EAR_close
36	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	4.96e-37	7.53e-39	940	34	17400	22.7	1.5	EAR_close
37	6	5-AASATA	STREME-5	5-AASATA	AASATA	AASATA	8.84e-32	1.31e-33	2470	89.3	61800	80.6	1.11	EAR_close
38	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	2.38e-31	3.42e-33	700	25.3	12300	16	1.58	EAR_close
39	2	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	1.82e-28	2.55e-30	639	23.1	11200	14.6	1.58	EAR_close
40	7	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	7.65e-28	1.04e-29	2470	89.3	62300	81.2	1.1	EAR_close
41	8	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	9.08e-28	1.21e-29	2640	95.3	68300	89.1	1.07	EAR_close
42	2	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	1.03e-26	1.34e-28	555	20	9440	12.3	1.63	EAR_close
43	3	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	1.58e-26	2.01e-28	698	25.2	12700	16.6	1.52	EAR_close
44	8	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	1.9e-26	2.36e-28	1770	63.9	40700	53.1	1.2	EAR_close
45	2	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	6.52e-26	7.92e-28	445	16.1	7090	9.25	1.74	EAR_close
46	8	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	1.36e-25	1.61e-27	2490	89.9	63100	82.3	1.09	EAR_close
47	7	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	4.05e-25	4.7e-27	2150	77.6	52100	68	1.14	EAR_close
48	8	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	5.47e-25	6.22e-27	2500	90.5	63700	83.1	1.09	EAR_close
49	3	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	4.23e-24	4.72e-26	1240	44.9	26700	34.8	1.29	EAR_close
50	8	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	2.75e-23	3e-25	2480	89.4	62900	82.1	1.09	EAR_close
51	4	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	3.04e-23	3.26e-25	2680	96.6	70200	91.6	1.05	EAR_close
52	9	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	3.25e-23	3.41e-25	2420	87.2	60900	79.5	1.1	EAR_close
53	8	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	6.27e-23	6.46e-25	2320	83.7	57700	75.3	1.11	EAR_close
54	8	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	9.77e-23	9.89e-25	2420	87.4	61100	79.7	1.1	EAR_close
55	10	MA1645.1 (NKX2-2)	STREME-7	7-ACTCAA	ACTCAA	NKX2-2	2.27e-22	2.25e-24	919	33.2	18600	24.3	1.37	EAR_close
56	8	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	2.55e-22	2.48e-24	2340	84.4	58500	76.3	1.11	EAR_close
57	8	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	2.9e-22	2.78e-24	2140	77.3	52300	68.3	1.13	EAR_close
58	11	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	4.28e-22	4.03e-24	2590	93.4	66900	87.4	1.07	EAR_close
59	2	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	4.47e-21	4.14e-23	333	12	5100	6.65	1.81	EAR_close
60	12	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	6.03e-21	5.49e-23	2690	97.3	71200	93	1.05	EAR_close
61	2	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	1.21e-20	1.09e-22	523	18.9	9310	12.2	1.56	EAR_close
62	8	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	1.32e-20	1.17e-22	2490	90	63800	83.3	1.08	EAR_close
63	7	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	1.8e-20	1.56e-22	2140	77.2	52600	68.6	1.13	EAR_close
64	8	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	2.98e-20	2.55e-22	2560	92.5	66300	86.5	1.07	EAR_close
65	13	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	2.86e-19	2.4e-21	2120	76.5	52100	68	1.12	EAR_close
66	8	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	3.66e-19	3.03e-21	2600	94	67900	88.6	1.06	EAR_close
67	7	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	6.64e-19	5.41e-21	2370	85.7	60200	78.5	1.09	EAR_close
68	14	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	1.43e-18	1.15e-20	2350	85	59600	77.8	1.09	EAR_close
69	15	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	2.65e-18	2.1e-20	2150	77.5	53200	69.4	1.12	EAR_close
70	8	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	5.14e-18	4.01e-20	1740	63	41400	54	1.17	EAR_close
71	16	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	7.35e-18	5.65e-20	615	22.2	11800	15.4	1.45	EAR_close
72	8	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	7.89e-18	5.98e-20	1490	53.9	34500	45	1.2	EAR_close
73	2	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	8.7e-18	6.51e-20	884	31.9	18400	24	1.33	EAR_close
74	7	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	1.24e-17	9.13e-20	2240	80.8	56100	73.2	1.1	EAR_close
75	8	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	1.76e-17	1.28e-19	2160	78	53700	70.1	1.11	EAR_close
76	8	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	1.81e-17	1.3e-19	2600	93.9	67900	88.6	1.06	EAR_close
77	9	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	2.01e-17	1.43e-19	2440	88.1	62500	81.5	1.08	EAR_close
78	11	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	2.24e-17	1.57e-19	2670	96.4	70500	92	1.05	EAR_close
79	13	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	3.31e-17	2.29e-19	2500	90.2	64500	84.1	1.07	EAR_close
80	9	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	3.95e-17	2.7e-19	2500	90.2	64500	84.2	1.07	EAR_close
81	16	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	4.96e-17	3.34e-19	2500	90.1	64400	84.1	1.07	EAR_close
82	9	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	6.15e-17	4.1e-19	2620	94.6	68800	89.8	1.05	EAR_close
83	15	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	8.49e-17	5.59e-19	2020	72.9	49600	64.7	1.13	EAR_close
84	9	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	9.38e-17	6.1e-19	2710	97.8	72200	94.3	1.04	EAR_close
85	9	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	1.08e-16	6.96e-19	2460	88.8	63300	82.6	1.08	EAR_close
86	8	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	1.96e-16	1.25e-18	2570	92.7	67000	87.4	1.06	EAR_close
87	9	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	2.5e-16	1.57e-18	2400	86.8	61600	80.3	1.08	EAR_close
88	8	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	3.15e-16	1.95e-18	1480	53.5	34400	44.9	1.19	EAR_close
89	8	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	6.4e-16	3.93e-18	1960	70.7	47900	62.6	1.13	EAR_close
90	17	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	7.84e-16	4.76e-18	2300	83.2	58400	76.2	1.09	EAR_close
91	7	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	9.28e-16	5.57e-18	2100	75.9	52300	68.2	1.11	EAR_close
92	8	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	9.59e-16	5.69e-18	2610	94.4	68700	89.6	1.05	EAR_close
93	8	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	1.92e-15	1.13e-17	2310	83.6	58800	76.7	1.09	EAR_close
94	15	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	1.97e-15	1.14e-17	2410	87.2	62000	80.9	1.08	EAR_close
95	15	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	2.6e-15	1.5e-17	1460	52.6	33900	44.2	1.19	EAR_close
96	8	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	3.72e-15	2.12e-17	1860	67.1	45200	59	1.14	EAR_close
97	8	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	3.81e-15	2.15e-17	2750	99.5	74500	97.2	1.02	EAR_close
98	8	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	5.81e-15	3.24e-17	2480	89.6	64300	83.9	1.07	EAR_close
99	9	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	8.92e-15	4.92e-17	2450	88.6	63400	82.7	1.07	EAR_close
100	8	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	9.57e-15	5.23e-17	1950	70.4	48000	62.6	1.13	EAR_close
101	15	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	1.08e-14	5.83e-17	2130	76.8	53200	69.5	1.11	EAR_close
102	9	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	1.3e-14	6.94e-17	2720	98.4	73100	95.4	1.03	EAR_close
103	18	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	1.73e-14	9.18e-17	915	33.1	19700	25.7	1.29	EAR_close
104	8	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	3.9e-14	2.05e-16	1500	54.2	35400	46.2	1.17	EAR_close
105	9	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	3.99e-14	2.08e-16	2260	81.8	57600	75.1	1.09	EAR_close
106	8	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	4.31e-14	2.22e-16	2240	80.7	56600	73.9	1.09	EAR_close
107	15	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	7.37e-14	3.77e-16	2210	79.7	55800	72.8	1.09	EAR_close
108	8	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	8.41e-14	4.25e-16	1910	68.9	46900	61.2	1.13	EAR_close
109	8	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	8.8e-14	4.41e-16	1450	52.4	34000	44.4	1.18	EAR_close
110	8	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	1.84e-13	9.16e-16	1950	70.5	48300	63	1.12	EAR_close
111	4	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	2.08e-13	1.02e-15	2590	93.6	68300	89.1	1.05	EAR_close
112	9	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	2.24e-13	1.09e-15	2360	85.4	60700	79.2	1.08	EAR_close
113	9	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	2.62e-13	1.26e-15	2690	97.2	71800	93.7	1.04	EAR_close
114	8	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	3.27e-13	1.57e-15	1570	56.6	37400	48.8	1.16	EAR_close
115	31	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	4.08e-13	1.94e-15	704	25.4	14600	19.1	1.33	EAR_close
116	19	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	4.3e-13	2.03e-15	2550	92	66700	87.1	1.06	EAR_close
117	20	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	6.49e-13	3.03e-15	2220	80.2	56400	73.6	1.09	EAR_close
118	8	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	7.71e-13	3.57e-15	2250	81.2	57200	74.7	1.09	EAR_close
119	8	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	1.34e-12	6.14e-15	1820	65.8	44700	58.3	1.13	EAR_close
120	3	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	1.67e-12	7.62e-15	992	35.8	22100	28.8	1.25	EAR_close
121	16	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	2.06e-12	9.32e-15	2590	93.7	68500	89.4	1.05	EAR_close
122	15	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	3.57e-12	1.6e-14	790	28.5	16900	22.1	1.29	EAR_close
123	8	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	4.99e-12	2.22e-14	1980	71.6	49500	64.6	1.11	EAR_close
124	7	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	5.26e-12	2.32e-14	2180	78.7	55300	72.2	1.09	EAR_close
125	8	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	6.11e-12	2.67e-14	2000	72.1	49900	65.1	1.11	EAR_close
126	21	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	9.86e-12	4.27e-14	2700	97.5	72400	94.4	1.03	EAR_close
127	8	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	1.43e-11	6.14e-14	1310	47.4	30700	40.1	1.18	EAR_close
128	8	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	1.62e-11	6.9e-14	2010	72.5	50400	65.7	1.1	EAR_close
129	22	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	1.7e-11	7.21e-14	2290	82.7	58800	76.7	1.08	EAR_close
130	8	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	1.83e-11	7.68e-14	1720	62	42000	54.8	1.13	EAR_close
131	9	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	1.96e-11	8.16e-14	2380	86	61600	80.4	1.07	EAR_close
132	17	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	2.17e-11	8.98e-14	2390	86.4	62000	80.9	1.07	EAR_close
133	7	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	3.19e-11	1.31e-13	2270	82.2	58400	76.2	1.08	EAR_close
134	15	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	3.28e-11	1.34e-13	531	19.2	10700	13.9	1.38	EAR_close
135	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	5.65e-11	2.29e-13	2000	72.2	50200	65.5	1.1	EAR_close
136	23	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	6.03e-11	2.42e-13	1850	67	46000	60	1.12	EAR_close
137	20	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	6.91e-11	2.76e-13	2150	77.6	54600	71.2	1.09	EAR_close
138	7	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	7.31e-11	2.89e-13	1960	71	49200	64.2	1.11	EAR_close
139	15	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	8.75e-11	3.44e-13	619	22.4	12900	16.8	1.33	EAR_close
140	15	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	9.36e-11	3.65e-13	1360	49	32200	42	1.17	EAR_close
141	18	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	2.19e-10	8.47e-13	916	33.1	20500	26.8	1.24	EAR_close
142	1	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	3.21e-10	1.24e-12	2540	91.9	67100	87.5	1.05	EAR_close
143	8	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	1.19e-09	4.54e-12	1900	68.6	47600	62.1	1.1	EAR_close
144	8	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	1.3e-09	4.92e-12	1950	70.5	49100	64.1	1.1	EAR_close
145	8	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	1.38e-09	5.21e-12	2560	92.5	67800	88.4	1.05	EAR_close
146	8	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	1.49e-09	5.56e-12	1980	71.6	50000	65.2	1.1	EAR_close
147	8	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	1.75e-09	6.5e-12	2020	72.9	51100	66.6	1.09	EAR_close
148	8	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	1.96e-09	7.25e-12	1780	64.4	44400	57.9	1.11	EAR_close
149	11	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	2.1e-09	7.71e-12	2070	74.9	52800	68.8	1.09	EAR_close
150	19	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	2.66e-09	9.7e-12	2560	92.6	67900	88.6	1.05	EAR_close
151	8	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	2.7e-09	9.75e-12	2080	75.1	52900	69.1	1.09	EAR_close
152	7	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	3.11e-09	1.12e-11	1670	60.3	41100	53.7	1.12	EAR_close
153	9	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	6.44e-09	2.3e-11	2710	97.9	73200	95.5	1.03	EAR_close
154	4	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	8.03e-09	2.85e-11	2350	85	61300	80	1.06	EAR_close
155	15	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	9.86e-09	3.47e-11	1840	66.3	46000	60	1.1	EAR_close
156	12	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	1.22e-08	4.26e-11	2670	96.5	71800	93.6	1.03	EAR_close
157	24	MA0664.1	MLXIPL	MA0664.1	RTCACGTGAT	MLXIPL	1.24e-08	4.31e-11	1560	56.4	38300	49.9	1.13	EAR_close
158	15	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	1.64e-08	5.68e-11	1370	49.5	33000	43.1	1.15	EAR_close
159	4	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	2.66e-08	9.13e-11	2530	91.3	66900	87.3	1.05	EAR_close
160	4	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	2.72e-08	9.29e-11	2020	72.8	51300	67	1.09	EAR_close
161	3	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	3.12e-08	1.06e-10	2500	90.3	66000	86.1	1.05	EAR_close
162	10	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	3.45e-08	1.16e-10	2270	82	58900	76.8	1.07	EAR_close
163	8	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	4.79e-08	1.61e-10	1560	56.4	38400	50.1	1.13	EAR_close
164	20	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	5.2e-08	1.73e-10	2120	76.5	54400	70.9	1.08	EAR_close
165	8	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	6.12e-08	2.03e-10	1340	48.3	32300	42.2	1.15	EAR_close
166	8	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	1.23e-07	4.06e-10	2100	75.7	53800	70.2	1.08	EAR_close
167	8	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	1.36e-07	4.45e-10	1320	47.5	31800	41.5	1.15	EAR_close
168	15	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	1.39e-07	4.53e-10	1300	46.9	31300	40.9	1.15	EAR_close
169	8	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	1.4e-07	4.54e-10	2170	78.5	56100	73.2	1.07	EAR_close
170	20	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	2.23e-07	7.18e-10	1740	63	43700	57	1.1	EAR_close
171	7	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	2.45e-07	7.83e-10	1760	63.6	44200	57.6	1.1	EAR_close
172	25	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	2.98e-07	9.45e-10	2400	86.8	63100	82.4	1.05	EAR_close
173	9	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	3.07e-07	9.69e-10	2730	98.8	74300	96.9	1.02	EAR_close
174	13	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	3.52e-07	1.1e-09	2370	85.7	62200	81.2	1.06	EAR_close
175	11	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	4.18e-07	1.31e-09	1910	69.2	48700	63.5	1.09	EAR_close
176	26	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	4.36e-07	1.35e-09	2690	97.1	72500	94.6	1.03	EAR_close
177	27	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	4.89e-07	1.51e-09	2320	83.6	60500	79	1.06	EAR_close
178	8	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	5.45e-07	1.67e-09	1440	52.2	35500	46.3	1.13	EAR_close
179	12	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	6.98e-07	2.13e-09	1440	52	35300	46.1	1.13	EAR_close
180	17	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	8.34e-07	2.53e-09	2400	86.9	63300	82.6	1.05	EAR_close
181	17	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	8.46e-07	2.55e-09	2080	75.1	53500	69.9	1.08	EAR_close
182	8	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	9.94e-07	2.98e-09	1630	59	40800	53.3	1.11	EAR_close
183	28	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	1.05e-06	3.15e-09	766	27.7	17400	22.7	1.22	EAR_close
184	8	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	1.07e-06	3.17e-09	1790	64.7	45300	59.1	1.1	EAR_close
185	1	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	1.3e-06	3.85e-09	2400	86.7	63200	82.5	1.05	EAR_close
186	29	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	1.43e-06	4.21e-09	1960	71	50300	65.6	1.08	EAR_close
187	15	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	1.44e-06	4.22e-09	550	19.9	11900	15.6	1.28	EAR_close
188	30	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	1.46e-06	4.23e-09	1150	41.6	27700	36.1	1.15	EAR_close
189	8	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	1.97e-06	5.69e-09	1580	56.9	39300	51.3	1.11	EAR_close
190	8	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	2.19e-06	6.29e-09	1390	50.1	34100	44.4	1.13	EAR_close
191	31	MA0592.3 (ESRRA)	STREME-4	4-AGGTCA	AGGTCA	ESRRA	4.66e-06	1.33e-08	2460	88.9	65200	85.1	1.04	EAR_close
192	32	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	5.66e-06	1.61e-08	708	25.6	16100	21	1.22	EAR_close
193	46	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	6.01e-06	1.7e-08	2460	88.9	65200	85.1	1.04	EAR_close
194	4	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	6.18e-06	1.74e-08	2420	87.6	64100	83.6	1.05	EAR_close
195	33	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	6.57e-06	1.84e-08	212	7.66	3880	5.07	1.52	EAR_close
196	10	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	6.68e-06	1.86e-08	1490	53.8	37000	48.3	1.11	EAR_close
197	8	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	7.82e-06	2.17e-08	1100	39.8	26500	34.6	1.15	EAR_close
198	32	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	8.35e-06	2.3e-08	345	12.5	7020	9.16	1.36	EAR_close
199	34	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	1.08e-05	2.97e-08	2110	76.2	54700	71.4	1.07	EAR_close
200	35	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	1.22e-05	3.33e-08	1330	47.9	32600	42.6	1.13	EAR_close
201	8	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	1.27e-05	3.45e-08	1470	53	36500	47.6	1.11	EAR_close
202	15	MA0656.1	JDP2	MA0656.1	GATGACGTCAYC	JDP2	1.28e-05	3.46e-08	235	8.49	4450	5.8	1.47	EAR_close
203	30	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	1.44e-05	3.88e-08	842	30.4	19700	25.6	1.19	EAR_close
204	27	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	1.77e-05	4.75e-08	1660	60	41900	54.7	1.1	EAR_close
205	15	MA0834.1	ATF7	MA0834.1	NDATGACGTCATMV	ATF7	2.38e-05	6.35e-08	318	11.5	6440	8.41	1.37	EAR_close
206	36	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	2.41e-05	6.4e-08	1720	62.3	43800	57.1	1.09	EAR_close
207	15	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	2.82e-05	7.44e-08	1280	46.1	31400	41	1.13	EAR_close
208	37	MA1627.1 (Wt1)	STREME-6	6-CCTCCCCCA	CCTCCCCCA	Wt1	3.35e-05	8.8e-08	316	11.4	6420	8.37	1.37	EAR_close
209	8	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	3.94e-05	1.03e-07	1220	43.9	29800	38.8	1.13	EAR_close
210	4	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	4.49e-05	1.17e-07	2390	86.3	63200	82.5	1.05	EAR_close
211	32	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	4.79e-05	1.24e-07	621	22.4	14100	18.3	1.22	EAR_close
212	21	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	5.52e-05	1.42e-07	2560	92.5	68600	89.5	1.03	EAR_close
213	15	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	5.9e-05	1.51e-07	966	34.9	23100	30.1	1.16	EAR_close
214	15	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	5.98e-05	1.53e-07	1700	61.3	43100	56.2	1.09	EAR_close
215	15	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	6.79e-05	1.72e-07	1750	63.3	44700	58.3	1.09	EAR_close
216	33	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	8.17e-05	2.07e-07	225	8.13	4320	5.64	1.45	EAR_close
217	4	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	9.3e-05	2.34e-07	2230	80.6	58500	76.4	1.05	EAR_close
218	20	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	0.000125	3.14e-07	451	16.3	9840	12.8	1.27	EAR_close
219	45	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	0.00013	3.25e-07	2630	95	71000	92.6	1.03	EAR_close
220	15	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	0.000149	3.71e-07	1750	63.3	44800	58.4	1.08	EAR_close
221	38	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	0.000157	3.88e-07	1330	48.2	33200	43.3	1.11	EAR_close
222	33	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	0.000164	4.04e-07	143	5.17	2500	3.26	1.59	EAR_close
223	8	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	0.000169	4.13e-07	1730	62.5	44200	57.7	1.08	EAR_close
224	8	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	0.00017	4.15e-07	1810	65.3	46400	60.5	1.08	EAR_close
225	8	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	0.000184	4.46e-07	820	29.6	19400	25.3	1.17	EAR_close
226	18	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	0.000214	5.18e-07	577	20.8	13100	17.1	1.22	EAR_close
227	35	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	0.000223	5.36e-07	828	29.9	19600	25.6	1.17	EAR_close
228	15	MA0840.1	Creb5	MA0840.1	NATGACGTCAYH	Creb5	0.000285	6.83e-07	366	13.2	7800	10.2	1.3	EAR_close
229	8	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	0.00031	7.4e-07	1210	43.9	30000	39.1	1.12	EAR_close
230	15	MA1951.1	FOS	MA1951.1	BGATGACGTCATCR	FOS	0.000318	7.55e-07	610	22	14000	18.2	1.21	EAR_close
231	39	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	0.000324	7.67e-07	1900	68.6	49100	64.1	1.07	EAR_close
232	33	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	0.000363	8.55e-07	77	2.78	1130	1.48	1.91	EAR_close
233	8	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	0.000506	1.19e-06	1020	36.8	24800	32.4	1.14	EAR_close
234	21	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	0.000641	1.5e-06	2610	94.2	70300	91.7	1.03	EAR_close
235	4	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	0.000681	1.58e-06	2560	92.4	68800	89.7	1.03	EAR_close
236	40	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	0.000697	1.61e-06	1770	64	45600	59.5	1.08	EAR_close
237	24	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	0.000819	1.89e-06	906	32.7	21800	28.5	1.15	EAR_close
238	4	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	0.000919	2.11e-06	2360	85.1	62600	81.6	1.04	EAR_close
239	32	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	0.000952	2.18e-06	507	18.3	11400	14.9	1.23	EAR_close
240	8	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	0.00102	2.31e-06	608	22	14000	18.3	1.2	EAR_close
241	8	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	0.00115	2.61e-06	2000	72.4	52300	68.2	1.06	EAR_close
242	13	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	0.0013	2.92e-06	2310	83.6	61300	80	1.04	EAR_close
243	32	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	0.0018	4.06e-06	1640	59.2	42000	54.8	1.08	EAR_close
244	8	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	0.00182	4.07e-06	753	27.2	17900	23.4	1.17	EAR_close
245	15	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	0.00274	6.11e-06	2000	72.3	52300	68.3	1.06	EAR_close
246	7	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	0.00314	6.97e-06	1790	64.7	46300	60.4	1.07	EAR_close
247	32	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	0.00353	7.81e-06	473	17.1	10700	14	1.22	EAR_close
248	8	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	0.00357	7.86e-06	1210	43.7	30200	39.5	1.11	EAR_close
249	44	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	0.00362	7.94e-06	1010	36.4	24700	32.3	1.13	EAR_close
250	8	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	0.00442	9.65e-06	862	31.1	20900	27.3	1.14	EAR_close
9	44	MA1596.1 (ZNF460)	MEME-3	CCHCHSCCWCC	CCHCHSCCWCC	ZNF460	0.0045	5e-04	1000	36.3	25400	33.1	1.1	EAR_close
251	10	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	0.00452	9.84e-06	2040	73.7	53500	69.8	1.06	EAR_close
252	32	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	0.00459	9.94e-06	649	23.4	15300	20	1.18	EAR_close
253	8	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	0.00462	9.97e-06	992	35.8	24400	31.8	1.13	EAR_close
254	30	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	0.00478	1.03e-05	1160	41.9	28900	37.7	1.11	EAR_close
255	41	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	0.0054	1.16e-05	1990	72	52200	68.1	1.06	EAR_close
256	42	MA0029.1	Mecom	MA0029.1	AAGAYAAGATAANA	Mecom	0.00659	1.41e-05	62	2.24	922	1.2	1.89	EAR_close
257	30	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.00719	1.53e-05	422	15.2	9500	12.4	1.23	EAR_close
258	32	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	0.00815	1.72e-05	377	13.6	8380	10.9	1.25	EAR_close
259	3	MA0783.1	PKNOX2	MA0783.1	TGACAGGTGTCA	PKNOX2	0.00852	1.8e-05	201	7.26	4060	5.3	1.38	EAR_close
260	20	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	0.00861	1.81e-05	2680	96.7	72800	95	1.02	EAR_close
10	45	MA1731.1 (ZNF768)	MEME-6	TCTCYYTMTCTCTYT	TCTCYYTMTCTCTYT	ZNF768	0.0091	0.00091	203	7.33	4440	5.79	1.27	EAR_close
261	31	MA1996.1	Nr1H2	MA1996.1	NNRAGGTCANN	Nr1H2	0.011	2.31e-05	1000	36.2	24800	32.3	1.12	EAR_close
262	30	MA0816.1	Ascl2	MA0816.1	ARCAGCTGCY	Ascl2	0.0118	2.47e-05	2140	77.2	56500	73.7	1.05	EAR_close
263	15	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	0.0157	3.26e-05	766	27.7	18500	24.2	1.15	EAR_close
264	31	MA0071.1	RORA	MA0071.1	AWMWAGGTCA	RORA	0.0166	3.45e-05	497	18	11500	15	1.2	EAR_close
265	9	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	0.0169	3.49e-05	1550	55.8	39800	51.9	1.08	EAR_close
266	20	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	0.0182	3.75e-05	1780	64.3	46300	60.5	1.06	EAR_close
267	30	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	0.0187	3.82e-05	1460	52.7	37300	48.7	1.08	EAR_close
268	27	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	0.019	3.88e-05	2660	95.9	72100	94.1	1.02	EAR_close
269	31	MA0017.2	NR2F1	MA0017.2	CARAGGTCAMVNG	NR2F1	0.0199	4.05e-05	455	16.4	10500	13.6	1.21	EAR_close
270	31	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	0.0213	4.31e-05	1360	49.1	34600	45.2	1.09	EAR_close
271	30	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	0.024	4.83e-05	746	27	18100	23.6	1.14	EAR_close
272	32	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	0.028	5.62e-05	371	13.4	8360	10.9	1.23	EAR_close
273	43	MA0164.1	Nr2e3	MA0164.1	CAAGCTT	Nr2e3	0.0344	6.89e-05	595	21.5	14100	18.5	1.17	EAR_close
274	15	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	0.0346	6.91e-05	2380	86.2	63900	83.4	1.03	EAR_close
275	8	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	0.0421	8.36e-05	545	19.7	12900	16.8	1.17	EAR_close
276	15	MA0828.2	SREBF2	MA0828.2	WWATCACGTGATWW	SREBF2	0.048	9.5e-05	206	7.44	4310	5.62	1.33	EAR_close
11	46	MA0090.3 (TEAD1)	MEME-4	CAYTCCAGCCT	CAYTCCAGCCT	TEAD1	0.0508	0.00462	13	0.47	142	0.19	2.71	EAR_close
12	47	GAGACRGRGTCTCRC	MEME-7	GAGACRGRGTCTCRC	GAGACRGRGTCTCRC	GAGACRGRGTCTCRC	0.0912	0.0076	331	12	7980	10.4	1.15	EAR_close
13	48	8-AACTGTGGAGA	STREME-8	8-AACTGTGGAGA	AACTGTGGAGA	AACTGTGGAGA	0.192	0.0148	397	14.3	9840	12.8	1.12	EAR_close
14	49	MA1125.1 (ZNF384)	MEME-2	AAAAAAAAAAARAAA	AAAAAAAAAAARAAA	ZNF384	0.619	0.0442	28	1.01	533	0.7	1.5	EAR_close
15	50	MA1581.1 (ZBTB6)	MEME-8	GGCTCAAGYGATYCT	GGCTCAAGYGATYCT	ZBTB6	1.34	0.0896	124	4.48	3020	3.94	1.15	EAR_close
16	51	GCCTGTARTCCCAGC	MEME-5	GCCTGTARTCCCAGC	GCCTGTARTCCCAGC	GCCTGTARTCCCAGC	1.9	0.119	7	0.25	111	0.14	1.98	EAR_close

ER_rat <- 1.25
mrc_type <- "EAR_close"
EAR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of EAR_close-1.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

EAR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*.8), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.8,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of EAR_close-2.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_open data

ESR_open_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_open_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_open_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_open_sea_all <- rbind(ESR_open_sea_disc, ESR_open_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

ESR_open_combo <- ESR_open_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_open_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_open")

ESR_open_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	10-CACACATGCACACAC	STREME-10	10-CACACATGCACACAC	10-CACACATGCACACAC	CACACATGCACACAC	1.8e-189	1.3e-189	549	9.72	1370	1.78	5.46	ESR_open
2	1	GTGYRTGTGTGTRTG	MEME-7	GTGYRTGTGTGTRTG	GTGYRTGTGTGTRTG	GTGYRTGTGTGTRTG	9.06e-176	3.27e-176	537	9.5	1420	1.85	5.14	ESR_open
3	1	MA1107.2 (KLF9)	MEME-1	TGTGTGTGTGTGTGT	TGTGTGTGTGTGTGT	KLF9	5.74e-169	1.38e-169	476	8.42	1140	1.48	5.68	ESR_open
4	1	MA1107.2 (KLF9)	STREME-3	3-ATGTGTGTGTG	ATGTGTGTGTG	KLF9	8.48e-155	1.53e-155	499	8.83	1390	1.82	4.87	ESR_open
5	1	2-CACACACAYACACA	STREME-2	2-CACACACAYACACA	CACACACAYACACA	CACACACAYACACA	1.42e-145	2.05e-146	409	7.24	967	1.26	5.74	ESR_open
6	1	ACACAYRYACACACA	MEME-8	ACACAYRYACACACA	ACACAYRYACACACA	ACACAYRYACACACA	1.82e-144	2.19e-145	423	7.49	1050	1.37	5.46	ESR_open
7	2	MA1990.1 (Gli1)	STREME-4	4-ACACACCACACACAC	ACACACCACACACAC	Gli1	3.29e-134	3.39e-135	267	4.73	375	0.49	9.67	ESR_open
8	2	ACACACCACACACA	MEME-6	ACACACCACACACA	ACACACCACACACA	ACACACCACACACA	5.12e-133	4.62e-134	204	3.61	164	0.21	16.9	ESR_open
9	1	6-GTGTGTRTG	STREME-6	6-GTGTGTRTG	GTGTGTRTG	GTGTGTRTG	9.95e-132	7.98e-133	757	13.4	3510	4.58	2.93	ESR_open
10	1	MA1107.2 (KLF9)	MEME-11	CAYACACACACACAY	CAYACACACACACAY	KLF9	1.58e-120	1.14e-121	360	6.37	910	1.19	5.37	ESR_open
11	3	MA0491.2 (JUND)	STREME-1	1-DATGASTCATH	DATGASTCATH	JUND	3.23e-120	2.12e-121	698	12.4	3250	4.24	2.92	ESR_open
12	3	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	1.1e-103	6.59e-105	765	13.5	4130	5.39	2.51	ESR_open
13	3	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	4.66e-103	2.59e-104	820	14.5	4630	6.04	2.41	ESR_open
14	3	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	4.3e-102	2.22e-103	785	13.9	4340	5.66	2.46	ESR_open
15	3	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	7.98e-99	3.84e-100	687	12.2	3570	4.65	2.62	ESR_open
16	3	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	1.41e-98	6.37e-100	609	10.8	2930	3.82	2.82	ESR_open
17	3	MA0476.1 (FOS)	MEME-4	TGASTCAT	TGASTCAT	FOS	1.78e-98	7.55e-100	1150	20.3	7860	10.2	1.98	ESR_open
18	2	TGTGTGGTGTGTGTG	MEME-2	TGTGTGGTGTGTGTG	TGTGTGGTGTGTGTG	TGTGTGGTGTGTGTG	2.06e-98	8.28e-100	331	5.86	949	1.24	4.74	ESR_open
19	3	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	1.36e-97	5.16e-99	572	10.1	2650	3.46	2.93	ESR_open
20	3	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	2.01e-97	7.25e-99	719	12.7	3870	5.05	2.52	ESR_open
21	3	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	1.95e-95	6.72e-97	864	15.3	5210	6.8	2.25	ESR_open
22	3	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	5.64e-95	1.85e-96	935	16.6	5890	7.69	2.15	ESR_open
23	3	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	6.01e-95	1.88e-96	699	12.4	3750	4.9	2.53	ESR_open
24	3	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	5.57e-94	1.67e-95	900	15.9	5590	7.29	2.19	ESR_open
25	3	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	1.94e-92	5.6e-94	828	14.6	4960	6.47	2.27	ESR_open
26	3	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	5.46e-92	1.52e-93	819	14.5	4890	6.38	2.27	ESR_open
27	3	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	7.93e-92	2.12e-93	643	11.4	3340	4.36	2.61	ESR_open
28	3	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	7.75e-89	2e-90	1060	18.8	7320	9.55	1.97	ESR_open
29	3	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	2.65e-87	6.59e-89	551	9.75	2670	3.49	2.8	ESR_open
30	3	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	2.12e-86	5.11e-88	1100	19.4	7720	10.1	1.92	ESR_open
31	3	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	4.78e-86	1.11e-87	530	9.38	2530	3.3	2.85	ESR_open
32	3	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	4.12e-85	9.3e-87	493	8.73	2250	2.94	2.97	ESR_open
33	3	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	4.93e-82	1.08e-83	890	15.8	5830	7.61	2.07	ESR_open
34	4	MA1155.1	ZSCAN4	MA1155.1	TGCACACACTGAAAA	ZSCAN4	1.85e-81	3.92e-83	481	8.51	2220	2.9	2.94	ESR_open
35	3	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	4.22e-79	8.7e-81	478	8.46	2240	2.93	2.89	ESR_open
36	3	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	5.19e-77	1.04e-78	707	12.5	4250	5.55	2.26	ESR_open
37	3	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	6.28e-76	1.23e-77	405	7.17	1740	2.27	3.17	ESR_open
38	3	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	5.1e-75	9.68e-77	1210	21.5	9380	12.2	1.76	ESR_open
39	3	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	8.47e-73	1.57e-74	1120	19.9	8520	11.1	1.79	ESR_open
40	5	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	6.85e-72	1.24e-73	519	9.19	2720	3.55	2.59	ESR_open
41	1	5-CATACA	STREME-5	5-CATACA	CATACA	CATACA	1.45e-63	2.56e-65	2510	44.4	25300	33	1.35	ESR_open
42	3	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	1.08e-61	1.85e-63	625	11.1	3910	5.1	2.17	ESR_open
43	6	MA0525.2 (TP63)	STREME-11	11-ACATGT	11-ACATGT	TP63	1.71e-54	2.86e-56	3070	54.4	33300	43.4	1.25	ESR_open
44	7	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	1.41e-51	2.32e-53	2910	51.5	31300	40.9	1.26	ESR_open
45	8	7-ATGTAC	STREME-7	7-ATGTAC	ATGTAC	ATGTAC	9.75e-43	1.56e-44	2920	51.7	32200	42	1.23	ESR_open
46	5	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	8.89e-41	1.4e-42	742	13.1	5800	7.57	1.74	ESR_open
47	9	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	2.58e-38	3.96e-40	2430	43	26100	34.1	1.26	ESR_open
48	6	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	6.52e-30	9.8e-32	138	2.44	511	0.67	3.68	ESR_open
49	10	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	4.89e-29	7.21e-31	523	9.26	4030	5.25	1.76	ESR_open
50	11	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	2.99e-28	4.31e-30	3320	58.7	38900	50.8	1.16	ESR_open
51	11	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	2.03e-27	2.88e-29	2270	40.2	25100	32.7	1.23	ESR_open
52	12	MA0073.1	RREB1	MA0073.1	CCCCMAAMCAMCCMCMMMCV	RREB1	4.18e-27	5.8e-29	530	9.38	4180	5.46	1.72	ESR_open
53	3	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	4.74e-25	6.45e-27	549	9.72	4480	5.84	1.67	ESR_open
54	11	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	5.51e-25	7.36e-27	3870	68.4	46900	61.2	1.12	ESR_open
55	7	MA0623.2	NEUROG1	MA0623.2	RACATATGTY	NEUROG1	7e-24	9.19e-26	1550	27.4	16200	21.2	1.29	ESR_open
56	13	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	3.79e-23	4.89e-25	2380	42	26800	35	1.2	ESR_open
57	13	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	1.36e-22	1.73e-24	3480	61.6	41800	54.6	1.13	ESR_open
58	14	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	2.54e-22	3.16e-24	745	13.2	6790	8.85	1.49	ESR_open
59	7	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	2.6e-22	3.18e-24	2210	39.2	24800	32.4	1.21	ESR_open
60	11	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	4.79e-22	5.76e-24	2750	48.7	31900	41.7	1.17	ESR_open
61	7	MA0678.1	OLIG2	MA0678.1	AMCATATGKT	OLIG2	1.2e-21	1.42e-23	3000	53.1	35300	46.1	1.15	ESR_open
62	3	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	1e-20	1.16e-22	520	9.2	4390	5.72	1.61	ESR_open
63	7	MA0819.2	CLOCK	MA0819.2	NRACACGTGB	CLOCK	1.27e-20	1.46e-22	3070	54.3	36400	47.4	1.14	ESR_open
64	9	MA1718.1	ZNF8	MA1718.1	GTATGGATATACCACAKTTT	ZNF8	1.3e-20	1.47e-22	520	9.2	4390	5.73	1.61	ESR_open
65	13	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	1.54e-20	1.71e-22	2100	37.3	23600	30.8	1.21	ESR_open
66	11	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	2.41e-20	2.64e-22	3080	54.5	36600	47.7	1.14	ESR_open
67	11	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	1.03e-18	1.1e-20	5120	90.6	66200	86.4	1.05	ESR_open
68	7	MA0622.1	Mlxip	MA0622.1	BCACGTGK	Mlxip	1.04e-18	1.1e-20	93	1.65	358	0.47	3.55	ESR_open
69	15	MA1125.1 (ZNF384)	MEME-3	WWTTTTTWTWWTTTT	WWTTTTTWTWWTTTT	ZNF384	1.75e-18	1.83e-20	1630	28.9	17800	23.2	1.24	ESR_open
70	3	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	1.82e-18	1.88e-20	2140	38	24400	31.8	1.19	ESR_open
71	11	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	1.95e-18	1.99e-20	2440	43.2	28300	36.9	1.17	ESR_open
72	7	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	2.65e-18	2.66e-20	507	8.97	4380	5.71	1.57	ESR_open
73	3	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	4.01e-18	3.97e-20	1560	27.7	17000	22.2	1.25	ESR_open
74	13	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	2.12e-17	2.07e-19	4400	77.9	55500	72.4	1.08	ESR_open
75	13	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	2.73e-17	2.62e-19	4160	73.6	51900	67.8	1.09	ESR_open
76	11	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	8.18e-17	7.77e-19	4870	86.2	62500	81.5	1.06	ESR_open
77	16	9-ATKHYWRDMAT	STREME-9	9-ATKHYWRDMAT	ATKHYWRDMAT	ATKHYWRDMAT	1.58e-16	1.48e-18	1090	19.3	11300	14.7	1.31	ESR_open
78	11	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	2.3e-16	2.12e-18	4720	83.6	60300	78.7	1.06	ESR_open
79	11	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	5.79e-16	5.29e-18	2400	42.4	28000	36.5	1.16	ESR_open
80	17	MA0052.4 (MEF2A)	STREME-8	8-AHAAATATTTT	AHAAATATTTT	MEF2A	6.45e-16	5.81e-18	728	12.9	7030	9.17	1.41	ESR_open
81	3	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	1.31e-15	1.16e-17	4120	72.8	51600	67.3	1.08	ESR_open
82	11	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	1.81e-15	1.59e-17	1340	23.7	14400	18.8	1.26	ESR_open
83	7	MA0059.1	MAX::MYC	MA0059.1	RASCACGTGGT	MAX::MYC	2.99e-15	2.6e-17	2040	36.1	23400	30.5	1.18	ESR_open
84	11	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	3.82e-15	3.27e-17	4200	74.4	52900	69	1.08	ESR_open
85	11	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	3.85e-15	3.27e-17	1640	29	18300	23.8	1.22	ESR_open
86	11	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	6.74e-15	5.65e-17	2550	45.1	30100	39.3	1.15	ESR_open
87	11	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	9.6e-15	7.96e-17	4230	74.9	53400	69.6	1.08	ESR_open
88	18	MA0804.1	TBX19	MA0804.1	DTTMRCACMTAGGTGTGAAW	TBX19	7.04e-14	5.77e-16	1610	28.4	18000	23.5	1.21	ESR_open
89	11	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	3.59e-13	2.91e-15	728	12.9	7250	9.46	1.36	ESR_open
90	7	MA0818.2	BHLHE22	MA0818.2	AMCATATGKY	BHLHE22	6.01e-13	4.82e-15	1720	30.4	19500	25.5	1.19	ESR_open
91	7	MA0827.1	OLIG3	MA0827.1	AMCATATGBY	OLIG3	1.36e-12	1.08e-14	1960	34.8	22800	29.7	1.17	ESR_open
92	11	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	2.83e-12	2.22e-14	2420	42.9	28800	37.6	1.14	ESR_open
93	11	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	7.65e-12	5.94e-14	2680	47.5	32400	42.2	1.12	ESR_open
94	7	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	1.34e-11	1.03e-13	172	3.04	1200	1.56	1.96	ESR_open
95	7	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	1.97e-11	1.5e-13	123	2.18	744	0.97	2.26	ESR_open
96	19	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	4.16e-11	3.12e-13	2020	35.7	23700	30.9	1.16	ESR_open
97	11	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	5.6e-11	4.17e-13	2090	37	24700	32.2	1.15	ESR_open
98	13	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	5.83e-11	4.29e-13	3940	69.7	49700	64.9	1.07	ESR_open
99	11	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	6.5e-11	4.74e-13	4120	72.9	52300	68.2	1.07	ESR_open
100	20	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	6.95e-11	5.01e-13	3810	67.4	47900	62.5	1.08	ESR_open
101	11	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	7.26e-11	5.19e-13	4970	88	64700	84.4	1.04	ESR_open
102	11	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	9.65e-11	6.83e-13	5370	95.1	71000	92.6	1.03	ESR_open
103	21	CTCCCRARKWGCTGG	MEME-5	CTCCCRARKWGCTGG	CTCCCRARKWGCTGG	CTCCCRARKWGCTGG	1.42e-10	9.93e-13	181	3.2	1320	1.72	1.87	ESR_open
104	7	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	2.16e-10	1.5e-12	274	4.85	2290	2.99	1.63	ESR_open
105	22	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	2.25e-10	1.55e-12	3960	70.1	50200	65.5	1.07	ESR_open
106	18	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	2.91e-10	1.98e-12	3840	68	48500	63.3	1.07	ESR_open
107	23	MA1602.1	ZSCAN29	MA1602.1	YGTCTACRCNGN	ZSCAN29	3.97e-10	2.68e-12	1830	32.4	21400	27.9	1.16	ESR_open
108	11	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	4.18e-10	2.8e-12	1750	30.9	20300	26.5	1.17	ESR_open
109	3	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	5.13e-10	3.4e-12	2880	51	35300	46	1.11	ESR_open
110	3	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	7.31e-10	4.8e-12	2210	39.2	26400	34.5	1.14	ESR_open
111	11	MA0030.1	FOXF2	MA0030.1	BNAASGTAAACAAD	FOXF2	7.73e-10	5.03e-12	1230	21.7	13700	17.9	1.22	ESR_open
112	19	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	1.86e-09	1.2e-11	1430	25.4	16400	21.4	1.19	ESR_open
113	7	MA0817.1	BHLHE23	MA0817.1	AAACATATGBTN	BHLHE23	5.14e-09	3.28e-11	1150	20.3	12800	16.7	1.22	ESR_open
114	2	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	8.81e-09	5.58e-11	4540	80.4	58700	76.6	1.05	ESR_open
115	7	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	2.16e-08	1.35e-10	205	3.63	1660	2.17	1.68	ESR_open
116	18	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	3.28e-08	2.04e-10	524	9.27	5270	6.88	1.35	ESR_open
117	24	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	3.5e-08	2.16e-10	1660	29.4	19500	25.4	1.16	ESR_open
118	25	TGGCTCAYGCCTGTA	MEME-9	TGGCTCAYGCCTGTA	TGGCTCAYGCCTGTA	TGGCTCAYGCCTGTA	7.52e-08	4.6e-10	178	3.15	1410	1.83	1.73	ESR_open
119	11	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	8.28e-08	5.02e-10	3080	54.5	38400	50.1	1.09	ESR_open
120	7	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	1.79e-07	1.08e-09	489	8.65	4920	6.42	1.35	ESR_open
121	11	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	5.6e-07	3.34e-09	2200	38.8	26700	34.8	1.12	ESR_open
122	14	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	8.1e-07	4.79e-09	1000	17.7	11300	14.7	1.21	ESR_open
123	26	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	1.35e-06	7.89e-09	777	13.8	8500	11.1	1.24	ESR_open
124	7	MA0825.1	MNT	MA0825.1	RVCACGTGMH	MNT	2.3e-06	1.34e-08	3630	64.3	46200	60.4	1.07	ESR_open
125	11	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	4.25e-06	2.45e-08	4320	76.5	56000	73.1	1.05	ESR_open
126	7	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	5.09e-06	2.92e-08	172	3.04	1430	1.87	1.64	ESR_open
127	21	12-GCACTTTGGGAGGC	STREME-12	12-GCACTTTGGGAGGC	12-GCACTTTGGGAGGC	GCACTTTGGGAGGC	5.58e-06	3.17e-08	65	1.15	377	0.49	2.37	ESR_open
128	11	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	5.91e-06	3.33e-08	1940	34.4	23600	30.7	1.12	ESR_open
129	20	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	6.92e-06	3.87e-08	3290	58.3	41700	54.4	1.07	ESR_open
130	7	MA0871.2	TFEC	MA0871.2	NVCACGTGACN	TFEC	1.09e-05	6.05e-08	1320	23.4	15500	20.3	1.16	ESR_open
131	3	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	1.18e-05	6.5e-08	4300	76	55700	72.7	1.05	ESR_open
132	7	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	1.35e-05	7.38e-08	511	9.04	5370	7	1.29	ESR_open
133	20	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	1.73e-05	9.4e-08	3530	62.5	45000	58.8	1.06	ESR_open
134	7	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	2.65e-05	1.43e-07	1540	27.3	18500	24.1	1.14	ESR_open
135	2	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	2.75e-05	1.47e-07	358	6.34	3580	4.67	1.36	ESR_open
136	7	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	2.97e-05	1.58e-07	276	4.88	2630	3.43	1.43	ESR_open
137	7	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	5.08e-05	2.68e-07	238	4.21	2220	2.89	1.46	ESR_open
138	7	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	6.86e-05	3.59e-07	299	5.29	2920	3.82	1.39	ESR_open
139	7	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	7.65e-05	3.97e-07	2170	38.4	26800	35	1.1	ESR_open
140	11	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	7.72e-05	3.98e-07	1830	32.5	22300	29.1	1.11	ESR_open
141	18	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	9.54e-05	4.88e-07	1220	21.6	14400	18.7	1.15	ESR_open
142	11	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	0.000128	6.5e-07	3190	56.4	40500	52.9	1.07	ESR_open
143	7	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	0.000204	1.03e-06	3000	53.1	38000	49.6	1.07	ESR_open
144	14	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	0.000226	1.13e-06	528	9.35	5710	7.45	1.26	ESR_open
145	7	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	0.000259	1.28e-06	1170	20.7	13800	18	1.15	ESR_open
146	7	MA0826.1	OLIG1	MA0826.1	AMCATATGKT	OLIG1	0.00026	1.28e-06	536	9.49	5820	7.59	1.25	ESR_open
147	7	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	0.000303	1.49e-06	2760	48.8	34800	45.4	1.08	ESR_open
148	7	MA1559.1	SNAI3	MA1559.1	RRCAGGTGYA	SNAI3	0.000437	2.12e-06	1540	27.3	18600	24.3	1.12	ESR_open
149	13	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	0.000439	2.12e-06	2300	40.8	28700	37.5	1.09	ESR_open
150	13	MA0619.1	LIN54	MA0619.1	DTTTRAATH	LIN54	0.000714	3.44e-06	750	13.3	8530	11.1	1.19	ESR_open
151	7	MA1621.1	Rbpjl	MA1621.1	NNVACACCTGTBNN	Rbpjl	0.000781	3.73e-06	1120	19.8	13200	17.2	1.15	ESR_open
152	24	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	0.000829	3.94e-06	4610	81.6	60500	78.9	1.03	ESR_open
153	26	MA0660.1	MEF2B	MA0660.1	RCTAWAAATAGC	MEF2B	0.00105	4.96e-06	861	15.2	9960	13	1.17	ESR_open
154	3	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	0.00118	5.52e-06	2280	40.4	28600	37.2	1.08	ESR_open
155	7	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	0.00129	5.99e-06	398	7.04	4220	5.5	1.28	ESR_open
156	2	MA0002.2	Runx1	MA0002.2	BBYTGTGGTTT	Runx1	0.00151	6.96e-06	3710	65.6	47900	62.5	1.05	ESR_open
157	27	13-GTCTCTACTAAAA	STREME-13	13-GTCTCTACTAAAA	13-GTCTCTACTAAAA	GTCTCTACTAAAA	0.00163	7.49e-06	221	3.91	2140	2.79	1.41	ESR_open
158	3	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	0.00164	7.49e-06	2630	46.6	33300	43.4	1.07	ESR_open
159	14	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	0.00263	1.19e-05	501	8.87	5510	7.19	1.24	ESR_open
160	28	MA1546.1	PAX3	MA1546.1	YSGTCACGSYWATTAN	PAX3	0.00283	1.28e-05	3270	57.8	42000	54.7	1.06	ESR_open
161	29	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	0.00313	1.4e-05	3020	53.4	38600	50.3	1.06	ESR_open
162	14	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	0.00322	1.44e-05	2010	35.6	25100	32.7	1.09	ESR_open
163	30	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	0.00551	2.44e-05	1730	30.6	21400	27.9	1.1	ESR_open
164	7	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	0.00597	2.63e-05	2260	39.9	28400	37	1.08	ESR_open
165	31	MA1580.1	ZBTB32	MA1580.1	TGTACAGTAW	ZBTB32	0.0132	5.78e-05	1340	23.8	16400	21.4	1.11	ESR_open
24	34	TTGAGSYCAGGAGTT	MEME-12	TTGAGSYCAGGAGTT	TTGAGSYCAGGAGTT	TTGAGSYCAGGAGTT	0.0135	0.000562	46	0.81	357	0.47	1.78	ESR_open
166	22	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	0.0151	6.56e-05	5140	91.1	68500	89.3	1.02	ESR_open
167	32	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	0.0174	7.53e-05	3570	63.2	46300	60.4	1.05	ESR_open
168	7	MA0692.1	TFEB	MA0692.1	RYCACGTGAC	TFEB	0.0192	8.23e-05	3140	55.6	40500	52.8	1.05	ESR_open
169	19	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	0.0283	0.000121	2080	36.8	26200	34.1	1.08	ESR_open
170	19	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	0.0285	0.000121	589	10.4	6760	8.81	1.18	ESR_open
171	32	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	0.0308	0.00013	4570	80.8	60200	78.6	1.03	ESR_open
172	33	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	0.0449	0.000188	1450	25.6	17900	23.3	1.1	ESR_open
173	18	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	0.0483	0.000201	368	6.51	4040	5.27	1.24	ESR_open
25	35	MA0090.3 (TEAD1)	MEME-10	AGGCTGGAGTGCAGT	AGGCTGGAGTGCAGT	TEAD1	2.57	0.103	177	3.13	2170	2.83	1.11	ESR_open

ER_rat <- 1.25
mrc_type <- "ESR_open"
ESR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_open-1.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*10), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./10,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_open-2.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_close data

ESR_close_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_close_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_close_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_close_sea_all <- rbind(ESR_close_sea_disc, ESR_close_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

ESR_close_combo <- ESR_close_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_close_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_close")

ESR_close_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0774.1 (MEIS2)	STREME-1	1-CTGWCAG	CTGWCAG	MEIS2	2.24e-135	1.58e-135	4660	65.3	38300	49.9	1.31	ESR_close
2	1	MA0797.1 (TGIF2)	STREME-10	10-SCTGTCA	10-SCTGTCA	TGIF2	4.08e-118	1.44e-118	2640	37	18400	24	1.54	ESR_close
3	2	MA1653.1 (ZNF148)	STREME-2	2-CCCWSCCC	CCCWSCCC	ZNF148	1.01e-112	2.38e-113	5030	70.4	43500	56.8	1.24	ESR_close
4	1	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	5.18e-111	9.15e-112	3170	44.3	23700	30.9	1.43	ESR_close
5	3	MA1565.1 (TBX18)	STREME-6	6-CACCTCY	CACCTCY	TBX18	7.08e-93	1e-93	2870	40.2	21600	28.2	1.43	ESR_close
6	2	MA1522.1 (MAZ)	MEME-1	GRGGWGGRGGSAGGG	GRGGWGGRGGSAGGG	MAZ	3.53e-90	4.16e-91	2790	39.1	21000	27.4	1.43	ESR_close
7	4	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	8.13e-84	8.2e-85	2890	40.4	22200	29	1.4	ESR_close
8	4	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	4.77e-70	4.21e-71	2520	35.3	19300	25.2	1.4	ESR_close
9	5	3-CAGSCTG	STREME-3	3-CAGSCTG	CAGSCTG	CAGSCTG	1.78e-67	1.32e-68	2560	35.9	19900	25.9	1.39	ESR_close
10	6	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	1.87e-67	1.32e-68	813	11.4	4300	5.61	2.03	ESR_close
11	7	MA0808.1 (TEAD3)	MEME-3	SWGGVAKG	SWGGVAKG	TEAD3	2.03e-65	1.31e-66	4150	58.1	36300	47.4	1.23	ESR_close
12	8	MA1645.1 (NKX2-2)	STREME-11	11-CCTCTCA	11-CCTCTCA	NKX2-2	1.84e-62	1.08e-63	5290	74	49200	64.2	1.15	ESR_close
13	4	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	2.3e-60	1.25e-61	1070	15	6600	8.61	1.75	ESR_close
14	4	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	5.84e-57	2.95e-58	3960	55.5	34800	45.4	1.22	ESR_close
15	1	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	6.44e-57	3.03e-58	2220	31	17100	22.3	1.39	ESR_close
16	1	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	8.27e-57	3.65e-58	4000	56	35200	45.9	1.22	ESR_close
17	9	GCYCTGRG	MEME-9	GCYCTGRG	GCYCTGRG	GCYCTGRG	3.94e-56	1.64e-57	2870	40.2	23500	30.7	1.31	ESR_close
18	4	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	1.37e-55	5.38e-57	2600	36.5	20900	27.3	1.34	ESR_close
19	6	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	1.78e-55	6.6e-57	828	11.6	4750	6.2	1.87	ESR_close
20	4	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	7.04e-54	2.48e-55	6200	86.8	60700	79.2	1.09	ESR_close
21	4	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	1.4e-53	4.71e-55	2290	32.1	18000	23.5	1.37	ESR_close
22	10	MA1721.1 (ZNF93)	MEME-2	CWGCAGCH	CWGCAGCH	ZNF93	3.38e-53	1.08e-54	3480	48.8	30000	39.2	1.25	ESR_close
23	4	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	9.97e-53	3.06e-54	4470	62.6	40600	53	1.18	ESR_close
24	11	4-AGGCCAG	STREME-4	4-AGGCCAG	AGGCCAG	AGGCCAG	2.38e-52	6.99e-54	6140	86	60200	78.5	1.1	ESR_close
25	4	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	2.12e-50	5.99e-52	4450	62.4	40600	53	1.18	ESR_close
26	12	MA1726.1 (ZNF331)	STREME-8	8-AGKGCC	AGKGCC	ZNF331	2.46e-50	6.67e-52	2400	33.6	19200	25	1.34	ESR_close
27	4	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	2.88e-50	7.54e-52	4310	60.3	39000	50.9	1.19	ESR_close
28	4	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	8.38e-50	2.11e-51	4540	63.6	41600	54.3	1.17	ESR_close
29	4	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	1.54e-48	3.75e-50	4240	59.4	38400	50.2	1.19	ESR_close
30	4	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	4.47e-48	1.05e-49	2730	38.2	22600	29.5	1.29	ESR_close
31	13	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	3.63e-46	8.27e-48	6280	87.9	62200	81.2	1.08	ESR_close
32	4	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	1.78e-45	3.92e-47	4160	58.3	37800	49.3	1.18	ESR_close
33	14	MA0672.1 (NKX2-3)	STREME-7	7-CCACTTGA	CCACTTGA	NKX2-3	5.33e-45	1.14e-46	941	13.2	6040	7.87	1.67	ESR_close
34	4	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	1.6e-43	3.31e-45	4400	61.7	40600	52.9	1.17	ESR_close
35	4	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	4.24e-43	8.55e-45	4650	65.1	43300	56.5	1.15	ESR_close
36	15	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	9.76e-43	1.88e-44	4090	57.3	37200	48.6	1.18	ESR_close
37	4	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	9.84e-43	1.88e-44	4340	60.8	39900	52	1.17	ESR_close
38	16	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	3.1e-42	5.76e-44	5440	76.2	52400	68.4	1.12	ESR_close
39	4	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	4.46e-42	8.08e-44	3120	43.7	27000	35.3	1.24	ESR_close
40	14	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	2.56e-40	4.51e-42	1040	14.6	7120	9.29	1.58	ESR_close
41	14	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	1.36e-37	2.34e-39	1700	23.8	13300	17.3	1.38	ESR_close
42	4	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	2.58e-37	4.34e-39	4900	68.6	46500	60.7	1.13	ESR_close
43	17	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	4.97e-37	8.17e-39	4310	60.4	40100	52.3	1.16	ESR_close
44	1	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	3.19e-36	5.13e-38	2200	30.9	18200	23.8	1.3	ESR_close
45	4	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	3.57e-35	5.6e-37	6220	87.1	62200	81.2	1.07	ESR_close
46	18	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	9.15e-34	1.4e-35	5980	83.7	59400	77.5	1.08	ESR_close
47	19	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	1.57e-33	2.35e-35	4850	67.9	46300	60.4	1.12	ESR_close
48	20	MA1728.1 (ZNF549)	STREME-16	16-CTGCCCAC	16-CTGCCCAC	ZNF549	1.04e-32	1.53e-34	3210	45	28700	37.4	1.2	ESR_close
49	4	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	6.01e-32	8.66e-34	5600	78.4	55000	71.7	1.09	ESR_close
50	37	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	1.05e-30	1.49e-32	3190	44.6	28600	37.3	1.2	ESR_close
51	21	MA1981.1 (ZNF530)	MEME-5	CAGRGSCWGGG	CAGRGSCWGGG	ZNF530	2.47e-30	3.43e-32	948	13.3	6720	8.77	1.51	ESR_close
52	22	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	1.13e-29	1.54e-31	5660	79.3	55900	72.9	1.09	ESR_close
53	23	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	2.83e-29	3.77e-31	4280	59.9	40400	52.7	1.14	ESR_close
54	24	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	1.12e-28	1.47e-30	6560	91.8	66900	87.3	1.05	ESR_close
55	4	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	1.24e-28	1.59e-30	4030	56.4	37700	49.2	1.15	ESR_close
56	6	MA0739.1	Hic1	MA0739.1	RTGCCAACY	Hic1	3.74e-28	4.72e-30	2440	34.1	21100	27.6	1.24	ESR_close
57	25	MA0154.4 (EBF1)	STREME-9	9-CCCWGGG	CCCWGGG	EBF1	7.82e-28	9.69e-30	901	12.6	6430	8.39	1.51	ESR_close
58	26	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	9.18e-28	1.12e-29	6560	91.8	67000	87.4	1.05	ESR_close
59	27	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	1.32e-26	1.58e-28	5630	78.8	55800	72.8	1.08	ESR_close
60	28	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	7.04e-26	8.15e-28	6250	87.6	63300	82.6	1.06	ESR_close
61	29	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	7.04e-26	8.15e-28	4230	59.3	40200	52.4	1.13	ESR_close
62	24	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	8.11e-26	9.24e-28	6780	94.9	70000	91.4	1.04	ESR_close
63	30	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	1.26e-25	1.41e-27	4840	67.8	46900	61.2	1.11	ESR_close
64	14	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	2.39e-24	2.64e-26	1110	15.5	8520	11.1	1.4	ESR_close
65	24	MA0816.1	Ascl2	MA0816.1	ARCAGCTGCY	Ascl2	5.45e-24	5.92e-26	4590	64.3	44300	57.8	1.11	ESR_close
66	18	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	1.85e-23	1.98e-25	6420	89.9	65500	85.5	1.05	ESR_close
67	24	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	2.7e-23	2.84e-25	1290	18	10200	13.4	1.35	ESR_close
68	50	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	5.31e-23	5.52e-25	6400	89.7	65400	85.3	1.05	ESR_close
69	24	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	5.6e-23	5.73e-25	6100	85.5	61700	80.5	1.06	ESR_close
70	18	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	7.1e-23	7.16e-25	5870	82.2	59000	76.9	1.07	ESR_close
71	13	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	3.07e-22	3.05e-24	1220	17.1	9690	12.6	1.35	ESR_close
72	5	CCAGSCWG	MEME-6	CCAGSCWG	CCAGSCWG	CCAGSCWG	4.12e-22	4.05e-24	766	10.7	5520	7.2	1.49	ESR_close
73	31	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	4.3e-22	4.15e-24	4770	66.7	46400	60.6	1.1	ESR_close
74	32	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	1.09e-21	1.04e-23	3470	48.6	32500	42.4	1.15	ESR_close
75	33	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	3.77e-21	3.55e-23	4230	59.2	40600	53	1.12	ESR_close
76	1	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	1.28e-20	1.19e-22	3000	42	27600	36	1.17	ESR_close
77	4	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	1.47e-20	1.35e-22	6580	92.2	67800	88.4	1.04	ESR_close
78	34	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	5.38e-20	4.87e-22	6470	90.6	66400	86.6	1.05	ESR_close
79	35	MA0842.2 (NRL)	STREME-13	13-AAGTCTGCTGAAGC	13-AAGTCTGCTGAAGC	NRL	8.16e-20	7.29e-22	30	0.42	13	0.02	23.8	ESR_close
80	24	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	1.24e-19	1.1e-21	1110	15.5	8800	11.5	1.35	ESR_close
81	36	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	1.43e-19	1.25e-21	4620	64.8	45100	58.9	1.1	ESR_close
82	37	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	2.37e-19	2.04e-21	2480	34.7	22300	29.2	1.19	ESR_close
83	6	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	2.57e-19	2.18e-21	5610	78.6	56300	73.5	1.07	ESR_close
84	1	MA0796.1	TGIF1	MA0796.1	TGACAGCTGTCA	TGIF1	2.61e-19	2.19e-21	240	3.36	1240	1.62	2.09	ESR_close
85	24	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	5.47e-19	4.54e-21	1090	15.3	8710	11.4	1.35	ESR_close
86	4	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	9.01e-19	7.4e-21	3780	52.9	36000	47	1.13	ESR_close
87	24	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	1.04e-18	8.45e-21	3730	52.2	35500	46.4	1.13	ESR_close
88	24	MA0521.2	Tcf12	MA0521.2	NNACAGCTGTNN	Tcf12	2.06e-17	1.66e-19	1370	19.2	11500	15	1.28	ESR_close
89	37	MA0482.2 (GATA4)	STREME-5	5-CAGATAAGG	CAGATAAGG	GATA4	3.9e-17	3.09e-19	469	6.57	3160	4.12	1.6	ESR_close
90	38	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	4.12e-17	3.24e-19	6120	85.7	62400	81.4	1.05	ESR_close
91	20	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	5.44e-17	4.18e-19	6160	86.3	63000	82.2	1.05	ESR_close
92	6	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	5.45e-17	4.18e-19	227	3.18	1200	1.57	2.03	ESR_close
93	6	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	5.74e-17	4.36e-19	2550	35.7	23400	30.5	1.17	ESR_close
94	23	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	6.07e-17	4.56e-19	2850	39.9	26500	34.5	1.16	ESR_close
95	23	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	9.03e-17	6.71e-19	6090	85.3	62200	81.1	1.05	ESR_close
96	34	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	9.49e-17	6.98e-19	4190	58.6	40700	53.1	1.1	ESR_close
97	24	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	3.02e-16	2.2e-18	839	11.8	6520	8.5	1.38	ESR_close
98	39	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	3.34e-16	2.4e-18	4780	66.9	47200	61.6	1.09	ESR_close
99	23	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	3.98e-16	2.84e-18	4770	66.8	47200	61.6	1.09	ESR_close
100	14	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	6.97e-16	4.92e-18	3290	46.1	31200	40.7	1.13	ESR_close
101	50	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	1.13e-15	7.88e-18	6460	90.5	66700	87	1.04	ESR_close
102	26	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	1.54e-15	1.07e-17	6570	92	68100	88.8	1.04	ESR_close
103	4	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	1.74e-15	1.19e-17	4480	62.7	44000	57.4	1.09	ESR_close
104	24	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	2.36e-15	1.6e-17	6150	86.2	63000	82.2	1.05	ESR_close
105	14	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	2.54e-15	1.71e-17	488	6.83	3410	4.44	1.54	ESR_close
106	1	MA0783.1	PKNOX2	MA0783.1	TGACAGGTGTCA	PKNOX2	2.93e-15	1.95e-17	191	2.67	980	1.28	2.1	ESR_close
107	40	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	1.7e-14	1.12e-16	6750	94.6	70400	91.9	1.03	ESR_close
108	41	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	3.93e-14	2.57e-16	6740	94.4	70300	91.7	1.03	ESR_close
109	23	MA0745.2	SNAI2	MA0745.2	NBGCACCTGTMNY	SNAI2	5.8e-14	3.76e-16	6000	84.1	61400	80.1	1.05	ESR_close
110	42	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	7.36e-14	4.73e-16	4550	63.7	45000	58.7	1.09	ESR_close
111	34	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	2.51e-13	1.6e-15	6450	90.3	66800	87.1	1.04	ESR_close
112	4	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	3.99e-13	2.52e-15	5900	82.6	60200	78.6	1.05	ESR_close
113	24	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	4.07e-13	2.54e-15	4400	61.6	43400	56.6	1.09	ESR_close
114	31	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	6.97e-13	4.31e-15	961	13.5	7910	10.3	1.31	ESR_close
115	1	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	8.75e-13	5.38e-15	2850	39.9	27000	35.2	1.14	ESR_close
116	43	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	1.38e-12	8.43e-15	5260	73.6	53000	69.2	1.06	ESR_close
117	28	MA0504.1	NR2C2	MA0504.1	VGRGGTCARAGGTCA	NR2C2	2.07e-12	1.25e-14	3150	44.1	30100	39.3	1.12	ESR_close
118	18	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	2.15e-12	1.29e-14	4650	65.1	46300	60.4	1.08	ESR_close
119	24	MA1641.1	MYF5	MA1641.1	NVACAGCTGTBN	MYF5	9.78e-12	5.8e-14	2410	33.8	22500	29.4	1.15	ESR_close
120	24	MA0048.2	NHLH1	MA0048.2	CGCAGCTGCK	NHLH1	1.46e-11	8.6e-14	1820	25.5	16500	21.5	1.18	ESR_close
121	23	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	1.53e-11	8.92e-14	5590	78.3	56900	74.2	1.05	ESR_close
122	44	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	2.2e-11	1.27e-13	3620	50.6	35200	46	1.1	ESR_close
123	34	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	3.71e-11	2.13e-13	5160	72.3	52100	68	1.06	ESR_close
124	24	MA1472.2	Bhlha15	MA1472.2	NVACAGCTGTBN	Bhlha15	4.55e-11	2.58e-13	1850	25.9	16900	22	1.18	ESR_close
125	28	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	4.56e-11	2.58e-13	4490	62.9	44700	58.4	1.08	ESR_close
126	45	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	5.73e-11	3.21e-13	5970	83.6	61400	80.1	1.04	ESR_close
127	24	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	1.05e-10	5.86e-13	1910	26.8	17500	22.9	1.17	ESR_close
128	23	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	1.64e-10	9.04e-13	4360	61.1	43400	56.7	1.08	ESR_close
129	23	MA1558.1	SNAI1	MA1558.1	DRCAGGTGYD	SNAI1	1.66e-10	9.04e-13	4750	66.5	47700	62.2	1.07	ESR_close
130	24	MA0500.2	MYOG	MA0500.2	NDRCAGCTGYHN	MYOG	1.66e-10	9.04e-13	981	13.7	8300	10.8	1.27	ESR_close
131	23	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	2.11e-10	1.14e-12	1760	24.7	16100	21	1.18	ESR_close
132	46	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	2.35e-10	1.25e-12	1380	19.3	12200	15.9	1.21	ESR_close
133	47	14-CTTATAGATAAAA	STREME-14	14-CTTATAGATAAAA	14-CTTATAGATAAAA	CTTATAGATAAAA	3.18e-10	1.69e-12	20	0.28	15	0.02	14.1	ESR_close
134	48	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	3.86e-10	2.04e-12	675	9.45	5410	7.06	1.34	ESR_close
135	50	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	4.27e-10	2.23e-12	6680	93.6	69900	91.2	1.03	ESR_close
136	30	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	6.61e-10	3.43e-12	4830	67.6	48600	63.4	1.07	ESR_close
137	30	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	1.04e-09	5.36e-12	5850	81.9	60100	78.4	1.04	ESR_close
138	49	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	1.47e-09	7.53e-12	6930	97.1	73100	95.4	1.02	ESR_close
139	24	MA1109.1	NEUROD1	MA1109.1	NRACAGATGGYNN	NEUROD1	1.51e-09	7.69e-12	6060	84.9	62600	81.7	1.04	ESR_close
140	50	MA0697.2 (Zic3)	STREME-15	15-CAGCAGG	15-CAGCAGG	Zic3	1.62e-09	8.15e-12	7050	98.7	74700	97.4	1.01	ESR_close
141	51	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	2.15e-09	1.08e-11	5100	71.4	51700	67.5	1.06	ESR_close
142	52	MA1153.1	Smad4	MA1153.1	TGTCTRGM	Smad4	5.78e-09	2.87e-11	1430	20	12800	16.8	1.19	ESR_close
143	1	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	7.92e-09	3.91e-11	537	7.52	4220	5.51	1.37	ESR_close
144	24	MA1559.1	SNAI3	MA1559.1	RRCAGGTGYA	SNAI3	1.58e-08	7.73e-11	4200	58.9	42000	54.8	1.07	ESR_close
145	23	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	2.71e-08	1.32e-10	2140	29.9	20200	26.3	1.14	ESR_close
146	37	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	2.79e-08	1.35e-10	1090	15.3	9620	12.6	1.22	ESR_close
147	37	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	3e-08	1.44e-10	2140	30	20200	26.3	1.14	ESR_close
148	37	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	3.79e-08	1.81e-10	880	12.3	7540	9.84	1.25	ESR_close
149	53	MA1600.1	ZNF684	MA1600.1	RYACAGTCCACCCCTTKR	ZNF684	5.73e-08	2.72e-10	1930	27.1	18100	23.6	1.15	ESR_close
150	54	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	5.87e-08	2.77e-10	6490	90.9	67800	88.5	1.03	ESR_close
151	23	MA1566.2	TBX3	MA1566.2	RAGGTGTGAAV	TBX3	6.16e-08	2.88e-10	4740	66.3	47900	62.5	1.06	ESR_close
152	26	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	9.32e-08	4.33e-10	6700	93.8	70300	91.8	1.02	ESR_close
153	38	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	1.28e-07	5.89e-10	6350	89	66200	86.4	1.03	ESR_close
154	26	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	1.49e-07	6.84e-10	6750	94.5	70900	92.5	1.02	ESR_close
155	37	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	1.67e-07	7.59e-10	2080	29.1	19600	25.6	1.13	ESR_close
156	6	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	2.52e-07	1.14e-09	146	2.04	865	1.13	1.82	ESR_close
157	24	MA1100.2	ASCL1	MA1100.2	VGCAGCTGCN	ASCL1	2.9e-07	1.31e-09	6980	97.8	73900	96.4	1.01	ESR_close
158	55	MA0831.3	TFE3	MA0831.3	GTCACGTGAC	TFE3	3.5e-07	1.57e-09	1430	20	13100	17	1.17	ESR_close
159	56	MA1726.1	ZNF331	MA1726.1	NMYTGCAGAGCCCH	ZNF331	3.8e-07	1.69e-09	6100	85.4	63300	82.6	1.03	ESR_close
160	6	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	7.05e-07	3.11e-09	1920	26.8	18100	23.6	1.14	ESR_close
161	23	MA0690.2	TBX21	MA0690.2	TTTCACACCTT	TBX21	9.44e-07	4.14e-09	3990	55.9	40000	52.2	1.07	ESR_close
162	57	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	1.04e-06	4.53e-09	2960	41.4	29000	37.8	1.1	ESR_close
163	24	MA0820.1	FIGLA	MA0820.1	WMCACCTGKW	FIGLA	2.73e-06	1.18e-08	4690	65.7	47700	62.2	1.06	ESR_close
164	24	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	4.49e-06	1.93e-08	1570	21.9	14600	19.1	1.15	ESR_close
165	58	MA0059.1 (MAX::MYC)	STREME-12	12-ACAGAGCACCTGG	12-ACAGAGCACCTGG	MAX::MYC	5.41e-06	2.32e-08	13	0.18	10	0.01	13.7	ESR_close
166	48	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	5.81e-06	2.47e-08	4240	59.4	42900	55.9	1.06	ESR_close
167	24	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	7.4e-06	3.13e-08	5960	83.4	61900	80.7	1.03	ESR_close
168	37	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	1.66e-05	6.96e-08	1830	25.6	17400	22.7	1.13	ESR_close
169	49	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	2.09e-05	8.73e-08	1170	16.4	10700	14	1.17	ESR_close
170	33	MA0130.1	ZNF354C	MA0130.1	MTCCAC	ZNF354C	2.44e-05	1.01e-07	2390	33.5	23300	30.3	1.1	ESR_close
171	59	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	4.28e-05	1.77e-07	2310	32.4	22500	29.4	1.1	ESR_close
172	60	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	0.000114	4.67e-07	1370	19.1	12800	16.7	1.15	ESR_close
173	24	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	0.000162	6.59e-07	1080	15.1	9920	12.9	1.17	ESR_close
174	46	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	0.000184	7.45e-07	373	5.22	3020	3.94	1.33	ESR_close
175	28	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	0.00019	7.67e-07	3220	45.1	32200	42	1.07	ESR_close
176	61	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	0.000193	7.73e-07	4580	64.2	46900	61.1	1.05	ESR_close
177	62	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	0.000253	1.01e-06	5930	83	61800	80.6	1.03	ESR_close
178	40	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	0.000367	1.46e-06	5460	76.5	56600	73.8	1.04	ESR_close
179	15	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	0.000424	1.67e-06	2580	36.1	25400	33.2	1.09	ESR_close
180	63	MA0065.2	Pparg::Rxra	MA0065.2	STRGGGCARAGGKCA	Pparg::Rxra	0.000435	1.71e-06	4380	61.4	44700	58.4	1.05	ESR_close
181	24	MA1619.1	Ptf1A	MA1619.1	NNACAGCTGTNN	Ptf1A	0.00049	1.91e-06	2630	36.8	26000	34	1.09	ESR_close
182	59	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	0.000635	2.47e-06	4920	68.9	50700	66.1	1.04	ESR_close
183	24	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	0.00108	4.15e-06	5320	74.5	55100	71.9	1.04	ESR_close
184	24	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	0.00118	4.53e-06	3210	44.9	32200	42	1.07	ESR_close
185	24	MA0692.1	TFEB	MA0692.1	RYCACGTGAC	TFEB	0.00125	4.76e-06	1310	18.3	12400	16.2	1.14	ESR_close
186	18	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	0.00161	6.1e-06	1670	23.4	16100	21.1	1.11	ESR_close
187	64	17-CTCTGAAGAGAGCAG	STREME-17	17-CTCTGAAGAGAGCAG	17-CTCTGAAGAGAGCAG	CTCTGAAGAGAGCAG	0.00192	7.26e-06	84	1.18	503	0.66	1.81	ESR_close
188	23	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	0.00199	7.47e-06	1260	17.6	11900	15.5	1.14	ESR_close
189	28	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	0.00245	9.16e-06	6400	89.6	67300	87.8	1.02	ESR_close
190	65	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	0.00361	1.34e-05	6790	95	71800	93.8	1.01	ESR_close
191	66	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	0.00398	1.47e-05	4510	63.2	46400	60.5	1.04	ESR_close
192	67	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	0.00406	1.49e-05	3710	52	37700	49.2	1.06	ESR_close
193	66	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	0.00415	1.52e-05	6280	87.9	65900	86	1.02	ESR_close
194	23	MA1565.1	TBX18	MA1565.1	DRAGGTGTGAAR	TBX18	0.00784	2.85e-05	3810	53.4	38900	50.7	1.05	ESR_close
195	1	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	0.0082	2.97e-05	129	1.81	905	1.18	1.54	ESR_close
196	48	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	0.00898	3.24e-05	317	4.44	2630	3.43	1.3	ESR_close
197	65	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	0.0107	3.85e-05	619	8.67	5570	7.27	1.19	ESR_close
198	18	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	0.0111	3.96e-05	1750	24.4	17100	22.2	1.1	ESR_close
199	23	MA1621.1	Rbpjl	MA1621.1	NNVACACCTGTBNN	Rbpjl	0.0115	4.09e-05	4500	63	46300	60.5	1.04	ESR_close
200	18	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	0.0131	4.64e-05	1630	22.9	15900	20.7	1.1	ESR_close
201	28	MA0730.1	RARA	MA0730.1	AGGTCAHSYAAAGGTCA	RARA	0.0137	4.82e-05	106	1.48	718	0.94	1.6	ESR_close
202	39	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	0.0153	5.36e-05	5800	81.2	60700	79.2	1.03	ESR_close
203	66	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	0.0163	5.66e-05	982	13.8	9240	12	1.14	ESR_close
204	68	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	0.0195	6.74e-05	3670	51.3	37400	48.8	1.05	ESR_close
205	54	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	0.0229	7.89e-05	6860	96	72800	94.9	1.01	ESR_close
206	65	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	0.0294	0.000101	6900	96.6	73300	95.6	1.01	ESR_close
207	59	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	0.0301	0.000103	5010	70.1	52000	67.8	1.03	ESR_close
208	65	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	0.0377	0.000128	6950	97.4	74000	96.5	1.01	ESR_close
209	48	MA1468.1	ATOH7	MA1468.1	AVCATATGBY	ATOH7	0.0407	0.000137	6420	89.9	67700	88.3	1.02	ESR_close
210	48	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	0.043	0.000144	5340	74.8	55700	72.6	1.03	ESR_close
211	69	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	0.0488	0.000163	3990	55.9	41000	53.5	1.04	ESR_close
24	70	MA1731.1 (ZNF768)	MEME-8	WCTYTCTCTCTCTCT	WCTYTCTCTCTCTCT	ZNF768	0.456	0.019	312	4.37	2950	3.85	1.14	ESR_close
25	71	MA1107.2 (KLF9)	MEME-7	TGTGTGTGTGTGTGT	TGTGTGTGTGTGTGT	KLF9	1.16	0.0462	846	11.8	8560	11.2	1.06	ESR_close
26	72	MA1125.1 (ZNF384)	MEME-4	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	18.7	0.72	47	0.66	546	0.71	0.942	ESR_close

ER_rat <- 1.25
mrc_type <- "ESR_close"
ESR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_close-1.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.75), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.75,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_close-2.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_opcl data

ESR_opcl_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_opcl_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_opcl_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_opcl_sea_all <- rbind(ESR_opcl_sea_disc, ESR_opcl_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

ESR_opcl_combo <- ESR_opcl_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_opcl_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_opcl")

ESR_opcl_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0808.1 (TEAD3)	MEME-1	TGGAATKY	TGGAATKY	TEAD3	7.39e-12	5.4e-12	76	41.5	13100	17.1	2.44	ESR_opcl
2	2	MA1580.1 (ZBTB32)	STREME-2	2-TACAGT	TACAGT	ZBTB32	4.25e-08	1.12e-08	165	90.2	53600	70	1.29	ESR_opcl
3	3	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	4.61e-08	1.12e-08	154	84.2	47600	62.1	1.36	ESR_opcl
4	4	5-ATTAGAA	STREME-5	5-ATTAGAA	ATTAGAA	ATTAGAA	5.33e-07	8.69e-08	165	90.2	54800	71.4	1.26	ESR_opcl
5	1	MA0090.3 (TEAD1)	STREME-3	3-ATTCCATAM	ATTCCATAM	TEAD1	5.94e-07	8.69e-08	149	81.4	46200	60.3	1.35	ESR_opcl
6	5	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	8.16e-07	9.94e-08	152	83.1	47900	62.5	1.33	ESR_opcl
7	3	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	2.72e-06	2.85e-07	121	66.1	34100	44.5	1.49	ESR_opcl
8	1	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	1e-05	9.18e-07	89	48.6	22000	28.8	1.7	ESR_opcl
9	6	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	2.21e-05	1.79e-06	162	88.5	54800	71.5	1.24	ESR_opcl
10	7	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	3.81e-05	2.6e-06	135	73.8	41600	54.3	1.36	ESR_opcl
11	8	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	3.91e-05	2.6e-06	165	90.2	56800	74.1	1.22	ESR_opcl
12	3	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	8.09e-05	4.93e-06	165	90.2	57100	74.6	1.21	ESR_opcl
13	1	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	0.000122	6.88e-06	66	36.1	15000	19.6	1.86	ESR_opcl
14	9	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	0.000146	7.61e-06	123	67.2	37000	48.2	1.4	ESR_opcl
15	3	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	0.000244	1.12e-05	106	57.9	30100	39.3	1.48	ESR_opcl
16	8	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	0.000244	1.12e-05	140	76.5	44900	58.6	1.31	ESR_opcl
17	10	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	0.000322	1.38e-05	154	84.2	51900	67.8	1.24	ESR_opcl
18	11	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	0.000402	1.63e-05	113	61.8	33300	43.4	1.43	ESR_opcl
6	23	4-VWWDTAHWWB	STREME-4	4-VWWDTAHWWB	VWWDTAHWWB	VWWDTAHWWB	0.000454	7.56e-05	73	39.9	20500	26.7	1.5	ESR_opcl
19	12	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	0.000513	1.97e-05	136	74.3	43500	56.7	1.31	ESR_opcl
20	5	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	0.000628	2.3e-05	135	73.8	43100	56.3	1.31	ESR_opcl
21	13	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	0.000806	2.81e-05	153	83.6	51900	67.8	1.24	ESR_opcl
22	13	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	0.000905	3.01e-05	140	76.5	45700	59.6	1.29	ESR_opcl
23	10	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	0.000978	3.11e-05	154	84.2	52500	68.6	1.23	ESR_opcl
24	10	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	0.00112	3.33e-05	158	86.3	54700	71.4	1.21	ESR_opcl
25	14	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	0.00114	3.33e-05	133	72.7	42600	55.5	1.31	ESR_opcl
26	13	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	0.00177	4.99e-05	164	89.6	58200	75.9	1.18	ESR_opcl
27	15	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	0.00189	5.13e-05	107	58.5	31700	41.3	1.42	ESR_opcl
28	13	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	0.00198	5.18e-05	121	66.1	37600	49	1.35	ESR_opcl
29	8	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	0.00238	6.01e-05	151	82.5	51500	67.3	1.23	ESR_opcl
30	13	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	0.00266	6.48e-05	135	73.8	44000	57.4	1.29	ESR_opcl
31	16	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	0.00282	6.66e-05	117	63.9	36100	47.1	1.36	ESR_opcl
32	10	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	0.00371	8.47e-05	128	70	41000	53.5	1.31	ESR_opcl
33	8	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	0.0039	8.64e-05	133	72.7	43300	56.5	1.29	ESR_opcl
34	8	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	0.00461	9.91e-05	150	82	51400	67.1	1.22	ESR_opcl
35	8	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	0.00505	0.000105	91	49.7	25800	33.7	1.48	ESR_opcl
36	17	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	0.00567	0.000115	163	89.1	58300	76.1	1.17	ESR_opcl
37	5	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	0.00596	0.000118	156	85.2	54600	71.3	1.2	ESR_opcl
38	8	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	0.00619	0.000119	166	90.7	60000	78.3	1.16	ESR_opcl
39	13	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	0.00686	0.000129	165	90.2	59500	77.6	1.16	ESR_opcl
40	13	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	0.00713	0.00013	133	72.7	43700	57	1.28	ESR_opcl
41	8	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	0.00808	0.000144	135	73.8	44700	58.3	1.27	ESR_opcl
42	8	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	0.00835	0.000145	148	80.9	50800	66.3	1.22	ESR_opcl
43	13	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	0.0118	2e-04	117	63.9	37000	48.2	1.33	ESR_opcl
44	13	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	0.0133	0.000221	114	62.3	35800	46.7	1.34	ESR_opcl
45	5	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	0.0143	0.000231	171	93.4	63400	82.7	1.13	ESR_opcl
46	13	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	0.0145	0.000231	101	55.2	30400	39.7	1.4	ESR_opcl
47	18	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	0.0184	0.000287	131	71.6	43400	56.6	1.27	ESR_opcl
48	19	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	0.0223	0.000339	120	65.6	38700	50.5	1.3	ESR_opcl
49	20	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	0.0234	0.000349	160	87.4	57500	75.1	1.17	ESR_opcl
50	21	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	0.0247	0.000357	54	29.5	13200	17.2	1.74	ESR_opcl
51	8	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	0.0253	0.000357	79	43.2	22200	28.9	1.5	ESR_opcl
52	17	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	0.0257	0.000357	127	69.4	41800	54.6	1.27	ESR_opcl
53	22	1-MAWWTK	STREME-1	1-MAWWTK	MAWWTK	MAWWTK	0.0259	0.000357	102	55.7	31200	40.7	1.37	ESR_opcl
54	17	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	0.029	0.000392	110	60.1	34600	45.1	1.34	ESR_opcl
55	7	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	0.0307	0.000408	88	48.1	25700	33.6	1.44	ESR_opcl
56	12	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	0.0319	0.000417	114	62.3	36300	47.4	1.32	ESR_opcl
57	13	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	0.0331	0.000424	124	67.8	40700	53.1	1.28	ESR_opcl
58	9	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	0.0369	0.000465	98	53.6	29800	38.9	1.38	ESR_opcl
59	8	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	0.0394	0.000489	161	88	58400	76.2	1.16	ESR_opcl
60	8	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	0.043	0.000523	170	92.9	63400	82.7	1.12	ESR_opcl
61	8	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	0.0454	0.000544	146	79.8	51000	66.5	1.2	ESR_opcl
62	8	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	0.0463	0.000545	156	85.2	55900	73	1.17	ESR_opcl
63	5	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	0.047	0.000545	142	77.6	49100	64	1.21	ESR_opcl

ER_rat <- 1.25
mrc_type <- "ESR_opcl"
ESR_opcl_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_opcl-1.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_opcl_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*.1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_opcl-2.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_clop data

ESR_clop_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_clop_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_clop_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_clop_sea_all <- rbind(ESR_clop_sea_disc, ESR_clop_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

ESR_clop_combo <- ESR_clop_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_clop_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_clop")

ESR_clop_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1138.1 (FOSL2::JUNB)	MEME-1	TGASTCAT	TGASTCAT	FOSL2::JUNB	6.64e-111	3.58e-111	342	53.2	11200	14.6	3.64	ESR_clop
2	1	MA1134.1 (FOS::JUNB)	STREME-1	1-DVTGASTCABH	DVTGASTCABH	FOS::JUNB	1.11e-108	3e-109	321	49.9	9920	12.9	3.86	ESR_clop
3	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	4.53e-106	8.14e-107	308	47.9	9250	12.1	3.98	ESR_clop
4	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	7.21e-100	9.73e-101	325	50.5	11000	14.4	3.53	ESR_clop
5	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	6.71e-97	7.23e-98	327	50.9	11400	14.9	3.41	ESR_clop
6	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	6.26e-96	5.63e-97	312	48.5	10400	13.6	3.57	ESR_clop
7	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	9.26e-96	7.13e-97	283	44	8440	11	4	ESR_clop
8	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	1.09e-95	7.34e-97	296	46	9320	12.2	3.79	ESR_clop
9	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	1.5e-95	8.96e-97	288	44.8	8790	11.5	3.91	ESR_clop
10	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	2.34e-95	1.26e-96	319	49.6	11000	14.3	3.47	ESR_clop
11	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	9.45e-95	4.64e-96	309	48.1	10300	13.5	3.58	ESR_clop
12	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	2.03e-93	9.11e-95	309	48.1	10400	13.6	3.53	ESR_clop
13	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	5.96e-93	2.47e-94	287	44.6	8950	11.7	3.83	ESR_clop
14	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	2.88e-92	1.11e-93	319	49.6	11300	14.7	3.37	ESR_clop
15	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	1.4e-91	5.03e-93	275	42.8	8260	10.8	3.97	ESR_clop
16	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	1.01e-90	3.42e-92	272	42.3	8140	10.6	3.99	ESR_clop
17	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	1.57e-90	4.98e-92	358	55.7	14600	19	2.93	ESR_clop
18	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	3.54e-90	1.06e-91	267	41.5	7860	10.3	4.06	ESR_clop
19	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	1.72e-88	4.87e-90	390	60.6	17700	23	2.63	ESR_clop
20	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	8.49e-88	2.29e-89	269	41.8	8190	10.7	3.92	ESR_clop
21	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	1.19e-85	3.06e-87	385	59.9	17600	22.9	2.61	ESR_clop
22	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	4.19e-85	1.03e-86	255	39.7	7510	9.8	4.06	ESR_clop
23	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	2.89e-83	6.77e-85	264	41.1	8260	10.8	3.82	ESR_clop
24	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	1.11e-81	2.5e-83	294	45.7	10500	13.7	3.34	ESR_clop
25	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	6.96e-81	1.5e-82	240	37.3	6910	9.02	4.15	ESR_clop
26	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	7.34e-80	1.52e-81	296	46	10800	14.2	3.26	ESR_clop
27	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	1.49e-77	2.97e-79	293	45.6	10900	14.2	3.22	ESR_clop
28	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	4.35e-76	8.38e-78	215	33.4	5780	7.54	4.45	ESR_clop
29	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	1.58e-52	2.93e-54	360	56	20300	26.5	2.11	ESR_clop
30	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	1.21e-45	2.17e-47	304	47.3	16200	21.1	2.24	ESR_clop
31	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	8.08e-40	1.41e-41	252	39.2	12600	16.4	2.39	ESR_clop
32	2	MA1970.1 (TRPS1)	STREME-2	2-WAGATRABNWA	WAGATRABNWA	TRPS1	1.26e-38	2.12e-40	344	53.5	21500	28	1.91	ESR_clop
33	1	MA0676.1 (Nr2e1)	STREME-3	3-AGTCAW	AGTCAW	Nr2e1	2.34e-37	3.82e-39	515	80.1	42200	55	1.46	ESR_clop
34	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	1.52e-34	2.41e-36	161	25	6250	8.16	3.08	ESR_clop
35	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	6.19e-33	9.53e-35	477	74.2	38300	50	1.49	ESR_clop
36	2	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	5.56e-25	8.33e-27	372	57.8	28000	36.5	1.59	ESR_clop
37	2	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	8.37e-24	1.22e-25	334	51.9	24100	31.5	1.65	ESR_clop
38	2	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	2.28e-22	3.24e-24	588	91.4	57900	75.6	1.21	ESR_clop
39	3	MA0018.4 (CREB1)	STREME-4	4-ACATCA	ACATCA	CREB1	5.02e-22	6.95e-24	447	69.5	37900	49.4	1.41	ESR_clop
40	4	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	5.22e-22	7.04e-24	513	79.8	46600	60.8	1.31	ESR_clop
41	2	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	5.51e-22	7.25e-24	445	69.2	37600	49.1	1.41	ESR_clop
42	5	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	6.83e-22	8.77e-24	524	81.5	48200	62.9	1.3	ESR_clop
43	6	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	3.83e-21	4.81e-23	539	83.8	50600	66	1.27	ESR_clop
44	5	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	5.5e-21	6.74e-23	411	63.9	33800	44.1	1.45	ESR_clop
45	7	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	7.56e-21	9.06e-23	588	91.4	58400	76.2	1.2	ESR_clop
46	8	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	9.14e-21	1.07e-22	565	87.9	54700	71.4	1.23	ESR_clop
47	7	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	9.41e-21	1.08e-22	483	75.1	42900	56	1.34	ESR_clop
48	2	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	1.23e-20	1.39e-22	460	71.5	40000	52.2	1.37	ESR_clop
49	5	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	1.26e-20	1.39e-22	535	83.2	50200	65.5	1.27	ESR_clop
50	5	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	1.44e-20	1.55e-22	480	74.6	42600	55.6	1.34	ESR_clop
51	9	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	8.37e-20	8.85e-22	485	75.4	43500	56.8	1.33	ESR_clop
52	5	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	1.42e-19	1.47e-21	472	73.4	41900	54.7	1.34	ESR_clop
53	10	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	1.67e-19	1.7e-21	534	83	50500	65.8	1.26	ESR_clop
54	5	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	1.76e-19	1.76e-21	550	85.5	52800	68.9	1.24	ESR_clop
55	11	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	2.22e-19	2.17e-21	567	88.2	55500	72.4	1.22	ESR_clop
56	5	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	3.73e-19	3.55e-21	592	92.1	59700	77.8	1.18	ESR_clop
57	5	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	3.75e-19	3.55e-21	608	94.6	62500	81.6	1.16	ESR_clop
58	5	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	5.66e-19	5.27e-21	591	91.9	59500	77.7	1.18	ESR_clop
59	12	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	8.36e-19	7.63e-21	559	86.9	54400	71	1.22	ESR_clop
60	5	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	8.49e-19	7.63e-21	431	67	37000	48.3	1.39	ESR_clop
61	13	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	1.06e-18	9.37e-21	612	95.2	63400	82.8	1.15	ESR_clop
62	4	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	2.15e-18	1.84e-20	482	75	43700	57	1.32	ESR_clop
63	12	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	2.15e-18	1.84e-20	629	97.8	67100	87.5	1.12	ESR_clop
64	12	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	2.65e-18	2.24e-20	630	98	67300	87.8	1.12	ESR_clop
65	12	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	4.17e-18	3.46e-20	610	94.9	63200	82.5	1.15	ESR_clop
66	5	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	1.11e-17	9.06e-20	467	72.6	42000	54.8	1.33	ESR_clop
67	5	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	1.42e-17	1.14e-19	574	89.3	57200	74.7	1.2	ESR_clop
68	5	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	1.68e-17	1.33e-19	599	93.2	61400	80.2	1.16	ESR_clop
69	10	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	2.38e-17	1.86e-19	594	92.4	60600	79.1	1.17	ESR_clop
70	5	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	3.87e-17	2.98e-19	496	77.1	46000	60	1.29	ESR_clop
71	5	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	6.05e-17	4.59e-19	491	76.4	45400	59.3	1.29	ESR_clop
72	6	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	6.88e-17	5.15e-19	499	77.6	46500	60.7	1.28	ESR_clop
73	5	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	8.18e-17	6.04e-19	596	92.7	61100	79.8	1.16	ESR_clop
74	2	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	1.02e-16	7.44e-19	596	92.7	61200	79.8	1.16	ESR_clop
75	2	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	1.07e-16	7.71e-19	452	70.3	40400	52.8	1.33	ESR_clop
76	5	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	1.28e-16	9.05e-19	576	89.6	57900	75.5	1.19	ESR_clop
77	5	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	1.38e-16	9.64e-19	621	96.6	65900	86	1.12	ESR_clop
78	5	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	2.24e-16	1.55e-18	551	85.7	54100	70.6	1.21	ESR_clop
79	14	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	2.99e-16	2.04e-18	451	70.1	40500	52.8	1.33	ESR_clop
80	5	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	3.2e-16	2.16e-18	576	89.6	58000	75.7	1.18	ESR_clop
81	5	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	1.63e-15	1.09e-17	603	93.8	62800	82	1.14	ESR_clop
82	5	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	2.85e-15	1.87e-17	549	85.4	54200	70.8	1.21	ESR_clop
83	5	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	3.03e-15	1.97e-17	510	79.3	48700	63.5	1.25	ESR_clop
84	5	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	5.2e-15	3.34e-17	436	67.8	39100	51	1.33	ESR_clop
85	5	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	5.56e-15	3.53e-17	554	86.2	55100	71.9	1.2	ESR_clop
86	5	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	8.74e-15	5.48e-17	623	96.9	66900	87.2	1.11	ESR_clop
87	5	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	9.45e-15	5.86e-17	547	85.1	54100	70.6	1.2	ESR_clop
88	5	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	1.23e-14	7.53e-17	593	92.2	61400	80.1	1.15	ESR_clop
89	10	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	1.87e-14	1.13e-16	537	83.5	52800	68.9	1.21	ESR_clop
90	5	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	2.25e-14	1.35e-16	616	95.8	65600	85.6	1.12	ESR_clop
91	5	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	2.61e-14	1.52e-16	393	61.1	34100	44.5	1.37	ESR_clop
92	5	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	2.61e-14	1.52e-16	604	93.9	63400	82.7	1.14	ESR_clop
93	5	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	2.62e-14	1.52e-16	370	57.5	31400	41	1.41	ESR_clop
94	15	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	2.92e-14	1.68e-16	569	88.5	57700	75.2	1.18	ESR_clop
95	5	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	3.72e-14	2.11e-16	607	94.4	64000	83.5	1.13	ESR_clop
96	10	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	4.71e-14	2.65e-16	515	80.1	49900	65	1.23	ESR_clop
97	5	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	1.15e-13	6.42e-16	601	93.5	63100	82.3	1.14	ESR_clop
98	12	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	1.55e-13	8.53e-16	588	91.4	61000	79.5	1.15	ESR_clop
99	5	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	1.69e-13	9.19e-16	607	94.4	64200	83.8	1.13	ESR_clop
100	5	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	1.94e-13	1.05e-15	621	96.6	66900	87.3	1.11	ESR_clop
101	10	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	2.33e-13	1.25e-15	552	85.8	55400	72.3	1.19	ESR_clop
102	13	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	3.35e-13	1.77e-15	588	91.4	61100	79.7	1.15	ESR_clop
103	12	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	3.6e-13	1.89e-15	484	75.3	46000	60.1	1.25	ESR_clop
104	5	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	3.75e-13	1.94e-15	522	81.2	51200	66.8	1.22	ESR_clop
105	5	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	3.97e-13	2.04e-15	565	87.9	57500	75	1.17	ESR_clop
106	1	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	4.74e-13	2.41e-15	292	45.4	23200	30.2	1.51	ESR_clop
107	16	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	5.49e-13	2.77e-15	600	93.3	63200	82.4	1.13	ESR_clop
108	5	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	5.97e-13	2.98e-15	603	93.8	63700	83.1	1.13	ESR_clop
109	17	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	6.69e-13	3.31e-15	602	93.6	63600	82.9	1.13	ESR_clop
110	5	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	7.8e-13	3.82e-15	560	87.1	56800	74.2	1.17	ESR_clop
111	12	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	7.93e-13	3.85e-15	590	91.8	61600	80.3	1.14	ESR_clop
112	5	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	8.9e-13	4.29e-15	556	86.5	56300	73.4	1.18	ESR_clop
113	5	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	1.08e-12	5.13e-15	611	95	65200	85.1	1.12	ESR_clop
114	5	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	1.32e-12	6.26e-15	494	76.8	47600	62.1	1.24	ESR_clop
115	5	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	1.39e-12	6.54e-15	321	49.9	26500	34.6	1.44	ESR_clop
116	5	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	1.56e-12	7.28e-15	501	77.9	48600	63.4	1.23	ESR_clop
117	5	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	1.79e-12	8.26e-15	508	79	49600	64.7	1.22	ESR_clop
118	5	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	2.18e-12	9.95e-15	616	95.8	66300	86.5	1.11	ESR_clop
119	5	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	2.22e-12	1.01e-14	516	80.2	50700	66.2	1.21	ESR_clop
120	5	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	2.33e-12	1.05e-14	521	81	51400	67.1	1.21	ESR_clop
121	18	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	2.44e-12	1.09e-14	545	84.8	54800	71.5	1.19	ESR_clop
122	2	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	3.16e-12	1.4e-14	295	45.9	23800	31.1	1.48	ESR_clop
123	5	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	3.69e-12	1.61e-14	357	55.5	30800	40.2	1.38	ESR_clop
124	5	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	3.71e-12	1.61e-14	604	93.9	64200	83.7	1.12	ESR_clop
125	12	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	3.93e-12	1.69e-14	564	87.7	57700	75.3	1.16	ESR_clop
126	10	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	4.06e-12	1.74e-14	479	74.5	45800	59.8	1.25	ESR_clop
127	5	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	4.13e-12	1.75e-14	567	88.2	58200	75.9	1.16	ESR_clop
128	5	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	4.47e-12	1.88e-14	417	64.8	38000	49.6	1.31	ESR_clop
129	12	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	5.64e-12	2.36e-14	625	97.2	68200	89	1.09	ESR_clop
130	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	6.87e-12	2.85e-14	296	46	24100	31.4	1.47	ESR_clop
131	12	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	7.55e-12	3.11e-14	618	96.1	66800	87.2	1.1	ESR_clop
132	5	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	8.21e-12	3.36e-14	533	82.9	53300	69.6	1.19	ESR_clop
133	12	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	8.94e-12	3.62e-14	597	92.8	63100	82.4	1.13	ESR_clop
134	5	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	1.55e-11	6.22e-14	620	96.4	67300	87.8	1.1	ESR_clop
135	6	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	1.67e-11	6.66e-14	343	53.3	29500	38.5	1.39	ESR_clop
136	5	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	2e-11	7.93e-14	618	96.1	67000	87.4	1.1	ESR_clop
137	5	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	3.48e-11	1.37e-13	564	87.7	58100	75.8	1.16	ESR_clop
138	5	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	3.85e-11	1.51e-13	589	91.6	62000	81	1.13	ESR_clop
139	5	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	3.96e-11	1.54e-13	404	62.8	36800	48.1	1.31	ESR_clop
140	9	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	9.48e-11	3.65e-13	382	59.4	34400	44.8	1.33	ESR_clop
141	5	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	1.04e-10	4e-13	501	77.9	49400	64.5	1.21	ESR_clop
142	6	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	1.24e-10	4.7e-13	338	52.6	29300	38.2	1.38	ESR_clop
143	5	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	1.39e-10	5.25e-13	381	59.2	34300	44.8	1.32	ESR_clop
144	19	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	1.5e-10	5.6e-13	573	89.1	59800	78	1.14	ESR_clop
145	5	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	1.65e-10	6.13e-13	540	84	54900	71.6	1.17	ESR_clop
146	20	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	1.89e-10	6.97e-13	533	82.9	53900	70.4	1.18	ESR_clop
147	12	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	2.61e-10	9.58e-13	494	76.8	48700	63.5	1.21	ESR_clop
148	10	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	2.84e-10	1.03e-12	512	79.6	51100	66.7	1.19	ESR_clop
149	5	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	4.61e-10	1.67e-12	423	65.8	39700	51.8	1.27	ESR_clop
150	17	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	6.44e-10	2.31e-12	512	79.6	51300	66.9	1.19	ESR_clop
151	21	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	8.88e-10	3.17e-12	237	36.9	18600	24.3	1.52	ESR_clop
152	12	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	1.16e-09	4.12e-12	495	77	49100	64.1	1.2	ESR_clop
153	5	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	1.38e-09	4.85e-12	594	92.4	63500	82.8	1.12	ESR_clop
154	5	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	1.78e-09	6.22e-12	437	68	41700	54.4	1.25	ESR_clop
155	11	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	2.65e-09	9.22e-12	586	91.1	62300	81.3	1.12	ESR_clop
156	5	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	3.66e-09	1.26e-11	579	90	61300	80	1.13	ESR_clop
157	5	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	3.94e-09	1.35e-11	547	85.1	56500	73.8	1.15	ESR_clop
158	12	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	7.81e-09	2.67e-11	465	72.3	45600	59.5	1.22	ESR_clop
159	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	1.05e-08	3.57e-11	184	28.6	13600	17.8	1.62	ESR_clop
160	10	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	1.13e-08	3.8e-11	496	77.1	49700	64.9	1.19	ESR_clop
161	22	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	1.23e-08	4.11e-11	563	87.6	59100	77.1	1.14	ESR_clop
162	5	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	1.48e-08	4.93e-11	286	44.5	24400	31.8	1.4	ESR_clop
163	19	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	1.6e-08	5.29e-11	618	96.1	68000	88.7	1.08	ESR_clop
164	21	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	1.87e-08	6.15e-11	452	70.3	44100	57.6	1.22	ESR_clop
165	5	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	2.22e-08	7.27e-11	428	66.6	41100	53.7	1.24	ESR_clop
166	10	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	2.84e-08	9.24e-11	541	84.1	56100	73.2	1.15	ESR_clop
167	5	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	2.88e-08	9.31e-11	532	82.7	54800	71.6	1.16	ESR_clop
168	17	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	3.67e-08	1.18e-10	468	72.8	46300	60.4	1.21	ESR_clop
169	17	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	4.22e-08	1.35e-10	499	77.6	50400	65.8	1.18	ESR_clop
170	21	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	4.59e-08	1.46e-10	547	85.1	57100	74.4	1.14	ESR_clop
171	21	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	5.15e-08	1.62e-10	523	81.3	53700	70.1	1.16	ESR_clop
172	23	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	5.6e-08	1.76e-10	286	44.5	24700	32.2	1.38	ESR_clop
173	24	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	5.79e-08	1.81e-10	598	93	64800	84.6	1.1	ESR_clop
174	5	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	6.21e-08	1.92e-10	583	90.7	62400	81.5	1.11	ESR_clop
175	20	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	8.84e-08	2.72e-10	571	88.8	60700	79.2	1.12	ESR_clop
176	13	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	1.32e-07	4.06e-10	585	91	62900	82.1	1.11	ESR_clop
177	11	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	4.76e-07	1.45e-09	392	61	37400	48.9	1.25	ESR_clop
178	5	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	7.06e-07	2.14e-09	397	61.7	38100	49.8	1.24	ESR_clop
179	9	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	7.54e-07	2.27e-09	411	63.9	39900	52	1.23	ESR_clop
180	13	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	7.67e-07	2.3e-09	537	83.5	56300	73.4	1.14	ESR_clop
181	21	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	8.59e-07	2.56e-09	433	67.3	42600	55.6	1.21	ESR_clop
182	21	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	1.09e-06	3.24e-09	400	62.2	38600	50.4	1.24	ESR_clop
183	21	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	1.17e-06	3.45e-09	528	82.1	55100	71.9	1.14	ESR_clop
184	5	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	1.22e-06	3.56e-09	499	77.6	51200	66.8	1.16	ESR_clop
185	20	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	2.12e-06	6.17e-09	79	12.3	4600	6	2.07	ESR_clop
186	13	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	2.71e-06	7.85e-09	468	72.8	47400	61.8	1.18	ESR_clop
187	1	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	3.23e-06	9.32e-09	366	56.9	34800	45.4	1.25	ESR_clop
188	25	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	3.27e-06	9.38e-09	553	86	58800	76.8	1.12	ESR_clop
189	5	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	4.09e-06	1.17e-08	329	51.2	30500	39.8	1.29	ESR_clop
190	24	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	4.27e-06	1.21e-08	575	89.4	62100	81	1.1	ESR_clop
191	5	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	5.23e-06	1.47e-08	500	77.8	51700	67.4	1.15	ESR_clop
192	5	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	5.25e-06	1.47e-08	408	63.4	40000	52.2	1.22	ESR_clop
193	13	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	5.27e-06	1.47e-08	406	63.1	39800	51.9	1.22	ESR_clop
194	17	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	5.53e-06	1.54e-08	259	40.3	22700	29.6	1.36	ESR_clop
195	17	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	8.66e-06	2.39e-08	530	82.4	55900	72.9	1.13	ESR_clop
196	5	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	1.14e-05	3.13e-08	603	93.8	66600	86.9	1.08	ESR_clop
197	26	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	1.38e-05	3.77e-08	440	68.4	44200	57.7	1.19	ESR_clop
198	27	MA1581.1 (ZBTB6)	MEME-11	CCTGGGCTCAAGYRA	CCTGGGCTCAAGYRA	ZBTB6	1.56e-05	4.24e-08	23	3.58	648	0.85	4.4	ESR_clop
199	5	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	1.76e-05	4.78e-08	521	81	54800	71.5	1.13	ESR_clop
200	9	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	1.85e-05	4.99e-08	244	38	21300	27.8	1.37	ESR_clop
201	23	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	2.12e-05	5.69e-08	550	85.5	58900	76.8	1.11	ESR_clop
202	28	MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	2.52e-05	6.73e-08	247	38.4	21700	28.4	1.36	ESR_clop
203	4	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	2.63e-05	6.99e-08	255	39.7	22600	29.5	1.35	ESR_clop
204	17	MA0838.1	CEBPG	MA0838.1	ATTRCGCAAY	CEBPG	3.11e-05	8.23e-08	83	12.9	5250	6.86	1.9	ESR_clop
205	12	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	3.17e-05	8.35e-08	362	56.3	34900	45.6	1.24	ESR_clop
206	19	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	3.7e-05	9.68e-08	399	62	39400	51.4	1.21	ESR_clop
207	5	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	4.14e-05	1.08e-07	342	53.2	32600	42.6	1.25	ESR_clop
208	29	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	4.25e-05	1.1e-07	169	26.3	13600	17.7	1.49	ESR_clop
209	5	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	5.03e-05	1.3e-07	464	72.2	47600	62.1	1.16	ESR_clop
210	12	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	5.72e-05	1.47e-07	356	55.4	34400	44.9	1.24	ESR_clop
211	19	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	6.82e-05	1.74e-07	413	64.2	41300	53.9	1.19	ESR_clop
212	30	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	7.6e-05	1.93e-07	599	93.2	66400	86.6	1.08	ESR_clop
213	19	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	7.69e-05	1.94e-07	426	66.2	42900	56	1.18	ESR_clop
214	28	MA1125.1 (ZNF384)	STREME-7	7-AGAAAAAAAAAW	AGAAAAAAAAAW	ZNF384	7.71e-05	1.94e-07	68	10.6	4060	5.3	2.02	ESR_clop
215	19	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	8.82e-05	2.21e-07	594	92.4	65600	85.6	1.08	ESR_clop
216	13	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	0.000102	2.55e-07	535	83.2	57200	74.6	1.12	ESR_clop
217	26	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	0.000125	3.12e-07	500	77.8	52500	68.5	1.14	ESR_clop
218	18	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	0.000149	3.69e-07	283	44	26200	34.2	1.29	ESR_clop
219	12	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	0.00015	3.7e-07	346	53.8	33500	43.7	1.23	ESR_clop
220	31	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	0.000197	4.82e-07	575	89.4	63000	82.2	1.09	ESR_clop
221	5	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	0.000238	5.81e-07	396	61.6	39600	51.6	1.19	ESR_clop
222	5	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	0.000298	7.24e-07	333	51.8	32100	41.9	1.24	ESR_clop
223	5	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	0.000365	8.82e-07	313	48.7	29900	39	1.25	ESR_clop
224	32	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	0.000382	9.21e-07	431	67	44000	57.4	1.17	ESR_clop
225	5	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	0.000608	1.46e-06	540	84	58300	76.1	1.1	ESR_clop
226	33	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	0.000612	1.46e-06	365	56.8	36100	47.2	1.21	ESR_clop
227	26	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	0.000618	1.47e-06	268	41.7	24900	32.5	1.29	ESR_clop
228	12	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	0.000629	1.49e-06	32	4.98	1400	1.83	2.79	ESR_clop
229	34	MA1973.1 (ZKSCAN3)	MEME-3	TGTYRCCCAGGCTGG	TGTYRCCCAGGCTGG	ZKSCAN3	0.000755	1.78e-06	91	14.2	6420	8.38	1.7	ESR_clop
230	23	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	0.000776	1.82e-06	495	77	52400	68.4	1.13	ESR_clop
231	23	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	0.000932	2.18e-06	540	84	58400	76.2	1.1	ESR_clop
232	19	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	0.000961	2.23e-06	387	60.2	38900	50.8	1.19	ESR_clop
233	35	6-AGGTTGCAAT	STREME-6	6-AGGTTGCAAT	AGGTTGCAAT	AGGTTGCAAT	0.00104	2.41e-06	48	7.47	2670	3.49	2.18	ESR_clop
234	36	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	0.00111	2.55e-06	544	84.6	59000	77	1.1	ESR_clop
235	37	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	0.00115	2.65e-06	436	67.8	45000	58.7	1.16	ESR_clop
236	38	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	0.00117	2.68e-06	539	83.8	58400	76.2	1.1	ESR_clop
237	39	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	0.00164	3.74e-06	325	50.5	31700	41.4	1.22	ESR_clop
238	38	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	0.00173	3.93e-06	577	89.7	63800	83.2	1.08	ESR_clop
239	16	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	0.00192	4.34e-06	334	51.9	32800	42.8	1.21	ESR_clop
240	23	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	0.00198	4.45e-06	482	75	51000	66.5	1.13	ESR_clop
241	40	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	0.00209	4.67e-06	407	63.3	41600	54.3	1.17	ESR_clop
242	23	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	0.00222	4.96e-06	173	26.9	14900	19.4	1.39	ESR_clop
243	1	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	0.00224	4.96e-06	148	23	12300	16	1.45	ESR_clop
244	7	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	0.00231	5.1e-06	279	43.4	26500	34.6	1.26	ESR_clop
245	41	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	0.00238	5.24e-06	625	97.2	71300	93	1.04	ESR_clop
246	23	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	0.00248	5.44e-06	463	72	48600	63.4	1.14	ESR_clop
247	9	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	0.00282	6.16e-06	314	48.8	30600	39.9	1.22	ESR_clop
248	42	8-STAYCTCAT	STREME-8	8-STAYCTCAT	STAYCTCAT	STAYCTCAT	0.00329	7.15e-06	519	80.7	56000	73	1.11	ESR_clop
249	21	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	0.00341	7.38e-06	551	85.7	60300	78.7	1.09	ESR_clop
12	46	GYGAGACYCTGTCTC	MEME-7	GYGAGACYCTGTCTC	GYGAGACYCTGTCTC	GYGAGACYCTGTCTC	0.00344	0.000286	11	1.71	335	0.44	4.25	ESR_clop
250	21	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	0.00349	7.53e-06	240	37.3	22300	29	1.29	ESR_clop
251	23	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	0.00356	7.64e-06	381	59.2	38600	50.4	1.18	ESR_clop
252	17	MA0837.2	CEBPE	MA0837.2	KATTGCGCAATM	CEBPE	0.00366	7.83e-06	95	14.8	7060	9.22	1.62	ESR_clop
253	5	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	0.00369	7.87e-06	266	41.4	25200	32.9	1.26	ESR_clop
254	23	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	0.00381	8.09e-06	120	18.7	9530	12.4	1.51	ESR_clop
255	19	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	0.00387	8.18e-06	518	80.6	55900	72.9	1.11	ESR_clop
256	6	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	0.00396	8.33e-06	136	21.2	11200	14.6	1.46	ESR_clop
257	21	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	0.00418	8.77e-06	123	19.1	9850	12.8	1.5	ESR_clop
258	17	MA0466.3	CEBPB	MA0466.3	KATTGCGCAATM	CEBPB	0.0046	9.61e-06	64	9.95	4220	5.5	1.83	ESR_clop
259	12	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	0.00492	1.03e-05	232	36.1	21500	28	1.29	ESR_clop
260	43	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	0.00505	1.05e-05	112	17.4	8790	11.5	1.53	ESR_clop
13	47	MA0682.2 (PITX1)	MEME-4	GCTGGGATTACAGGC	GCTGGGATTACAGGC	PITX1	0.00531	0.000408	66	10.3	5030	6.57	1.58	ESR_clop
261	13	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	0.00582	1.2e-05	481	74.8	51200	66.8	1.12	ESR_clop
262	5	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	0.00587	1.21e-05	333	51.8	33100	43.1	1.2	ESR_clop
263	5	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	0.00588	1.21e-05	354	55	35500	46.4	1.19	ESR_clop
264	16	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	0.00855	1.75e-05	98	15.2	7510	9.8	1.57	ESR_clop
265	12	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	0.00985	2.01e-05	38	5.91	2080	2.72	2.23	ESR_clop
266	44	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	0.0112	2.26e-05	482	75	51500	67.2	1.12	ESR_clop
267	5	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	0.0114	2.3e-05	195	30.3	17600	23	1.32	ESR_clop
268	12	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	0.0116	2.33e-05	420	65.3	43800	57.1	1.14	ESR_clop
269	23	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	0.0121	2.42e-05	153	23.8	13200	17.2	1.39	ESR_clop
270	5	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	0.0154	3.08e-05	247	38.4	23500	30.6	1.26	ESR_clop
271	21	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	0.0167	3.32e-05	224	34.8	20900	27.3	1.28	ESR_clop
14	48	MA1515.1 (KLF2)	MEME-10	GCYRGGCRTGGTGGC	GCYRGGCRTGGTGGC	KLF2	0.0173	0.00124	28	4.35	1720	2.24	2.01	ESR_clop
272	41	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	0.0189	3.75e-05	583	90.7	65300	85.2	1.06	ESR_clop
273	16	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	0.0242	4.77e-05	406	63.1	42300	55.2	1.15	ESR_clop
274	17	MA0843.1	TEF	MA0843.1	BRTTACRTAAYM	TEF	0.0242	4.77e-05	220	34.2	20600	26.9	1.28	ESR_clop
275	21	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	0.0249	4.89e-05	126	19.6	10500	13.8	1.43	ESR_clop
276	5	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	0.0258	5.04e-05	286	44.5	28100	36.6	1.22	ESR_clop
277	45	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	0.0291	5.66e-05	417	64.8	43700	57	1.14	ESR_clop
278	29	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	0.0304	5.89e-05	611	95	69500	90.7	1.05	ESR_clop
279	23	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	0.0362	6.99e-05	347	54	35300	46.1	1.17	ESR_clop
280	21	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	0.0446	8.59e-05	227	35.3	21600	28.2	1.26	ESR_clop
15	49	MA1107.2 (KLF9)	MEME-8	GTGWGTGTRDRTGTG	GTGWGTGTRDRTGTG	KLF9	0.0519	0.00346	17	2.64	925	1.21	2.31	ESR_clop
16	50	5-ACTCCA	STREME-5	5-ACTCCA	ACTCCA	ACTCCA	0.156	0.00975	568	88.3	65100	85	1.04	ESR_clop
17	35	GCTCACTGCAACCTC	MEME-6	GCTCACTGCAACCTC	GCTCACTGCAACCTC	GCTCACTGCAACCTC	0.377	0.0222	4	0.62	119	0.16	4.96	ESR_clop
18	51	MA1596.1 (ZNF460)	MEME-5	CCTRYCTCWBCCTCY	CCTRYCTCWBCCTCY	ZNF460	0.545	0.0303	402	62.5	45000	58.8	1.07	ESR_clop
19	52	GATYRYRCCACTGCA	MEME-9	GATYRYRCCACTGCA	GATYRYRCCACTGCA	GATYRYRCCACTGCA	19	1	0	0	2	0	39.7	ESR_clop

ER_rat <- 1.25
mrc_type <- "ESR_clop"
ESR_clop_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_clop-1.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

ESR_clop_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of ESR_clop-2.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

LR_open data

LR_open_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
LR_open_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
LR_open_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
LR_open_sea_all <- rbind(LR_open_sea_disc, LR_open_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

LR_open_combo <- LR_open_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., LR_open_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="LR_open")

LR_open_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	DATGASTCATH	FOS::JUNB	0	0	11700	50.9	12000	15.6	3.26	LR_open
2	1	MA1988.1 (Atf3)	MEME-1	DRTGACTCAYH	DRTGACTCAYH	Atf3	0	0	11500	49.9	11500	15.1	3.32	LR_open
3	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	0	0	11600	50.2	12000	15.6	3.22	LR_open
4	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	0	0	12100	52.4	13200	17.3	3.03	LR_open
5	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	0	0	11900	51.6	12800	16.7	3.09	LR_open
6	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	0	0	11100	48	11000	14.3	3.36	LR_open
7	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	0	0	12400	53.7	14100	18.4	2.91	LR_open
8	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	0	0	12400	53.6	14200	18.5	2.9	LR_open
9	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	0	0	10300	44.5	9450	12.3	3.61	LR_open
10	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	0	0	11500	50	12300	16	3.13	LR_open
11	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	0	0	11900	51.7	13200	17.2	3.01	LR_open
12	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	0	0	12100	52.4	13600	17.7	2.95	LR_open
13	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	0	0	10900	47.4	10900	14.3	3.32	LR_open
14	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	0	0	10700	46.4	10400	13.6	3.4	LR_open
15	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	0	0	12000	52	13400	17.5	2.96	LR_open
16	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	0	0	12300	53.4	14300	18.6	2.87	LR_open
17	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	0	0	11700	50.8	12800	16.7	3.04	LR_open
18	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	0	0	11400	49.5	12200	15.9	3.11	LR_open
19	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	0	0	12100	52.6	14000	18.2	2.89	LR_open
20	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	0	0	12700	55	15400	20.1	2.73	LR_open
21	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	0	0	11300	49	12300	16	3.06	LR_open
22	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	0	0	11500	49.7	12700	16.6	2.99	LR_open
23	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	0	0	11600	50.4	13100	17.1	2.95	LR_open
24	1	MA0476.1 (FOS)	STREME-10	10-TGANTCA	10-TGANTCA	FOS	0	0	10600	46.1	10900	14.2	3.24	LR_open
25	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	0	0	10000	43.6	9660	12.6	3.46	LR_open
26	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	0	0	9840	42.7	9300	12.1	3.52	LR_open
27	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	0	0	10800	46.9	12100	15.7	2.98	LR_open
28	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	0	0	9410	40.8	9010	11.8	3.47	LR_open
29	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	0	0	8980	38.9	8420	11	3.54	LR_open
30	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	0	0	12000	52.2	19300	25.1	2.08	LR_open
31	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	0	0	10200	44.2	15000	19.5	2.27	LR_open
32	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	0	0	11600	50.5	19700	25.7	1.97	LR_open
33	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	0	0	10900	47.1	19700	25.7	1.83	LR_open
34	2	2-ATKMAT	STREME-2	2-ATKMAT	ATKMAT	ATKMAT	0	0	17900	77.8	45100	58.9	1.32	LR_open
35	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	0	0	9690	42	18100	23.7	1.78	LR_open
36	3	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	0	0	20300	87.9	55500	72.5	1.21	LR_open
37	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	0	0	17600	76.2	44800	58.4	1.3	LR_open
38	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	0	0	16300	70.7	40200	52.5	1.35	LR_open
39	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	0	0	20000	86.6	54700	71.3	1.21	LR_open
40	4	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	0	0	17700	76.9	45700	59.7	1.29	LR_open
41	5	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	0	0	19800	85.7	54200	70.7	1.21	LR_open
42	6	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	0	0	20300	87.9	56400	73.6	1.19	LR_open
43	7	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	0	0	18700	81.3	50100	65.4	1.24	LR_open
44	8	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	0	0	20000	86.7	55600	72.5	1.2	LR_open
45	8	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	0	0	20000	86.6	55600	72.6	1.19	LR_open
46	9	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	0	0	18300	79.6	49000	63.9	1.24	LR_open
47	9	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	0	0	17200	74.6	44700	58.3	1.28	LR_open
48	7	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	0	0	17600	76.5	46500	60.6	1.26	LR_open
49	6	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	0	0	21100	91.7	61100	79.7	1.15	LR_open
50	10	3-WTVWBAW	STREME-3	3-WTVWBAW	WTVWBAW	WTVWBAW	0	0	21300	92.4	61900	80.8	1.14	LR_open
51	8	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	0	0	21000	91.1	60500	79	1.15	LR_open
52	6	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	0	0	21300	92.2	61800	80.6	1.14	LR_open
53	4	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	0	0	14900	64.8	37000	48.3	1.34	LR_open
54	6	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	0	0	20600	89.4	58900	76.8	1.16	LR_open
55	8	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	0	0	21500	93.1	63000	82.3	1.13	LR_open
56	7	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	0	0	21000	91.1	60900	79.4	1.15	LR_open
57	7	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	0	0	19200	83.4	53200	69.4	1.2	LR_open
58	11	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	0	0	20800	90.4	60100	78.4	1.15	LR_open
59	12	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	0	0	16200	70.5	42000	54.8	1.29	LR_open
60	8	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	0	0	18800	81.7	51800	67.6	1.21	LR_open
61	13	15-HHATDD	STREME-15	15-HHATDD	15-HHATDD	HHATDD	0	0	22000	95.2	65600	85.6	1.11	LR_open
62	7	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	0	0	18800	81.6	51800	67.6	1.21	LR_open
63	4	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	0	0	13300	57.8	32200	42	1.38	LR_open
64	7	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	0	0	19300	83.6	53700	70	1.19	LR_open
65	14	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	0	0	19500	84.5	54600	71.3	1.19	LR_open
66	7	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	0	0	19700	85.6	55700	72.7	1.18	LR_open
67	9	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	0	0	17000	73.9	45200	59	1.25	LR_open
68	8	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	0	0	19800	86	56100	73.2	1.17	LR_open
69	4	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	0	0	12900	56	31000	40.5	1.38	LR_open
70	8	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	0	0	21800	94.4	64900	84.7	1.11	LR_open
71	8	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	0	0	18300	79.2	50000	65.3	1.21	LR_open
72	15	4-TRTAYA	STREME-4	4-TRTAYA	TRTAYA	TRTAYA	0	0	21600	93.7	64300	83.9	1.12	LR_open
73	9	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	0	0	18500	80.1	51000	66.5	1.2	LR_open
74	6	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	0	0	21000	91	61400	80.1	1.14	LR_open
75	7	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	0	0	20400	88.5	58900	76.8	1.15	LR_open
76	7	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	0	0	17900	77.7	48900	63.8	1.22	LR_open
77	8	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	0	0	18700	81	51800	67.6	1.2	LR_open
78	7	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	0	0	18100	78.5	49600	64.7	1.21	LR_open
79	6	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	0	0	20800	90.2	60700	79.2	1.14	LR_open
80	16	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	0	0	21500	93.4	64000	83.6	1.12	LR_open
81	17	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	0	0	19600	84.9	55600	72.6	1.17	LR_open
82	7	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	0	0	18100	78.4	49700	64.9	1.21	LR_open
83	7	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	0	0	20600	89.4	60000	78.3	1.14	LR_open
84	14	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	0	0	20600	89.2	59900	78.1	1.14	LR_open
85	7	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	0	0	16200	70.5	43100	56.2	1.25	LR_open
86	6	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	0	0	21800	94.4	65400	85.4	1.11	LR_open
87	6	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	0	0	21400	92.7	63600	82.9	1.12	LR_open
88	7	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	0	0	18900	81.9	53100	69.3	1.18	LR_open
89	18	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	0	0	20000	86.9	57800	75.4	1.15	LR_open
90	19	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	0	0	21300	92.4	63300	82.6	1.12	LR_open
91	7	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	2.01084717857387e-321	2.01084717857387e-321	15900	68.9	42000	54.8	1.26	LR_open
92	7	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	5.41001882196165e-319	2.46044691628941e-321	20700	90	60900	79.5	1.13	LR_open
93	20	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	2.05000188100679e-318	9.19950232556401e-321	19300	83.8	55000	71.7	1.17	LR_open
94	7	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	3.58000001561162e-316	1.5900020614463e-318	19300	83.7	54900	71.6	1.17	LR_open
95	21	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	9.99999998481684e-316	4.39000053349656e-318	17100	74.1	46400	60.5	1.22	LR_open
96	7	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	1.69000000005259e-314	7.32999991728063e-317	20700	89.8	60800	79.3	1.13	LR_open
97	7	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	1.94000000001886e-313	8.35000002412995e-316	21100	91.6	62600	81.7	1.12	LR_open
98	7	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	1.40999999999996e-311	6.01000000011395e-314	14000	60.5	35500	46.3	1.31	LR_open
99	6	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	1.38e-309	5.80999999999765e-312	21300	92.5	63600	83	1.11	LR_open
100	22	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	3.88e-308	1.61999999999998e-310	17000	73.8	46300	60.5	1.22	LR_open
101	7	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	2.54e-304	1.05e-306	19400	84	55400	72.2	1.16	LR_open
102	6	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	2.59e-300	1.06e-302	18800	81.3	53000	69.2	1.18	LR_open
103	7	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	8.19999999999999e-297	3.32e-299	20200	87.6	58800	76.8	1.14	LR_open
104	6	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	1.66e-296	6.67e-299	20700	89.9	61100	79.8	1.13	LR_open
105	23	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	1.78e-296	7.06e-299	21100	91.5	62800	81.9	1.12	LR_open
106	7	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	1.98e-296	7.78e-299	18400	79.7	51600	67.3	1.18	LR_open
107	16	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	2.79e-296	1.09e-298	21600	93.8	65200	85.1	1.1	LR_open
108	7	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	1.82e-293	7.03e-296	21200	92.2	63500	82.9	1.11	LR_open
109	7	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	5.02e-289	1.92e-291	16000	69.5	43100	56.2	1.24	LR_open
110	7	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	8.62e-289	3.27e-291	18500	80.1	52100	67.9	1.18	LR_open
111	24	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	9.99999999999999e-287	3.77e-289	14600	63.3	38100	49.7	1.27	LR_open
112	14	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	6.55e-286	2.44e-288	19100	82.7	54500	71.1	1.16	LR_open
113	21	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	9.44999999999999e-286	3.49e-288	17500	75.8	48400	63.1	1.2	LR_open
114	7	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	1.93e-285	7.07e-288	18100	78.6	50800	66.3	1.19	LR_open
115	6	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	2.76e-283	1e-285	17300	75.2	47900	62.5	1.2	LR_open
116	7	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	1.07e-282	3.84e-285	16700	72.4	45600	59.5	1.22	LR_open
117	7	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	2.84e-282	1.01e-284	13300	57.8	33900	44.2	1.31	LR_open
118	7	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	2.18e-280	7.7e-283	18500	80	52200	68.1	1.18	LR_open
119	7	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	1.49e-277	5.22e-280	19600	84.9	56700	74	1.15	LR_open
120	25	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	1.54e-275	5.34e-278	21200	92.1	63700	83.1	1.11	LR_open
121	7	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	2.32e-275	8e-278	20100	87.1	58700	76.6	1.14	LR_open
122	7	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	2.37e-275	8.11e-278	20900	90.6	62200	81.2	1.12	LR_open
123	6	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	4.31e-275	1.46e-277	20800	90.4	62000	80.9	1.12	LR_open
124	7	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	8.21e-275	2.76e-277	13200	57.2	33600	43.8	1.3	LR_open
125	25	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	1.45e-273	4.84e-276	21600	93.8	65600	85.5	1.1	LR_open
126	6	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	5.53e-273	1.83e-275	19900	86.4	58100	75.8	1.14	LR_open
127	7	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	4.31e-272	1.41e-274	15700	68	42100	55	1.24	LR_open
128	26	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	1.57e-271	5.1e-274	19300	83.5	55500	72.4	1.15	LR_open
129	7	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	6.84e-269	2.21e-271	15400	67	41400	54	1.24	LR_open
130	6	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	1.23e-268	3.94e-271	20200	87.6	59300	77.4	1.13	LR_open
131	11	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	1.23e-267	3.9e-270	17400	75.6	48600	63.4	1.19	LR_open
132	7	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	1.94e-267	6.12e-270	20600	89.4	61100	79.7	1.12	LR_open
133	27	6-TTAAAA	STREME-6	6-TTAAAA	TTAAAA	TTAAAA	1.28e-265	4.01e-268	22000	95.3	67300	87.8	1.08	LR_open
134	9	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	1.96e-265	6.11e-268	9990	43.3	23600	30.8	1.41	LR_open
135	7	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	2.13e-263	6.57e-266	21900	95	67100	87.5	1.09	LR_open
136	6	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	5.67e-263	1.74e-265	22000	95.5	67600	88.2	1.08	LR_open
137	6	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	1.17e-262	3.57e-265	15300	66.5	41100	53.7	1.24	LR_open
138	7	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	2.74e-262	8.28e-265	14700	63.8	39000	50.9	1.25	LR_open
139	21	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	7.89e-260	2.37e-262	20600	89.3	61200	79.8	1.12	LR_open
140	7	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	1.31e-259	3.89e-262	19400	84	56200	73.3	1.15	LR_open
141	7	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	7.27e-259	2.15e-261	19400	84.3	56400	73.5	1.15	LR_open
142	16	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	1.43e-255	4.21e-258	22200	96.2	68600	89.5	1.08	LR_open
143	7	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	1.66e-254	4.84e-257	22000	95.3	67500	88.1	1.08	LR_open
144	7	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	1.86e-254	5.38e-257	14500	62.9	38400	50.2	1.25	LR_open
145	7	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	4.56e-254	1.31e-256	21300	92.2	64100	83.7	1.1	LR_open
146	25	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	1.93e-253	5.51e-256	20400	88.4	60300	78.7	1.12	LR_open
147	7	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	1.13e-251	3.2e-254	18600	80.8	53400	69.7	1.16	LR_open
148	14	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	1.41e-250	3.96e-253	14500	62.9	38500	50.3	1.25	LR_open
149	7	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	6.38e-248	1.79e-250	18600	80.8	53400	69.7	1.16	LR_open
150	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	1.88e-247	5.22e-250	4730	20.5	8800	11.5	1.79	LR_open
151	22	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	2.99e-247	8.26e-250	18700	81.2	53800	70.2	1.16	LR_open
152	7	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	8.81999999999999e-247	2.42e-249	20300	87.9	60000	78.2	1.12	LR_open
153	7	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	4.26e-246	1.16e-248	17800	77	50200	65.5	1.18	LR_open
154	22	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	2.43e-245	6.57e-248	16200	70.2	44500	58.1	1.21	LR_open
155	7	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	5.37e-245	1.45e-247	21100	91.5	63500	82.9	1.1	LR_open
156	7	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	6.97e-244	1.86e-246	20800	90.2	62300	81.3	1.11	LR_open
157	7	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	7.5e-244	1.99e-246	19800	85.8	58100	75.8	1.13	LR_open
158	7	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	1.9e-243	5e-246	15800	68.5	43100	56.2	1.22	LR_open
159	28	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	4.08e-243	1.07e-245	17900	77.6	50800	66.2	1.17	LR_open
160	7	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	1.08e-242	2.82e-245	20600	89.2	61300	80	1.12	LR_open
161	20	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	3.5e-242	9.07e-245	13100	56.8	34000	44.3	1.28	LR_open
162	7	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	1.07e-241	2.74e-244	17100	74.1	47700	62.3	1.19	LR_open
163	9	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	3.37e-241	8.62e-244	17100	74	47700	62.3	1.19	LR_open
164	7	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	8.72e-241	2.22e-243	16900	73.1	47000	61.3	1.19	LR_open
165	9	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	3.22e-239	8.15e-242	19600	85	57400	74.9	1.14	LR_open
166	20	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	1.04e-235	2.62e-238	19200	83.2	55800	72.8	1.14	LR_open
167	7	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	2.81e-235	7.02e-238	19100	82.9	55600	72.5	1.14	LR_open
168	7	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	6e-235	1.49e-237	15800	68.6	43400	56.6	1.21	LR_open
169	21	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	2.43e-234	5.98e-237	16200	70.1	44600	58.2	1.2	LR_open
170	16	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	1.4e-231	3.43e-234	22300	96.6	69400	90.5	1.07	LR_open
171	7	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	2.32e-231	5.66e-234	21500	93.3	65600	85.6	1.09	LR_open
172	7	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	7.65e-231	1.85e-233	21600	93.5	65800	85.9	1.09	LR_open
173	7	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	1.37e-230	3.29e-233	18200	79.1	52300	68.2	1.16	LR_open
174	25	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	5.23e-229	1.25e-231	21800	94.7	67100	87.6	1.08	LR_open
175	7	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	6.14e-228	1.46e-230	16800	73	47200	61.5	1.19	LR_open
176	6	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	3.35e-227	7.94e-230	21700	93.9	66300	86.6	1.08	LR_open
177	7	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	4.49e-227	1.06e-229	17800	77.1	50600	66	1.17	LR_open
178	7	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	3.68e-226	8.63e-229	15800	68.7	43600	56.9	1.21	LR_open
179	7	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	6.48e-225	1.51e-227	12900	55.8	33500	43.7	1.28	LR_open
180	7	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	5.78e-224	1.34e-226	18000	78.2	51600	67.4	1.16	LR_open
181	16	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	4.74e-223	1.09e-225	22000	95.5	68100	88.9	1.07	LR_open
182	29	5-AACMAA	STREME-5	5-AACMAA	AACMAA	AACMAA	2.3e-219	5.26e-222	18500	80.1	53300	69.6	1.15	LR_open
183	6	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	1.12e-217	2.55e-220	12800	55.6	33500	43.7	1.27	LR_open
184	7	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	8.34e-216	1.89e-218	14100	61.1	37800	49.3	1.24	LR_open
185	7	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	6.5e-215	1.46e-217	12800	55.4	33400	43.6	1.27	LR_open
186	7	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	9.70999999999999e-215	2.18e-217	15800	68.7	43900	57.2	1.2	LR_open
187	30	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	1.63e-213	3.63e-216	19400	84.4	57300	74.7	1.13	LR_open
188	7	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	4.82e-212	1.07e-214	17100	74	48300	63.1	1.17	LR_open
189	6	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	8.24e-211	1.82e-213	19500	84.6	57600	75.1	1.13	LR_open
190	7	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	7.63e-210	1.67e-212	12500	54.3	32700	42.7	1.27	LR_open
191	7	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	1.13e-209	2.47e-212	18300	79.2	52800	68.8	1.15	LR_open
192	9	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	1.8e-209	3.9e-212	16400	71.2	46100	60.1	1.19	LR_open
193	6	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	2.38e-209	5.14e-212	15000	65.2	41100	53.7	1.21	LR_open
194	7	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	2.47e-209	5.31e-212	20500	88.8	61500	80.2	1.11	LR_open
195	25	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	1.47e-208	3.14e-211	21300	92.4	65100	84.9	1.09	LR_open
196	7	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	1.12e-206	2.38e-209	21900	95	67800	88.5	1.07	LR_open
197	7	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	1.75e-205	3.71e-208	10900	47.3	27600	36	1.32	LR_open
198	7	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	2.09e-205	4.41e-208	16800	72.9	47500	62	1.18	LR_open
199	14	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	1.02e-202	2.14e-205	15100	65.7	41700	54.4	1.21	LR_open
200	7	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	2.03e-202	4.22e-205	20200	87.7	60600	79.1	1.11	LR_open
201	31	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	5.56e-201	1.15e-203	21300	92.5	65200	85.1	1.09	LR_open
202	7	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	1.02e-198	2.11e-201	14800	64.3	40700	53.1	1.21	LR_open
203	7	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	6.93e-198	1.42e-200	17700	76.9	51000	66.6	1.15	LR_open
204	7	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	2.33e-196	4.77e-199	21500	93.2	66000	86.2	1.08	LR_open
205	7	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	7.31e-195	1.49e-197	11900	51.6	30900	40.4	1.28	LR_open
206	7	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	1.39e-193	2.81e-196	22300	96.6	69800	91.1	1.06	LR_open
207	21	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	1.39e-190	2.79e-193	18000	78.2	52300	68.3	1.15	LR_open
208	7	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	5.67e-188	1.14e-190	20800	90.3	63300	82.6	1.09	LR_open
209	73	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	4.77e-187	9.52e-190	14700	63.6	40400	52.7	1.21	LR_open
210	6	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	3.36e-186	6.67e-189	16800	72.7	47800	62.4	1.17	LR_open
211	32	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	6.74e-186	1.33e-188	13300	57.7	35800	46.8	1.24	LR_open
212	9	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	3.09e-184	6.08e-187	14500	63	40000	52.2	1.21	LR_open
213	21	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	3.66e-184	7.17e-187	14000	60.8	38300	50	1.22	LR_open
214	31	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	1.88e-183	3.66e-186	21800	94.5	67700	88.3	1.07	LR_open
215	7	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	1.05e-181	2.04e-184	15000	65	41600	54.3	1.2	LR_open
216	33	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	1.27e-181	2.45e-184	19500	84.6	58200	75.9	1.12	LR_open
217	7	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	3.79e-181	7.28e-184	17900	77.8	52200	68.1	1.14	LR_open
218	34	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	1.08e-179	2.06e-182	18400	79.9	54000	70.5	1.13	LR_open
219	7	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	1.17e-178	2.23e-181	15600	67.5	43700	57	1.18	LR_open
220	35	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	2.29e-177	4.34e-180	12700	55.2	34100	44.5	1.24	LR_open
221	36	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	2.33e-177	4.4e-180	21800	94.5	67700	88.3	1.07	LR_open
222	7	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	4.89e-176	9.19e-179	12700	55.2	34100	44.5	1.24	LR_open
223	33	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	8.19e-176	1.53e-178	19100	82.8	56700	73.9	1.12	LR_open
224	7	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	2.07e-175	3.85e-178	10000	43.4	25400	33.1	1.31	LR_open
225	16	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	3.28e-173	6.08e-176	19600	85	58700	76.6	1.11	LR_open
226	7	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	1.15e-171	2.12e-174	14100	61.1	38700	50.6	1.21	LR_open
227	7	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	2.33e-171	4.28e-174	11700	50.8	30900	40.3	1.26	LR_open
228	37	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	9.85e-171	1.8e-173	21900	94.9	68300	89.1	1.07	LR_open
229	8	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	1.19e-169	2.16e-172	8690	37.7	21400	27.9	1.35	LR_open
230	7	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	1.67e-169	3.03e-172	10400	44.9	26600	34.7	1.3	LR_open
231	33	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	1.25e-167	2.26e-170	19400	84	57900	75.5	1.11	LR_open
232	6	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	3.6e-167	6.46e-170	22200	96.4	70000	91.3	1.06	LR_open
233	7	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	1.09e-166	1.94e-169	13300	57.6	36200	47.2	1.22	LR_open
234	18	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	1.89e-166	3.36e-169	19700	85.5	59200	77.3	1.11	LR_open
235	38	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	7.17e-165	1.27e-167	21000	91.1	64500	84.2	1.08	LR_open
236	16	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	6.45e-164	1.14e-166	19000	82.3	56400	73.6	1.12	LR_open
237	25	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	2.31e-163	4.06e-166	20000	86.6	60300	78.7	1.1	LR_open
238	9	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	7.77e-163	1.36e-165	15200	65.9	42800	55.8	1.18	LR_open
239	22	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	1.36e-161	2.38e-164	9510	41.3	24100	31.4	1.31	LR_open
240	7	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	3.85e-158	6.68e-161	20100	87.2	61000	79.5	1.1	LR_open
241	14	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	2.03e-157	3.52e-160	11300	48.8	29700	38.8	1.26	LR_open
242	36	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	7.5e-156	1.29e-158	17000	73.6	49200	64.2	1.15	LR_open
243	39	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	1.82e-152	3.12e-155	17200	74.5	50100	65.4	1.14	LR_open
244	4	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	2.35e-152	4.02e-155	5570	24.2	12500	16.3	1.48	LR_open
245	40	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	5.34e-145	9.09e-148	18700	81	55700	72.7	1.11	LR_open
246	9	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	9.15e-145	1.55e-147	15600	67.6	44600	58.1	1.16	LR_open
247	41	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	1.46e-143	2.47e-146	19900	86.2	60300	78.7	1.09	LR_open
248	20	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	3.43e-142	5.77e-145	10200	44	26600	34.7	1.27	LR_open
249	19	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	8.45e-141	1.41e-143	20000	86.6	60800	79.3	1.09	LR_open
250	20	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	8.53e-141	1.42e-143	12500	54.2	34200	44.7	1.21	LR_open
251	23	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	6.36e-140	1.06e-142	18500	80.2	55100	72	1.11	LR_open
252	42	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	4.8e-137	7.93e-140	16900	73.2	49300	64.4	1.14	LR_open
253	43	MA0629.1	Rhox11	MA0629.1	ANKNCGCTGTWAWDVRW	Rhox11	1.46e-135	2.41e-138	19900	86.2	60600	79	1.09	LR_open
254	7	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	2.85e-135	4.68e-138	9650	41.8	25100	32.8	1.28	LR_open
255	9	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	8.61e-133	1.41e-135	7610	33	18900	24.6	1.34	LR_open
256	7	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	1.82e-132	2.97e-135	9710	42.1	25400	33.2	1.27	LR_open
257	23	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	6.55e-130	1.06e-132	22200	96.4	70500	92	1.05	LR_open
258	7	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	6.64e-130	1.07e-132	18300	79.2	54600	71.2	1.11	LR_open
259	12	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	2.81e-129	4.52e-132	18900	82.2	57100	74.5	1.1	LR_open
260	9	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	6.45e-129	1.03e-131	7540	32.7	18800	24.5	1.34	LR_open
261	7	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	7.96e-126	1.27e-128	8560	37.1	22000	28.7	1.29	LR_open
262	44	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	1.71e-125	2.72e-128	21000	90.9	65100	84.9	1.07	LR_open
263	9	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	1.48e-124	2.34e-127	11300	48.9	30600	39.9	1.22	LR_open
264	12	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	1.05e-123	1.66e-126	22100	95.7	69900	91.2	1.05	LR_open
265	45	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	1.72e-122	2.71e-125	5330	23.1	12400	16.1	1.43	LR_open
266	44	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	2.79e-120	4.37e-123	19600	85.2	60000	78.3	1.09	LR_open
267	46	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	1.48e-118	2.31e-121	16800	72.6	49400	64.4	1.13	LR_open
268	36	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	2.94e-116	4.57e-119	22100	95.7	70000	91.3	1.05	LR_open
269	30	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	5.54e-115	8.58e-118	18300	79.3	55000	71.8	1.1	LR_open
270	33	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	9.47e-114	1.46e-116	18300	79.5	55200	72	1.1	LR_open
271	23	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	3.76e-112	5.78e-115	13400	58.2	38000	49.6	1.17	LR_open
272	47	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	1.04e-109	1.59e-112	21000	91.2	65700	85.8	1.06	LR_open
273	12	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	2.06e-109	3.15e-112	18500	80.4	56100	73.3	1.1	LR_open
274	12	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	1.49e-105	2.26e-108	16400	70.9	48300	63.1	1.12	LR_open
275	12	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	8.8e-105	1.33e-107	17800	77.3	53700	70	1.1	LR_open
276	48	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	7.13e-103	1.08e-105	13500	58.7	38800	50.6	1.16	LR_open
277	19	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	9.71e-101	1.46e-103	9040	39.2	24100	31.5	1.24	LR_open
278	20	MA0873.1	HOXD12	MA0873.1	RGTCGTAAAAH	HOXD12	1.09e-99	1.63e-102	8810	38.2	23400	30.6	1.25	LR_open
279	6	MA0593.1	FOXP2	MA0593.1	RWGTAAACAVR	FOXP2	3.58e-99	5.36e-102	7350	31.9	18900	24.7	1.29	LR_open
280	12	MA0843.1	TEF	MA0843.1	BRTTACRTAAYM	TEF	7.54e-99	1.12e-101	8020	34.8	21000	27.4	1.27	LR_open
281	49	MA0678.1	OLIG2	MA0678.1	AMCATATGKT	OLIG2	3.5e-97	5.19e-100	15300	66.3	44800	58.5	1.13	LR_open
282	50	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	6.52e-97	9.64e-100	18000	78.2	54600	71.2	1.1	LR_open
283	34	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	7.77e-97	1.14e-99	17100	74	51200	66.8	1.11	LR_open
284	7	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	9.15e-96	1.34e-98	5800	25.2	14300	18.7	1.35	LR_open
285	12	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	4.11e-95	6.01e-98	19300	83.9	59500	77.6	1.08	LR_open
286	12	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	3.3e-94	4.81e-97	14400	62.4	41900	54.6	1.14	LR_open
287	25	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	2.74e-93	3.98e-96	12700	55.2	36300	47.4	1.16	LR_open
288	30	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	9.88e-93	1.43e-95	20500	88.9	64000	83.4	1.07	LR_open
289	22	MA0030.1	FOXF2	MA0030.1	BNAASGTAAACAAD	FOXF2	1.87e-92	2.7e-95	5410	23.5	13200	17.3	1.36	LR_open
290	20	MA0594.2	HOXA9	MA0594.2	RTCGTWAHNN	HOXA9	9.94e-92	1.43e-94	22000	95.6	70300	91.8	1.04	LR_open
291	51	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	1.62e-91	2.32e-94	17000	73.7	51000	66.6	1.11	LR_open
292	52	MA0520.1	Stat6	MA0520.1	BDBTTCCWSAGAAVY	Stat6	2.59e-88	3.69e-91	9180	39.8	25000	32.6	1.22	LR_open
293	21	MA0838.1	CEBPG	MA0838.1	ATTRCGCAAY	CEBPG	9.71e-88	1.38e-90	6870	29.8	17800	23.2	1.29	LR_open
294	53	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	5.09e-87	7.22e-90	15900	68.9	47300	61.7	1.12	LR_open
295	47	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	1.67e-85	2.36e-88	19500	84.5	60300	78.6	1.07	LR_open
296	38	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	7.89e-85	1.11e-87	22000	95.4	70300	91.7	1.04	LR_open
297	54	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	3.84e-82	5.39e-85	18700	80.9	57300	74.8	1.08	LR_open
298	25	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	9.04e-82	1.26e-84	8630	37.4	23400	30.5	1.23	LR_open
299	12	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	4.36e-81	6.08e-84	7230	31.4	19000	24.8	1.26	LR_open
300	55	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	4.44e-79	6.17e-82	15500	67	46100	60.1	1.12	LR_open
301	56	MA0687.1	SPIC	MA0687.1	HAAAAGVGGAAGTA	SPIC	2.15e-78	2.98e-81	19400	84.3	60300	78.7	1.07	LR_open
302	16	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	1.09e-77	1.5e-80	21100	91.5	66700	87	1.05	LR_open
303	50	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	2.08e-76	2.87e-79	20800	90.3	65600	85.6	1.05	LR_open
304	7	MA0621.1	mix-a	MA0621.1	NDTTAATTAGN	mix-a	3.17e-76	4.34e-79	6120	26.6	15800	20.6	1.29	LR_open
305	12	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	4.02e-75	5.5e-78	17100	74	51800	67.6	1.09	LR_open
306	56	MA1952.1	FOXJ2::ELF1	MA1952.1	RTAAACMGGAAGTR	FOXJ2::ELF1	6.78e-75	9.24e-78	20300	87.9	63600	82.9	1.06	LR_open
307	57	MA0069.1	PAX6	MA0069.1	TTCACGCWTSANTK	PAX6	2.31e-74	3.14e-77	14200	61.6	41900	54.7	1.13	LR_open
308	7	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	2.38e-74	3.23e-77	8060	35	21800	28.5	1.23	LR_open
309	50	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	4.38e-74	5.91e-77	22500	97.5	72600	94.8	1.03	LR_open
310	36	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	1.1e-73	1.49e-76	12700	54.9	36700	48	1.14	LR_open
311	73	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	4.53e-72	6.08e-75	10800	46.9	30700	40.1	1.17	LR_open
312	16	MA0515.1	Sox6	MA0515.1	CCWTTGTYYY	Sox6	2.02e-70	2.7e-73	5940	25.8	15400	20.1	1.28	LR_open
313	49	MA0827.1	OLIG3	MA0827.1	AMCATATGBY	OLIG3	4.09e-70	5.44e-73	15700	68	47200	61.5	1.11	LR_open
314	45	MA0468.1	DUX4	MA0468.1	TAAYYYAATCA	DUX4	2.33e-69	3.09e-72	5280	22.9	13400	17.5	1.31	LR_open
315	12	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	9.06e-69	1.2e-71	20000	86.6	62600	81.7	1.06	LR_open
316	12	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	1.45e-68	1.91e-71	20100	87.2	63100	82.3	1.06	LR_open
317	55	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	4.56e-67	5.99e-70	12300	53.2	35700	46.6	1.14	LR_open
318	19	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	1.85e-65	2.43e-68	10300	44.8	29400	38.4	1.17	LR_open
319	38	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	2.5e-64	3.27e-67	19000	82.4	59100	77.2	1.07	LR_open
320	53	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	1.46e-63	1.9e-66	21100	91.3	66900	87.3	1.05	LR_open
321	42	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	4.9e-63	6.37e-66	20800	90.4	66000	86.2	1.05	LR_open
322	33	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	5.02e-63	6.5e-66	17400	75.4	53300	69.6	1.08	LR_open
323	12	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	8.9e-62	1.15e-64	19300	83.7	60300	78.7	1.06	LR_open
324	58	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	5.29e-61	6.8e-64	18100	78.4	55900	72.9	1.07	LR_open
325	20	MA1506.1	HOXD10	MA1506.1	RGTCGTAAAAH	HOXD10	7.92e-61	1.02e-63	5600	24.3	14700	19.1	1.27	LR_open
326	59	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	1.02e-60	1.31e-63	11500	49.8	33400	43.5	1.14	LR_open
327	60	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	7.85e-60	1e-62	18600	80.6	57700	75.3	1.07	LR_open
328	7	MA0702.2	LMX1A	MA0702.2	TTAATTAM	LMX1A	5.52e-59	7.02e-62	5960	25.8	15800	20.6	1.25	LR_open
329	55	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	1.25e-58	1.58e-61	16700	72.4	51100	66.7	1.09	LR_open
330	31	MA0517.1	STAT1::STAT2	MA0517.1	THAGTTTCRKTTTCY	STAT1::STAT2	3.23e-57	4.08e-60	11900	51.4	34700	45.3	1.14	LR_open
331	61	MA1125.1 (ZNF384)	MEME-2	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	5.1e-57	6.43e-60	3490	15.2	8490	11.1	1.37	LR_open
332	49	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	5.34e-57	6.7e-60	20800	90.1	66000	86.1	1.05	LR_open
333	62	MA0479.1	FOXH1	MA0479.1	BNSAATCCACA	FOXH1	4.49e-56	5.62e-59	5480	23.8	14500	18.9	1.26	LR_open
334	21	MA0837.2	CEBPE	MA0837.2	KATTGCGCAATM	CEBPE	5.07e-56	6.33e-59	3020	13.1	7140	9.32	1.4	LR_open
335	31	MA0772.1	IRF7	MA0772.1	HCGAAARYGAAAVT	IRF7	1.93e-55	2.4e-58	8140	35.3	22800	29.7	1.19	LR_open
336	63	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	1.71e-53	2.12e-56	6690	29	18200	23.8	1.22	LR_open
337	64	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	1.79e-53	2.22e-56	16300	70.5	49800	64.9	1.09	LR_open
338	65	MA1105.2	GRHL2	MA1105.2	NRAACAGGTTYN	GRHL2	1.64e-52	2.02e-55	19600	85.2	61800	80.7	1.06	LR_open
339	37	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	5.38e-52	6.61e-55	20900	90.4	66400	86.7	1.04	LR_open
340	73	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	8.57e-52	1.05e-54	6220	27	16900	22	1.23	LR_open
341	66	MA1592.1	ZNF274	MA1592.1	NRTRTGAGTTCTCGYN	ZNF274	2.59e-51	3.16e-54	6160	26.7	16700	21.8	1.23	LR_open
342	67	MA0619.1	LIN54	MA0619.1	DTTTRAATH	LIN54	5.32e-49	6.49e-52	5510	23.9	14800	19.3	1.24	LR_open
343	49	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	1.01e-48	1.23e-51	15500	67.4	47500	62	1.09	LR_open
344	68	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	1.61e-48	1.95e-51	21900	95.1	70700	92.3	1.03	LR_open
345	46	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	2.08e-45	2.51e-48	18200	79	57000	74.4	1.06	LR_open
346	69	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	2.91e-44	3.51e-47	21900	95.1	70800	92.4	1.03	LR_open
347	65	MA0743.2	SCRT1	MA0743.2	NDWKCAACAGGTGKNN	SCRT1	1.33e-42	1.59e-45	17600	76.3	54900	71.6	1.07	LR_open
348	7	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	2.96e-42	3.55e-45	21600	93.8	69700	91	1.03	LR_open
349	51	MA1534.1	NR1I3	MA1534.1	RTGAACTTT	NR1I3	5.09e-42	6.09e-45	15200	65.9	46600	60.8	1.08	LR_open
350	49	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	1.32e-41	1.57e-44	11900	51.7	35600	46.4	1.11	LR_open
351	19	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	5.47e-40	6.49e-43	4220	18.3	11100	14.5	1.26	LR_open
352	20	MA1503.1	HOXB9	MA1503.1	GTCGTAAAAH	HOXB9	1.47e-39	1.75e-42	2360	10.2	5670	7.4	1.39	LR_open
353	23	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	2.29e-39	2.71e-42	15100	65.5	46400	60.5	1.08	LR_open
354	55	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	2.78e-38	3.27e-41	13800	59.9	42100	54.9	1.09	LR_open
355	47	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	2.74e-37	3.22e-40	19500	84.5	61900	80.7	1.05	LR_open
356	7	MA0784.2	POU1F1	MA0784.2	ANCTMATTWGCATAWT	POU1F1	1.35e-35	1.58e-38	1960	8.51	4620	6.03	1.41	LR_open
357	70	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	1.96e-35	2.28e-38	1500	6.51	3340	4.35	1.5	LR_open
358	71	MA0684.2	RUNX3	MA0684.2	NHAACCTCAANN	RUNX3	2.01e-35	2.34e-38	18000	78.2	56700	74	1.06	LR_open
359	46	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	6.53e-35	7.59e-38	20000	86.5	63600	83	1.04	LR_open
360	68	MA0494.1	Nr1h3::Rxra	MA0494.1	TGACCTNNAGTRACCYYDN	Nr1h3::Rxra	1.1e-34	1.28e-37	18200	79	57400	75	1.05	LR_open
361	70	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	1.34e-34	1.55e-37	259	1.12	276	0.36	3.12	LR_open
362	12	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	2.82e-34	3.25e-37	4720	20.5	12900	16.8	1.22	LR_open
363	51	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	4.35e-34	4.99e-37	21700	94.2	70300	91.7	1.03	LR_open
364	49	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	9.29e-34	1.06e-36	14800	64	45500	59.4	1.08	LR_open
365	72	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	4.58e-33	5.23e-36	22700	98.6	74500	97.2	1.01	LR_open
366	44	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	1.07e-32	1.21e-35	11500	49.9	34700	45.2	1.1	LR_open
367	73	MA0682.2 (PITX1)	MEME-3	AAGTGCTGGGATTAC	AAGTGCTGGGATTAC	PITX1	2.12e-32	2.41e-35	1930	8.36	4600	6	1.39	LR_open
368	14	MA1473.1	CDX4	MA1473.1	GGYMATAAAAC	CDX4	5.78e-32	6.55e-35	2590	11.2	6540	8.53	1.32	LR_open
369	70	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	9e-32	1.02e-34	411	1.78	609	0.79	2.25	LR_open
370	73	MA1547.2	PITX2	MA1547.2	YTAATCCY	PITX2	1.58e-29	1.78e-32	1850	8.04	4460	5.82	1.38	LR_open
371	71	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	2.14e-29	2.4e-32	22900	99.5	75600	98.6	1.01	LR_open
372	21	MA0466.3	CEBPB	MA0466.3	KATTGCGCAATM	CEBPB	3.39e-29	3.8e-32	473	2.05	775	1.01	2.03	LR_open
373	11	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	3.99e-29	4.46e-32	3500	15.2	9330	12.2	1.25	LR_open
374	49	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	8.52e-29	9.5e-32	6940	30.1	20100	26.2	1.15	LR_open
375	49	MA0826.1	OLIG1	MA0826.1	AMCATATGKT	OLIG1	1.35e-28	1.5e-31	6340	27.5	18200	23.7	1.16	LR_open
376	12	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	4.02e-28	4.46e-31	3360	14.6	8960	11.7	1.25	LR_open
377	20	MA0485.2	HOXC9	MA0485.2	GTCGTAAAAH	HOXC9	1.4e-27	1.55e-30	1160	5.01	2550	3.33	1.51	LR_open
378	54	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	1.66e-27	1.83e-30	19500	84.6	62400	81.4	1.04	LR_open
379	73	MA1547.2 (PITX2)	STREME-11	11-CTGGGAYTAC	11-CTGGGAYTAC	PITX2	1.25e-26	1.37e-29	2780	12	7250	9.46	1.27	LR_open
380	47	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	1.34e-26	1.47e-29	11000	47.8	33400	43.6	1.1	LR_open
381	74	MA1580.1	ZBTB32	MA1580.1	TGTACAGTAW	ZBTB32	9.31e-26	1.02e-28	4260	18.5	11800	15.4	1.2	LR_open
382	65	MA0647.1	GRHL1	MA0647.1	AAAACCGGTTTD	GRHL1	2.36e-25	2.57e-28	6950	30.2	20300	26.5	1.14	LR_open
383	63	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	2.79e-25	3.04e-28	4430	19.2	12300	16.1	1.19	LR_open
384	20	MA0651.2	HOXC11	MA0651.2	AGGTCGTAAAAH	HOXC11	3.99e-25	4.33e-28	2340	10.1	5990	7.82	1.3	LR_open
385	75	9-CACTTTGGGAG	STREME-9	9-CACTTTGGGAG	CACTTTGGGAG	CACTTTGGGAG	6.84e-25	7.4e-28	325	1.41	481	0.63	2.25	LR_open
386	46	MA0137.3	STAT1	MA0137.3	TTTCYRGGAAA	STAT1	7.71e-25	8.32e-28	11300	49	34400	44.9	1.09	LR_open
387	46	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	9.74e-25	1.05e-27	9190	39.9	27500	35.9	1.11	LR_open
388	76	TAGAGAYRGGGTTTC	MEME-5	TAGAGAYRGGGTTTC	TAGAGAYRGGGTTTC	TAGAGAYRGGGTTTC	5.75e-24	6.18e-27	460	2	803	1.05	1.91	LR_open
389	42	MA1956.1	FOXO1::FLI1	MA1956.1	GTAAACAGGAAGTK	FOXO1::FLI1	7.75e-24	8.3e-27	3970	17.2	11000	14.3	1.2	LR_open
390	46	MA0519.1	Stat5a::Stat5b	MA0519.1	DTTTCCMAGAA	Stat5a::Stat5b	1.55e-23	1.66e-26	10800	46.7	32700	42.7	1.09	LR_open
391	12	MA0840.1	Creb5	MA0840.1	NATGACGTCAYH	Creb5	1.74e-22	1.86e-25	2660	11.6	7050	9.2	1.26	LR_open
392	36	MA1421.1	TCF7L1	MA1421.1	AAAGATCAAAGG	TCF7L1	3.78e-22	4.02e-25	3600	15.6	9910	12.9	1.21	LR_open
393	49	MA0817.1	BHLHE23	MA0817.1	AAACATATGBTN	BHLHE23	4.49e-22	4.76e-25	2340	10.1	6090	7.95	1.28	LR_open
394	25	MA0029.1	Mecom	MA0029.1	AAGAYAAGATAANA	Mecom	6.14e-21	6.5e-24	2150	9.32	5570	7.27	1.28	LR_open
395	30	MA0610.1	DMRT3	MA0610.1	MATGTATCAAN	DMRT3	1.93e-20	2.03e-23	6940	30.1	20500	26.8	1.12	LR_open
396	77	MA1585.1	ZKSCAN1	MA1585.1	AYAGTAGGTS	ZKSCAN1	3.2e-20	3.37e-23	11100	48.1	34000	44.4	1.08	LR_open
397	46	MA0463.2	BCL6	MA0463.2	NYGCTTTCKAGGAAYN	BCL6	1.63e-19	1.72e-22	13500	58.4	42000	54.8	1.07	LR_open
398	58	MA1148.1	PPARA::RXRA	MA1148.1	AWNTRGGTYAAAGGTCAN	PPARA::RXRA	3.42e-19	3.58e-22	10600	46.1	32600	42.5	1.08	LR_open
399	78	MA0164.1	Nr2e3	MA0164.1	CAAGCTT	Nr2e3	8.6e-19	8.98e-22	5150	22.4	14900	19.5	1.15	LR_open
400	68	MA0072.1	RORA	MA0072.1	NWWAWBTAGGTCAR	RORA	2.02e-18	2.1e-21	1970	8.56	5130	6.7	1.28	LR_open
401	79	MA1973.1 (ZKSCAN3)	MEME-6	TGTYRCCCAGGCTGG	TGTYRCCCAGGCTGG	ZKSCAN3	2.27e-18	2.35e-21	383	1.66	685	0.89	1.86	LR_open
402	7	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	1.02e-17	1.06e-20	14100	61.1	44200	57.7	1.06	LR_open
403	50	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	1.57e-17	1.63e-20	17900	77.6	57200	74.6	1.04	LR_open
404	80	MA0019.1	Ddit3::Cebpa	MA0019.1	VNRTGCAATMCC	Ddit3::Cebpa	5.11e-17	5.28e-20	9860	42.8	30200	39.4	1.09	LR_open
405	54	MA0804.1	TBX19	MA0804.1	DTTMRCACMTAGGTGTGAAW	TBX19	4.27e-16	4.39e-19	6420	27.9	19100	24.9	1.12	LR_open
406	7	MA1546.1	PAX3	MA1546.1	YSGTCACGSYWATTAN	PAX3	4.4e-16	4.52e-19	12800	55.6	40100	52.3	1.06	LR_open
407	7	MA0703.2	LMX1B	MA0703.2	AWTTTAATTAA	LMX1B	1.47e-15	1.5e-18	1690	7.34	4400	5.74	1.28	LR_open
408	42	MA1955.1	FOXO1::ELK3	MA1955.1	RWMAACAGGAAGTN	FOXO1::ELK3	1.81e-15	1.85e-18	12400	54	38800	50.7	1.06	LR_open
409	47	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	2.07e-15	2.11e-18	17800	77.2	57000	74.4	1.04	LR_open
410	11	MA0660.1	MEF2B	MA0660.1	RCTAWAAATAGC	MEF2B	2.13e-15	2.17e-18	3010	13	8390	10.9	1.19	LR_open
411	51	MA1996.1	Nr1H2	MA1996.1	NNRAGGTCANN	Nr1H2	2.69e-15	2.73e-18	15600	67.5	49400	64.4	1.05	LR_open
412	81	MA1596.1 (ZNF460)	STREME-14	14-ACCTCAGCCTCC	14-ACCTCAGCCTCC	ZNF460	2.93e-15	2.96e-18	309	1.34	544	0.71	1.89	LR_open
413	54	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	3.38e-15	3.41e-18	20000	86.9	64800	84.6	1.03	LR_open
414	82	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	1.23e-14	1.24e-17	3940	17.1	11300	14.8	1.16	LR_open
415	83	MA1714.1	ZNF675	MA1714.1	RGGVHYMGGAGGMCAAAATGD	ZNF675	4.09e-13	4.11e-16	11000	47.9	34400	44.9	1.07	LR_open
416	42	MA1950.1	FLI1::FOXI1	MA1950.1	RTAAACAGGAARYN	FLI1::FOXI1	8.14e-13	8.16e-16	16700	72.6	53600	69.9	1.04	LR_open
417	79	MA1973.1 (ZKSCAN3)	STREME-8	8-CCAGCCTGGGYRAC	CCAGCCTGGGYRAC	ZKSCAN3	2.85e-12	2.85e-15	329	1.43	633	0.83	1.73	LR_open
418	50	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	2.99e-12	2.98e-15	16300	70.6	52000	67.8	1.04	LR_open
419	65	MA0744.2	SCRT2	MA0744.2	NNWGCAACAGGTGDNN	SCRT2	3.4e-12	3.38e-15	16700	72.3	53300	69.6	1.04	LR_open
420	84	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	7.78e-12	7.72e-15	20800	90.3	67800	88.5	1.02	LR_open
421	85	MA1107.2 (KLF9)	STREME-13	13-ACCACACMCA	13-ACCACACMCA	KLF9	1.29e-11	1.28e-14	478	2.07	1030	1.35	1.54	LR_open
422	86	MA1949.1	FLI1::DRGX	MA1949.1	ACCGGAAGTAATTAT	FLI1::DRGX	1.88e-11	1.86e-14	13600	59.1	43100	56.2	1.05	LR_open
423	87	12-CTCCTGGGCTCAA	STREME-12	12-CTCCTGGGCTCAA	12-CTCCTGGGCTCAA	CTCCTGGGCTCAA	2.42e-11	2.39e-14	197	0.85	323	0.42	2.03	LR_open
424	58	MA1541.1	NR6A1	MA1541.1	NYCAAGKTCAAGKTCAN	NR6A1	4.41e-11	4.34e-14	15700	68.2	50300	65.6	1.04	LR_open
425	47	MA0484.2	HNF4G	MA0484.2	DNCAAAGTCCANN	HNF4G	1.26e-09	1.24e-12	8880	38.5	27600	36	1.07	LR_open
426	49	MA1467.2	Atoh1	MA1467.2	RVCAGATGGYN	Atoh1	2.92e-09	2.85e-12	21000	91	68600	89.5	1.02	LR_open
427	46	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	8.46e-09	8.26e-12	19400	84.1	63000	82.2	1.02	LR_open
428	55	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	1.54e-08	1.5e-11	4230	18.3	12600	16.4	1.11	LR_open
429	58	MA0160.2	NR4A2	MA0160.2	BWAAAGGTCA	NR4A2	1.69e-08	1.64e-11	13100	56.9	41700	54.5	1.05	LR_open
430	88	MA1980.1	ZNF418	MA1980.1	MDGAGGCTAAAAGCA	ZNF418	1.8e-08	1.74e-11	3520	15.2	10400	13.5	1.13	LR_open
431	89	MA1594.1	ZNF382	MA1594.1	AGGRGAYATCACYACMGAYCCCAC	ZNF382	4.24e-08	4.1e-11	2160	9.35	6120	7.99	1.17	LR_open
432	81	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	4.47e-08	4.31e-11	234	1.01	454	0.59	1.72	LR_open
433	49	MA0607.2	BHLHA15	MA0607.2	ACCATATGGT	BHLHA15	4.65e-08	4.48e-11	4680	20.3	14100	18.4	1.1	LR_open
434	71	MA0002.2	Runx1	MA0002.2	BBYTGTGGTTT	Runx1	8.42e-08	8.09e-11	2880	12.5	8400	11	1.14	LR_open
435	49	MA1123.2	TWIST1	MA1123.2	NNDCCAGATGTBN	TWIST1	9.32e-08	8.93e-11	22100	96	72900	95.1	1.01	LR_open
436	90	MA0770.1	HSF2	MA0770.1	TTCTAGAAYRTTC	HSF2	1.13e-07	1.08e-10	6730	29.2	20700	27	1.08	LR_open
437	12	MA0656.1	JDP2	MA0656.1	GATGACGTCAYC	JDP2	4.43e-07	4.22e-10	2100	9.09	5990	7.82	1.16	LR_open
438	58	MA0071.1	RORA	MA0071.1	AWMWAGGTCA	RORA	5.08e-07	4.83e-10	5910	25.6	18100	23.6	1.08	LR_open
439	42	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	7.16e-07	6.8e-10	22000	95.4	72400	94.4	1.01	LR_open
440	85	MA0732.1 (EGR3)	STREME-7	7-CACCCACACAC	CACCCACACAC	EGR3	8.82e-07	8.36e-10	268	1.16	563	0.73	1.59	LR_open
441	65	MA1968.1	TFCP2	MA1968.1	AAACCGGTTY	TFCP2	1.3e-06	1.23e-09	16000	69.4	51600	67.3	1.03	LR_open
442	91	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	1.44e-06	1.35e-09	18400	79.7	59700	77.9	1.02	LR_open
443	38	MA1525.2	NFATC4	MA1525.2	AAYGGAAAMW	NFATC4	2.19e-06	2.07e-09	1880	8.15	5360	6.99	1.17	LR_open
444	20	MA1958.1	HOXD12::ELK1	MA1958.1	DRVCGGAAGTCGTAAAD	HOXD12::ELK1	8.81e-06	8.27e-09	988	4.29	2660	3.48	1.23	LR_open
445	12	MA1951.1	FOS	MA1951.1	BGATGACGTCATCR	FOS	8.97e-06	8.4e-09	4980	21.6	15300	19.9	1.09	LR_open
446	58	MA0141.3	ESRRB	MA0141.3	TCAAGGTCAWW	ESRRB	1.16e-05	1.08e-08	6540	28.4	20300	26.5	1.07	LR_open
447	55	MA0831.3	TFE3	MA0831.3	GTCACGTGAC	TFE3	1.94e-05	1.81e-08	4220	18.3	12800	16.8	1.09	LR_open
448	8	MA0507.2	POU2F2	MA0507.2	AWTATGCAAATKAG	POU2F2	4.59e-05	4.27e-08	274	1.19	612	0.8	1.49	LR_open
449	90	MA0486.2	HSF1	MA0486.2	TTCTAGAAYRTTC	HSF1	6.3e-05	5.85e-08	3310	14.4	9970	13	1.1	LR_open
450	55	MA0828.2	SREBF2	MA0828.2	WWATCACGTGATWW	SREBF2	8.43e-05	7.81e-08	1560	6.76	4460	5.81	1.16	LR_open
451	54	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	9.18e-05	8.49e-08	22300	96.6	73500	95.9	1.01	LR_open
452	54	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	0.00011	1.01e-07	2540	11	7520	9.82	1.12	LR_open
453	49	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.000121	1.11e-07	2520	10.9	7490	9.77	1.12	LR_open
454	58	MA0643.1	Esrrg	MA0643.1	TCAAGGTCAH	Esrrg	0.000125	1.15e-07	8370	36.3	26400	34.5	1.05	LR_open
455	71	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	0.000168	1.54e-07	244	1.06	542	0.71	1.5	LR_open
456	49	MA0818.2	BHLHE22	MA0818.2	AMCATATGKY	BHLHE22	0.000277	2.53e-07	654	2.84	1730	2.25	1.26	LR_open
457	81	MA1596.1 (ZNF460)	MEME-4	RGGAGGCBGAGGHKG	RGGAGGCBGAGGHKG	ZNF460	0.00031	2.83e-07	196	0.85	418	0.55	1.56	LR_open
458	42	MA1954.1	FOXO1::ELK1	MA1954.1	RWMAACAGGAAGTD	FOXO1::ELK1	0.000317	2.88e-07	13100	57	42200	55.1	1.03	LR_open
459	54	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	0.000495	4.5e-07	1350	5.86	3860	5.04	1.16	LR_open
460	54	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	0.00132	1.19e-06	3760	16.3	11500	15	1.08	LR_open
461	86	MA1937.1	ERF::HOXB13	MA1937.1	VSCGGAARYNRTWAAN	ERF::HOXB13	0.00148	1.34e-06	8280	35.9	26200	34.2	1.05	LR_open
462	91	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	0.0017	1.54e-06	6690	29	21000	27.5	1.06	LR_open
463	12	MA0605.2	ATF3	MA0605.2	RRTGACGTCAYY	ATF3	0.0023	2.07e-06	670	2.91	1810	2.36	1.23	LR_open
464	81	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	0.00315	2.83e-06	928	4.02	2600	3.39	1.19	LR_open
465	54	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	0.0036	3.23e-06	1890	8.19	5600	7.3	1.12	LR_open
466	82	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	0.00585	5.23e-06	2230	9.67	6690	8.73	1.11	LR_open
467	58	MA0592.3	ESRRA	MA0592.3	NBTCAAGGTCAHN	ESRRA	0.00677	6.04e-06	8130	35.3	25900	33.7	1.05	LR_open
468	55	MA0692.1	TFEB	MA0692.1	RYCACGTGAC	TFEB	0.00807	7.19e-06	4500	19.5	14000	18.3	1.07	LR_open
469	92	MA1983.1	ZNF582	MA1983.1	TCTGTTACTTGCAGCCAAAWG	ZNF582	0.00898	7.98e-06	4190	18.2	13000	16.9	1.07	LR_open
470	33	MA0870.1	Sox1	MA0870.1	AACAATANCATTGTT	Sox1	0.0109	9.66e-06	662	2.87	1820	2.37	1.21	LR_open
471	53	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	0.012	1.06e-05	22500	97.6	74400	97.1	1.01	LR_open
472	91	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	0.0136	1.2e-05	7640	33.1	24300	31.7	1.05	LR_open
473	42	MA1579.1	ZBTB26	MA1579.1	NNCTCCAGAAANNNN	ZBTB26	0.0163	1.44e-05	1000	4.35	2860	3.74	1.16	LR_open
474	49	MA0623.2	NEUROG1	MA0623.2	RACATATGTY	NEUROG1	0.023	2.02e-05	601	2.61	1640	2.15	1.22	LR_open
475	31	MA0653.1	IRF9	MA0653.1	AACGAAACCGAAACT	IRF9	0.0293	2.57e-05	86	0.37	164	0.21	1.75	LR_open
476	54	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	0.0307	2.68e-05	2520	10.9	7680	10	1.09	LR_open
477	93	MA0130.1	ZNF354C	MA0130.1	MTCCAC	ZNF354C	0.0356	3.11e-05	1010	4.39	2920	3.81	1.15	LR_open

ER_rat <- 1.25
mrc_type <- "LR_open"
LR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of LR_open-1.png

Version	Author	Date
6638b27	reneeisnowhere	2025-05-12
7b1c18d	reneeisnowhere	2025-05-08

LR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
#   mutate(
#   RANK = as.numeric(RANK),
#   log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y)) + 1e-5 * (max(RANK, na.rm = TRUE) - RANK)
# ) %>% 
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*3), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./3,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of LR_open-2.png

Version	Author	Date
6638b27	reneeisnowhere	2025-05-12
7b1c18d	reneeisnowhere	2025-05-08

LR_close data

LR_close_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
LR_close_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
LR_close_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
LR_close_sea_all <- rbind(LR_close_sea_disc, LR_close_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

LR_close_combo <- LR_close_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., LR_close_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="LR_close")

LR_close_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR

RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0774.1 (MEIS2)	STREME-1	1-DGCTGTCA	DGCTGTCA	MEIS2	2.35e-143	1.55e-143	8140	48.6	29000	37.8	1.29	LR_close
2	1	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	3.53e-106	1.16e-106	6100	36.4	21200	27.7	1.32	LR_close
3	1	MA0774.1 (MEIS2)	STREME-3	3-CTGTCWG	CTGTCWG	MEIS2	2.75e-79	6.03e-80	10800	64.4	43200	56.4	1.14	LR_close
4	2	MA0672.1 (NKX2-3)	STREME-2	2-CCACTTRA	CCACTTRA	NKX2-3	7.25e-77	1.19e-77	5860	35	21200	27.6	1.27	LR_close
5	2	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	3.82e-63	5.03e-64	6830	40.8	25900	33.8	1.21	LR_close
6	1	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	1.42e-62	1.56e-63	2080	12.4	6200	8.08	1.53	LR_close
7	1	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	1.37e-57	1.29e-58	7070	42.2	27200	35.4	1.19	LR_close
8	3	MA0739.1 (Hic1)	STREME-5	5-ATGCCA	ATGCCA	Hic1	6.58e-54	5.41e-55	12500	74.8	52600	68.6	1.09	LR_close
9	2	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	1.07e-47	7.84e-49	2700	16.1	9020	11.8	1.37	LR_close
10	4	MA0140.2 (GATA1::TAL1)	STREME-6	6-WGATAA	WGATAA	GATA1::TAL1	1.41e-46	9.31e-48	10700	64.1	44400	57.9	1.11	LR_close
11	2	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	1.65e-45	9.9e-47	6820	40.7	26600	34.7	1.17	LR_close
12	5	MA1655.1 (ZNF341)	STREME-11	11-ACAGCCA	11-ACAGCCA	ZNF341	2.22e-38	1.22e-39	12200	73	51900	67.7	1.08	LR_close
13	2	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	2.88e-34	1.46e-35	4780	28.5	18200	23.8	1.2	LR_close
14	6	MA1972.1 (ZFP14)	STREME-12	12-CAGGGCCT	12-CAGGGCCT	ZFP14	1.36e-33	6.39e-35	8330	49.7	34000	44.4	1.12	LR_close
15	7	8-CTGCACA	STREME-8	8-CTGCACA	CTGCACA	CTGCACA	1.95e-33	8.55e-35	14700	87.5	64200	83.7	1.05	LR_close
16	8	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	1.1e-31	4.51e-33	16000	95.4	71200	92.9	1.03	LR_close
17	9	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	2.26e-31	8.75e-33	9160	54.7	37900	49.5	1.1	LR_close
18	10	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	8.13e-31	2.97e-32	15500	92.4	68500	89.4	1.03	LR_close
19	11	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	2.48e-30	8.58e-32	15400	91.7	67900	88.6	1.03	LR_close
20	1	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	8.5e-30	2.8e-31	3760	22.5	14100	18.4	1.22	LR_close
21	1	MA0739.1	Hic1	MA0739.1	RTGCCAACY	Hic1	1.73e-29	5.39e-31	7070	42.2	28600	37.3	1.13	LR_close
22	8	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	1.8e-29	5.39e-31	15800	94.2	70200	91.6	1.03	LR_close
23	8	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	2.11e-29	6.05e-31	15500	92.5	68700	89.6	1.03	LR_close
24	12	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	1.03e-27	2.84e-29	10200	60.8	42900	56	1.09	LR_close
25	13	7-AGCACT	STREME-7	7-AGCACT	AGCACT	AGCACT	1.59e-26	4.17e-28	15400	91.9	68300	89.1	1.03	LR_close
26	10	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	1.41e-25	3.57e-27	15800	94.6	70700	92.3	1.03	LR_close
27	8	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	2.16e-25	5.27e-27	15800	94.1	70200	91.6	1.03	LR_close
28	8	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	2.64e-25	6.2e-27	15800	94	70200	91.6	1.03	LR_close
29	8	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	3.64e-25	8.25e-27	15700	93.6	69800	91	1.03	LR_close
30	9	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	1.39e-24	3.06e-26	11200	66.8	47800	62.3	1.07	LR_close
31	8	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	1.46e-24	3.09e-26	15200	90.8	67400	88	1.03	LR_close
32	8	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	1.63e-24	3.27e-26	14500	86.6	63800	83.3	1.04	LR_close
33	8	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	1.64e-24	3.27e-26	15800	94.4	70600	92.1	1.03	LR_close
34	14	10-WGKGCMCW	STREME-10	10-WGKGCMCW	10-WGKGCMCW	WGKGCMCW	2.27e-24	4.39e-26	8290	49.5	34400	44.9	1.1	LR_close
35	15	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	3.53e-24	6.63e-26	15000	89.3	66200	86.3	1.04	LR_close
36	8	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	6.76e-24	1.24e-25	14500	86.3	63600	83	1.04	LR_close
37	16	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	1.65e-23	2.86e-25	8520	50.9	35500	46.4	1.1	LR_close
38	8	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	1.65e-23	2.86e-25	15000	89.3	66200	86.4	1.03	LR_close
39	8	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	3.18e-23	5.37e-25	15100	90.1	66800	87.2	1.03	LR_close
40	17	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	6.01e-23	9.88e-25	15300	91.2	67800	88.4	1.03	LR_close
41	18	CTGCCTGCCTG	MEME-5	CTGCCTGCCTG	CTGCCTGCCTG	CTGCCTGCCTG	1.66e-22	2.67e-24	10700	63.9	45600	59.6	1.07	LR_close
42	12	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	3.36e-22	5.26e-24	6680	39.9	27300	35.6	1.12	LR_close
43	8	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	1.1e-21	1.68e-23	15200	90.5	67300	87.8	1.03	LR_close
44	8	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	1.66e-21	2.49e-23	15300	91.6	68200	89	1.03	LR_close
45	8	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	2.11e-21	3.09e-23	15900	95	71300	93	1.02	LR_close
46	12	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	1.52e-20	2.17e-22	9180	54.8	38800	50.6	1.08	LR_close
47	8	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	2.64e-20	3.7e-22	14700	87.8	65100	84.9	1.03	LR_close
48	19	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	3.21e-20	4.32e-22	15300	91.2	67900	88.6	1.03	LR_close
49	8	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	3.21e-20	4.32e-22	14500	86.8	64300	83.9	1.04	LR_close
50	10	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	7.33e-20	9.65e-22	16300	97.3	73400	95.8	1.02	LR_close
51	4	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	2.71e-19	3.5e-21	15300	91.3	68100	88.8	1.03	LR_close
52	19	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	7.26e-19	9.19e-21	15400	92	68700	89.6	1.03	LR_close
53	16	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	9.42e-19	1.17e-20	2800	16.7	10600	13.8	1.21	LR_close
54	8	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	1.19e-18	1.45e-20	14800	88.5	65800	85.8	1.03	LR_close
55	8	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	1.32e-18	1.58e-20	14900	88.9	66100	86.2	1.03	LR_close
56	8	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	2.21e-18	2.6e-20	14000	83.6	61700	80.6	1.04	LR_close
57	15	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	2.62e-18	3.03e-20	15200	91	67900	88.6	1.03	LR_close
58	16	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	3.63e-18	4.12e-20	2830	16.9	10700	14	1.2	LR_close
59	9	MA0670.1	NFIA	MA0670.1	NDTGCCAAND	NFIA	3.98e-18	4.42e-20	1670	9.98	5930	7.74	1.29	LR_close
60	8	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	4.03e-18	4.42e-20	14800	88.3	65600	85.6	1.03	LR_close
61	4	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	7.07e-18	7.62e-20	4260	25.4	16900	22.1	1.15	LR_close
62	16	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	7.21e-18	7.65e-20	2810	16.8	10700	13.9	1.2	LR_close
63	16	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	1.22e-17	1.28e-19	2770	16.6	10500	13.8	1.2	LR_close
64	19	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	3.08e-17	3.17e-19	13900	82.7	61100	79.7	1.04	LR_close
65	8	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	4.67e-17	4.73e-19	15500	92.8	69500	90.6	1.02	LR_close
66	20	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	6.2e-17	6.18e-19	14800	88.5	65800	85.9	1.03	LR_close
67	2	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	7.81e-17	7.67e-19	1360	8.14	4740	6.18	1.32	LR_close
68	8	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	8.53e-17	8.26e-19	15700	94	70500	92	1.02	LR_close
69	19	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	1.11e-16	1.06e-18	15100	89.9	67000	87.4	1.03	LR_close
70	19	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	1.4e-16	1.32e-18	15100	90	67100	87.5	1.03	LR_close
71	21	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	1.93e-16	1.79e-18	8310	49.6	35100	45.8	1.08	LR_close
72	8	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	5.56e-16	5.08e-18	16200	96.8	73000	95.3	1.02	LR_close
73	20	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	5.77e-16	5.2e-18	15000	89.4	66600	87	1.03	LR_close
74	4	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	6.79e-16	6.04e-18	5350	32	21900	28.5	1.12	LR_close
75	8	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	1e-15	8.8e-18	13700	82	60600	79.1	1.04	LR_close
76	8	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	1.13e-15	9.8e-18	15800	94.1	70700	92.2	1.02	LR_close
77	9	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	4.8e-15	4.1e-17	3010	18	11700	15.3	1.18	LR_close
78	8	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	8.03e-15	6.78e-17	13700	81.9	60500	79	1.04	LR_close
79	4	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	1.09e-14	9.05e-17	14400	85.9	63800	83.3	1.03	LR_close
80	19	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	1.17e-14	9.64e-17	15600	93	69700	91	1.02	LR_close
81	10	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	1.87e-14	1.52e-16	16100	95.9	72300	94.3	1.02	LR_close
82	1	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	2e-14	1.61e-16	1400	8.33	4960	6.48	1.29	LR_close
83	22	MA0018.4 (CREB1)	STREME-4	4-GTGATGACA	GTGATGACA	CREB1	2.17e-14	1.72e-16	380	2.27	1030	1.35	1.69	LR_close
84	1	MA0783.1	PKNOX2	MA0783.1	TGACAGGTGTCA	PKNOX2	4.23e-14	3.32e-16	587	3.5	1790	2.34	1.5	LR_close
85	23	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	5.05e-14	3.91e-16	15800	94.3	70900	92.5	1.02	LR_close
86	12	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	5.4e-14	4.13e-16	10100	60.2	43500	56.7	1.06	LR_close
87	8	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	6.31e-14	4.77e-16	13700	81.9	60600	79.1	1.04	LR_close
88	8	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	6.57e-14	4.87e-16	14600	87.1	64900	84.6	1.03	LR_close
89	19	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	6.59e-14	4.87e-16	15900	94.7	71300	93	1.02	LR_close
90	21	MA0816.1	Ascl2	MA0816.1	ARCAGCTGCY	Ascl2	8.08e-14	5.91e-16	6000	35.8	24900	32.5	1.1	LR_close
91	9	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	1.04e-13	7.43e-16	2500	14.9	9590	12.5	1.19	LR_close
92	8	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	1.05e-13	7.43e-16	16000	95.7	72200	94.2	1.02	LR_close
93	16	MA1472.2	Bhlha15	MA1472.2	NVACAGCTGTBN	Bhlha15	1.05e-13	7.43e-16	7560	45.2	32000	41.7	1.08	LR_close
94	8	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	1.28e-13	8.99e-16	15800	94.6	71200	92.9	1.02	LR_close
95	24	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	1.82e-13	1.26e-15	13600	81.1	60000	78.3	1.04	LR_close
96	19	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	2.96e-13	2.03e-15	14400	85.9	63900	83.4	1.03	LR_close
97	1	MA0796.1	TGIF1	MA0796.1	TGACAGCTGTCA	TGIF1	3.08e-13	2.09e-15	643	3.84	2030	2.64	1.45	LR_close
98	8	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	3.22e-13	2.16e-15	14900	89	66500	86.8	1.03	LR_close
99	19	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	3.39e-13	2.25e-15	14400	86.1	64100	83.6	1.03	LR_close
100	8	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	4.86e-13	3.2e-15	13400	79.8	59000	77	1.04	LR_close
101	25	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	1.02e-12	6.62e-15	14100	84	62400	81.4	1.03	LR_close
102	8	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	1.03e-12	6.62e-15	14100	84.2	62600	81.6	1.03	LR_close
103	26	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	2.89e-12	1.85e-14	7540	45	32000	41.7	1.08	LR_close
104	16	MA1641.1	MYF5	MA1641.1	NVACAGCTGTBN	MYF5	3.34e-12	2.12e-14	5420	32.4	22500	29.3	1.1	LR_close
105	8	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	5.67e-12	3.55e-14	13300	79.3	58700	76.6	1.04	LR_close
106	8	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	5.74e-12	3.56e-14	14900	88.9	66500	86.8	1.02	LR_close
107	1	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	8.56e-12	5.27e-14	2200	13.1	8440	11	1.19	LR_close
108	2	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	9.62e-12	5.86e-14	1260	7.5	4510	5.89	1.27	LR_close
109	8	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	1.22e-11	7.34e-14	13600	81.3	60300	78.7	1.03	LR_close
110	19	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	1.54e-11	9.2e-14	16200	96.9	73300	95.7	1.01	LR_close
111	8	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	2.27e-11	1.34e-13	15400	92	69100	90.1	1.02	LR_close
112	22	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	2.51e-11	1.47e-13	14000	83.8	62300	81.3	1.03	LR_close
113	27	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	4.59e-11	2.67e-13	16400	97.9	74200	96.8	1.01	LR_close
114	28	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	4.95e-11	2.85e-13	14900	88.8	66500	86.8	1.02	LR_close
115	21	MA0665.1	MSC	MA0665.1	AACAGCTGTT	MSC	5.14e-11	2.94e-13	7620	45.5	32500	42.4	1.07	LR_close
116	17	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	5.25e-11	2.98e-13	15500	92.3	69400	90.5	1.02	LR_close
117	19	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	5.57e-11	3.13e-13	14900	89	66600	87	1.02	LR_close
118	8	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	5.66e-11	3.16e-13	16300	97.4	73700	96.2	1.01	LR_close
119	2	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	5.72e-11	3.16e-13	9320	55.6	40200	52.5	1.06	LR_close
120	8	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	5.97e-11	3.28e-13	11800	70.6	51900	67.7	1.04	LR_close
121	8	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	6.86e-11	3.73e-13	15300	91.1	68400	89.2	1.02	LR_close
122	19	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	2.43e-10	1.31e-12	14400	86.2	64400	84	1.03	LR_close
123	15	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	2.71e-10	1.45e-12	11900	71	52300	68.2	1.04	LR_close
124	29	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	3.79e-10	2.01e-12	14500	86.6	64700	84.5	1.03	LR_close
125	30	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	4.71e-10	2.48e-12	15100	89.9	67400	88	1.02	LR_close
126	4	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	1.37e-09	7.13e-12	5300	31.7	22200	28.9	1.09	LR_close
127	25	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	1.5e-09	7.75e-12	14100	84.3	62900	82	1.03	LR_close
128	8	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	1.71e-09	8.81e-12	15800	94.1	71000	92.6	1.02	LR_close
129	31	MA1566.2	TBX3	MA1566.2	RAGGTGTGAAV	TBX3	1.73e-09	8.82e-12	6030	36	25400	33.2	1.08	LR_close
130	21	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	1.97e-09	9.95e-12	3360	20.1	13600	17.8	1.13	LR_close
131	9	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	2.21e-09	1.11e-11	1210	7.21	4420	5.77	1.25	LR_close
132	19	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	2.64e-09	1.32e-11	13800	82.4	61400	80.1	1.03	LR_close
133	8	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	2.86e-09	1.41e-11	16500	98.5	74800	97.7	1.01	LR_close
134	8	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	4.36e-09	2.14e-11	14500	86.6	64800	84.6	1.02	LR_close
135	8	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	5.67e-09	2.76e-11	13300	79.5	59100	77.1	1.03	LR_close
136	10	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	6.01e-09	2.91e-11	15500	92.8	69900	91.2	1.02	LR_close
137	8	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	6.28e-09	3.02e-11	12400	74.3	55000	71.7	1.04	LR_close
138	8	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	8.3e-09	3.96e-11	12800	76.6	56800	74.1	1.03	LR_close
139	29	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	1.96e-08	9.28e-11	14400	86.2	64500	84.2	1.02	LR_close
140	20	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	2.01e-08	9.43e-11	11500	68.7	50600	66.1	1.04	LR_close
141	47	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	3.39e-08	1.58e-10	14300	85.4	63900	83.4	1.02	LR_close
142	4	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	3.96e-08	1.84e-10	12300	73.6	54500	71.1	1.03	LR_close
143	26	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	5.27e-08	2.43e-10	15800	94.3	71300	93	1.01	LR_close
144	8	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	7.16e-08	3.27e-10	12700	76.1	56500	73.7	1.03	LR_close
145	21	MA0669.1	NEUROG2	MA0669.1	RACATATGTC	NEUROG2	7.49e-08	3.4e-10	6030	36	25600	33.4	1.08	LR_close
146	8	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	9.89e-08	4.46e-10	16300	97.6	74100	96.6	1.01	LR_close
147	32	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	1.33e-07	5.94e-10	14500	86.6	64900	84.7	1.02	LR_close
148	10	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	1.34e-07	5.94e-10	15600	93.2	70400	91.8	1.02	LR_close
149	23	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	1.49e-07	6.58e-10	16400	98.1	74600	97.3	1.01	LR_close
150	15	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	1.63e-07	7.15e-10	12700	75.6	56200	73.3	1.03	LR_close
151	16	MA0521.2	Tcf12	MA0521.2	NNACAGCTGTNN	Tcf12	1.66e-07	7.24e-10	4200	25.1	17500	22.8	1.1	LR_close
152	8	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	2.78e-07	1.2e-09	13400	80.2	59800	78	1.03	LR_close
153	19	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	3.84e-07	1.65e-09	14400	85.8	64300	83.9	1.02	LR_close
154	31	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	5.03e-07	2.15e-09	9790	58.5	42800	55.9	1.05	LR_close
155	2	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	1.26e-06	5.33e-09	15900	94.7	71600	93.4	1.01	LR_close
156	31	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	2.45e-06	1.03e-08	6060	36.2	25900	33.8	1.07	LR_close
157	26	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	2.98e-06	1.25e-08	15400	91.9	69400	90.5	1.02	LR_close
158	8	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	5.33e-06	2.22e-08	11600	69	51100	66.7	1.03	LR_close
159	20	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	7.94e-06	3.29e-08	11800	70.2	52100	68	1.03	LR_close
160	8	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	9.6e-06	3.95e-08	14600	87.1	65500	85.4	1.02	LR_close
161	1	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	1.02e-05	4.17e-08	986	5.89	3700	4.82	1.22	LR_close
162	31	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	1.16e-05	4.7e-08	3400	20.3	14100	18.4	1.1	LR_close
163	8	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	1.5e-05	6.04e-08	13200	79	59000	77	1.03	LR_close
164	8	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	1.69e-05	6.79e-08	10800	64.7	47800	62.4	1.04	LR_close
165	31	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	1.74e-05	6.88e-08	3940	23.5	16500	21.6	1.09	LR_close
166	33	MA1573.2 (Thap11)	STREME-9	9-CTGGGAAATGTAGTY	CTGGGAAATGTAGTY	Thap11	1.74e-05	6.88e-08	33	0.2	37	0.05	4.09	LR_close
167	8	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	1.92e-05	7.57e-08	4760	28.4	20200	26.4	1.08	LR_close
168	34	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	2.38e-05	9.33e-08	15700	93.9	71100	92.7	1.01	LR_close
169	8	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	2.61e-05	1.02e-07	13600	81.1	60800	79.3	1.02	LR_close
170	27	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	2.69e-05	1.04e-07	14800	88.4	66500	86.8	1.02	LR_close
171	16	MA0500.2	MYOG	MA0500.2	NDRCAGCTGYHN	MYOG	2.99e-05	1.15e-07	12500	74.4	55500	72.4	1.03	LR_close
172	23	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	4.51e-05	1.73e-07	15900	94.8	71900	93.8	1.01	LR_close
173	11	MA1153.1	Smad4	MA1153.1	TGTCTRGM	Smad4	6.81e-05	2.59e-07	2560	15.3	10500	13.7	1.11	LR_close
174	34	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	9.27e-05	3.51e-07	15200	91	68700	89.7	1.01	LR_close
175	32	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	0.000124	4.66e-07	13600	81.4	61100	79.7	1.02	LR_close
176	35	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	0.000149	5.56e-07	14200	84.9	63800	83.3	1.02	LR_close
177	33	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	0.000161	5.98e-07	49	0.29	84	0.11	2.69	LR_close
178	21	MA0832.1	Tcf21	MA0832.1	RYAACAGCTGTTRN	Tcf21	0.000165	6.06e-07	1660	9.89	6620	8.64	1.15	LR_close
179	23	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	0.000165	6.06e-07	10800	64.6	47900	62.5	1.03	LR_close
180	15	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	0.000166	6.06e-07	12900	77.3	57800	75.4	1.02	LR_close
181	8	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	0.000188	6.82e-07	10100	60.4	44700	58.3	1.04	LR_close
182	19	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	0.000202	7.32e-07	16500	98.4	75000	97.8	1.01	LR_close
183	31	MA0690.2	TBX21	MA0690.2	TTTCACACCTT	TBX21	0.000274	9.84e-07	5910	35.3	25500	33.3	1.06	LR_close
184	36	MA0130.1	ZNF354C	MA0130.1	MTCCAC	ZNF354C	0.000367	1.31e-06	14500	86.3	65000	84.8	1.02	LR_close
185	8	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	0.000371	1.32e-06	10500	62.6	46400	60.5	1.03	LR_close
186	9	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	0.000375	1.33e-06	1070	6.41	4160	5.42	1.18	LR_close
187	31	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.00049	1.73e-06	4600	27.4	19600	25.6	1.07	LR_close
188	21	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	0.000493	1.73e-06	4260	25.4	18100	23.7	1.08	LR_close
189	8	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	0.000516	1.79e-06	9990	59.6	44100	57.6	1.04	LR_close
190	16	MA0820.1	FIGLA	MA0820.1	WMCACCTGKW	FIGLA	0.000606	2.1e-06	16000	95.4	72400	94.4	1.01	LR_close
191	16	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	0.000664	2.29e-06	15600	93.2	70600	92.1	1.01	LR_close
192	16	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	0.000721	2.47e-06	13200	78.5	58900	76.8	1.02	LR_close
193	9	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.000745	2.54e-06	12900	77.2	57800	75.5	1.02	LR_close
194	37	MA0071.1	RORA	MA0071.1	AWMWAGGTCA	RORA	0.000895	3.04e-06	2490	14.9	10300	13.5	1.1	LR_close
195	16	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	0.00114	3.84e-06	1910	11.4	7810	10.2	1.12	LR_close
196	8	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	0.00139	4.66e-06	13400	80.2	60200	78.6	1.02	LR_close
197	38	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	0.00141	4.71e-06	14000	83.8	63100	82.3	1.02	LR_close
198	16	MA1619.1	Ptf1A	MA1619.1	NNACAGCTGTNN	Ptf1A	0.00148	4.93e-06	8400	50.1	36900	48.2	1.04	LR_close
199	8	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	0.00218	7.21e-06	12300	73.5	55000	71.8	1.02	LR_close
200	39	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	0.00323	1.06e-05	15700	93.5	70900	92.5	1.01	LR_close
201	16	MA1558.1	SNAI1	MA1558.1	DRCAGGTGYD	SNAI1	0.00337	1.1e-05	13900	83.2	62600	81.7	1.02	LR_close
202	31	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	0.00363	1.18e-05	5920	35.4	25700	33.6	1.05	LR_close
203	8	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	0.00432	1.4e-05	10500	62.8	46800	61	1.03	LR_close
204	8	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	0.00449	1.45e-05	16500	98.8	75400	98.3	1	LR_close
205	16	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	0.00598	1.92e-05	14300	85.3	64300	83.9	1.02	LR_close
206	40	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	0.0062	1.98e-05	13100	78.4	58900	76.9	1.02	LR_close
207	20	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	0.00642	2.04e-05	10300	61.5	45800	59.7	1.03	LR_close
208	39	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	0.0088	2.78e-05	14900	89.2	67500	88.1	1.01	LR_close
209	16	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	0.00903	2.84e-05	4420	26.4	19000	24.8	1.06	LR_close
210	16	MA1559.1	SNAI3	MA1559.1	RRCAGGTGYA	SNAI3	0.00948	2.97e-05	10000	59.7	44400	57.9	1.03	LR_close
211	16	MA0623.2	NEUROG1	MA0623.2	RACATATGTY	NEUROG1	0.0106	3.31e-05	1140	6.83	4560	5.95	1.15	LR_close
212	16	MA1100.2	ASCL1	MA1100.2	VGCAGCTGCN	ASCL1	0.0135	4.19e-05	14000	83.9	63300	82.5	1.02	LR_close
213	41	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	0.0136	4.19e-05	15600	93.1	70600	92.2	1.01	LR_close
214	8	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	0.015	4.62e-05	11000	65.4	48900	63.7	1.03	LR_close
215	21	MA0818.2	BHLHE22	MA0818.2	AMCATATGKY	BHLHE22	0.018	5.5e-05	5050	30.1	21900	28.5	1.06	LR_close
216	27	MA1547.2	PITX2	MA1547.2	YTAATCCY	PITX2	0.0203	6.17e-05	5610	33.5	24400	31.9	1.05	LR_close
217	10	MA0870.1	Sox1	MA0870.1	AACAATANCATTGTT	Sox1	0.0204	6.19e-05	552	3.3	2080	2.71	1.22	LR_close
218	8	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	0.0211	6.37e-05	10800	64.6	48300	63	1.03	LR_close
219	37	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	0.0224	6.72e-05	14900	89	67300	87.8	1.01	LR_close
220	42	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	0.0251	7.52e-05	12800	76.4	57400	74.9	1.02	LR_close
221	31	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	0.0275	8.15e-05	1760	10.5	7260	9.47	1.11	LR_close
222	31	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	0.0275	8.15e-05	9800	58.5	43500	56.8	1.03	LR_close
223	21	MA0607.2	BHLHA15	MA0607.2	ACCATATGGT	BHLHA15	0.0283	8.34e-05	4590	27.4	19800	25.9	1.06	LR_close
224	16	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.03	8.8e-05	1590	9.51	6550	8.54	1.11	LR_close
225	19	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	0.0405	0.000119	10800	64.4	48200	62.8	1.03	LR_close
226	40	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	0.0419	0.000122	13200	78.9	59400	77.5	1.02	LR_close
227	8	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	0.0439	0.000127	13100	78.1	58800	76.7	1.02	LR_close
228	43	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	0.0468	0.000135	15200	90.6	68700	89.6	1.01	LR_close
14	44	MA1107.2 (KLF9)	MEME-3	ACACACACACACACA	ACACACACACACACA	KLF9	1.26	0.0902	22	0.13	68	0.09	1.53	LR_close
15	45	MA1723.1 (PRDM9)	MEME-2	DGGRGVWGGGRRGAG	DGGRGVWGGGRRGAG	PRDM9	11.3	0.75	501	2.99	2340	3.05	0.982	LR_close
16	46	MA1125.1 (ZNF384)	MEME-1	AAAAWAAAAAAARAA	AAAAWAAAAAAARAA	ZNF384	17	1	190	1.13	1100	1.44	0.792	LR_close
17	47	MA0139.1 (CTCF)	MEME-4	SYGCCMYCTGSTGGY	SYGCCMYCTGSTGGY	CTCF	17	1	1890	11.3	10400	13.6	0.831	LR_close

ER_rat <- 1.25
mrc_type <- "LR_close"
LR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of LR_close-1.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

LR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*2.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./2.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Past versions of LR_close-2.png

Version	Author	Date
7b1c18d	reneeisnowhere	2025-05-08

meme_motifs_EAR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/xstreme.txt")
meme_motifs_ESR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/xstreme.txt")
meme_motifs_LR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/xstreme.txt")
meme_motifs_EAR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/xstreme.txt")
meme_motifs_ESR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/xstreme.txt")
meme_motifs_LR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/xstreme.txt")
meme_motifs_ESR_opcl <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/xstreme.txt")
meme_motifs_ESR_clop <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/xstreme.txt")

making table of significant

full_motifs_dataframe <- bind_rows(EAR_close_combo,
          ESR_close_combo,
          LR_close_combo,
          EAR_open_combo,
          ESR_open_combo,
          LR_open_combo,
          ESR_clop_combo,
          ESR_opcl_combo)


for_supplemental <- full_motifs_dataframe %>% 
  dplyr::select(CLUSTER:EVALUE.y, ENR_RATIO,mrc_type) %>%  
  dplyr::filter(ENR_RATIO>1.25) %>% 
 dplyr::filter(EVALUE.y<0.05) %>%  
  group_by(mrc_type,CLUSTER) %>% 
  summarize(ID=paste(unique(ID), collapse = ";"),
            ALT_ID=paste(unique(ALT_ID), collapse = ";"),
            motif_name=paste(unique(motif_name),collapse="; "),
            mrc=unique(mrc_type),
            sig_val=paste0(min(EVALUE.y),"-",max(EVALUE.y)),
            order_val=min(EVALUE.y)) %>% 
    arrange(mrc,order_val) 
# write_delim(for_supplemental,"data/Final_four_data/re_analysis/motif_cluster_dataframe.txt",delim="\t")
  
  
  for_supplemental

# A tibble: 160 × 8
# Groups:   mrc_type [8]
   mrc_type  CLUSTER ID                ALT_ID motif_name mrc   sig_val order_val
   <chr>       <int> <chr>             <chr>  <chr>      <chr> <chr>       <dbl>
 1 EAR_close       1 1-VTGASTCAB;MA16… STREM… FOS; BACH… EAR_… 4.82e-…  4.82e-72
 2 EAR_close       2 2-GWGATAA;MA0766… STREM… GATA2; GA… EAR_… 6.53e-…  6.53e-61
 3 EAR_close       3 MA0774.1;MA0498.… MEIS2… MEIS2; ME… EAR_… 1.58e-…  1.58e-26
 4 EAR_close      10 7-ACTCAA          STREM… NKX2-2     EAR_… 2.27e-…  2.27e-22
 5 EAR_close      16 MA0035.4          GATA1  GATA1      EAR_… 7.35e-…  7.35e-18
 6 EAR_close      18 MA0842.2          NRL    NRL        EAR_… 1.73e-…  1.73e-14
 7 EAR_close      31 MA1632.1          ATF2   ATF2       EAR_… 4.08e-…  4.08e-13
 8 EAR_close      15 MA0595.1;MA0596.… SREBF… SREBF1; S… EAR_… 3.57e-…  3.57e-12
 9 EAR_close      33 MA1643.1;MA0119.… NFIB;… NFIB; NFI… EAR_… 6.57e-…  6.57e- 6
10 EAR_close      32 MA0802.1          TBR1   TBR1       EAR_… 8.35e-…  8.35e- 6
# ℹ 150 more rows

  full_motifs_dataframe %>% 
    dplyr::filter(mrc_type=="LR_open")

    RANK CLUSTER            SIM_MOTIF         ALT_ID               ID
1      1       1 MA1134.1 (FOS::JUNB)       STREME-1    1-DATGASTCATH
2      2       1      MA1988.1 (Atf3)         MEME-1      DRTGACTCAYH
3      3       1             MA1144.1    FOSL2::JUND         MA1144.1
4      4       1             MA1135.1     FOSB::JUNB         MA1135.1
5      5       1             MA1134.1      FOS::JUNB         MA1134.1
6      6       1             MA0477.2          FOSL1         MA0477.2
7      7       1             MA1138.1    FOSL2::JUNB         MA1138.1
8      8       1             MA0476.1            FOS         MA0476.1
9      9       1             MA0489.2            Jun         MA0489.2
10    10       1             MA0490.2           JUNB         MA0490.2
11    11       1             MA1130.1     FOSL2::JUN         MA1130.1
12    12       1             MA1141.1      FOS::JUND         MA1141.1
13    13       1             MA0462.2      BATF::JUN         MA0462.2
14    14       1             MA1634.1           BATF         MA1634.1
15    15       1             MA1988.1           Atf3         MA1988.1
16    16       1             MA0099.3       FOS::JUN         MA0099.3
17    17       1             MA0491.2           JUND         MA0491.2
18    18       1             MA0835.2          BATF3         MA0835.2
19    19       1             MA1128.1     FOSL1::JUN         MA1128.1
20    20       1             MA1633.2          BACH1         MA1633.2
21    21       1             MA1928.1           BNC2         MA1928.1
22    22       1             MA1137.1    FOSL1::JUNB         MA1137.1
23    23       1             MA0478.1          FOSL2         MA0478.1
24    24       1       MA0476.1 (FOS)      STREME-10       10-TGANTCA
25    25       1             MA0655.1           JDP2         MA0655.1
26    26       1             MA1142.1    FOSL1::JUND         MA1142.1
27    27       1             MA1132.1      JUN::JUNB         MA1132.1
28    28       1             MA1101.2          BACH2         MA1101.2
29    29       1             MA0841.1           NFE2         MA0841.1
30    30       1             MA0089.2   MAFG::NFE2L1         MA0089.2
31    31       1             MA0496.3           MAFK         MA0496.3
32    32       1             MA0501.1      MAF::NFE2         MA0501.1
33    33       1             MA0150.2         Nfe2l2         MA0150.2
34    34       2             2-ATKMAT       STREME-2         2-ATKMAT
35    35       1             MA0659.3           Mafg         MA0659.3
36    36       3             MA0676.1          Nr2e1         MA0676.1
37    37       1             MA1113.2           PBX2         MA1113.2
38    38       1             MA1639.1          MEIS1         MA1639.1
39    39       1             MA1640.1          MEIS2         MA1640.1
40    40       4             MA0790.1         POU4F1         MA0790.1
41    41       5             MA1978.1        ZNF354A         MA1978.1
42    42       6             MA0845.1          FOXB1         MA0845.1
43    43       7             MA0886.1           EMX2         MA0886.1
44    44       8             MA0788.1         POU3F3         MA0788.1
45    45       8             MA0786.1         POU3F1         MA0786.1
46    46       9             MA0680.2           Pax7         MA0680.2
47    47       9             MA0681.2         PHOX2B         MA0681.2
48    48       7             MA0902.2          HOXB2         MA0902.2
49    49       6             MA0032.2          FOXC1         MA0032.2
50    50      10            3-WTVWBAW       STREME-3        3-WTVWBAW
51    51       8             MA0785.1         POU2F1         MA0785.1
52    52       6             MA0041.2          FOXD3         MA0041.2
53    53       4             MA0791.1         POU4F3         MA0791.1
54    54       6             MA0846.1          FOXC2         MA0846.1
55    55       8             MA0792.1        POU5F1B         MA0792.1
56    56       7             MA0710.1           NOTO         MA0710.1
57    57       7             MA0628.1         POU6F1         MA0628.1
58    58      11             MA0052.4          MEF2A         MA0052.4
59    59      12             MA1143.1    FOSL1::JUND         MA1143.1
60    60       8             MA0787.1         POU3F2         MA0787.1
61    61      13            15-HHATDD      STREME-15        15-HHATDD
62    62       7             MA1963.1          SATB1         MA1963.1
63    63       4             MA0046.2          HNF1A         MA0046.2
64    64       7             MA0713.1         PHOX2A         MA0713.1
65    65      14             MA0901.2         HOXB13         MA0901.2
66    66       7             MA0793.1         POU6F2         MA0793.1
67    67       9             MA0679.2        ONECUT1         MA0679.2
68    68       8             MA0627.2         POU2F3         MA0627.2
69    69       4             MA0153.2          HNF1B         MA0153.2
70    70       8             MA1115.1         POU5F1         MA1115.1
71    71       8             MA0142.1   Pou5f1::Sox2         MA0142.1
72    72      15             4-TRTAYA       STREME-4         4-TRTAYA
73    73       9             MA1471.1          BARX2         MA1471.1
74    74       6             MA0148.4          FOXA1         MA0148.4
75    75       7             MA0723.2           VAX2         MA0723.2
76    76       7             MA0722.1           VAX1         MA0722.1
77    77       8             MA0789.1         POU3F4         MA0789.1
78    78       7             MA1549.1         POU6F1         MA1549.1
79    79       6             MA1607.1          Foxl2         MA1607.1
80    80      16             MA0084.1            SRY         MA0084.1
81    81      17             MA0602.1         Arid5a         MA0602.1
82    82       7             MA0706.1          MEOX2         MA0706.1
83    83       7             MA0675.1         NKX6-2         MA0675.1
84    84      14             MA0465.2           CDX2         MA0465.2
85    85       7             MA1502.1          HOXB8         MA1502.1
86    86       6             MA0047.3          FOXA2         MA0047.3
87    87       6             MA0481.3          FOXP1         MA0481.3
88    88       7             MA1481.1           DRGX         MA1481.1
89    89      18             MA1603.1          Dmrt1         MA1603.1
90    90      19             MA0495.3           MAFF         MA0495.3
91    91       7             MA0910.2          HOXD8         MA0910.2
92    92       7             MA0027.2            EN1         MA0027.2
93    93      20             MA0905.1         HOXC10         MA0905.1
94    94       7             MA0718.1            RAX         MA0718.1
95    95      21             MA0025.2          NFIL3         MA0025.2
96    96       7             MA0716.1          PRRX1         MA0716.1
97    97       7             MA0720.1          Shox2         MA0720.1
98    98       7             MA0158.2          HOXA5         MA0158.2
99    99       6             MA1683.1          FOXA3         MA1683.1
100  100      22             MA1487.2          FOXE1         MA1487.2
101  101       7             MA0704.1           Lhx4         MA0704.1
102  102       6             MA1606.1          Foxf1         MA1606.1
103  103       7             MA0644.2           ESX1         MA0644.2
104  104       6             MA1103.2          FOXK2         MA1103.2
105  105      23             MA1480.1           DPRX         MA1480.1
106  106       7             MA0899.1         HOXA10         MA0899.1
107  107      16             MA1152.1          SOX15         MA1152.1
108  108       7             MA0882.1           DLX6         MA0882.1
109  109       7             MA0601.1         Arid3b         MA0601.1
110  110       7             MA0658.1           LHX6         MA0658.1
111  111      24             MA1124.1          ZNF24         MA1124.1
112  112      14             MA0650.3         Hoxa13         MA0650.3
113  113      21             MA1636.1          CEBPG         MA1636.1
114  114       7             MA0700.2           LHX2         MA0700.2
115  115       6             MA0031.1          FOXD1         MA0031.1
116  116       7             MA0654.1            ISX         MA0654.1
117  117       7             MA0715.1          PROP1         MA0715.1
118  118       7             MA0674.1         NKX6-1         MA0674.1
119  119       7             MA0880.1           Dlx3         MA0880.1
120  120      25             MA1104.2          GATA6         MA1104.2
121  121       7             MA0661.1          MEOX1         MA0661.1
122  122       7             MA0881.1           Dlx4         MA0881.1
123  123       6             MA0033.2          FOXL1         MA0033.2
124  124       7             MA0612.2           EMX1         MA0612.2
125  125      25             MA0035.4          GATA1         MA0035.4
126  126       6             MA0042.2          FOXI1         MA0042.2
127  127       7             MA0707.2           MNX1         MA0707.2
128  128      26             MA0108.2            TBP         MA0108.2
129  129       7             MA0903.1          HOXB3         MA0903.1
130  130       6             MA0848.1          FOXO4         MA0848.1
131  131      11             MA0497.1          MEF2C         MA0497.1
132  132       7             MA0721.1           UNCX         MA0721.1
133  133      27             6-TTAAAA       STREME-6         6-TTAAAA
134  134       9             MA0611.2            Dux         MA0611.2
135  135       7             MA0725.1           VSX1         MA0725.1
136  136       6             MA0157.3          Foxo3         MA0157.3
137  137       6             MA0851.1          Foxj3         MA0851.1
138  138       7             MA1495.1          HOXA1         MA1495.1
139  139      21             MA0102.4          CEBPA         MA0102.4
140  140       7             MA0888.1           EVX2         MA0888.1
141  141       7             MA0879.2           DLX1         MA0879.2
142  142      16             MA0868.2           SOX8         MA0868.2
143  143       7             MA0726.1           VSX2         MA0726.1
144  144       7             MA1505.1          HOXC8         MA1505.1
145  145       7             MA0068.2           PAX4         MA0068.2
146  146      25             MA0036.3          GATA2         MA0036.3
147  147       7             MA0630.1           SHOX         MA0630.1
148  148      14             MA1125.1         ZNF384         MA1125.1
149  149       7             MA0890.1           GBX2         MA0890.1
150  150       1             MA0591.1    Bach1::Mafk         MA0591.1
151  151      22             MA1489.1          FOXN3         MA1489.1
152  152       7             MA0634.1           ALX3         MA0634.1
153  153       7             MA0125.1          Nobox         MA0125.1
154  154      22             MA0847.3          FOXD2         MA0847.3
155  155       7             MA0876.1            BSX         MA0876.1
156  156       7             MA1476.2           Dlx5         MA1476.2
157  157       7             MA0635.1         BARHL2         MA0635.1
158  158       7             MA0904.2          HOXB5         MA0904.2
159  159      28             MA1657.1         ZNF652         MA1657.1
160  160       7             MA0662.1          MIXL1         MA0662.1
161  161      20             MA0908.1         HOXD11         MA0908.1
162  162       7             MA0887.1           EVX1         MA0887.1
163  163       9             MA0755.1           CUX2         MA0755.1
164  164       7             MA0709.1           Msx3         MA0709.1
165  165       9             MA0122.3         Nkx3-2         MA0122.3
166  166      20             MA0911.1         Hoxa11         MA0911.1
167  167       7             MA1518.2           Lhx1         MA1518.2
168  168       7             MA0892.1           GSX1         MA0892.1
169  169      21             MA0043.3            HLF         MA0043.3
170  170      16             MA0077.1           SOX9         MA0077.1
171  171       7             MA0648.1            GSC         MA0648.1
172  172       7             MA0885.2           Dlx2         MA0885.2
173  173       7             MA0717.1           RAX2         MA0717.1
174  174      25             MA1970.1          TRPS1         MA1970.1
175  175       7             MA0909.3         Hoxd13         MA0909.3
176  176       6             MA0480.2          Foxo1         MA0480.2
177  177       7             MA0889.1           GBX1         MA0889.1
178  178       7             MA0724.1          VENTX         MA0724.1
179  179       7             MA0701.2           LHX9         MA0701.2
180  180       7             MA0666.2           MSX1         MA0666.2
181  181      16             MA0143.4           SOX2         MA0143.4
182  182      29             5-AACMAA       STREME-5         5-AACMAA
183  183       6             MA0613.1          FOXG1         MA0613.1
184  184       7             MA1530.1         NKX6-3         MA1530.1
185  185       7             MA1463.1          ARGFX         MA1463.1
186  186       7             MA0132.2           PDX1         MA0132.2
187  187      30             MA1479.1         DMRTC2         MA1479.1
188  188       7             MA0875.1          BARX1         MA0875.1
189  189       6             MA0852.2          FOXK1         MA0852.2
190  190       7             MA1519.1           LHX5         MA1519.1
191  191       7             MA0708.2           MSX2         MA0708.2
192  192       9             MA0898.1           Hmx3         MA0898.1
193  193       6             MA0614.1          Foxj2         MA0614.1
194  194       7             MA0712.2           OTX2         MA0712.2
195  195      25             MA0037.4          Gata3         MA0037.4
196  196       7             MA0891.1           GSC2         MA0891.1
197  197       7             MA0912.2          HOXD3         MA0912.2
198  198       7             MA0894.1          HESX1         MA0894.1
199  199      14             MA0913.2          HOXD9         MA0913.2
200  200       7             MA0699.1           LBX2         MA0699.1
201  201      31             MA0050.3           Irf1         MA0050.3
202  202       7             MA1498.2          HOXA7         MA1498.2
203  203       7             MA1500.1          HOXB6         MA1500.1
204  204       7             MA1497.1          HOXA6         MA1497.1
205  205       7             MA1499.1          HOXB4         MA1499.1
206  206       7             MA0895.1         HMBOX1         MA0895.1
207  207      21             MA0836.2          CEBPD         MA0836.2
208  208       7             MA1608.1           Isl1         MA1608.1
209  209      73             MA0682.2          PITX1         MA0682.2
210  210       6             MA0849.1          FOXO6         MA0849.1
211  211      32             MA1974.1         ZNF211         MA1974.1
212  212       9             MA0754.2           CUX1         MA0754.2
213  213      21             MA0833.2           ATF4         MA0833.2
214  214      31             MA1623.1          Stat2         MA1623.1
215  215       7             MA0705.1           Lhx8         MA0705.1
216  216      33             MA0514.2           Sox3         MA0514.2
217  217       7             MA1496.1          HOXA4         MA1496.1
218  218      34             MA1562.1          SOX14         MA1562.1
219  219       7             MA0642.2            EN2         MA0642.2
220  220      35             MA0151.1         Arid3a         MA0151.1
221  221      36             MA0769.2           TCF7         MA0769.2
222  222       7             MA0853.1           Alx4         MA0853.1
223  223      33             MA0867.2           SOX4         MA0867.2
224  224       7             MA0900.2          HOXA2         MA0900.2
225  225      16             MA1120.1          SOX13         MA1120.1
226  226       7             MA1504.1          HOXC4         MA1504.1
227  227       7             MA0854.1           Alx1         MA0854.1
228  228      37             MA0914.1           ISL2         MA0914.1
229  229       8             MA1962.1   POU2F1::SOX2         MA1962.1
230  230       7             MA0075.3          PRRX2         MA0075.3
231  231      33             MA1563.2          SOX18         MA1563.2
232  232       6             MA0850.1          FOXP3         MA0850.1
233  233       7             MA0618.1           LBX1         MA0618.1
234  234      18             MA0442.2          SOX10         MA0442.2
235  235      38             MA0606.2          Nfat5         MA0606.2
236  236      16             MA0078.2          Sox17         MA0078.2
237  237      25             MA0482.2          GATA4         MA0482.2
238  238       9             MA0897.1           Hmx2         MA0897.1
239  239      22             MA0040.1          Foxq1         MA0040.1
240  240       7             MA0893.2           GSX2         MA0893.2
241  241      14             MA0878.3           CDX1         MA0878.3
242  242      36             MA0523.1         TCF7L2         MA0523.1
243  243      39             MA1729.1         ZNF680         MA1729.1
244  244       4             MA0683.1         POU4F2         MA0683.1
245  245      40             MA1960.1      MGA::EVX1         MA1960.1
246  246       9             MA0896.1           Hmx1         MA0896.1
247  247      41             MA0877.3         BARHL1         MA0877.3
248  248      20             MA0906.1         HOXC12         MA0906.1
249  249      19             MA0117.2           Mafb         MA0117.2
250  250      20             MA0907.1         HOXC13         MA0907.1
251  251      23             MA0711.1           OTX1         MA0711.1
252  252      42             MA1709.1           ZIM3         MA1709.1
253  253      43             MA0629.1         Rhox11         MA0629.1
254  254       7             MA1577.1           TLX2         MA1577.1
255  255       9             MA0757.1        ONECUT3         MA0757.1
256  256       7             MA0874.1            Arx         MA0874.1
257  257      23             MA0714.1          PITX3         MA0714.1
258  258       7             MA0467.2            Crx         MA0467.2
259  259      12             MA1126.1       FOS::JUN         MA1126.1
260  260       9             MA0780.1           PAX3         MA0780.1
261  261       7             MA1507.1          HOXD4         MA1507.1
262  262      44             MA1119.1           SIX2         MA1119.1
263  263       9             MA0070.1           PBX1         MA0070.1
264  264      12             MA0018.4          CREB1         MA0018.4
265  265      45             MA0884.2           DUXA         MA0884.2
266  266      44             MA1118.1           SIX1         MA1118.1
267  267      46             MA0144.2          STAT3         MA0144.2
268  268      36             MA0768.2           Lef1         MA0768.2
269  269      30             MA1707.1         DMRTA1         MA1707.1
270  270      33             MA0095.3            Yy1         MA0095.3
271  271      23             MA0883.1          Dmbx1         MA0883.1
272  272      47             MA0809.2          TEAD4         MA0809.2
273  273      12             MA1150.1           RORB         MA1150.1
274  274      12             MA1632.1           ATF2         MA1632.1
275  275      12             MA1131.1     FOSL2::JUN         MA1131.1
276  276      48             MA1588.1         ZNF136         MA1588.1
277  277      19             MA0842.2            NRL         MA0842.2
278  278      20             MA0873.1         HOXD12         MA0873.1
279  279       6             MA0593.1          FOXP2         MA0593.1
280  280      12             MA0843.1            TEF         MA0843.1
281  281      49             MA0678.1          OLIG2         MA0678.1
282  282      50             MA0063.2         NKX2-5         MA0063.2
283  283      34             MA1561.1          SOX12         MA1561.1
284  284       7             MA0135.1           Lhx3         MA0135.1
285  285      12             MA1127.1      FOSB::JUN         MA1127.1
286  286      12             MA1139.1    FOSL2::JUNB         MA1139.1
287  287      25             MA0766.2          GATA5         MA0766.2
288  288      30             MA1478.1         DMRTA2         MA1478.1
289  289      22             MA0030.1          FOXF2         MA0030.1
290  290      20             MA0594.2          HOXA9         MA0594.2
291  291      51             MA0693.3            Vdr         MA0693.3
292  292      52             MA0520.1          Stat6         MA0520.1
293  293      21             MA0838.1          CEBPG         MA0838.1
294  294      53             MA0782.2         PKNOX1         MA0782.2
295  295      47             MA0090.3          TEAD1         MA0090.3
296  296      38             MA0152.2         Nfatc2         MA0152.2
297  297      54             MA0689.1          TBX20         MA0689.1
298  298      25             MA0140.2    GATA1::TAL1         MA0140.2
299  299      12             MA0639.1            DBP         MA0639.1
300  300      55             MA0620.3           MITF         MA0620.3
301  301      56             MA0687.1           SPIC         MA0687.1
302  302      16             MA0087.2           Sox5         MA0087.2
303  303      50             MA1523.1        MSANTD3         MA1523.1
304  304       7             MA0621.1          mix-a         MA0621.1
305  305      12             MA1145.1    FOSL2::JUND         MA1145.1
306  306      56             MA1952.1    FOXJ2::ELF1         MA1952.1
307  307      57             MA0069.1           PAX6         MA0069.1
308  308       7             MA1501.1          HOXB7         MA1501.1
309  309      50             MA1994.1         Nkx2-1         MA1994.1
310  310      36             MA1991.1          Hnf1A         MA1991.1
311  311      73             MA0483.1          Gfi1B         MA0483.1
312  312      16             MA0515.1           Sox6         MA0515.1
313  313      49             MA0827.1          OLIG3         MA0827.1
314  314      45             MA0468.1           DUX4         MA0468.1
315  315      12             MA1129.1     FOSL1::JUN         MA1129.1
316  316      12             MA1133.1      JUN::JUNB         MA1133.1
317  317      55             MA0626.1          Npas2         MA0626.1
318  318      19             MA1520.1            MAF         MA1520.1
319  319      38             MA0624.2         Nfatc1         MA0624.2
320  320      53             MA0498.2          MEIS1         MA0498.2
321  321      42             MA1953.1    FOXO1::ELF1         MA1953.1
322  322      33             MA0869.2          Sox11         MA0869.2
323  323      12             MA1136.1     FOSB::JUNB         MA1136.1
324  324      58             MA1112.2          NR4A1         MA1112.2
325  325      20             MA1506.1         HOXD10         MA1506.1
326  326      59             MA0631.1           Six3         MA0631.1
327  327      60             MA1975.1         ZNF214         MA1975.1
328  328       7             MA0702.2          LMX1A         MA0702.2
329  329      55             MA0093.3           USF1         MA0093.3
330  330      31             MA0517.1   STAT1::STAT2         MA0517.1
331  331      61    MA1125.1 (ZNF384)         MEME-2  AAAAAAAAAAAAAAA
332  332      49             MA0461.2          Atoh1         MA0461.2
333  333      62             MA0479.1          FOXH1         MA0479.1
334  334      21             MA0837.2          CEBPE         MA0837.2
335  335      31             MA0772.1           IRF7         MA0772.1
336  336      63             MA0596.1         SREBF2         MA0596.1
337  337      64             MA1720.1          ZNF85         MA1720.1
338  338      65             MA1105.2          GRHL2         MA1105.2
339  339      37             MA0124.2         Nkx3-1         MA0124.2
340  340      73             MA0038.2           GFI1         MA0038.2
341  341      66             MA1592.1         ZNF274         MA1592.1
342  342      67             MA0619.1          LIN54         MA0619.1
343  343      49             MA1108.2           MXI1         MA1108.2
344  344      68             MA1151.1           RORC         MA1151.1
345  345      46             MA1625.1         Stat5b         MA1625.1
346  346      69             MA0508.3          PRDM1         MA0508.3
347  347      65             MA0743.2          SCRT1         MA0743.2
348  348       7             MA1644.1           NFYC         MA1644.1
349  349      51             MA1534.1          NR1I3         MA1534.1
350  350      49             MA1618.1          Ptf1a         MA1618.1
351  351      19             MA1521.1           MAFA         MA1521.1
352  352      20             MA1503.1          HOXB9         MA1503.1
353  353      23             MA0719.1         RHOXF1         MA0719.1
354  354      55             MA0829.2         SREBF1         MA0829.2
355  355      47             MA1121.1          TEAD2         MA1121.1
356  356       7             MA0784.2         POU1F1         MA0784.2
357  357      70             MA0861.1           TP73         MA0861.1
358  358      71             MA0684.2          RUNX3         MA0684.2
359  359      46             MA1624.1         Stat5a         MA1624.1
360  360      68             MA0494.1    Nr1h3::Rxra         MA0494.1
361  361      70             MA0106.3           TP53         MA0106.3
362  362      12             MA0492.1           JUND         MA0492.1
363  363      51             MA1111.1          NR2F2         MA1111.1
364  364      49             MA1524.2          Msgn1         MA1524.2
365  365      72             MA1593.1         ZNF317         MA1593.1
366  366      44             MA2001.1           Six4         MA2001.1
367  367      73     MA0682.2 (PITX1)         MEME-3  AAGTGCTGGGATTAC
368  368      14             MA1473.1           CDX4         MA1473.1
369  369      70             MA0525.2           TP63         MA0525.2
370  370      73             MA1547.2          PITX2         MA1547.2
371  371      71             MA1989.1         Bcl11B         MA1989.1
372  372      21             MA0466.3          CEBPB         MA0466.3
373  373      11             MA0773.1          MEF2D         MA0773.1
374  374      49             MA1570.1          TFAP4         MA1570.1
375  375      49             MA0826.1          OLIG1         MA0826.1
376  376      12             MA0488.1            JUN         MA0488.1
377  377      20             MA0485.2          HOXC9         MA0485.2
378  378      54             MA0800.1          EOMES         MA0800.1
379  379      73     MA1547.2 (PITX2)      STREME-11    11-CTGGGAYTAC
380  380      47             MA0808.1          TEAD3         MA0808.1
381  381      74             MA1580.1         ZBTB32         MA1580.1
382  382      65             MA0647.1          GRHL1         MA0647.1
383  383      63             MA0595.1         SREBF1         MA0595.1
384  384      20             MA0651.2         HOXC11         MA0651.2
385  385      75        9-CACTTTGGGAG       STREME-9    9-CACTTTGGGAG
386  386      46             MA0137.3          STAT1         MA0137.3
387  387      46             MA0518.1          Stat4         MA0518.1
388  388      76      TAGAGAYRGGGTTTC         MEME-5  TAGAGAYRGGGTTTC
389  389      42             MA1956.1    FOXO1::FLI1         MA1956.1
390  390      46             MA0519.1 Stat5a::Stat5b         MA0519.1
391  391      12             MA0840.1          Creb5         MA0840.1
392  392      36             MA1421.1         TCF7L1         MA1421.1
393  393      49             MA0817.1        BHLHE23         MA0817.1
394  394      25             MA0029.1          Mecom         MA0029.1
395  395      30             MA0610.1          DMRT3         MA0610.1
396  396      77             MA1585.1        ZKSCAN1         MA1585.1
397  397      46             MA0463.2           BCL6         MA0463.2
398  398      58             MA1148.1    PPARA::RXRA         MA1148.1
399  399      78             MA0164.1          Nr2e3         MA0164.1
400  400      68             MA0072.1           RORA         MA0072.1
401  401      79   MA1973.1 (ZKSCAN3)         MEME-6  TGTYRCCCAGGCTGG
402  402       7             MA0060.3           NFYA         MA0060.3
403  403      50             MA1645.1         NKX2-2         MA1645.1
404  404      80             MA0019.1   Ddit3::Cebpa         MA0019.1
405  405      54             MA0804.1          TBX19         MA0804.1
406  406       7             MA1546.1           PAX3         MA1546.1
407  407       7             MA0703.2          LMX1B         MA0703.2
408  408      42             MA1955.1    FOXO1::ELK3         MA1955.1
409  409      47             MA0114.4          HNF4A         MA0114.4
410  410      11             MA0660.1          MEF2B         MA0660.1
411  411      51             MA1996.1          Nr1H2         MA1996.1
412  412      81    MA1596.1 (ZNF460)      STREME-14  14-ACCTCAGCCTCC
413  413      54             MA0802.1           TBR1         MA0802.1
414  414      82             MA0698.1         ZBTB18         MA0698.1
415  415      83             MA1714.1         ZNF675         MA1714.1
416  416      42             MA1950.1    FLI1::FOXI1         MA1950.1
417  417      79   MA1973.1 (ZKSCAN3)       STREME-8 8-CCAGCCTGGGYRAC
418  418      50             MA1114.1           PBX3         MA1114.1
419  419      65             MA0744.2          SCRT2         MA0744.2
420  420      84             MA0101.1            REL         MA0101.1
421  421      85      MA1107.2 (KLF9)      STREME-13    13-ACCACACMCA
422  422      86             MA1949.1     FLI1::DRGX         MA1949.1
423  423      87     12-CTCCTGGGCTCAA      STREME-12 12-CTCCTGGGCTCAA
424  424      58             MA1541.1          NR6A1         MA1541.1
425  425      47             MA0484.2          HNF4G         MA0484.2
426  426      49             MA1467.2          Atoh1         MA1467.2
427  427      46             MA1116.1           RBPJ         MA1116.1
428  428      55             MA1995.1          Npas4         MA1995.1
429  429      58             MA0160.2          NR4A2         MA0160.2
430  430      88             MA1980.1         ZNF418         MA1980.1
431  431      89             MA1594.1         ZNF382         MA1594.1
432  432      81             MA1596.1         ZNF460         MA1596.1
433  433      49             MA0607.2        BHLHA15         MA0607.2
434  434      71             MA0002.2          Runx1         MA0002.2
435  435      49             MA1123.2         TWIST1         MA1123.2
436  436      90             MA0770.1           HSF2         MA0770.1
437  437      12             MA0656.1           JDP2         MA0656.1
438  438      58             MA0071.1           RORA         MA0071.1
439  439      42             MA1508.1          IKZF1         MA1508.1
440  440      85      MA0732.1 (EGR3)       STREME-7    7-CACCCACACAC
441  441      65             MA1968.1          TFCP2         MA1968.1
442  442      91             MA1572.1        TGIF2LY         MA1572.1
443  443      38             MA1525.2         NFATC4         MA1525.2
444  444      20             MA1958.1   HOXD12::ELK1         MA1958.1
445  445      12             MA1951.1            FOS         MA1951.1
446  446      58             MA0141.3          ESRRB         MA0141.3
447  447      55             MA0831.3           TFE3         MA0831.3
448  448       8             MA0507.2         POU2F2         MA0507.2
449  449      90             MA0486.2           HSF1         MA0486.2
450  450      55             MA0828.2         SREBF2         MA0828.2
451  451      54             MA0688.1           TBX2         MA0688.1
452  452      54             MA0803.1          TBX15         MA0803.1
453  453      49             MA1638.1          HAND2         MA1638.1
454  454      58             MA0643.1          Esrrg         MA0643.1
455  455      71             MA0511.2          RUNX2         MA0511.2
456  456      49             MA0818.2        BHLHE22         MA0818.2
457  457      81    MA1596.1 (ZNF460)         MEME-4  RGGAGGCBGAGGHKG
458  458      42             MA1954.1    FOXO1::ELK1         MA1954.1
459  459      54             MA0805.1           TBX1         MA0805.1
460  460      54             MA0807.1           TBX5         MA0807.1
461  461      86             MA1937.1    ERF::HOXB13         MA1937.1
462  462      91             MA0797.1          TGIF2         MA0797.1
463  463      12             MA0605.2           ATF3         MA0605.2
464  464      81             MA1587.1         ZNF135         MA1587.1
465  465      54             MA0801.1            MGA         MA0801.1
466  466      82             MA0691.1          TFAP4         MA0691.1
467  467      58             MA0592.3          ESRRA         MA0592.3
468  468      55             MA0692.1           TFEB         MA0692.1
469  469      92             MA1983.1         ZNF582         MA1983.1
470  470      33             MA0870.1           Sox1         MA0870.1
471  471      53             MA0775.1          MEIS3         MA0775.1
472  472      91             MA0667.1           MYF6         MA0667.1
473  473      42             MA1579.1         ZBTB26         MA1579.1
474  474      49             MA0623.2        NEUROG1         MA0623.2
475  475      31             MA0653.1           IRF9         MA0653.1
476  476      54             MA0806.1           TBX4         MA0806.1
477  477      93             MA0130.1        ZNF354C         MA0130.1
                 CONSENSUS.x      motif_name      EVALUE.y        QVALUE    TP
1                DATGASTCATH       FOS::JUNB  0.000000e+00  0.000000e+00 11729
2                DRTGACTCAYH            Atf3  0.000000e+00  0.000000e+00 11509
3                 KATGACTCAT     FOSL2::JUND  0.000000e+00  0.000000e+00 11579
4                 KRTGASTCAT      FOSB::JUNB  0.000000e+00  0.000000e+00 12079
5               KATGASTCATHN       FOS::JUNB  0.000000e+00  0.000000e+00 11894
6              NNATGACTCATNN           FOSL1  0.000000e+00  0.000000e+00 11077
7                 KRTGASTCAT     FOSL2::JUNB  0.000000e+00  0.000000e+00 12375
8                DVTGASTCATB             FOS  0.000000e+00  0.000000e+00 12368
9               NVTGACTCATNN             Jun  0.000000e+00  0.000000e+00 10270
10             NNATGACTCATNN            JUNB  0.000000e+00  0.000000e+00 11535
11              NNRTGAGTCAYN      FOSL2::JUN  0.000000e+00  0.000000e+00 11914
12             NKATGAGTCATNN       FOS::JUND  0.000000e+00  0.000000e+00 12070
13               DATGACTCATH       BATF::JUN  0.000000e+00  0.000000e+00 10924
14               DATGACTCATH            BATF  0.000000e+00  0.000000e+00 10696
15               NRTGACTCABN            Atf3  0.000000e+00  0.000000e+00 11989
16                ATGAGTCAYM        FOS::JUN  0.000000e+00  0.000000e+00 12324
17             NNATGACTCATNN            JUND  0.000000e+00  0.000000e+00 11713
18               DATGACTCATH           BATF3  0.000000e+00  0.000000e+00 11419
19             NKATGACTCATNN      FOSL1::JUN  0.000000e+00  0.000000e+00 12116
20                 ATGACTCAT           BACH1  0.000000e+00  0.000000e+00 12677
21              NDRTGAGTCABN            BNC2  0.000000e+00  0.000000e+00 11306
22             NDRTGACTCATNN     FOSL1::JUNB  0.000000e+00  0.000000e+00 11464
23               KRRTGASTCAB           FOSL2  0.000000e+00  0.000000e+00 11626
24                10-TGANTCA             FOS  0.000000e+00  0.000000e+00 10636
25                 ATGACTCAT            JDP2  0.000000e+00  0.000000e+00 10045
26                NRTGACTCAT     FOSL1::JUND  0.000000e+00  0.000000e+00  9837
27                KATGACKCAT       JUN::JUNB  0.000000e+00  0.000000e+00 10803
28       DWANCATGASTCATSNTWH           BACH2  0.000000e+00  0.000000e+00  9412
29               VATGACTCATS            NFE2  0.000000e+00  0.000000e+00  8975
30          NVNATGACTCAGCADW    MAFG::NFE2L1  0.000000e+00  0.000000e+00 12027
31           NGMTGACTCAGCMNH            MAFK  0.000000e+00  0.000000e+00 10201
32           ATGACTCAGCANWTY       MAF::NFE2  0.000000e+00  0.000000e+00 11642
33           CASNATGACTCAGCA          Nfe2l2  0.000000e+00  0.000000e+00 10857
34                    ATKMAT          ATKMAT  0.000000e+00  0.000000e+00 17941
35           NWGMTGACTCAGCAN            Mafg  0.000000e+00  0.000000e+00  9692
36                 AAAAGTCAA           Nr2e1  0.000000e+00  0.000000e+00 20274
37             NHCATAAATCAHN            PBX2  0.000000e+00  0.000000e+00 17570
38             NHCATMAATCAHN           MEIS1  0.000000e+00  0.000000e+00 16297
39           NNATGATTTATGDNH           MEIS2  0.000000e+00  0.000000e+00 19957
40            ATGMATAATTAATG          POU4F1  0.000000e+00  0.000000e+00 17723
41     HWAADWATAAATGRAYWAWTT         ZNF354A  0.000000e+00  0.000000e+00 19759
42               WATGTAAATAT           FOXB1  0.000000e+00  0.000000e+00 20261
43                VBTAATTARB            EMX2  0.000000e+00  0.000000e+00 18738
44             WWTATGCWAATTW          POU3F3  0.000000e+00  0.000000e+00 19999
45              WTATGCWAATKW          POU3F1  0.000000e+00  0.000000e+00 19966
46           DWTAATCAATTAWNH            Pax7  0.000000e+00  0.000000e+00 18342
47          WWTAATCAAATTAWWW          PHOX2B  0.000000e+00  0.000000e+00 17189
48                  SYAATTAS           HOXB2  0.000000e+00  0.000000e+00 17648
49               WAWGTAAAYAW           FOXC1  0.000000e+00  0.000000e+00 21146
50                   WTVWBAW         WTVWBAW  0.000000e+00  0.000000e+00 21308
51              AWTATGCWAATK          POU2F1  0.000000e+00  0.000000e+00 21014
52          WAWGHAAATAAACARY           FOXD3  0.000000e+00  0.000000e+00 21264
53          RTGMATWATTAATGAR          POU4F3  0.000000e+00  0.000000e+00 14937
54              WAWGTAAACAWW           FOXC2  0.000000e+00  0.000000e+00 20601
55                 TATGCWAAT         POU5F1B  0.000000e+00  0.000000e+00 21474
56                NYTAATTAVN            NOTO  0.000000e+00  0.000000e+00 21007
57                AYTAATTART          POU6F1  0.000000e+00  0.000000e+00 19220
58           DDCTAAAAATAGMHH           MEF2A  0.000000e+00  0.000000e+00 20833
59                RTGACGTMAY     FOSL1::JUND  0.000000e+00  0.000000e+00 16250
60              WTATGCWAATKA          POU3F2  0.000000e+00  0.000000e+00 18845
61                 15-HHATDD          HHATDD  0.000000e+00  0.000000e+00 21956
62             WWDCTAATAAHWW           SATB1  0.000000e+00  0.000000e+00 18821
63           DRTTAATNATTAACN           HNF1A  0.000000e+00  0.000000e+00 13337
64               TAATYYAATTA          PHOX2A  0.000000e+00  0.000000e+00 19263
65            WDCCAATAAAAWWW          HOXB13  0.000000e+00  0.000000e+00 19479
66                ASCTMATTAW          POU6F2  0.000000e+00  0.000000e+00 19745
67          WAAAAATCAATAAWWN         ONECUT1  0.000000e+00  0.000000e+00 17033
68             NWTATGCAAATNH          POU2F3  0.000000e+00  0.000000e+00 19816
69             GTTAATNATTAAY           HNF1B  0.000000e+00  0.000000e+00 12899
70               WHATGCAAATN          POU5F1  0.000000e+00  0.000000e+00 21753
71           CWTTGTYATGCAAAT    Pou5f1::Sox2  0.000000e+00  0.000000e+00 18270
72                    TRTAYA          TRTAYA  0.000000e+00  0.000000e+00 21613
73              NWWAAYMATTAN           BARX2  0.000000e+00  0.000000e+00 18474
74              WWGTAAACATNN           FOXA1  0.000000e+00  0.000000e+00 20978
75                  BYAATTAV            VAX2  0.000000e+00  0.000000e+00 20411
76                  YTAATTAH            VAX1  0.000000e+00  0.000000e+00 17918
77                 TATGCWAAT          POU3F4  0.000000e+00  0.000000e+00 18676
78                RTAATGAGVN          POU6F1  0.000000e+00  0.000000e+00 18089
79            DDWATGTAAACANN           Foxl2  0.000000e+00  0.000000e+00 20808
80                 NWWAACAAT             SRY  0.000000e+00  0.000000e+00 21532
81            SYAATATTGVDANH          Arid5a  0.000000e+00  0.000000e+00 19575
82                DSTAATTAWN           MEOX2  0.000000e+00  0.000000e+00 18080
83                  NYMATTAA          NKX6-2  0.000000e+00  0.000000e+00 20603
84              NDGCAATAAAWN            CDX2  0.000000e+00  0.000000e+00 20558
85                  GYMATTAM           HOXB8  0.000000e+00  0.000000e+00 16248
86               RWGTAAACANN           FOXA2  0.000000e+00  0.000000e+00 21770
87               NDGTAAACANH           FOXP1  0.000000e+00  0.000000e+00 21368
88                  YYAATTAN            DRGX  0.000000e+00  0.000000e+00 18888
89             GHTACAAAGTADC           Dmrt1  0.000000e+00  0.000000e+00 20045
90          DWGTCAGCATTTTWHN            MAFF  0.000000e+00  0.000000e+00 21298
91                  GYMATTAM           HOXD8 2.010847e-321 2.010847e-321 15882
92                  SYAATTAV             EN1 5.410019e-319 2.460447e-321 20748
93                GTCRTAAAAH          HOXC10 2.050002e-318 9.199502e-321 19325
94                RYYAATTARH             RAX 3.580000e-316 1.590002e-318 19294
95             NRTTATGYAATNN           NFIL3 1.000000e-315 4.390001e-318 17076
96                  YYAATTAR           PRRX1 1.690000e-314 7.330000e-317 20702
97                  YYAATTAR           Shox2 1.940000e-313 8.350000e-316 21115
98                  GYMATTAS           HOXA5 1.410000e-311 6.010000e-314 13954
99               DWGTAAACANN           FOXA3 1.380000e-309 5.810000e-312 21317
100           VYTAAAYAAACAAH           FOXE1 3.880000e-308 1.620000e-310 17028
101                 YTAATTAR            Lhx4 2.540000e-304 1.050000e-306 19366
102              DWRTAAACANN           Foxf1 2.590000e-300 1.060000e-302 18754
103                 YYAATTAN            ESX1 8.200000e-297 3.320000e-299 20186
104              DDGTAAACANN           FOXK2 1.660000e-296 6.670000e-299 20724
105               AGATAATCCN            DPRX 1.780000e-296 7.060000e-299 21091
106              DGYMATAAAAH          HOXA10 1.980000e-296 7.780000e-299 18369
107               CYWTTGTTHW           SOX15 2.790000e-296 1.090000e-298 21623
108                 VYAATTAN            DLX6 1.820000e-293 7.030000e-296 21247
109              ATATTAATWAN          Arid3b 5.020000e-289 1.920000e-291 16029
110               RCTAATTARY            LHX6 8.620000e-289 3.270000e-291 18460
111            CATTCATTCATTC           ZNF24 1.000000e-286 3.770000e-289 14594
112             NNCCAATAAAAN          Hoxa13 6.550000e-286 2.440000e-288 19065
113          NDATGATGCAATMHH           CEBPG 9.450000e-286 3.490000e-288 17468
114              DDCCAATTADN            LHX2 1.930000e-285 7.070000e-288 18117
115                 GTAAACAW           FOXD1 2.760000e-283 1.000000e-285 17329
116                 YYAATTAR             ISX 1.070000e-282 3.840000e-285 16688
117              TAATYWAATTA           PROP1 2.840000e-282 1.010000e-284 13316
118                 NTMATTAA          NKX6-1 2.180000e-280 7.700000e-283 18456
119                 NYAATTAN            Dlx3 1.490000e-277 5.220000e-280 19584
120            HWWTCTTATCTNH           GATA6 1.540000e-275 5.340000e-278 21231
121               VSTAATTAHC           MEOX1 2.320000e-275 8.000000e-278 20073
122                 VYAATTAN            Dlx4 2.370000e-275 8.110000e-278 20899
123                  RTAAACA           FOXL1 4.310000e-275 1.460000e-277 20843
124                 BTAATTAS            EMX1 8.210000e-275 2.760000e-277 13183
125              NHCTAATCTDH           GATA1 1.450000e-273 4.840000e-276 21627
126                  GTAAACA           FOXI1 5.530000e-273 1.830000e-275 19918
127                 VYRATTAK            MNX1 4.310000e-272 1.410000e-274 15668
128          STATAAAWRSVVVBN             TBP 1.570000e-271 5.100000e-274 19259
129               NNYMATTARN           HOXB3 6.840000e-269 2.210000e-271 15441
130                  GTAAACA           FOXO4 1.230000e-268 3.940000e-271 20185
131          DDDCYAAAAATAGMW           MEF2C 1.230000e-267 3.900000e-270 17430
132                 YYAATTAV            UNCX 1.940000e-267 6.120000e-270 20615
133                   TTAAAA          TTAAAA 1.280000e-265 4.010000e-268 21969
134         NTGATTBAATCAVWNN             Dux 1.960000e-265 6.110000e-268  9993
135                 YTAATTAN            VSX1 2.130000e-263 6.570000e-266 21910
136             NDGTAAACARNN           Foxo3 5.670000e-263 1.740000e-265 22011
137        NDAADGTAAACAAANNM           Foxj3 1.170000e-262 3.570000e-265 15334
138                 STAATTAS           HOXA1 2.740000e-262 8.280000e-265 14717
139           NDATTGCACAATHN           CEBPA 7.890000e-260 2.370000e-262 20597
140               VVTAATTAVB            EVX2 1.310000e-259 3.890000e-262 19377
141                 VYAATTAN            DLX1 7.270000e-259 2.150000e-261 19426
142               MGAACAATRG            SOX8 1.430000e-255 4.210000e-258 22192
143                 CTAATTAN            VSX2 1.660000e-254 4.840000e-257 21982
144                 KTAATTAM           HOXC8 1.860000e-254 5.380000e-257 14506
145                 CTAATTAG            PAX4 4.560000e-254 1.310000e-256 21256
146              NBCTTATCTNH           GATA2 1.930000e-253 5.510000e-256 20371
147                 HTAATTRR            SHOX 1.130000e-251 3.200000e-254 18641
148             DNWMAAAAAAAA          ZNF384 1.410000e-250 3.960000e-253 14509
149               RSYAATTARN            GBX2 6.380000e-248 1.790000e-250 18623
150          RSSATGACTCAGCAB     Bach1::Mafk 1.880000e-247 5.220000e-250  4733
151                 GTAAACAA           FOXN3 2.990000e-247 8.260000e-250 18725
152               YYYAATTANV            ALX3 8.820000e-247 2.420000e-249 20261
153                 TAATTRSY           Nobox 4.260000e-246 1.160000e-248 17763
154             SYTAARYAAACA           FOXD2 2.430000e-245 6.570000e-248 16196
155                 SYVATTAV             BSX 5.370000e-245 1.450000e-247 21090
156             NDGCAATTAGNN            Dlx5 6.970000e-244 1.860000e-246 20805
157               VHTAAAYGRT          BARHL2 7.500000e-244 1.990000e-246 19789
158                 STAATTAS           HOXB5 1.900000e-243 5.000000e-246 15786
159             BAAAGRGTTAAN          ZNF652 4.080000e-243 1.070000e-245 17899
160               NBYAATTAVN           MIXL1 1.080000e-242 2.820000e-245 20568
161               RTCGTAAAAH          HOXD11 3.500000e-242 9.070000e-245 13106
162               VVTAATTABS            EVX1 1.070000e-241 2.740000e-244 17075
163               TRATCGATAW            CUX2 3.370000e-241 8.620000e-244 17063
164                 SCAATTAN            Msx3 8.720000e-241 2.220000e-243 16854
165            WWAAMCACTTAAN          Nkx3-2 3.220000e-239 8.150000e-242 19596
166             RGTCGTAAAANT          Hoxa11 1.040000e-235 2.620000e-238 19184
167       NNNTGCTAATTAGCANNN            Lhx1 2.810000e-235 7.020000e-238 19115
168               NCYMATTAVN            GSX1 6.000000e-235 1.490000e-237 15820
169           NNRTTATGCAACHN             HLF 2.430000e-234 5.980000e-237 16171
170                CYATTGTTY            SOX9 1.400000e-231 3.430000e-234 22283
171               VYTAATCCSY             GSC 2.320000e-231 5.660000e-234 21506
172             NDGCAATTAGNN            Dlx2 7.650000e-231 1.850000e-233 21556
173                 YYAATTAV            RAX2 1.370000e-230 3.290000e-233 18237
174             NHTCTTATCTNH           TRPS1 5.230000e-229 1.250000e-231 21829
175               NNCAATAAAW          Hoxd13 6.140000e-228 1.460000e-230 16836
176              NDGTAAACANN           Foxo1 3.350000e-227 7.940000e-230 21652
177               VCYAATTASY            GBX1 4.490000e-227 1.060000e-229 17770
178                AMCGATTAR           VENTX 3.680000e-226 8.630000e-229 15841
179                 CYAATTAR            LHX9 6.480000e-225 1.510000e-227 12863
180                 SCAATTAR            MSX1 5.780000e-224 1.340000e-226 18026
181              DNACAATGGNN            SOX2 4.740000e-223 1.090000e-225 22015
182                   AACMAA          AACMAA 2.300000e-219 5.260000e-222 18458
183                 RTAAACAW           FOXG1 1.120000e-217 2.550000e-220 12824
184                VYCATTAWW          NKX6-3 8.340000e-216 1.890000e-218 14086
185               DCTAATTARM           ARGFX 6.500000e-215 1.460000e-217 12776
186                 VYAATTAR            PDX1 9.710000e-215 2.180000e-217 15840
187             AATTGMTACATT          DMRTC2 1.630000e-213 3.630000e-216 19449
188                 VCMATTAV           BARX1 4.820000e-212 1.070000e-214 17072
189           NRDGTAAACAAGNN           FOXK1 8.240000e-211 1.820000e-213 19507
190                 STAATTAV            LHX5 7.630000e-210 1.670000e-212 12529
191                 SCAATTAV            MSX2 1.130000e-209 2.470000e-212 18253
192        ASAAGCAATTAAWRRAT            Hmx3 1.800000e-209 3.900000e-212 16428
193                 RTAAACAA           Foxj2 2.380000e-209 5.140000e-212 15021
194             NDRGGATTARNN            OTX2 2.470000e-209 5.310000e-212 20471
195             NHTCTTATCTNH           Gata3 1.470000e-208 3.140000e-211 21310
196               NYTAATCCBH            GSC2 1.120000e-206 2.380000e-209 21902
197                 CTAATTAC           HOXD3 1.750000e-205 3.710000e-208 10910
198               GHTAATTRRH           HESX1 2.090000e-205 4.410000e-208 16798
199               GYMATAAAAH           HOXD9 1.020000e-202 2.140000e-205 15139
200               NCYAATTARN            LBX2 2.030000e-202 4.220000e-205 20227
201          ANTGAAACTGAAASH            Irf1 5.560000e-201 1.150000e-203 21317
202                 SYMATTAV           HOXA7 1.020000e-198 2.110000e-201 14825
203                 BTAATKRC           HOXB6 6.930000e-198 1.420000e-200 17723
204               BGYMATTANN           HOXA6 2.330000e-196 4.770000e-199 21482
205                 RTMATTAR           HOXB4 7.310000e-195 1.490000e-197 11886
206               MYTAGTTAMS          HMBOX1 1.390000e-193 2.810000e-196 22269
207            NRTTGCACAAYHN           CEBPD 1.390000e-190 2.790000e-193 18035
208              NNCCATTAGNN            Isl1 5.670000e-188 1.140000e-190 20813
209                 YTAATCCH           PITX1 4.770000e-187 9.520000e-190 14674
210                  GTAAACA           FOXO6 3.360000e-186 6.670000e-189 16765
211          HWYATATACCAYRYW          ZNF211 6.740000e-186 1.330000e-188 13312
212               TAATCGATAM            CUX1 3.090000e-184 6.080000e-187 14532
213           DDATGATGCAATMN            ATF4 3.660000e-184 7.170000e-187 14029
214            RGAAACAGAAASH           Stat2 1.880000e-183 3.660000e-186 21797
215                 CTAATTAV            Lhx8 1.050000e-181 2.040000e-184 14978
216              DNACAATGGNN            Sox3 1.270000e-181 2.450000e-184 19517
217                 RTMATTAV           HOXA4 3.790000e-181 7.280000e-184 17940
218               CCGAACAATG           SOX14 1.080000e-179 2.060000e-182 18429
219                 VSYAATTA             EN2 1.170000e-178 2.230000e-181 15562
220                   ATYAAA          Arid3a 2.290000e-177 4.340000e-180 12739
221              NNCTTTGAWVT            TCF7 2.330000e-177 4.400000e-180 21781
222        CGCRYTAATTARYHNNY            Alx4 4.890000e-176 9.190000e-179 12724
223               RAACAAAGRV            SOX4 8.190000e-176 1.530000e-178 19098
224                 STAATTAS           HOXA2 2.070000e-175 3.850000e-178 10015
225              DVACAATGGNN           SOX13 3.280000e-173 6.080000e-176 19610
226                 VTMATTAN           HOXC4 1.150000e-171 2.120000e-174 14080
227        CGMRYTAATTARTNMNY            Alx1 2.330000e-171 4.280000e-174 11706
228                 GCAMTTAR            ISL2 9.850000e-171 1.800000e-173 21881
229        MATTTRCATMACAATRG    POU2F1::SOX2 1.190000e-169 2.160000e-172  8694
230                 CTAATTAN           PRRX2 1.670000e-169 3.030000e-172 10355
231                 AACAATDV           SOX18 1.250000e-167 2.260000e-170 19364
232                  RTAAACA           FOXP3 3.600000e-167 6.460000e-170 22232
233                 TTAATTAG            LBX1 1.090000e-166 1.940000e-169 13289
234              NDAACAAAGVN           SOX10 1.890000e-166 3.360000e-169 19710
235             NNATGGAAAAWN           Nfat5 7.170000e-165 1.270000e-167 21006
236           NNAGAACAATGGNN           Sox17 6.450000e-164 1.140000e-166 18966
237             NNCCTTATCTNH           GATA4 2.310000e-163 4.060000e-166 19967
238        ASAAGCAATTAAHVVRT            Hmx2 7.770000e-163 1.360000e-165 15196
239              HATTGTTTATW           Foxq1 1.360000e-161 2.380000e-164  9512
240                 SYMATTAR            GSX2 3.850000e-158 6.680000e-161 20102
241               GGYMATAAAA            CDX1 2.030000e-157 3.520000e-160 11251
242           DRASATCAAAGRVA          TCF7L2 7.500000e-156 1.290000e-158 16960
243          GNCCAAGAAGAATDA          ZNF680 1.820000e-152 3.120000e-155 17187
244         RTGCATAATTAATGAG          POU4F2 2.350000e-152 4.020000e-155  5570
245             RGGTGWTAATKD       MGA::EVX1 5.340000e-145 9.090000e-148 18677
246        VSVAGCAATTAAWGVDB            Hmx1 9.150000e-145 1.550000e-147 15575
247                 AMCGTTTA          BARHL1 1.460000e-143 2.470000e-146 19862
248              RGTCGTAAAAH          HOXC12 3.430000e-142 5.770000e-145 10150
249             AWWNTGCTGACD            Mafb 8.450000e-141 1.410000e-143 19960
250              BCTCGTAAAAH          HOXC13 8.530000e-141 1.420000e-143 12504
251                 HTAATCCS            OTX1 6.360000e-140 1.060000e-142 18484
252          RVMAACAGAAACCYM            ZIM3 4.800000e-137 7.930000e-140 16874
253        ANKNCGCTGTWAWDVRW          Rhox11 1.460000e-135 2.410000e-138 19879
254                 BYAATTAR            TLX2 2.850000e-135 4.680000e-138  9648
255           AAAAAATCRATAAH         ONECUT3 8.610000e-133 1.410000e-135  7609
256        VTBCRYTAATTARTKSW             Arx 1.820000e-132 2.970000e-135  9708
257                NYTAATCCC           PITX3 6.550000e-130 1.060000e-132 22227
258               NDGGATTANN             Crx 6.640000e-130 1.070000e-132 18269
259         DRTGACGTCATHNDTN        FOS::JUN 2.810000e-129 4.520000e-132 18942
260               TAATYRATTA            PAX3 6.450000e-129 1.030000e-131  7542
261                 VTMATTAD           HOXD4 7.960000e-126 1.270000e-128  8564
262         NNCTGAAACCTGATMY            SIX2 1.710000e-125 2.720000e-128 20956
263             HCATCAATCAAW            PBX1 1.480000e-124 2.340000e-127 11269
264            NNRTGATGTCAYN           CREB1 1.050000e-123 1.660000e-126 22070
265            YTRATTWAATYAR            DUXA 1.720000e-122 2.710000e-125  5331
266              GWAACCTGAKM            SIX1 2.790000e-120 4.370000e-123 19641
267              YTTCYKGGAAD           STAT3 1.480000e-118 2.310000e-121 16751
268           NNBCCTTTGATSTN            Lef1 2.940000e-116 4.570000e-119 22060
269             AWTTGWTACAWT          DMRTA1 5.540000e-115 8.580000e-118 18279
270             NNCAAAATGGCN             Yy1 9.470000e-114 1.460000e-116 18324
271        WDRWNMGGATTADKNNW           Dmbx1 3.760000e-112 5.780000e-115 13410
272             NNACATTCCARN           TEAD4 1.040000e-109 1.590000e-112 21039
273              AWWTRGGTCAH            RORB 2.060000e-109 3.150000e-112 18547
274            NNATGABGTCATN            ATF2 1.490000e-105 2.260000e-108 16351
275              GRTGACGTMAT      FOSL2::JUN 8.800000e-105 1.330000e-107 17832
276          RWATTCTTGGTTGRC          ZNF136 7.130000e-103 1.080000e-105 13542
277            AAWWNTGCTGACG             NRL 9.710000e-101 1.460000e-103  9042
278              RGTCGTAAAAH          HOXD12  1.090000e-99 1.630000e-102  8811
279              RWGTAAACAVR           FOXP2  3.580000e-99 5.360000e-102  7349
280             BRTTACRTAAYM             TEF  7.540000e-99 1.120000e-101  8024
281               AMCATATGKT           OLIG2  3.500000e-97 5.190000e-100 15276
282              NNCACTCAANN          NKX2-5  6.520000e-97 9.640000e-100 18032
283              ACCGAACAATV           SOX12  7.770000e-97  1.140000e-99 17072
284            WAATTAATTAWYY            Lhx3  9.150000e-96  1.340000e-98  5802
285              GATGACGTCAT       FOSB::JUN  4.110000e-95  6.010000e-98 19344
286             DATGACGTCATH     FOSL2::JUNB  3.300000e-94  4.810000e-97 14380
287               SWGATAASRN           GATA5  2.740000e-93  3.980000e-96 12727
288             AATTGHTACAWT          DMRTA2  9.880000e-93  1.430000e-95 20493
289           BNAASGTAAACAAD           FOXF2  1.870000e-92  2.700000e-95  5409
290               RTCGTWAHNN           HOXA9  9.940000e-92  1.430000e-94 22042
291              NNGAGTTCANN             Vdr  1.620000e-91  2.320000e-94 16995
292          BDBTTCCWSAGAAVY           Stat6  2.590000e-88  3.690000e-91  9183
293               ATTRCGCAAY           CEBPG  9.710000e-88  1.380000e-90  6874
294          NNTGAGTGACAGVNN          PKNOX1  5.090000e-87  7.220000e-90 15879
295            NNACATTCCAGSN           TEAD1  1.670000e-85  2.360000e-88 19480
296         NNRNAATGGAAANWNH          Nfatc2  7.890000e-85  1.110000e-87 21996
297              WAGGTGTGAAR           TBX20  3.840000e-82  5.390000e-85 18660
298       MTTATCWSNNNNNHVCAG     GATA1::TAL1  9.040000e-82  1.260000e-84  8629
299             NRTTACGTAAYV             DBP  4.360000e-81  6.080000e-84  7229
300       NNNDRTCACGTGAYHNNN            MITF  4.440000e-79  6.170000e-82 15458
301           HAAAAGVGGAAGTA            SPIC  2.150000e-78  2.980000e-81 19438
302            VRVAACAATGGNN            Sox5  1.090000e-77  1.500000e-80 21089
303               STVCACTCAC         MSANTD3  2.080000e-76  2.870000e-79 20816
304              NDTTAATTAGN           mix-a  3.170000e-76  4.340000e-79  6122
305          NNRTGACGTCAYHSN     FOSL2::JUND  4.020000e-75  5.500000e-78 17055
306           RTAAACMGGAAGTR     FOXJ2::ELF1  6.780000e-75  9.240000e-78 20271
307           TTCACGCWTSANTK            PAX6  2.310000e-74  3.140000e-77 14193
308               GGTAATTAVS           HOXB7  2.380000e-74  3.230000e-77  8057
309            NVCACTTGARHNN          Nkx2-1  4.380000e-74  5.910000e-77 22483
310           NBCCTTTGATSTBN           Hnf1A  1.100000e-73  1.490000e-76 12655
311              AAATCWCWGCH           Gfi1B  4.530000e-72  6.080000e-75 10809
312               CCWTTGTYYY            Sox6  2.020000e-70  2.700000e-73  5942
313               AMCATATGBY           OLIG3  4.090000e-70  5.440000e-73 15684
314              TAAYYYAATCA            DUX4  2.330000e-69  3.090000e-72  5278
315               ATGACGTCAT      FOSL1::JUN  9.060000e-69  1.200000e-71 19978
316             KRTGACGTCATN       JUN::JUNB  1.450000e-68  1.910000e-71 20101
317               NSCACGTGTN           Npas2  4.560000e-67  5.990000e-70 12271
318          NTGCTGASTCAGCAH             MAF  1.850000e-65  2.430000e-68 10329
319             NVATGGAAAAWN          Nfatc1  2.500000e-64  3.270000e-67 19005
320                  HTGACAD           MEIS1  1.460000e-63  1.900000e-66 21053
321           RTMAACAGGAAGTN     FOXO1::ELF1  4.900000e-63  6.370000e-66 20831
322             NRGAACAAAGVV           Sox11  5.020000e-63  6.500000e-66 17376
323               RTGACGTCAT      FOSB::JUNB  8.900000e-62  1.150000e-64 19308
324             NNAAAGGTCANN           NR4A1  5.290000e-61  6.800000e-64 18066
325              RGTCGTAAAAH          HOXD10  7.920000e-61  1.020000e-63  5598
326        DATRGGGTATCAYNWNT            Six3  1.020000e-60  1.310000e-63 11489
327          VWTCATCAABGTCCT          ZNF214  7.850000e-60  1.000000e-62 18574
328                 TTAATTAM           LMX1A  5.520000e-59  7.020000e-62  5956
329           NDGTCATGTGACHN            USF1  1.250000e-58  1.580000e-61 16704
330          THAGTTTCRKTTTCY    STAT1::STAT2  3.230000e-57  4.080000e-60 11852
331          AAAAAAAAAAAAAAA          ZNF384  5.100000e-57  6.430000e-60  3493
332               RMCATATGBY           Atoh1  5.340000e-57  6.700000e-60 20774
333              BNSAATCCACA           FOXH1  4.490000e-56  5.620000e-59  5485
334             KATTGCGCAATM           CEBPE  5.070000e-56  6.330000e-59  3017
335           HCGAAARYGAAAVT            IRF7  1.930000e-55  2.400000e-58  8144
336               RTGGGGTGAY          SREBF2  1.710000e-53  2.120000e-56  6688
337         DHDGAGATTACWKCAK           ZNF85  1.790000e-53  2.220000e-56 16256
338             NRAACAGGTTYN           GRHL2  1.640000e-52  2.020000e-55 19634
339                RCCACTTAA          Nkx3-1  5.380000e-52  6.610000e-55 20852
340             BMAATCACDGCA            GFI1  8.570000e-52  1.050000e-54  6222
341         NRTRTGAGTTCTCGYN          ZNF274  2.590000e-51  3.160000e-54  6163
342                DTTTRAATH           LIN54  5.320000e-49  6.490000e-52  5514
343               NNCACATGBN            MXI1  1.010000e-48  1.230000e-51 15546
344             NWAWNTRGGTCA            RORC  1.610000e-48  1.950000e-51 21924
345          NNNTTCCCAGAANNN          Stat5b  2.080000e-45  2.510000e-48 18218
346              YNCTTTCTCTH           PRDM1  2.910000e-44  3.510000e-47 21918
347         NDWKCAACAGGTGKNN           SCRT1  1.330000e-42  1.590000e-45 17594
348              RDCCAATCASN            NFYC  2.960000e-42  3.550000e-45 21631
349                RTGAACTTT           NR1I3  5.090000e-42  6.090000e-45 15197
350            NNACAGATGTTNN           Ptf1a  1.320000e-41  1.570000e-44 11910
351          NTGCTGASTCAGCAN            MAFA  5.470000e-40  6.490000e-43  4219
352               GTCGTAAAAH           HOXB9  1.470000e-39  1.750000e-42  2364
353                 NTRATCCN          RHOXF1  2.290000e-39  2.710000e-42 15095
354           DNATCACSTGATNH          SREBF1  2.780000e-38  3.270000e-41 13811
355            NYACATTCCWNNS           TEAD2  2.740000e-37  3.220000e-40 19482
356         ANCTMATTWGCATAWT          POU1F1  1.350000e-35  1.580000e-38  1963
357       DRCATGTCNNRACAYGYM            TP73  1.960000e-35  2.280000e-38  1500
358             NHAACCTCAANN           RUNX3  2.010000e-35  2.340000e-38 18023
359             NTTCCAAGAANH          Stat5a  6.530000e-35  7.590000e-38 19950
360      TGACCTNNAGTRACCYYDN     Nr1h3::Rxra  1.100000e-34  1.280000e-37 18217
361       RACATGYCCGGRCATGTY            TP53  1.340000e-34  1.550000e-37   259
362          DDDRATGABGTCATN            JUND  2.820000e-34  3.250000e-37  4725
363              NAAAGGTCANR           NR2F2  4.350000e-34  4.990000e-37 21712
364         VRRRACAAATGGTNNN           Msgn1  9.290000e-34  1.060000e-36 14760
365             WVACAGCAGAYW          ZNF317  4.580000e-33  5.230000e-36 22721
366              GDAACCTGANH            Six4  1.070000e-32  1.210000e-35 11505
367          AAGTGCTGGGATTAC           PITX1  2.120000e-32  2.410000e-35  1927
368              GGYMATAAAAC            CDX4  5.780000e-32  6.550000e-35  2593
369       RACATGTYGKGACATGTC            TP63  9.000000e-32  1.020000e-34   411
370                 YTAATCCY           PITX2  1.580000e-29  1.780000e-32  1853
371           NNAAACCACAARNN          Bcl11B  2.140000e-29  2.400000e-32 22938
372             KATTGCGCAATM           CEBPB  3.390000e-29  3.800000e-32   473
373             DCTAWAAATAGM           MEF2D  3.990000e-29  4.460000e-32  3499
374               AHCATRTGDT           TFAP4  8.520000e-29  9.500000e-32  6943
375               AMCATATGKT           OLIG1  1.350000e-28  1.500000e-31  6339
376            DDRATGATGTCAT             JUN  4.020000e-28  4.460000e-31  3363
377               GTCGTAAAAH           HOXC9  1.400000e-27  1.550000e-30  1155
378            RAGGTGTGAAAWN           EOMES  1.660000e-27  1.830000e-30 19512
379            11-CTGGGAYTAC           PITX2  1.250000e-26  1.370000e-29  2777
380                 RCATTCCW           TEAD3  1.340000e-26  1.470000e-29 11027
381               TGTACAGTAW          ZBTB32  9.310000e-26  1.020000e-28  4261
382             AAAACCGGTTTD           GRHL1  2.360000e-25  2.570000e-28  6954
383               VTCACCCCAY          SREBF1  2.790000e-25  3.040000e-28  4429
384             AGGTCGTAAAAH          HOXC11  3.990000e-25  4.330000e-28  2337
385              CACTTTGGGAG     CACTTTGGGAG  6.840000e-25  7.400000e-28   325
386              TTTCYRGGAAA           STAT1  7.710000e-25  8.320000e-28 11299
387           YTTCYRGGAARNVR           Stat4  9.740000e-25  1.050000e-27  9193
388          TAGAGAYRGGGTTTC TAGAGAYRGGGTTTC  5.750000e-24  6.180000e-27   460
389           GTAAACAGGAAGTK     FOXO1::FLI1  7.750000e-24  8.300000e-27  3968
390              DTTTCCMAGAA  Stat5a::Stat5b  1.550000e-23  1.660000e-26 10758
391             NATGACGTCAYH           Creb5  1.740000e-22  1.860000e-25  2662
392             AAAGATCAAAGG          TCF7L1  3.780000e-22  4.020000e-25  3601
393             AAACATATGBTN         BHLHE23  4.490000e-22  4.760000e-25  2337
394           AAGAYAAGATAANA           Mecom  6.140000e-21  6.500000e-24  2148
395              MATGTATCAAN           DMRT3  1.930000e-20  2.030000e-23  6941
396               AYAGTAGGTS         ZKSCAN1  3.200000e-20  3.370000e-23 11092
397         NYGCTTTCKAGGAAYN            BCL6  1.630000e-19  1.720000e-22 13462
398       AWNTRGGTYAAAGGTCAN     PPARA::RXRA  3.420000e-19  3.580000e-22 10622
399                  CAAGCTT           Nr2e3  8.600000e-19  8.980000e-22  5154
400           NWWAWBTAGGTCAR            RORA  2.020000e-18  2.100000e-21  1973
401          TGTYRCCCAGGCTGG         ZKSCAN3  2.270000e-18  2.350000e-21   383
402              RRCCAATCAGM            NFYA  1.020000e-17  1.060000e-20 14081
403           NNNCCACTCAANNN          NKX2-2  1.570000e-17  1.630000e-20 17892
404             VNRTGCAATMCC    Ddit3::Cebpa  5.110000e-17  5.280000e-20  9863
405     DTTMRCACMTAGGTGTGAAW           TBX19  4.270000e-16  4.390000e-19  6424
406         YSGTCACGSYWATTAN            PAX3  4.400000e-16  4.520000e-19 12818
407              AWTTTAATTAA           LMX1B  1.470000e-15  1.500000e-18  1693
408           RWMAACAGGAAGTN     FOXO1::ELK3  1.810000e-15  1.850000e-18 12438
409            DNCAAAGTCCANN           HNF4A  2.070000e-15  2.110000e-18 17800
410             RCTAWAAATAGC           MEF2B  2.130000e-15  2.170000e-18  3007
411              NNRAGGTCANN           Nr1H2  2.690000e-15  2.730000e-18 15563
412          14-ACCTCAGCCTCC          ZNF460  2.930000e-15  2.960000e-18   309
413               AGGTGTGAAA            TBR1  3.380000e-15  3.410000e-18 20030
414            NATCCAGATGTKB          ZBTB18  1.230000e-14  1.240000e-17  3938
415    RGGVHYMGGAGGMCAAAATGD          ZNF675  4.090000e-13  4.110000e-16 11036
416           RTAAACAGGAARYN     FLI1::FOXI1  8.140000e-13  8.160000e-16 16737
417           CCAGCCTGGGYRAC         ZKSCAN3  2.850000e-12  2.850000e-15   329
418        NNNTGAGTGACAGGBNN            PBX3  2.990000e-12  2.980000e-15 16266
419         NNWGCAACAGGTGDNN           SCRT2  3.400000e-12  3.380000e-15 16661
420               BGGRNWTTCC             REL  7.780000e-12  7.720000e-15 20818
421            13-ACCACACMCA            KLF9  1.290000e-11  1.280000e-14   478
422          ACCGGAAGTAATTAT      FLI1::DRGX  1.880000e-11  1.860000e-14 13616
423         12-CTCCTGGGCTCAA   CTCCTGGGCTCAA  2.420000e-11  2.390000e-14   197
424        NYCAAGKTCAAGKTCAN           NR6A1  4.410000e-11  4.340000e-14 15736
425            DNCAAAGTCCANN           HNF4G  1.260000e-09  1.240000e-12  8880
426              RVCAGATGGYN           Atoh1  2.920000e-09  2.850000e-12 20991
427               BVTGGGAANN            RBPJ  8.460000e-09  8.260000e-12 19397
428              NNTCGTGACHN           Npas4  1.540000e-08  1.500000e-11  4227
429               BWAAAGGTCA           NR4A2  1.690000e-08  1.640000e-11 13126
430          MDGAGGCTAAAAGCA          ZNF418  1.800000e-08  1.740000e-11  3516
431 AGGRGAYATCACYACMGAYCCCAC          ZNF382  4.240000e-08  4.100000e-11  2156
432         GCCTCMGCCTCCCRAG          ZNF460  4.470000e-08  4.310000e-11   234
433               ACCATATGGT         BHLHA15  4.650000e-08  4.480000e-11  4685
434              BBYTGTGGTTT           Runx1  8.420000e-08  8.090000e-11  2880
435            NNDCCAGATGTBN          TWIST1  9.320000e-08  8.930000e-11 22146
436            TTCTAGAAYRTTC            HSF2  1.130000e-07  1.080000e-10  6727
437             GATGACGTCAYC            JDP2  4.430000e-07  4.220000e-10  2096
438               AWMWAGGTCA            RORA  5.080000e-07  4.830000e-10  5907
439             VVAACAGGAARN           IKZF1  7.160000e-07  6.800000e-10 22001
440              CACCCACACAC            EGR3  8.820000e-07  8.360000e-10   268
441               AAACCGGTTY           TFCP2  1.300000e-06  1.230000e-09 15992
442             TGACAGCTGTCA         TGIF2LY  1.440000e-06  1.350000e-09 18384
443               AAYGGAAAMW          NFATC4  2.190000e-06  2.070000e-09  1878
444        DRVCGGAAGTCGTAAAD    HOXD12::ELK1  8.810000e-06  8.270000e-09   988
445           BGATGACGTCATCR             FOS  8.970000e-06  8.400000e-09  4984
446              TCAAGGTCAWW           ESRRB  1.160000e-05  1.080000e-08  6537
447               GTCACGTGAC            TFE3  1.940000e-05  1.810000e-08  4223
448           AWTATGCAAATKAG          POU2F2  4.590000e-05  4.270000e-08   274
449            TTCTAGAAYRTTC            HSF1  6.300000e-05  5.850000e-08  3311
450           WWATCACGTGATWW          SREBF2  8.430000e-05  7.810000e-08  1558
451              DAGGTGTGAAA            TBX2  9.180000e-05  8.490000e-08 22280
452                 AGGTGTGA           TBX15  1.100000e-04  1.010000e-07  2535
453               NVCAGATGNN           HAND2  1.210000e-04  1.110000e-07  2523
454               TCAAGGTCAH           Esrrg  1.250000e-04  1.150000e-07  8374
455                WAACCGCAA           RUNX2  1.680000e-04  1.540000e-07   244
456               AMCATATGKY         BHLHE22  2.770000e-04  2.530000e-07   654
457          RGGAGGCBGAGGHKG          ZNF460  3.100000e-04  2.830000e-07   196
458           RWMAACAGGAAGTD     FOXO1::ELK1  3.170000e-04  2.880000e-07 13136
459                 AGGTGTGA            TBX1  4.950000e-04  4.500000e-07  1352
460                 AGGTGTKA            TBX5  1.320000e-03  1.190000e-06  3756
461         VSCGGAARYNRTWAAN     ERF::HOXB13  1.480000e-03  1.340000e-06  8277
462             TGACAGSTGTCA           TGIF2  1.700000e-03  1.540000e-06  6690
463             RRTGACGTCAYY            ATF3  2.300000e-03  2.070000e-06   670
464           CCTCGACCTCCYRR          ZNF135  3.150000e-03  2.830000e-06   928
465                 AGGTGTGA             MGA  3.600000e-03  3.230000e-06  1889
466               AWCAGCTGWT           TFAP4  5.850000e-03  5.230000e-06  2230
467            NBTCAAGGTCAHN           ESRRA  6.770000e-03  6.040000e-06  8134
468               RYCACGTGAC            TFEB  8.070000e-03  7.190000e-06  4499
469    TCTGTTACTTGCAGCCAAAWG          ZNF582  8.980000e-03  7.980000e-06  4186
470          AACAATANCATTGTT            Sox1  1.090000e-02  9.660000e-06   662
471                 DTGACAGS           MEIS3  1.200000e-02  1.060000e-05 22507
472               AACARCTGTT            MYF6  1.360000e-02  1.200000e-05  7641
473          NNCTCCAGAAANNNN          ZBTB26  1.630000e-02  1.440000e-05  1002
474               RACATATGTY         NEUROG1  2.300000e-02  2.020000e-05   601
475          AACGAAACCGAAACT            IRF9  2.930000e-02  2.570000e-05    86
476                 AGGTGTGA            TBX4  3.070000e-02  2.680000e-05  2520
477                   MTCCAC         ZNF354C  3.560000e-02  3.110000e-05  1013
      TP.    FP   FP. ENR_RATIO mrc_type
1   50.87 11954 15.60      3.26  LR_open
2   49.92 11540 15.06      3.32  LR_open
3   50.22 11965 15.61      3.22  LR_open
4   52.39 13240 17.28      3.03  LR_open
5   51.59 12807 16.71      3.09  LR_open
6   48.04 10955 14.29      3.36  LR_open
7   53.67 14117 18.42      2.91  LR_open
8   53.64 14175 18.50      2.90  LR_open
9   44.54  9446 12.33      3.61  LR_open
10  50.03 12256 15.99      3.13  LR_open
11  51.67 13176 17.19      3.01  LR_open
12  52.35 13585 17.73      2.95  LR_open
13  47.38 10927 14.26      3.32  LR_open
14  46.39 10446 13.63      3.40  LR_open
15  52.00 13444 17.54      2.96  LR_open
16  53.45 14287 18.64      2.87  LR_open
17  50.80 12819 16.73      3.04  LR_open
18  49.53 12208 15.93      3.11  LR_open
19  52.55 13955 18.21      2.89  LR_open
20  54.98 15420 20.12      2.73  LR_open
21  49.04 12273 16.01      3.06  LR_open
22  49.72 12727 16.61      2.99  LR_open
23  50.43 13114 17.11      2.95  LR_open
24  46.13 10907 14.23      3.24  LR_open
25  43.57  9655 12.60      3.46  LR_open
26  42.67  9298 12.13      3.52  LR_open
27  46.86 12055 15.73      2.98  LR_open
28  40.82  9007 11.75      3.47  LR_open
29  38.93  8416 10.98      3.54  LR_open
30  52.16 19256 25.13      2.08  LR_open
31  44.24 14969 19.53      2.27  LR_open
32  50.49 19693 25.70      1.97  LR_open
33  47.09 19691 25.69      1.83  LR_open
34  77.81 45112 58.86      1.32  LR_open
35  42.04 18134 23.66      1.78  LR_open
36  87.93 55534 72.46      1.21  LR_open
37  76.21 44757 58.40      1.30  LR_open
38  70.68 40224 52.49      1.35  LR_open
39  86.56 54657 71.32      1.21  LR_open
40  76.87 45739 59.68      1.29  LR_open
41  85.70 54198 70.72      1.21  LR_open
42  87.88 56409 73.60      1.19  LR_open
43  81.27 50092 65.36      1.24  LR_open
44  86.74 55579 72.52      1.20  LR_open
45  86.60 55598 72.55      1.19  LR_open
46  79.55 48999 63.93      1.24  LR_open
47  74.55 44690 58.31      1.28  LR_open
48  76.54 46467 60.63      1.26  LR_open
49  91.72 61083 79.70      1.15  LR_open
50  92.42 61894 80.76      1.14  LR_open
51  91.14 60526 78.98      1.15  LR_open
52  92.23 61809 80.65      1.14  LR_open
53  64.79 37027 48.31      1.34  LR_open
54  89.35 58861 76.80      1.16  LR_open
55  93.14 63044 82.26      1.13  LR_open
56  91.11 60864 79.42      1.15  LR_open
57  83.36 53212 69.43      1.20  LR_open
58  90.36 60085 78.40      1.15  LR_open
59  70.48 42005 54.81      1.29  LR_open
60  81.74 51818 67.61      1.21  LR_open
61  95.23 65642 85.65      1.11  LR_open
62  81.63 51812 67.61      1.21  LR_open
63  57.85 32225 42.05      1.38  LR_open
64  83.55 53680 70.04      1.19  LR_open
65  84.49 54615 71.26      1.19  LR_open
66  85.64 55749 72.74      1.18  LR_open
67  73.88 45202 58.98      1.25  LR_open
68  85.95 56139 73.25      1.17  LR_open
69  55.95 31017 40.47      1.38  LR_open
70  94.35 64882 84.66      1.11  LR_open
71  79.24 50016 65.26      1.21  LR_open
72  93.74 64330 83.94      1.12  LR_open
73  80.13 50982 66.52      1.20  LR_open
74  90.99 61390 80.10      1.14  LR_open
75  88.53 58887 76.84      1.15  LR_open
76  77.72 48872 63.77      1.22  LR_open
77  81.00 51820 67.62      1.20  LR_open
78  78.46 49584 64.70      1.21  LR_open
79  90.25 60700 79.20      1.14  LR_open
80  93.39 64048 83.57      1.12  LR_open
81  84.90 55599 72.55      1.17  LR_open
82  78.42 49747 64.91      1.21  LR_open
83  89.36 60012 78.30      1.14  LR_open
84  89.17 59859 78.11      1.14  LR_open
85  70.47 43091 56.23      1.25  LR_open
86  94.42 65448 85.40      1.11  LR_open
87  92.68 63567 82.94      1.12  LR_open
88  81.92 53088 69.27      1.18  LR_open
89  86.94 57779 75.39      1.15  LR_open
90  92.38 63291 82.58      1.12  LR_open
91  68.88 41988 54.79      1.26  LR_open
92  89.99 60902 79.47      1.13  LR_open
93  83.82 54958 71.71      1.17  LR_open
94  83.68 54870 71.60      1.17  LR_open
95  74.06 46393 60.53      1.22  LR_open
96  89.79 60767 79.29      1.13  LR_open
97  91.58 62619 81.71      1.12  LR_open
98  60.52 35505 46.33      1.31  LR_open
99  92.46 63598 82.98      1.11  LR_open
100 73.85 46349 60.48      1.22  LR_open
101 84.00 55352 72.22      1.16  LR_open
102 81.34 53000 69.16      1.18  LR_open
103 87.55 58832 76.77      1.14  LR_open
104 89.89 61133 79.77      1.13  LR_open
105 91.48 62756 81.89      1.12  LR_open
106 79.67 51578 67.30      1.18  LR_open
107 93.78 65220 85.10      1.10  LR_open
108 92.15 63506 82.86      1.11  LR_open
109 69.52 43086 56.22      1.24  LR_open
110 80.07 52060 67.93      1.18  LR_open
111 63.30 38123 49.74      1.27  LR_open
112 82.69 54464 71.07      1.16  LR_open
113 75.76 48369 63.11      1.20  LR_open
114 78.58 50809 66.30      1.19  LR_open
115 75.16 47899 62.50      1.20  LR_open
116 72.38 45566 59.46      1.22  LR_open
117 57.76 33896 44.23      1.31  LR_open
118 80.05 52192 68.10      1.18  LR_open
119 84.94 56674 73.95      1.15  LR_open
120 92.08 63695 83.11      1.11  LR_open
121 87.06 58707 76.60      1.14  LR_open
122 90.64 62220 81.19      1.12  LR_open
123 90.40 61979 80.87      1.12  LR_open
124 57.18 33592 43.83      1.30  LR_open
125 93.80 65554 85.54      1.10  LR_open
126 86.39 58108 75.82      1.14  LR_open
127 67.96 42123 54.96      1.24  LR_open
128 83.53 55478 72.39      1.15  LR_open
129 66.97 41387 54.00      1.24  LR_open
130 87.55 59282 77.35      1.13  LR_open
131 75.60 48559 63.36      1.19  LR_open
132 89.41 61114 79.74      1.12  LR_open
133 95.29 67321 87.84      1.08  LR_open
134 43.34 23574 30.76      1.41  LR_open
135 95.03 67059 87.50      1.09  LR_open
136 95.47 67566 88.16      1.08  LR_open
137 66.51 41132 53.67      1.24  LR_open
138 63.83 39003 50.89      1.25  LR_open
139 89.33 61159 79.80      1.12  LR_open
140 84.04 56154 73.27      1.15  LR_open
141 84.26 56362 73.54      1.15  LR_open
142 96.25 68585 89.49      1.08  LR_open
143 95.34 67535 88.12      1.08  LR_open
144 62.92 38431 50.15      1.25  LR_open
145 92.19 64129 83.68      1.10  LR_open
146 88.35 60309 78.69      1.12  LR_open
147 80.85 53420 69.70      1.16  LR_open
148 62.93 38517 50.26      1.25  LR_open
149 80.77 53420 69.70      1.16  LR_open
150 20.53  8798 11.48      1.79  LR_open
151 81.22 53825 70.23      1.16  LR_open
152 87.88 59962 78.24      1.12  LR_open
153 77.04 50201 65.50      1.18  LR_open
154 70.25 44508 58.07      1.21  LR_open
155 91.47 63530 82.90      1.10  LR_open
156 90.24 62307 81.30      1.11  LR_open
157 85.83 58081 75.79      1.13  LR_open
158 68.47 43092 56.23      1.22  LR_open
159 77.63 50766 66.24      1.17  LR_open
160 89.21 61316 80.01      1.12  LR_open
161 56.84 33959 44.31      1.28  LR_open
162 74.06 47749 62.30      1.19  LR_open
163 74.01 47715 62.26      1.19  LR_open
164 73.10 46963 61.28      1.19  LR_open
165 84.99 57388 74.88      1.14  LR_open
166 83.21 55822 72.84      1.14  LR_open
167 82.91 55560 72.50      1.14  LR_open
168 68.62 43382 56.61      1.21  LR_open
169 70.14 44638 58.24      1.20  LR_open
170 96.65 69369 90.51      1.07  LR_open
171 93.28 65606 85.60      1.09  LR_open
172 93.49 65843 85.91      1.09  LR_open
173 79.10 52278 68.21      1.16  LR_open
174 94.68 67147 87.61      1.08  LR_open
175 73.02 47154 61.53      1.19  LR_open
176 93.91 66341 86.56      1.08  LR_open
177 77.07 50597 66.02      1.17  LR_open
178 68.71 43635 56.94      1.21  LR_open
179 55.79 33501 43.71      1.28  LR_open
180 78.18 51614 67.35      1.16  LR_open
181 95.48 68130 88.90      1.07  LR_open
182 80.06 53334 69.59      1.15  LR_open
183 55.62 33521 43.74      1.27  LR_open
184 61.09 37783 49.30      1.24  LR_open
185 55.41 33420 43.61      1.27  LR_open
186 68.70 43869 57.24      1.20  LR_open
187 84.36 57278 74.74      1.13  LR_open
188 74.05 48336 63.07      1.17  LR_open
189 84.61 57558 75.10      1.13  LR_open
190 54.34 32713 42.68      1.27  LR_open
191 79.17 52752 68.83      1.15  LR_open
192 71.25 46068 60.11      1.19  LR_open
193 65.15 41123 53.66      1.21  LR_open
194 88.79 61481 80.22      1.11  LR_open
195 92.43 65081 84.92      1.09  LR_open
196 94.99 67819 88.49      1.07  LR_open
197 47.32 27571 35.98      1.32  LR_open
198 72.86 47483 61.96      1.18  LR_open
199 65.66 41675 54.38      1.21  LR_open
200 87.73 60602 79.07      1.11  LR_open
201 92.46 65235 85.12      1.09  LR_open
202 64.30 40677 53.08      1.21  LR_open
203 76.87 51019 66.57      1.15  LR_open
204 93.17 66043 86.17      1.08  LR_open
205 51.55 30932 40.36      1.28  LR_open
206 96.59 69803 91.08      1.06  LR_open
207 78.22 52331 68.28      1.15  LR_open
208 90.27 63289 82.58      1.09  LR_open
209 63.65 40418 52.74      1.21  LR_open
210 72.71 47781 62.35      1.17  LR_open
211 57.74 35830 46.75      1.24  LR_open
212 63.03 39995 52.19      1.21  LR_open
213 60.85 38283 49.95      1.22  LR_open
214 94.54 67678 88.31      1.07  LR_open
215 64.96 41587 54.26      1.20  LR_open
216 84.65 58168 75.90      1.12  LR_open
217 77.81 52181 68.09      1.14  LR_open
218 79.93 54038 70.51      1.13  LR_open
219 67.50 43687 57.00      1.18  LR_open
220 55.25 34119 44.52      1.24  LR_open
221 94.47 67700 88.34      1.07  LR_open
222 55.19 34100 44.49      1.24  LR_open
223 82.83 56663 73.93      1.12  LR_open
224 43.44 25376 33.11      1.31  LR_open
225 85.05 58703 76.60      1.11  LR_open
226 61.07 38746 50.56      1.21  LR_open
227 50.77 30871 40.28      1.26  LR_open
228 94.90 68265 89.07      1.07  LR_open
229 37.71 21399 27.92      1.35  LR_open
230 44.91 26579 34.68      1.30  LR_open
231 83.99 57861 75.50      1.11  LR_open
232 96.43 69990 91.32      1.06  LR_open
233 57.64 36199 47.23      1.22  LR_open
234 85.49 59234 77.29      1.11  LR_open
235 91.11 64519 84.19      1.08  LR_open
236 82.26 56412 73.61      1.12  LR_open
237 86.60 60311 78.69      1.10  LR_open
238 65.91 42786 55.83      1.18  LR_open
239 41.26 24104 31.45      1.31  LR_open
240 87.19 60954 79.53      1.10  LR_open
241 48.80 29724 38.78      1.26  LR_open
242 73.56 49183 64.17      1.15  LR_open
243 74.54 50083 65.35      1.14  LR_open
244 24.16 12480 16.28      1.48  LR_open
245 81.01 55745 72.74      1.11  LR_open
246 67.55 44553 58.13      1.16  LR_open
247 86.15 60314 78.70      1.09  LR_open
248 44.02 26566 34.66      1.27  LR_open
249 86.57 60758 79.28      1.09  LR_open
250 54.23 34231 44.67      1.21  LR_open
251 80.17 55143 71.95      1.11  LR_open
252 73.19 49340 64.38      1.14  LR_open
253 86.22 60556 79.01      1.09  LR_open
254 41.85 25147 32.81      1.28  LR_open
255 33.00 18893 24.65      1.34  LR_open
256 42.11 25406 33.15      1.27  LR_open
257 96.40 70526 92.02      1.05  LR_open
258 79.24 54590 71.23      1.11  LR_open
259 82.16 57114 74.52      1.10  LR_open
260 32.71 18778 24.50      1.34  LR_open
261 37.14 21989 28.69      1.29  LR_open
262 90.89 65072 84.91      1.07  LR_open
263 48.88 30613 39.94      1.22  LR_open
264 95.72 69895 91.20      1.05  LR_open
265 23.12 12359 16.13      1.43  LR_open
266 85.19 59986 78.27      1.09  LR_open
267 72.65 49390 64.44      1.13  LR_open
268 95.68 69975 91.30      1.05  LR_open
269 79.28 55009 71.78      1.10  LR_open
270 79.48 55207 72.04      1.10  LR_open
271 58.16 38036 49.63      1.17  LR_open
272 91.25 65741 85.78      1.06  LR_open
273 80.44 56144 73.26      1.10  LR_open
274 70.92 48342 63.08      1.12  LR_open
275 77.34 53654 70.01      1.10  LR_open
276 58.74 38756 50.57      1.16  LR_open
277 39.22 24144 31.50      1.24  LR_open
278 38.22 23446 30.59      1.25  LR_open
279 31.87 18918 24.68      1.29  LR_open
280 34.80 21010 27.41      1.27  LR_open
281 66.26 44845 58.51      1.13  LR_open
282 78.21 54603 71.25      1.10  LR_open
283 74.05 51153 66.75      1.11  LR_open
284 25.16 14326 18.69      1.35  LR_open
285 83.90 59494 77.63      1.08  LR_open
286 62.37 41864 54.62      1.14  LR_open
287 55.20 36325 47.40      1.16  LR_open
288 88.88 63951 83.44      1.07  LR_open
289 23.46 13239 17.27      1.36  LR_open
290 95.60 70331 91.77      1.04  LR_open
291 73.71 51040 66.60      1.11  LR_open
292 39.83 24954 32.56      1.22  LR_open
293 29.81 17769 23.19      1.29  LR_open
294 68.87 47258 61.66      1.12  LR_open
295 84.49 60267 78.64      1.07  LR_open
296 95.40 70261 91.68      1.04  LR_open
297 80.93 57327 74.80      1.08  LR_open
298 37.43 23401 30.53      1.23  LR_open
299 31.35 19048 24.85      1.26  LR_open
300 67.05 46061 60.10      1.12  LR_open
301 84.31 60312 78.70      1.07  LR_open
302 91.47 66668 86.99      1.05  LR_open
303 90.28 65622 85.62      1.05  LR_open
304 26.55 15795 20.61      1.29  LR_open
305 73.97 51778 67.56      1.09  LR_open
306 87.92 63554 82.93      1.06  LR_open
307 61.56 41893 54.66      1.13  LR_open
308 34.95 21833 28.49      1.23  LR_open
309 97.51 72639 94.78      1.03  LR_open
310 54.89 36745 47.95      1.14  LR_open
311 46.88 30720 40.08      1.17  LR_open
312 25.77 15413 20.11      1.28  LR_open
313 68.03 47156 61.53      1.11  LR_open
314 22.89 13437 17.53      1.31  LR_open
315 86.65 62616 81.70      1.06  LR_open
316 87.18 63086 82.32      1.06  LR_open
317 53.22 35710 46.60      1.14  LR_open
318 44.80 29397 38.36      1.17  LR_open
319 82.43 59146 77.17      1.07  LR_open
320 91.31 66883 87.27      1.05  LR_open
321 90.35 66033 86.16      1.05  LR_open
322 75.36 53334 69.59      1.08  LR_open
323 83.74 60340 78.73      1.06  LR_open
324 78.36 55863 72.89      1.07  LR_open
325 24.28 14651 19.12      1.27  LR_open
326 49.83 33368 43.54      1.14  LR_open
327 80.56 57731 75.33      1.07  LR_open
328 25.83 15802 20.62      1.25  LR_open
329 72.45 51131 66.72      1.09  LR_open
330 51.41 34704 45.28      1.14  LR_open
331 15.15  8488 11.08      1.37  LR_open
332 90.10 65983 86.10      1.05  LR_open
333 23.79 14454 18.86      1.26  LR_open
334 13.09  7141  9.32      1.40  LR_open
335 35.32 22757 29.69      1.19  LR_open
336 29.01 18249 23.81      1.22  LR_open
337 70.51 49771 64.94      1.09  LR_open
338 85.16 61847 80.70      1.06  LR_open
339 90.44 66428 86.68      1.04  LR_open
340 26.99 16861 22.00      1.23  LR_open
341 26.73 16695 21.78      1.23  LR_open
342 23.92 14774 19.28      1.24  LR_open
343 67.43 47515 62.00      1.09  LR_open
344 95.09 70739 92.30      1.03  LR_open
345 79.02 56991 74.36      1.06  LR_open
346 95.06 70820 92.41      1.03  LR_open
347 76.31 54899 71.63      1.07  LR_open
348 93.82 69729 90.98      1.03  LR_open
349 65.91 46616 60.83      1.08  LR_open
350 51.66 35574 46.42      1.11  LR_open
351 18.30 11132 14.53      1.26  LR_open
352 10.25  5668  7.40      1.39  LR_open
353 65.47 46392 60.53      1.08  LR_open
354 59.90 42089 54.92      1.09  LR_open
355 84.50 61851 80.70      1.05  LR_open
356  8.51  4623  6.03      1.41  LR_open
357  6.51  3336  4.35      1.50  LR_open
358 78.17 56725 74.02      1.06  LR_open
359 86.53 63645 83.05      1.04  LR_open
360 79.01 57443 74.95      1.05  LR_open
361  1.12   276  0.36      3.12  LR_open
362 20.49 12880 16.81      1.22  LR_open
363 94.17 70280 91.70      1.03  LR_open
364 64.02 45529 59.41      1.08  LR_open
365 98.55 74463 97.16      1.01  LR_open
366 49.90 34677 45.25      1.10  LR_open
367  8.36  4598  6.00      1.39  LR_open
368 11.25  6536  8.53      1.32  LR_open
369  1.78   609  0.79      2.25  LR_open
370  8.04  4459  5.82      1.38  LR_open
371 99.49 75572 98.61      1.01  LR_open
372  2.05   775  1.01      2.03  LR_open
373 15.18  9331 12.18      1.25  LR_open
374 30.11 20070 26.19      1.15  LR_open
375 27.49 18163 23.70      1.16  LR_open
376 14.59  8956 11.69      1.25  LR_open
377  5.01  2551  3.33      1.51  LR_open
378 84.63 62375 81.39      1.04  LR_open
379 12.04  7248  9.46      1.27  LR_open
380 47.83 33436 43.63      1.10  LR_open
381 18.48 11793 15.39      1.20  LR_open
382 30.16 20280 26.46      1.14  LR_open
383 19.21 12333 16.09      1.19  LR_open
384 10.14  5991  7.82      1.30  LR_open
385  1.41   481  0.63      2.25  LR_open
386 49.01 34438 44.94      1.09  LR_open
387 39.87 27535 35.93      1.11  LR_open
388  2.00   803  1.05      1.91  LR_open
389 17.21 10971 14.32      1.20  LR_open
390 46.66 32732 42.71      1.09  LR_open
391 11.55  7048  9.20      1.26  LR_open
392 15.62  9914 12.94      1.21  LR_open
393 10.14  6091  7.95      1.28  LR_open
394  9.32  5568  7.27      1.28  LR_open
395 30.10 20510 26.76      1.12  LR_open
396 48.11 34045 44.42      1.08  LR_open
397 58.39 41983 54.78      1.07  LR_open
398 46.07 32563 42.49      1.08  LR_open
399 22.35 14916 19.46      1.15  LR_open
400  8.56  5134  6.70      1.28  LR_open
401  1.66   685  0.89      1.86  LR_open
402 61.07 44187 57.66      1.06  LR_open
403 77.60 57206 74.64      1.04  LR_open
404 42.78 30217 39.43      1.09  LR_open
405 27.86 19117 24.94      1.12  LR_open
406 55.60 40070 52.28      1.06  LR_open
407  7.34  4402  5.74      1.28  LR_open
408 53.95 38848 50.69      1.06  LR_open
409 77.20 57024 74.41      1.04  LR_open
410 13.04  8387 10.94      1.19  LR_open
411 67.50 49372 64.42      1.05  LR_open
412  1.34   544  0.71      1.89  LR_open
413 86.88 64837 84.60      1.03  LR_open
414 17.08 11318 14.77      1.16  LR_open
415 47.87 34377 44.86      1.07  LR_open
416 72.59 53556 69.88      1.04  LR_open
417  1.43   633  0.83      1.73  LR_open
418 70.55 51993 67.84      1.04  LR_open
419 72.26 53344 69.60      1.04  LR_open
420 90.29 67831 88.51      1.02  LR_open
421  2.07  1033  1.35      1.54  LR_open
422 59.06 43109 56.25      1.05  LR_open
423  0.85   323  0.42      2.03  LR_open
424 68.25 50287 65.62      1.04  LR_open
425 38.51 27575 35.98      1.07  LR_open
426 91.04 68595 89.50      1.02  LR_open
427 84.13 63024 82.23      1.02  LR_open
428 18.33 12610 16.45      1.11  LR_open
429 56.93 41739 54.46      1.05  LR_open
430 15.25 10359 13.52      1.13  LR_open
431  9.35  6124  7.99      1.17  LR_open
432  1.01   454  0.59      1.72  LR_open
433 20.32 14108 18.41      1.10  LR_open
434 12.49  8399 10.96      1.14  LR_open
435 96.05 72852 95.06      1.01  LR_open
436 29.18 20727 27.04      1.08  LR_open
437  9.09  5994  7.82      1.16  LR_open
438 25.62 18128 23.65      1.08  LR_open
439 95.42 72362 94.42      1.01  LR_open
440  1.16   563  0.73      1.59  LR_open
441 69.36 51565 67.28      1.03  LR_open
442 79.74 59712 77.91      1.02  LR_open
443  8.15  5357  6.99      1.17  LR_open
444  4.29  2665  3.48      1.23  LR_open
445 21.62 15260 19.91      1.09  LR_open
446 28.35 20302 26.49      1.07  LR_open
447 18.32 12842 16.76      1.09  LR_open
448  1.19   612  0.80      1.49  LR_open
449 14.36  9968 13.01      1.10  LR_open
450  6.76  4455  5.81      1.16  LR_open
451 96.63 73486 95.89      1.01  LR_open
452 10.99  7523  9.82      1.12  LR_open
453 10.94  7488  9.77      1.12  LR_open
454 36.32 26423 34.48      1.05  LR_open
455  1.06   542  0.71      1.50  LR_open
456  2.84  1726  2.25      1.26  LR_open
457  0.85   418  0.55      1.56  LR_open
458 56.97 42247 55.12      1.03  LR_open
459  5.86  3861  5.04      1.16  LR_open
460 16.29 11510 15.02      1.08  LR_open
461 35.90 26237 34.23      1.05  LR_open
462 29.02 21042 27.46      1.06  LR_open
463  2.91  1810  2.36      1.23  LR_open
464  4.02  2599  3.39      1.19  LR_open
465  8.19  5595  7.30      1.12  LR_open
466  9.67  6690  8.73      1.11  LR_open
467 35.28 25855 33.74      1.05  LR_open
468 19.51 13991 18.26      1.07  LR_open
469 18.16 12983 16.94      1.07  LR_open
470  2.87  1815  2.37      1.21  LR_open
471 97.62 74422 97.11      1.01  LR_open
472 33.14 24277 31.68      1.05  LR_open
473  4.35  2865  3.74      1.16  LR_open
474  2.61  1645  2.15      1.22  LR_open
475  0.37   164  0.21      1.75  LR_open
476 10.93  7677 10.02      1.09  LR_open
477  4.39  2919  3.81      1.15  LR_open

Session information

sessionInfo()

R version 4.4.2 (2024-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64
Running under: Windows 11 x64 (build 26100)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
 [1] motifmatchr_1.28.0                      
 [2] ggseqlogo_0.2                           
 [3] universalmotif_1.24.2                   
 [4] data.table_1.17.0                       
 [5] BSgenome.Hsapiens.UCSC.hg38_1.4.5       
 [6] BSgenome_1.74.0                         
 [7] BiocIO_1.16.0                           
 [8] MotifDb_1.48.0                          
 [9] Biostrings_2.74.1                       
[10] XVector_0.46.0                          
[11] TFBSTools_1.44.0                        
[12] JASPAR2022_0.99.8                       
[13] BiocFileCache_2.14.0                    
[14] dbplyr_2.5.0                            
[15] devtools_2.4.5                          
[16] usethis_3.1.0                           
[17] ggpubr_0.6.0                            
[18] BiocParallel_1.40.0                     
[19] Cormotif_1.52.0                         
[20] affy_1.84.0                             
[21] scales_1.3.0                            
[22] VennDiagram_1.7.3                       
[23] futile.logger_1.4.3                     
[24] gridExtra_2.3                           
[25] ggfortify_0.4.17                        
[26] edgeR_4.4.2                             
[27] limma_3.62.2                            
[28] rtracklayer_1.66.0                      
[29] org.Hs.eg.db_3.20.0                     
[30] TxDb.Hsapiens.UCSC.hg38.knownGene_3.20.0
[31] GenomicFeatures_1.58.0                  
[32] AnnotationDbi_1.68.0                    
[33] Biobase_2.66.0                          
[34] GenomicRanges_1.58.0                    
[35] GenomeInfoDb_1.42.3                     
[36] IRanges_2.40.1                          
[37] S4Vectors_0.44.0                        
[38] BiocGenerics_0.52.0                     
[39] ChIPseeker_1.42.1                       
[40] RColorBrewer_1.1-3                      
[41] broom_1.0.7                             
[42] kableExtra_1.4.0                        
[43] cowplot_1.1.3                           
[44] lubridate_1.9.4                         
[45] forcats_1.0.0                           
[46] stringr_1.5.1                           
[47] dplyr_1.1.4                             
[48] purrr_1.0.4                             
[49] readr_2.1.5                             
[50] tidyr_1.3.1                             
[51] tibble_3.2.1                            
[52] ggplot2_3.5.1                           
[53] tidyverse_2.0.0                         
[54] workflowr_1.7.1                         

loaded via a namespace (and not attached):
  [1] fs_1.6.5                               
  [2] matrixStats_1.5.0                      
  [3] bitops_1.0-9                           
  [4] DirichletMultinomial_1.48.0            
  [5] enrichplot_1.26.6                      
  [6] httr_1.4.7                             
  [7] profvis_0.4.0                          
  [8] tools_4.4.2                            
  [9] backports_1.5.0                        
 [10] utf8_1.2.4                             
 [11] R6_2.6.1                               
 [12] lazyeval_0.2.2                         
 [13] urlchecker_1.0.1                       
 [14] withr_3.0.2                            
 [15] preprocessCore_1.68.0                  
 [16] cli_3.6.4                              
 [17] formatR_1.14                           
 [18] labeling_0.4.3                         
 [19] sass_0.4.9                             
 [20] Rsamtools_2.22.0                       
 [21] systemfonts_1.2.1                      
 [22] yulab.utils_0.2.0                      
 [23] DOSE_4.0.0                             
 [24] svglite_2.1.3                          
 [25] R.utils_2.13.0                         
 [26] sessioninfo_1.2.3                      
 [27] plotrix_3.8-4                          
 [28] rstudioapi_0.17.1                      
 [29] RSQLite_2.3.9                          
 [30] generics_0.1.3                         
 [31] gridGraphics_0.5-1                     
 [32] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
 [33] gtools_3.9.5                           
 [34] car_3.1-3                              
 [35] GO.db_3.20.0                           
 [36] Matrix_1.7-3                           
 [37] abind_1.4-8                            
 [38] R.methodsS3_1.8.2                      
 [39] lifecycle_1.0.4                        
 [40] whisker_0.4.1                          
 [41] yaml_2.3.10                            
 [42] carData_3.0-5                          
 [43] SummarizedExperiment_1.36.0            
 [44] gplots_3.2.0                           
 [45] qvalue_2.38.0                          
 [46] SparseArray_1.6.2                      
 [47] blob_1.2.4                             
 [48] promises_1.3.2                         
 [49] pwalign_1.2.0                          
 [50] crayon_1.5.3                           
 [51] miniUI_0.1.1.1                         
 [52] ggtangle_0.0.6                         
 [53] lattice_0.22-6                         
 [54] annotate_1.84.0                        
 [55] KEGGREST_1.46.0                        
 [56] pillar_1.10.1                          
 [57] knitr_1.49                             
 [58] fgsea_1.32.2                           
 [59] rjson_0.2.23                           
 [60] boot_1.3-31                            
 [61] codetools_0.2-20                       
 [62] fastmatch_1.1-6                        
 [63] glue_1.8.0                             
 [64] getPass_0.2-4                          
 [65] ggfun_0.1.8                            
 [66] remotes_2.5.0                          
 [67] vctrs_0.6.5                            
 [68] png_0.1-8                              
 [69] treeio_1.30.0                          
 [70] poweRlaw_1.0.0                         
 [71] gtable_0.3.6                           
 [72] cachem_1.1.0                           
 [73] xfun_0.51                              
 [74] S4Arrays_1.6.0                         
 [75] mime_0.12                              
 [76] statmod_1.5.0                          
 [77] ellipsis_0.3.2                         
 [78] nlme_3.1-167                           
 [79] ggtree_3.14.0                          
 [80] bit64_4.6.0-1                          
 [81] filelock_1.0.3                         
 [82] rprojroot_2.0.4                        
 [83] bslib_0.9.0                            
 [84] affyio_1.76.0                          
 [85] KernSmooth_2.23-26                     
 [86] splitstackshape_1.4.8                  
 [87] seqLogo_1.72.0                         
 [88] colorspace_2.1-1                       
 [89] DBI_1.2.3                              
 [90] tidyselect_1.2.1                       
 [91] processx_3.8.6                         
 [92] bit_4.6.0                              
 [93] compiler_4.4.2                         
 [94] curl_6.2.1                             
 [95] git2r_0.35.0                           
 [96] xml2_1.3.7                             
 [97] DelayedArray_0.32.0                    
 [98] caTools_1.18.3                         
 [99] callr_3.7.6                            
[100] digest_0.6.37                          
[101] rmarkdown_2.29                         
[102] htmltools_0.5.8.1                      
[103] pkgconfig_2.0.3                        
[104] MatrixGenerics_1.18.1                  
[105] fastmap_1.2.0                          
[106] rlang_1.1.5                            
[107] htmlwidgets_1.6.4                      
[108] UCSC.utils_1.2.0                       
[109] shiny_1.10.0                           
[110] farver_2.1.2                           
[111] jquerylib_0.1.4                        
[112] jsonlite_1.9.1                         
[113] GOSemSim_2.32.0                        
[114] R.oo_1.27.0                            
[115] RCurl_1.98-1.16                        
[116] magrittr_2.0.3                         
[117] Formula_1.2-5                          
[118] GenomeInfoDbData_1.2.13                
[119] ggplotify_0.1.2                        
[120] patchwork_1.3.0                        
[121] munsell_0.5.1                          
[122] Rcpp_1.0.14                            
[123] ape_5.8-1                              
[124] stringi_1.8.4                          
[125] MASS_7.3-65                            
[126] zlibbioc_1.52.0                        
[127] plyr_1.8.9                             
[128] pkgbuild_1.4.6                         
[129] parallel_4.4.2                         
[130] ggrepel_0.9.6                          
[131] CNEr_1.42.0                            
[132] splines_4.4.2                          
[133] hms_1.1.3                              
[134] locfit_1.5-9.12                        
[135] ps_1.9.0                               
[136] igraph_2.1.4                           
[137] ggsignif_0.6.4                         
[138] reshape2_1.4.4                         
[139] pkgload_1.4.0                          
[140] TFMPvalue_0.0.9                        
[141] futile.options_1.0.1                   
[142] XML_3.99-0.18                          
[143] evaluate_1.0.3                         
[144] lambda.r_1.2.4                         
[145] BiocManager_1.30.25                    
[146] tzdb_0.4.0                             
[147] httpuv_1.6.15                          
[148] xtable_1.8-4                           
[149] restfulr_0.0.15                        
[150] tidytree_0.4.6                         
[151] rstatix_0.7.2                          
[152] later_1.4.1                            
[153] viridisLite_0.4.2                      
[154] aplot_0.2.5                            
[155] memoise_2.0.1                          
[156] GenomicAlignments_1.42.0               
[157] timechange_0.3.0